PYRG - HALSA - GREMLIN Contacts

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PYRG - CTP synthase

UniProt:	Q9HP32	Sequences: MPTETEYDPSLGSKFVFVTGGVMSGLGKGITAASLGRLLSNAGFDVTAVKIDPYLNVDAGTMNPYQHGEVYVLDDGGEVDLDLGNYERFLDEDMTSDHNVTTGKVYQDVIERERSGDYLGKTVQIIPHVTDDIKRRVREAAEGSDVCLVEVGGTVGDIEGMPFLEALRQFSHEQDDEDILFTHVTLVPYSKNGEQKTKPTQHSVKELRSIGLQPDILVGRCEDRLDPDVREKIALFCDVPMDAVFSNPDVEDIYHVPLTVEEEGLDQYVMEQFDMVEDALPAAQRSTEWRDLVTRERTGEVDIALVGKYALEDAYMSIHEALKHASLEAGVEVNVLWVDSEKMHDHHERRIADADGIVVAGGFGSRGTAGKIDAIQHAREHDVPFLGLCLGFQLAVVEYARNVLGMTGAHSAEIDEDTEYPVIDLLPEQYDLEDLGGTMRLGAHETAIEPGTLAHDLYGATSCTERHRHRYEVNPEYIDDLTADGLTFSGEAGNRMEIVEHDDHPFFFGTQFHPEYRSRPTRASPPFVGLLDAVLERADVAPAGSDADVEVTN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	553 (522)
Sequences:	2967 (1258)
Seq/√Len:	55.1

ECOLI - PYRG
BACSU - PYRG
HALSA - PYRG
SULSO - PYRG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
457_L	529_G	4.697	1.00
376_Q	380_E	4.650	1.00
304_A	354_A	4.188	1.00
302_D	334_N	4.108	1.00
302_D	336_L	3.887	1.00
300_E	334_N	3.779	1.00
375_I	394_L	3.768	1.00
408_G	420_Y	3.703	1.00
382_D	505_P	3.608	1.00
175_D	178_D	3.465	1.00
303_I	356_G	3.429	1.00
336_L	354_A	3.326	1.00
35_L	269_V	3.313	1.00
454_A	498_I	3.226	1.00
443_A	464_T	3.151	1.00
375_I	507_F	2.979	1.00
375_I	385_F	2.970	1.00
261_E	266_D	2.879	1.00
180_L	216_I	2.841	1.00
453_L	456_D	2.796	1.00
373_D	376_Q	2.776	1.00
479_D	483_A	2.773	1.00
344_H	347_H	2.695	1.00
452_T	487_T	2.675	1.00
394_L	397_V	2.653	1.00
357_I	378_A	2.642	1.00
399_Y	403_V	2.632	1.00
326_S	333_V	2.610	1.00
331_V	535_L	2.585	1.00
336_L	353_D	2.541	1.00
418_T	421_P	2.515	1.00
406_M	480_D	2.485	1.00
382_D	503_D	2.463	1.00
251_E	255_H	2.451	1.00
31_T	218_V	2.404	1.00
487_T	502_D	2.404	1.00
385_F	395_A	2.390	1.00
455_H	461_T	2.383	1.00
44_F	146_V	2.380	1.00
242_D	271_E	2.356	1.00
134_K	173_E	2.346	1.00
498_I	512_F	2.333	1.00
206_E	209_S	2.322	1.00
181_F	212_L	2.321	1.00
216_I	265_L	2.287	1.00
190_S	222_E	2.278	1.00
450_P	455_H	2.256	1.00
107_Q	111_E	2.254	1.00
91_D	522_R	2.247	1.00
406_M	420_Y	2.237	1.00
454_A	489_S	2.199	1.00
227_P	231_E	2.192	1.00
404_L	481_L	2.191	1.00
131_D	135_R	2.177	1.00
329_A	532_D	2.162	1.00
411_S	414_I	2.119	1.00
299_G	331_V	2.114	1.00
408_G	419_E	2.071	1.00
420_Y	477_Y	2.061	1.00
453_L	508_F	2.041	1.00
109_V	129_V	1.968	1.00
304_A	338_V	1.961	1.00
231_E	241_M	1.946	1.00
319_H	337_W	1.928	1.00
412_A	421_P	1.920	1.00
452_T	489_S	1.920	1.00
258_L	290_R	1.914	1.00
74_D	443_A	1.905	1.00
506_F	530_L	1.900	1.00
410_H	415_D	1.880	0.99
449_E	482_T	1.876	0.99
170_F	174_Q	1.864	0.99
108_D	132_D	1.842	0.99
481_L	486_L	1.840	0.99
359_V	385_F	1.836	0.99
66_Q	121_K	1.830	0.99
298_T	330_G	1.811	0.99
96_S	104_K	1.808	0.99
368_T	394_L	1.807	0.99
74_D	93_D	1.799	0.99
395_A	507_F	1.789	0.99
457_L	508_F	1.773	0.99
138_R	170_F	1.768	0.99
532_D	536_E	1.765	0.99
300_E	332_E	1.763	0.99
396_V	422_V	1.762	0.99
473_V	481_L	1.748	0.99
479_D	482_T	1.724	0.99
291_D	295_R	1.720	0.99
406_M	477_Y	1.705	0.99
40_S	91_D	1.694	0.99
132_D	135_R	1.672	0.99
450_P	461_T	1.672	0.99
15_F	141_A	1.671	0.99
295_R	330_G	1.619	0.98
369_A	372_I	1.616	0.98
109_V	118_Y	1.597	0.98
480_D	483_A	1.573	0.98
385_F	394_L	1.566	0.98
343_M	347_H	1.559	0.98
299_G	535_L	1.556	0.98
41_N	286_S	1.552	0.98
390_L	414_I	1.551	0.98
187_V	225_L	1.542	0.98
382_D	504_H	1.542	0.98
185_T	200_T	1.540	0.98
386_L	530_L	1.538	0.98
506_F	529_G	1.532	0.98
358_V	530_L	1.518	0.98
454_A	508_F	1.515	0.98
423_I	473_V	1.515	0.98
404_L	480_D	1.509	0.98
25_G	192_N	1.505	0.98
40_S	92_E	1.489	0.97
356_G	530_L	1.488	0.97
368_T	414_I	1.486	0.97
146_V	273_F	1.478	0.97
396_V	499_V	1.469	0.97
473_V	478_I	1.466	0.97
14_K	178_D	1.460	0.97
135_R	139_E	1.451	0.97
449_E	487_T	1.448	0.97
172_H	238_D	1.440	0.97
446_T	512_F	1.437	0.97
408_G	415_D	1.436	0.97
243_A	268_Y	1.432	0.97
164_L	210_I	1.430	0.97
32_A	148_L	1.429	0.97
443_A	517_R	1.427	0.97
183_H	203_S	1.412	0.96
406_M	419_E	1.412	0.96
446_T	490_G	1.409	0.96
448_I	454_A	1.403	0.96
112_R	117_D	1.402	0.96
368_T	390_L	1.401	0.96
392_F	473_V	1.401	0.96
108_D	136_R	1.398	0.96
517_R	524_S	1.390	0.96
343_M	350_R	1.386	0.96
399_Y	484_D	1.386	0.96
457_L	506_F	1.383	0.96
177_E	274_D	1.375	0.96
475_P	478_I	1.359	0.95
246_S	263_E	1.352	0.95
48_A	90_L	1.352	0.95
445_E	464_T	1.349	0.95
74_D	517_R	1.345	0.95
180_L	272_Q	1.345	0.95
247_N	260_V	1.343	0.95
264_G	267_Q	1.331	0.95
302_D	354_A	1.331	0.95
398_E	402_N	1.328	0.95
339_D	342_K	1.327	0.95
47_T	98_H	1.327	0.95
392_F	499_V	1.326	0.95
305_L	318_I	1.324	0.95
445_E	462_S	1.313	0.94
245_F	268_Y	1.310	0.94
217_L	233_I	1.310	0.94
343_M	374_A	1.306	0.94
396_V	473_V	1.304	0.94
35_L	182_T	1.290	0.94
375_I	398_E	1.279	0.94
328_E	523_A	1.275	0.94
55_L	129_V	1.272	0.94
151_V	167_L	1.270	0.93
429_Q	432_L	1.268	0.93
18_V	148_L	1.266	0.93
49_V	149_V	1.264	0.93
395_A	509_G	1.262	0.93
356_G	534_V	1.256	0.93
250_V	259_T	1.254	0.93
138_R	174_Q	1.252	0.93
410_H	418_T	1.244	0.93
502_D	505_P	1.235	0.92
167_L	181_F	1.234	0.92
302_D	353_D	1.233	0.92
205_K	209_S	1.230	0.92
55_L	102_T	1.228	0.92
137_V	170_F	1.227	0.92
93_D	519_R	1.224	0.92
486_L	499_V	1.218	0.92
221_C	246_S	1.210	0.92
303_I	534_V	1.209	0.92
104_K	136_R	1.203	0.91
376_Q	402_N	1.199	0.91
119_L	435_L	1.198	0.91
37_R	40_S	1.196	0.91
51_I	149_V	1.190	0.91
173_E	181_F	1.187	0.91
424_D	429_Q	1.181	0.91
475_P	496_M	1.178	0.91
171_S	179_I	1.176	0.90
195_Q	226_D	1.172	0.90
215_D	272_Q	1.169	0.90
102_T	129_V	1.161	0.90
451_G	456_D	1.155	0.90
404_L	484_D	1.155	0.90
31_T	184_V	1.153	0.90
16_V	180_L	1.149	0.89
447_A	462_S	1.145	0.89
451_G	455_H	1.144	0.89
448_I	490_G	1.143	0.89
357_I	383_V	1.141	0.89
226_D	229_V	1.139	0.89
349_R	352_A	1.135	0.89
453_L	506_F	1.133	0.89
448_I	452_T	1.133	0.89
106_Y	125_I	1.130	0.89
480_D	484_D	1.127	0.89
415_D	418_T	1.121	0.88
412_A	418_T	1.120	0.88
395_A	499_V	1.115	0.88
146_V	275_M	1.113	0.88
385_F	507_F	1.112	0.88
51_I	59_A	1.101	0.87
180_L	269_V	1.095	0.87
268_Y	272_Q	1.094	0.87
108_D	112_R	1.088	0.87
358_V	388_L	1.088	0.87
306_V	340_S	1.086	0.87
221_C	248_P	1.085	0.87
267_Q	271_E	1.082	0.86
399_Y	486_L	1.077	0.86
30_I	256_V	1.075	0.86
258_L	293_V	1.073	0.86
407_T	420_Y	1.073	0.86
501_H	504_H	1.072	0.86
14_K	273_F	1.069	0.86
359_V	395_A	1.069	0.86
322_L	333_V	1.064	0.85
91_D	519_R	1.064	0.85
227_P	241_M	1.064	0.85
31_T	247_N	1.062	0.85
208_R	238_D	1.060	0.85
297_R	330_G	1.052	0.85
427_P	494_N	1.052	0.85
51_I	137_V	1.050	0.85
37_R	41_N	1.046	0.84
457_L	530_L	1.044	0.84
51_I	85_N	1.042	0.84
348_E	381_H	1.036	0.84
255_H	293_V	1.029	0.83
171_S	181_F	1.027	0.83
386_L	508_F	1.024	0.83
369_A	401_R	1.022	0.83
464_T	517_R	1.022	0.83
47_T	147_C	1.016	0.83
396_V	481_L	1.016	0.83
344_H	373_D	1.015	0.83
31_T	260_V	1.011	0.82
345_D	373_D	1.010	0.82
343_M	373_D	1.010	0.82
488_F	496_M	1.008	0.82
208_R	213_Q	1.005	0.82
400_A	481_L	1.003	0.82
336_L	350_R	0.997	0.82
44_F	277_E	0.997	0.82
412_A	424_D	0.997	0.82
261_E	284_Q	0.990	0.81
292_L	327_L	0.984	0.81
252_D	293_V	0.978	0.80
529_G	532_D	0.978	0.80
448_I	455_H	0.978	0.80
358_V	371_K	0.975	0.80
182_T	269_V	0.974	0.80
420_Y	480_D	0.973	0.80
19_T	183_H	0.972	0.80
164_L	212_L	0.972	0.80
351_I	354_A	0.972	0.80
425_L	429_Q	0.972	0.80
396_V	486_L	0.971	0.80
171_S	176_D	0.971	0.80
358_V	378_A	0.971	0.80
270_M	277_E	0.970	0.80
312_E	337_W	0.969	0.80
338_V	354_A	0.964	0.79
379_R	398_E	0.963	0.79
100_V	136_R	0.962	0.79
318_I	388_L	0.958	0.79
204_V	214_P	0.958	0.79
424_D	427_P	0.956	0.79
125_I	129_V	0.956	0.79
325_A	528_V	0.951	0.78
290_R	294_T	0.948	0.78
482_T	488_F	0.948	0.78
233_I	244_V	0.947	0.78
454_A	510_T	0.936	0.77
318_I	361_G	0.934	0.77
174_Q	178_D	0.927	0.77
132_D	136_R	0.927	0.77
455_H	459_G	0.923	0.76
111_E	434_D	0.920	0.76
155_V	164_L	0.920	0.76
176_D	215_D	0.920	0.76
40_S	90_L	0.919	0.76
304_A	336_L	0.915	0.76
146_V	270_M	0.914	0.76
106_Y	162_P	0.910	0.75
219_G	233_I	0.907	0.75
392_F	510_T	0.904	0.75
224_R	248_P	0.903	0.75
375_I	397_V	0.897	0.74
305_L	319_H	0.896	0.74
44_F	270_M	0.893	0.74
200_T	233_I	0.890	0.74
165_E	168_R	0.890	0.74
501_H	507_F	0.889	0.73
390_L	411_S	0.889	0.73
266_D	284_Q	0.886	0.73
63_N	66_Q	0.885	0.73
141_A	147_C	0.884	0.73
115_S	434_D	0.883	0.73
325_A	329_A	0.882	0.73
92_E	519_R	0.877	0.72
326_S	531_L	0.876	0.72
262_E	290_R	0.874	0.72
59_A	85_N	0.870	0.72
426_L	429_Q	0.868	0.72
242_D	268_Y	0.865	0.71
119_L	439_M	0.862	0.71
271_E	274_D	0.861	0.71
313_D	318_I	0.861	0.71
42_A	266_D	0.861	0.71
97_D	139_E	0.859	0.71
445_E	492_A	0.858	0.71
447_A	461_T	0.858	0.71
37_R	521_T	0.857	0.71
445_E	491_E	0.855	0.71
49_V	59_A	0.854	0.70
329_A	531_L	0.851	0.70
463_C	524_S	0.845	0.70
259_T	262_E	0.837	0.69
94_M	98_H	0.837	0.69
105_V	136_R	0.837	0.69
45_D	143_G	0.835	0.69
109_V	164_L	0.834	0.69
138_R	173_E	0.833	0.69
188_P	200_T	0.831	0.68
316_M	323_K	0.830	0.68
224_R	246_S	0.830	0.68
41_N	284_Q	0.829	0.68
189_Y	192_N	0.829	0.68
399_Y	501_H	0.829	0.68
48_A	98_H	0.827	0.68
250_V	256_V	0.827	0.68
26_L	31_T	0.824	0.68
299_G	538_A	0.824	0.68
265_L	269_V	0.822	0.67
218_V	247_N	0.820	0.67
216_I	268_Y	0.819	0.67
55_L	109_V	0.818	0.67
190_S	223_D	0.817	0.67
195_Q	229_V	0.816	0.67
100_V	313_D	0.816	0.67
404_L	486_L	0.811	0.66
171_S	238_D	0.809	0.66
167_L	179_I	0.805	0.66
488_F	499_V	0.804	0.66
221_C	225_L	0.802	0.66
498_I	510_T	0.799	0.65
465_E	524_S	0.799	0.65
105_V	132_D	0.798	0.65
51_I	100_V	0.793	0.65
452_T	490_G	0.792	0.65
77_G	96_S	0.790	0.64
424_D	430_Y	0.790	0.64
185_T	188_P	0.786	0.64
372_I	394_L	0.786	0.64
420_Y	476_E	0.785	0.64
230_R	263_E	0.784	0.64
352_A	377_H	0.783	0.64
477_Y	480_D	0.782	0.64
355_D	538_A	0.782	0.64
377_H	381_H	0.782	0.64
453_L	503_D	0.781	0.63
140_A	147_C	0.780	0.63
382_D	502_D	0.779	0.63
49_V	148_L	0.773	0.63
343_M	348_E	0.771	0.62
347_H	351_I	0.770	0.62
44_F	145_D	0.769	0.62
397_V	410_H	0.769	0.62
453_L	457_L	0.768	0.62
321_A	325_A	0.768	0.62
299_G	330_G	0.766	0.62
177_E	272_Q	0.766	0.62
375_I	395_A	0.763	0.62
467_H	497_E	0.761	0.61
141_A	144_S	0.760	0.61
267_Q	277_E	0.755	0.61
74_D	464_T	0.754	0.61
357_I	530_L	0.750	0.60
356_G	386_L	0.748	0.60
325_A	333_V	0.748	0.60
243_A	272_Q	0.745	0.60
301_V	534_V	0.745	0.60
108_D	111_E	0.743	0.60
288_E	521_T	0.742	0.60
529_G	533_A	0.742	0.60
352_A	381_H	0.739	0.59
44_F	276_V	0.737	0.59
49_V	98_H	0.736	0.59
230_R	246_S	0.735	0.59
358_V	395_A	0.732	0.58
347_H	350_R	0.731	0.58
247_N	263_E	0.730	0.58
217_L	239_V	0.728	0.58
478_I	496_M	0.728	0.58
454_A	509_G	0.727	0.58
371_K	394_L	0.727	0.58
73_L	79_V	0.727	0.58
407_T	419_E	0.726	0.58
505_P	537_R	0.725	0.58
304_A	355_D	0.723	0.58
347_H	373_D	0.720	0.57
446_T	454_A	0.718	0.57
130_T	169_Q	0.717	0.57
499_V	507_F	0.717	0.57
302_D	355_D	0.717	0.57
93_D	443_A	0.715	0.57
325_A	531_L	0.715	0.57
428_E	439_M	0.714	0.57
297_R	332_E	0.714	0.57
523_A	528_V	0.713	0.56
499_V	509_G	0.713	0.56
26_L	184_V	0.713	0.56
174_Q	179_I	0.713	0.56
125_I	158_I	0.710	0.56
126_I	130_T	0.709	0.56
348_E	352_A	0.708	0.56
195_Q	223_D	0.708	0.56
62_M	70_V	0.705	0.56
73_L	77_G	0.704	0.56
42_A	270_M	0.703	0.55
388_L	510_T	0.703	0.55
74_D	516_Y	0.702	0.55
134_K	169_Q	0.702	0.55
378_A	385_F	0.701	0.55
216_I	263_E	0.701	0.55
369_A	410_H	0.699	0.55
261_E	283_A	0.698	0.55
187_V	246_S	0.697	0.55
451_G	487_T	0.697	0.55
338_V	343_M	0.697	0.55
240_P	272_Q	0.696	0.55
404_L	482_T	0.694	0.54
205_K	208_R	0.694	0.54
59_A	189_Y	0.693	0.54
19_T	203_S	0.693	0.54
312_E	319_H	0.691	0.54
124_Q	159_E	0.690	0.54
36_G	148_L	0.689	0.54
528_V	532_D	0.688	0.54
71_Y	93_D	0.686	0.54
447_A	491_E	0.684	0.53
288_E	291_D	0.684	0.53
353_D	383_V	0.684	0.53
325_A	328_E	0.681	0.53
318_I	429_Q	0.677	0.53
171_S	215_D	0.677	0.53
508_F	526_P	0.676	0.53
18_V	48_A	0.675	0.52
99_N	119_L	0.673	0.52
225_L	229_V	0.672	0.52
306_V	359_V	0.671	0.52
111_E	115_S	0.671	0.52
341_E	366_R	0.670	0.52
192_N	249_D	0.670	0.52
449_E	452_T	0.669	0.52
322_L	335_V	0.668	0.52
490_G	498_I	0.667	0.52
65_Y	71_Y	0.667	0.52
447_A	493_G	0.667	0.52
49_V	100_V	0.666	0.51
322_L	358_V	0.666	0.51
47_T	144_S	0.665	0.51
219_G	439_M	0.665	0.51
489_S	501_H	0.663	0.51
44_F	275_M	0.661	0.51
399_Y	481_L	0.661	0.51
26_L	186_L	0.661	0.51
256_V	263_E	0.660	0.51
191_K	234_A	0.659	0.51
266_D	270_M	0.659	0.51
318_I	360_A	0.658	0.51
104_K	108_D	0.658	0.51
374_A	378_A	0.657	0.50
77_G	104_K	0.657	0.50
71_Y	519_R	0.657	0.50
216_I	243_A	0.655	0.50
376_Q	381_H	0.653	0.50
57_V	62_M	0.650	0.50
25_G	247_N	0.650	0.50
446_T	498_I	0.649	0.50
179_I	212_L	0.649	0.50
402_N	407_T	0.649	0.50
473_V	498_I	0.648	0.50
455_H	460_A	0.646	0.49
270_M	275_M	0.645	0.49
292_L	521_T	0.644	0.49
478_I	488_F	0.644	0.49
404_L	408_G	0.644	0.49
392_F	512_F	0.641	0.49
35_L	265_L	0.641	0.49
131_D	231_E	0.640	0.49
46_V	479_D	0.640	0.49
519_R	522_R	0.639	0.49
125_I	162_P	0.639	0.49
255_H	258_L	0.639	0.49
372_I	375_I	0.637	0.48
151_V	164_L	0.636	0.48
146_V	277_E	0.635	0.48
390_L	394_L	0.634	0.48
55_L	125_I	0.631	0.48
368_T	397_V	0.631	0.48
473_V	496_M	0.631	0.48
25_G	197_T	0.630	0.48
358_V	510_T	0.630	0.48
311_L	314_A	0.629	0.47
342_K	350_R	0.628	0.47
368_T	410_H	0.628	0.47
399_Y	404_L	0.627	0.47
15_F	138_R	0.626	0.47
329_A	535_L	0.625	0.47
414_I	418_T	0.622	0.47
255_H	294_T	0.622	0.47
95_T	98_H	0.620	0.47
110_I	256_V	0.620	0.47
71_Y	90_L	0.619	0.46
112_R	135_R	0.619	0.46
13_S	147_C	0.617	0.46
44_F	260_V	0.617	0.46
35_L	218_V	0.616	0.46
55_L	337_W	0.615	0.46
91_D	521_T	0.615	0.46
388_L	527_F	0.614	0.46
372_I	376_Q	0.613	0.46
386_L	529_G	0.613	0.46
248_P	259_T	0.612	0.46
328_E	528_V	0.611	0.46
512_F	524_S	0.611	0.46
238_D	243_A	0.611	0.46
162_P	202_H	0.610	0.45
17_F	167_L	0.610	0.45
303_I	531_L	0.610	0.45
115_S	435_L	0.609	0.45
365_S	414_I	0.609	0.45
287_T	290_R	0.609	0.45
216_I	269_V	0.608	0.45
234_A	240_P	0.608	0.45
368_T	411_S	0.607	0.45
372_I	402_N	0.605	0.45
489_S	498_I	0.602	0.45
18_V	34_S	0.602	0.45
47_T	90_L	0.600	0.44
117_D	121_K	0.600	0.44
403_V	481_L	0.600	0.44
112_R	132_D	0.600	0.44
436_G	441_L	0.599	0.44
460_A	536_E	0.599	0.44
371_K	463_C	0.599	0.44
252_D	327_L	0.598	0.44
83_L	104_K	0.597	0.44
140_A	144_S	0.597	0.44
487_T	501_H	0.597	0.44
373_D	377_H	0.597	0.44
445_E	493_G	0.596	0.44
44_F	278_D	0.595	0.44
342_K	346_H	0.595	0.44
240_P	243_A	0.593	0.44
126_I	426_L	0.593	0.44
51_I	104_K	0.592	0.44
306_V	374_A	0.591	0.43
51_I	136_R	0.591	0.43
457_L	528_V	0.591	0.43
16_V	146_V	0.591	0.43
501_H	508_F	0.591	0.43
448_I	498_I	0.591	0.43
191_K	249_D	0.590	0.43
348_E	383_V	0.588	0.43
358_V	374_A	0.588	0.43
193_G	249_D	0.587	0.43
319_H	323_K	0.587	0.43
179_I	311_L	0.586	0.43
97_D	104_K	0.586	0.43
381_H	450_P	0.583	0.43
326_S	331_V	0.583	0.43
77_G	195_Q	0.583	0.43
386_L	510_T	0.582	0.42
49_V	85_N	0.582	0.42
534_V	537_R	0.581	0.42
237_C	490_G	0.579	0.42
312_E	318_I	0.579	0.42
137_V	167_L	0.578	0.42
378_A	395_A	0.577	0.42
26_L	174_Q	0.577	0.42
303_I	388_L	0.575	0.42
406_M	410_H	0.575	0.42
228_D	231_E	0.575	0.42
484_D	501_H	0.574	0.42
295_R	328_E	0.574	0.42
406_M	418_T	0.574	0.42
358_V	531_L	0.573	0.42
428_E	508_F	0.573	0.42
361_G	414_I	0.571	0.41
323_K	327_L	0.570	0.41
25_G	171_S	0.570	0.41
398_E	507_F	0.569	0.41
73_L	85_N	0.569	0.41
136_R	427_P	0.569	0.41
392_F	498_I	0.568	0.41
31_T	316_M	0.567	0.41
428_E	435_L	0.567	0.41
436_G	472_E	0.566	0.41
508_F	529_G	0.566	0.41
345_D	376_Q	0.566	0.41
207_L	212_L	0.565	0.41
449_E	489_S	0.565	0.41
394_L	414_I	0.565	0.41
203_S	207_L	0.565	0.41
126_I	355_D	0.565	0.41
99_N	102_T	0.564	0.41
396_V	399_Y	0.564	0.41
202_H	206_E	0.563	0.40
338_V	351_I	0.563	0.40
39_L	269_V	0.563	0.40
171_S	213_Q	0.563	0.40
376_Q	398_E	0.562	0.40
187_V	219_G	0.561	0.40
314_A	508_F	0.560	0.40
286_S	290_R	0.560	0.40
397_V	430_Y	0.559	0.40
446_T	495_R	0.559	0.40
292_L	361_G	0.558	0.40
134_K	238_D	0.558	0.40
329_A	528_V	0.558	0.40
140_A	143_G	0.557	0.40
314_A	394_L	0.555	0.40
107_Q	110_I	0.555	0.40
49_V	140_A	0.555	0.40
193_G	311_L	0.555	0.40
267_Q	270_M	0.554	0.40
324_H	518_S	0.553	0.39
425_L	430_Y	0.553	0.39
270_M	276_V	0.552	0.39
403_V	493_G	0.551	0.39
175_D	397_V	0.550	0.39
524_S	527_F	0.550	0.39
287_T	291_D	0.550	0.39
535_L	538_A	0.550	0.39
358_V	386_L	0.549	0.39
158_I	244_V	0.549	0.39
121_K	293_V	0.549	0.39
410_H	414_I	0.549	0.39
48_A	95_T	0.548	0.39
380_E	398_E	0.547	0.39
202_H	205_K	0.547	0.39
510_T	516_Y	0.546	0.39
296_E	330_G	0.546	0.39
205_K	213_Q	0.546	0.39
59_A	149_V	0.546	0.39
426_L	439_M	0.545	0.39
454_A	512_F	0.545	0.39
195_Q	221_C	0.545	0.39
47_T	63_N	0.545	0.39
352_A	536_E	0.544	0.39
139_E	274_D	0.543	0.38
472_E	495_R	0.543	0.38
26_L	192_N	0.542	0.38
40_S	93_D	0.542	0.38
251_E	402_N	0.542	0.38
357_I	377_H	0.542	0.38
425_L	432_L	0.541	0.38
506_F	526_P	0.541	0.38
25_G	266_D	0.540	0.38
504_H	527_F	0.540	0.38
31_T	335_V	0.539	0.38
61_T	437_G	0.539	0.38
112_R	136_R	0.539	0.38
40_S	519_R	0.539	0.38
48_A	92_E	0.539	0.38
435_L	439_M	0.538	0.38
392_F	509_G	0.538	0.38
311_L	386_L	0.538	0.38
130_T	236_F	0.538	0.38
219_G	225_L	0.537	0.38
450_P	460_A	0.537	0.38
250_V	255_H	0.537	0.38
452_T	488_F	0.537	0.38
77_G	186_L	0.536	0.38
340_S	509_G	0.536	0.38
386_L	509_G	0.535	0.38
237_C	306_V	0.534	0.38
292_L	325_A	0.534	0.38
63_N	512_F	0.534	0.38
108_D	135_R	0.534	0.38
184_V	256_V	0.534	0.38
453_L	502_D	0.533	0.37
446_T	463_C	0.533	0.37
176_D	240_P	0.532	0.37
126_I	185_T	0.532	0.37
410_H	421_P	0.532	0.37
144_S	217_L	0.532	0.37
404_L	502_D	0.531	0.37
406_M	412_A	0.531	0.37
184_V	238_D	0.531	0.37
168_R	186_L	0.531	0.37
426_L	517_R	0.530	0.37
261_E	286_S	0.530	0.37
530_L	534_V	0.530	0.37
62_M	66_Q	0.530	0.37
516_Y	520_P	0.529	0.37
112_R	191_K	0.528	0.37
40_S	316_M	0.528	0.37
98_H	316_M	0.528	0.37
261_E	264_G	0.527	0.37
368_T	501_H	0.527	0.37
304_A	378_A	0.526	0.37
30_I	305_L	0.526	0.37
213_Q	238_D	0.526	0.37
352_A	383_V	0.525	0.37
247_N	250_V	0.525	0.37
31_T	37_R	0.525	0.37
36_G	90_L	0.524	0.37
81_L	122_T	0.524	0.37
44_F	268_Y	0.523	0.36
444_H	491_E	0.523	0.36
136_R	171_S	0.523	0.36
533_A	536_E	0.522	0.36
14_K	146_V	0.521	0.36
233_I	246_S	0.521	0.36
318_I	327_L	0.521	0.36
261_E	290_R	0.521	0.36
318_I	527_F	0.521	0.36
16_V	371_K	0.521	0.36
473_V	477_Y	0.521	0.36
305_L	386_L	0.519	0.36
95_T	476_E	0.518	0.36
444_H	495_R	0.518	0.36
428_E	448_I	0.518	0.36
98_H	140_A	0.517	0.36
294_T	488_F	0.516	0.36
215_D	271_E	0.516	0.36
454_A	526_P	0.515	0.36
66_Q	360_A	0.515	0.36
325_A	509_G	0.515	0.36
339_D	394_L	0.515	0.36
519_R	523_A	0.514	0.36
100_V	155_V	0.514	0.36
36_G	394_L	0.513	0.35
197_T	249_D	0.513	0.35
129_V	162_P	0.512	0.35
478_I	482_T	0.511	0.35
301_V	324_H	0.511	0.35
187_V	249_D	0.511	0.35
126_I	206_E	0.510	0.35
85_N	499_V	0.510	0.35
116_G	157_D	0.510	0.35
389_C	436_G	0.509	0.35
106_Y	129_V	0.509	0.35
295_R	523_A	0.508	0.35
45_D	142_E	0.508	0.35
236_F	244_V	0.507	0.35
74_D	411_S	0.507	0.35
100_V	105_V	0.507	0.35
501_H	505_P	0.507	0.35
329_A	529_G	0.506	0.35
131_D	169_Q	0.506	0.35
473_V	512_F	0.506	0.35
85_N	189_Y	0.505	0.35
291_D	407_T	0.505	0.35
408_G	480_D	0.505	0.35
137_V	147_C	0.504	0.35
142_E	217_L	0.503	0.34
13_S	337_W	0.503	0.34
514_P	525_P	0.503	0.34
340_S	519_R	0.503	0.34
19_T	23_M	0.501	0.34
59_A	192_N	0.501	0.34
427_P	430_Y	0.501	0.34
378_A	383_V	0.500	0.34
446_T	491_E	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zdjA	4	0.9385	100	0.416	Contact Map
3nvaA	2	0.9403	100	0.437	Contact Map
1vcoA	4	0.9349	100	0.47	Contact Map
2vo1A	4	0.4087	100	0.486	Contact Map
1s1mA	4	0.9421	100	0.526	Contact Map
2v4uA	1	0.4521	100	0.796	Contact Map
2w7tA	1	0.4503	100	0.816	Contact Map
1l9xA	1	0.425	99.9	0.902	Contact Map
3uowA	2	0.4033	99.9	0.902	Contact Map
4l8fC	3	0.4195	99.9	0.904	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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