GREMLIN Database
GUAAB - GMP synthase [glutamine-hydrolyzing] subunit B
UniProt: Q9HP33 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (303)
Sequences: 2153 (768)
Seq/√Len: 44.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_K211_E5.0301.00
85_R113_T4.3261.00
114_V117_E3.5161.00
206_V210_R3.2551.00
226_W260_G3.1071.00
174_R180_E3.0311.00
15_I19_L2.9181.00
22_E121_T2.9151.00
174_R184_E2.9111.00
105_E109_R2.8891.00
257_S260_G2.8821.00
186_M228_A2.8291.00
37_A124_V2.7521.00
41_A124_V2.7371.00
216_V252_V2.7001.00
226_W257_S2.6631.00
25_I120_A2.6411.00
83_S203_P2.5801.00
295_T300_A2.5441.00
250_V287_V2.5351.00
279_R283_T2.4761.00
272_T276_L2.3981.00
268_L272_T2.3541.00
39_A178_L2.3321.00
13_A17_E2.2941.00
55_D79_V2.2771.00
53_Y59_M2.2741.00
245_V288_S2.2131.00
68_R79_V2.1811.00
89_E106_Q2.1801.00
53_Y64_T2.1731.00
68_R77_L2.1351.00
256_E266_Q2.0980.99
64_T79_V2.0810.99
132_R162_R2.0230.99
184_E223_Y1.9250.99
8_V172_V1.9250.99
93_V102_A1.9150.99
11_A14_E1.9110.99
207_A210_R1.8840.99
59_M64_T1.8820.99
281_A295_T1.8540.99
22_E122_Q1.8520.99
216_V276_L1.8490.99
62_G65_D1.8350.99
26_I124_V1.8300.99
84_D88_D1.7870.98
219_E279_R1.7580.98
25_I52_V1.7570.98
87_F206_V1.7550.98
85_R106_Q1.7340.98
225_P266_Q1.7000.98
109_R112_E1.6920.98
231_A304_Y1.6740.97
24_A124_V1.6400.97
274_Q278_S1.6380.97
240_K245_V1.6330.97
216_V230_A1.6290.97
65_D79_V1.5930.96
69_E73_Y1.5900.96
37_A41_A1.5780.96
251_A291_V1.5680.96
214_H218_D1.5620.96
203_P207_A1.5540.96
267_E274_Q1.5300.96
219_E222_A1.5050.95
240_K281_A1.4980.95
4_V172_V1.4890.95
225_P268_L1.4880.95
62_G66_E1.4730.95
202_T205_K1.4630.94
23_T48_Q1.4500.94
171_E174_R1.4490.94
35_S178_L1.4490.94
61_K214_H1.4410.94
41_A158_V1.4290.94
205_K248_H1.4290.94
265_A270_W1.4210.93
85_R89_E1.3740.92
64_T68_R1.3620.92
26_I41_A1.3580.92
240_K288_S1.3510.92
181_I221_E1.3390.91
212_A230_A1.3340.91
254_S266_Q1.3320.91
217_E228_A1.3320.91
91_A200_E1.3150.90
233_L251_A1.3130.90
7_F172_V1.3130.90
5_D175_H1.3040.90
180_E223_Y1.2850.89
18_A155_E1.2840.89
186_M217_E1.2820.89
89_E105_E1.2820.89
84_D203_P1.2790.89
55_D83_S1.2750.89
103_I194_A1.2600.88
50_V78_R1.2570.88
249_V291_V1.2570.88
18_A158_V1.2500.88
23_T50_V1.2490.88
106_Q110_E1.2490.88
36_T173_A1.2460.88
66_E181_I1.2430.88
218_D222_A1.2330.87
208_V287_V1.2330.87
106_Q109_R1.2310.87
252_V276_L1.2280.87
247_G286_E1.2250.87
219_E283_T1.2150.86
186_M220_L1.2140.86
87_F203_P1.2060.86
94_T200_E1.1990.86
264_R296_H1.1810.85
219_E275_R1.1810.85
255_V302_I1.1780.85
197_V210_R1.1690.84
55_D68_R1.1630.84
68_R72_D1.1610.84
121_T155_E1.1470.83
203_P206_V1.1450.83
112_E153_G1.1410.83
152_V157_I1.1390.83
8_V12_R1.1310.82
98_E102_A1.1290.82
291_V304_Y1.1260.82
14_E18_A1.1050.81
65_D69_E1.1040.81
35_S71_F1.0980.80
23_T119_D1.0870.80
220_L228_A1.0840.79
22_E48_Q1.0790.79
208_V248_H1.0770.79
80_V114_V1.0720.79
139_I242_D1.0700.79
78_R117_E1.0610.78
28_L71_F1.0540.77
218_D279_R1.0450.77
197_V206_V1.0450.77
273_L294_V1.0430.77
12_R44_A1.0340.76
220_L225_P1.0230.75
21_D48_Q1.0180.75
71_F77_L1.0150.75
265_A277_Q1.0130.75
124_V158_V1.0090.74
19_L158_V1.0060.74
230_A287_V1.0060.74
92_G200_E1.0000.74
28_L51_P0.9970.73
267_E271_E0.9930.73
236_A249_V0.9900.73
56_T106_Q0.9880.73
32_V173_A0.9870.73
224_E256_E0.9850.72
174_R183_S0.9760.72
39_A75_D0.9760.72
207_A211_E0.9710.71
230_A250_V0.9710.71
112_E152_V0.9700.71
136_E163_D0.9690.71
28_L77_L0.9670.71
26_I38_A0.9640.71
247_G281_A0.9610.71
173_A183_S0.9590.70
129_Y132_R0.9580.70
52_V114_V0.9580.70
26_I51_P0.9570.70
59_M67_I0.9560.70
13_A16_S0.9500.70
247_G285_D0.9440.69
256_E264_R0.9400.69
225_P254_S0.9390.69
130_P162_R0.9340.68
216_V254_S0.9340.68
45_V49_L0.9330.68
52_V120_A0.9310.68
82_A110_E0.9300.68
98_E105_E0.9260.68
174_R223_Y0.9250.68
70_V182_I0.9180.67
208_V286_E0.9010.66
26_I128_I0.8920.65
52_V80_V0.8870.64
58_L194_A0.8870.64
249_V304_Y0.8870.64
53_Y67_I0.8780.64
198_I247_G0.8710.63
16_S48_Q0.8710.63
7_F11_A0.8700.63
289_R293_D0.8620.62
150_E153_G0.8610.62
233_L249_V0.8600.62
9_E13_A0.8590.62
4_V7_F0.8580.62
27_A108_I0.8560.62
109_R151_R0.8520.61
277_Q295_T0.8520.61
58_L87_F0.8460.61
293_D305_E0.8430.60
151_R154_F0.8430.60
205_K232_V0.8420.60
213_T217_E0.8410.60
217_E221_E0.8370.60
15_I41_A0.8350.60
5_D10_D0.8330.59
235_R247_G0.8310.59
122_Q155_E0.8300.59
146_G149_P0.8290.59
89_E102_A0.8090.57
11_A15_I0.8050.57
8_V175_H0.8040.57
54_V110_E0.8030.57
58_L195_V0.8010.56
197_V201_V0.7930.56
55_D64_T0.7930.56
6_S9_E0.7910.56
186_M266_Q0.7860.55
83_S207_A0.7850.55
64_T81_D0.7850.55
83_S87_F0.7780.54
223_Y228_A0.7750.54
15_I158_V0.7750.54
19_L48_Q0.7720.54
139_I241_G0.7700.54
112_E151_R0.7690.53
78_R118_V0.7680.53
24_A41_A0.7630.53
63_E185_R0.7600.53
222_A275_R0.7570.52
51_P71_F0.7540.52
11_A172_V0.7520.52
58_L90_L0.7460.51
240_K247_G0.7430.51
56_T87_F0.7420.51
145_V148_L0.7410.51
239_V242_D0.7390.51
37_A161_M0.7370.50
6_S175_H0.7340.50
23_T120_A0.7300.50
3_D6_S0.7290.50
275_R279_R0.7280.49
88_D91_A0.7270.49
108_I146_G0.7260.49
274_Q277_Q0.7220.49
91_A203_P0.7170.48
135_S142_H0.7160.48
95_D98_E0.7150.48
128_I137_G0.7130.48
66_E214_H0.7090.48
254_S268_L0.7070.47
186_M223_Y0.7070.47
54_V80_V0.7060.47
218_D283_T0.7060.47
18_A122_Q0.7060.47
137_G195_V0.7030.47
198_I236_A0.7010.47
8_V43_E0.7000.47
275_R283_T0.6980.47
116_E153_G0.6920.46
221_E228_A0.6920.46
8_V15_I0.6900.46
278_S282_G0.6900.46
180_E184_E0.6860.45
93_V98_E0.6830.45
2_V129_Y0.6830.45
249_V300_A0.6800.45
236_A289_R0.6760.44
71_F173_A0.6740.44
225_P252_V0.6710.44
101_H141_S0.6690.44
294_V304_Y0.6690.44
73_Y181_I0.6680.44
211_E214_H0.6650.43
56_T234_G0.6640.43
205_K234_G0.6630.43
87_F210_R0.6630.43
209_C212_A0.6610.43
225_P256_E0.6580.43
62_G214_H0.6570.43
10_D14_E0.6560.43
128_I264_R0.6560.43
70_V75_D0.6560.43
24_A45_V0.6560.43
39_A48_Q0.6560.43
212_A250_V0.6550.42
273_L292_Y0.6530.42
151_R157_I0.6530.42
32_V35_S0.6520.42
252_V272_T0.6510.42
130_P137_G0.6490.42
277_Q294_V0.6490.42
85_R109_R0.6490.42
52_V115_A0.6490.42
264_R267_E0.6440.41
108_I148_L0.6430.41
161_M172_V0.6430.41
14_E17_E0.6410.41
109_R150_E0.6400.41
255_V263_A0.6390.41
15_I157_I0.6390.41
28_L49_L0.6390.41
49_L71_F0.6380.41
104_G142_H0.6380.41
74_M182_I0.6370.41
141_S260_G0.6360.41
85_R110_E0.6350.41
236_A288_S0.6340.41
110_E113_T0.6320.40
236_A251_A0.6320.40
27_A124_V0.6280.40
26_I49_L0.6260.40
132_R165_Y0.6240.40
23_T76_S0.6230.40
7_F164_L0.6210.39
216_V272_T0.6190.39
183_S186_M0.6170.39
62_G76_S0.6160.39
128_I260_G0.6150.39
242_D282_G0.6150.39
4_V175_H0.6140.39
55_D161_M0.6100.38
167_D242_D0.6090.38
27_A112_E0.6050.38
5_D278_S0.6050.38
272_T275_R0.6040.38
257_S264_R0.6030.38
249_V288_S0.6020.38
216_V228_A0.6020.38
209_C270_W0.6010.37
62_G77_L0.5990.37
233_L289_R0.5970.37
50_V76_S0.5970.37
172_V278_S0.5960.37
113_T117_E0.5930.37
147_G162_R0.5930.37
267_E270_W0.5920.37
265_A294_V0.5910.37
27_A76_S0.5900.37
104_G135_S0.5870.36
236_A304_Y0.5860.36
235_R248_H0.5840.36
209_C231_A0.5840.36
9_E43_E0.5830.36
128_I296_H0.5830.36
238_G244_R0.5830.36
241_G282_G0.5810.36
209_C304_Y0.5790.36
56_T136_E0.5790.36
115_A120_A0.5780.35
42_Y47_D0.5780.35
2_V7_F0.5770.35
71_F75_D0.5760.35
165_Y232_V0.5760.35
9_E21_D0.5720.35
234_G247_G0.5710.35
249_V260_G0.5710.35
278_S296_H0.5710.35
186_M225_P0.5650.34
146_G157_I0.5650.34
289_R305_E0.5640.34
230_A292_Y0.5630.34
51_P75_D0.5630.34
195_V256_E0.5620.34
277_Q281_A0.5620.34
108_I112_E0.5620.34
266_Q269_E0.5610.34
234_G249_V0.5590.34
103_I173_A0.5590.34
202_T232_V0.5580.34
128_I161_M0.5570.34
76_S172_V0.5570.34
140_K144_N0.5560.34
140_K143_H0.5540.33
109_R153_G0.5540.33
68_R71_F0.5530.33
112_E154_F0.5500.33
47_D76_S0.5440.33
88_D150_E0.5440.33
2_V236_A0.5440.33
108_I157_I0.5440.33
246_H289_R0.5430.32
43_E47_D0.5430.32
277_Q291_V0.5430.32
108_I158_V0.5400.32
108_I162_R0.5400.32
236_A265_A0.5400.32
130_P163_D0.5390.32
179_E182_I0.5390.32
197_V208_V0.5360.32
207_A287_V0.5340.32
216_V220_L0.5340.32
146_G162_R0.5330.32
165_Y195_V0.5330.32
216_V268_L0.5310.31
212_A216_V0.5310.31
204_E208_V0.5300.31
245_V264_R0.5300.31
234_G251_A0.5300.31
37_A178_L0.5300.31
29_S33_D0.5290.31
128_I257_S0.5270.31
194_A203_P0.5270.31
220_L302_I0.5270.31
70_V74_M0.5270.31
291_V305_E0.5260.31
18_A162_R0.5260.31
52_V117_E0.5250.31
122_Q157_I0.5230.31
20_G48_Q0.5230.31
4_V220_L0.5230.31
141_S158_V0.5220.31
39_A183_S0.5210.31
64_T83_S0.5210.31
231_A250_V0.5200.31
186_M216_V0.5200.31
216_V260_G0.5190.30
30_G33_D0.5190.30
96_P289_R0.5180.30
205_K247_G0.5180.30
291_V294_V0.5170.30
26_I35_S0.5170.30
267_E296_H0.5170.30
109_R272_T0.5170.30
13_A91_A0.5160.30
122_Q158_V0.5160.30
171_E175_H0.5150.30
17_E73_Y0.5130.30
71_F74_M0.5130.30
71_F76_S0.5120.30
254_S292_Y0.5100.30
71_F178_L0.5100.30
97_E141_S0.5090.30
137_G163_D0.5090.30
268_L276_L0.5080.30
35_S182_I0.5080.30
97_E101_H0.5080.30
22_E155_E0.5070.29
9_E16_S0.5060.29
141_S257_S0.5050.29
90_L102_A0.5050.29
108_I141_S0.5040.29
201_V206_V0.5040.29
136_E237_T0.5040.29
12_R16_S0.5040.29
226_W264_R0.5030.29
269_E272_T0.5030.29
83_S206_V0.5030.29
240_K284_I0.5020.29
75_D182_I0.5020.29
182_I260_G0.5010.29
109_R172_V0.5000.29
2_V6_S0.5000.29
118_V151_R0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uowA 2 0.918 100 0.327 Contact Map
1gpmA 3 0.9475 100 0.338 Contact Map
3tqiA 3 0.882 100 0.343 Contact Map
2ywbA 4 0.9213 100 0.349 Contact Map
2vxoA 2 0.9967 100 0.361 Contact Map
2dplA 2 0.9246 100 0.377 Contact Map
1xngA 2 0.7574 100 0.811 Contact Map
3sdbA 6 0.8066 99.9 0.818 Contact Map
3n05A 2 0.7902 99.9 0.833 Contact Map
2c5sA 2 0.6951 99.9 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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