GREMLIN Database
Q9HP29 - Uncharacterized protein
UniProt: Q9HP29 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (187)
Sequences: 5158 (3940)
Seq/√Len: 288.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_A119_A3.8861.00
152_T178_D3.8261.00
166_A172_T3.0011.00
21_P61_A2.9541.00
29_C87_A2.7761.00
122_L125_P2.6081.00
159_W176_E2.5751.00
81_R112_T2.5511.00
8_V83_A2.5161.00
7_L13_D2.4721.00
19_D64_R2.4311.00
152_T176_E2.4241.00
29_C61_A2.3371.00
163_V176_E2.3151.00
33_C80_A2.2761.00
95_A198_L2.2561.00
124_A183_F2.2281.00
88_G116_D2.1971.00
175_A193_T2.0311.00
63_L87_A1.9471.00
110_A120_A1.9101.00
106_A120_A1.9101.00
63_L83_A1.8561.00
86_W90_R1.8371.00
70_W73_G1.7971.00
81_R109_A1.7901.00
58_D195_G1.7871.00
134_D137_A1.7811.00
30_V60_L1.7801.00
9_P13_D1.7601.00
146_V169_D1.7391.00
33_C106_A1.7381.00
96_V106_A1.7211.00
80_A109_A1.7091.00
33_C67_Y1.7041.00
68_G72_G1.6821.00
68_G71_D1.6381.00
18_L63_L1.6131.00
149_A177_L1.6121.00
163_V167_R1.6061.00
148_V162_V1.5901.00
54_A58_D1.5411.00
54_A191_A1.4881.00
17_T43_R1.4781.00
123_L194_V1.4581.00
20_E61_A1.4421.00
49_Q53_A1.4161.00
16_A63_L1.4151.00
107_A122_L1.3931.00
138_A141_D1.3701.00
52_A64_R1.3701.00
30_V97_F1.3441.00
18_L61_A1.3321.00
81_R85_R1.3311.00
177_L193_T1.3211.00
150_Y162_V1.3091.00
17_T64_R1.2851.00
99_F124_A1.2831.00
121_S147_Q1.2581.00
65_F83_A1.2521.00
27_T61_A1.2361.00
97_F121_S1.2211.00
189_T193_T1.1941.00
150_Y159_W1.1861.00
85_R89_E1.1861.00
85_R114_E1.1761.00
175_A189_T1.1731.00
192_A196_E1.1591.00
30_V55_L1.1531.00
8_V16_A1.1411.00
31_V87_A1.1371.00
85_R116_D1.1281.00
80_A105_I1.1201.00
97_F123_L1.1191.00
163_V174_V1.1141.00
74_M108_L1.1081.00
7_L15_E1.1071.00
160_E163_V1.0931.00
32_A97_F1.0851.00
24_G27_T1.0821.00
84_I109_A1.0801.00
162_V174_V1.0751.00
34_P67_Y1.0621.00
69_D72_G1.0511.00
159_W163_V1.0391.00
33_C65_F1.0381.00
67_Y105_I1.0271.00
180_D184_V1.0251.00
147_Q197_F1.0191.00
149_A175_A1.0121.00
121_S198_L1.0031.00
68_G73_G0.9911.00
160_E164_E0.9891.00
159_W174_V0.9871.00
164_E167_R0.9861.00
32_A48_L0.9771.00
121_S194_V0.9761.00
54_A192_A0.9751.00
69_D73_G0.9741.00
43_R66_D0.9731.00
18_L21_P0.9631.00
39_H43_R0.9601.00
82_N85_R0.9581.00
31_V83_A0.9561.00
77_R109_A0.9511.00
114_E117_L0.9461.00
14_V65_F0.9351.00
76_E79_D0.9331.00
193_T196_E0.9301.00
136_A164_E0.9291.00
122_L146_V0.9211.00
128_E161_P0.9171.00
95_A121_S0.9071.00
60_L95_A0.9041.00
19_D62_C0.9031.00
51_V123_L0.9011.00
191_A195_G0.9011.00
73_G76_E0.8981.00
136_A139_L0.8951.00
28_A60_L0.8891.00
112_T138_A0.8811.00
78_E112_T0.8791.00
29_C93_H0.8701.00
78_E81_R0.8681.00
84_I117_L0.8671.00
39_H42_H0.8581.00
30_V95_A0.8481.00
120_A146_V0.8461.00
173_T193_T0.8461.00
43_R64_R0.8451.00
31_V84_I0.8351.00
127_A165_A0.8301.00
19_D56_V0.8281.00
10_G78_E0.8211.00
108_L138_A0.8211.00
150_Y174_V0.8181.00
122_L148_V0.8161.00
41_G45_D0.8111.00
148_V165_A0.8080.99
155_T180_D0.7900.99
21_P27_T0.7870.99
65_F80_A0.7790.99
61_A93_H0.7790.99
135_A139_L0.7790.99
55_L97_F0.7760.99
149_A190_V0.7740.99
35_P41_G0.7670.99
54_A188_G0.7640.99
140_T168_S0.7620.99
42_H45_D0.7580.99
125_P148_V0.7580.99
52_A56_V0.7560.99
103_G106_A0.7550.99
32_A62_C0.7530.99
147_Q175_A0.7500.99
148_V166_A0.7400.99
34_P100_S0.7340.99
103_G125_P0.7340.99
77_R108_L0.7320.99
189_T192_A0.7310.99
35_P100_S0.7290.99
23_D27_T0.7280.99
85_R88_G0.7260.99
56_V62_C0.7220.99
125_P162_V0.7210.99
139_L142_V0.7190.99
81_R114_E0.7170.99
86_W89_E0.7140.99
67_Y101_F0.7120.99
161_P164_E0.7120.99
77_R105_I0.7120.99
83_A87_A0.7110.99
26_A61_A0.7020.99
162_V165_A0.6990.99
107_A146_V0.6970.99
17_T20_E0.6930.98
166_A174_V0.6890.98
123_L183_F0.6830.98
40_R43_R0.6820.98
84_I116_D0.6820.98
110_A142_V0.6810.98
117_L120_A0.6760.98
8_V14_V0.6710.98
16_A83_A0.6700.98
101_F104_S0.6680.98
84_I94_T0.6670.98
16_A65_F0.6630.98
190_V194_V0.6630.98
152_T159_W0.6620.98
26_A92_A0.6550.98
15_E66_D0.6540.98
166_A171_E0.6520.98
32_A52_A0.6510.98
148_V172_T0.6460.98
128_E132_G0.6460.98
25_D28_A0.6430.97
107_A120_A0.6390.97
192_A195_G0.6350.97
60_L195_G0.6310.97
123_L190_V0.6300.97
95_A118_W0.6300.97
75_G79_D0.6230.97
67_Y80_A0.6190.97
16_A19_D0.6190.97
80_A83_A0.6160.97
9_P12_R0.6130.97
39_H44_G0.6130.97
15_E43_R0.6120.97
45_D182_F0.6070.96
96_V117_L0.6060.96
21_P26_A0.6050.96
119_A145_P0.6050.96
83_A86_W0.6040.96
77_R80_A0.6030.96
148_V174_V0.6020.96
119_A197_F0.6020.96
99_F183_F0.5990.96
96_V120_A0.5960.96
99_F123_L0.5950.96
35_P151_A0.5950.96
99_F182_F0.5940.96
53_A57_E0.5920.96
129_L132_G0.5900.96
104_S129_L0.5870.96
152_T163_V0.5860.96
128_E164_E0.5840.96
96_V109_A0.5820.96
159_W162_V0.5820.96
42_H99_F0.5760.95
30_V35_P0.5760.95
54_A57_E0.5740.95
47_R182_F0.5740.95
169_D172_T0.5730.95
17_T44_G0.5700.95
121_S125_P0.5690.95
149_A193_T0.5670.95
127_A161_P0.5660.95
188_G192_A0.5650.95
63_L86_W0.5640.95
79_D82_N0.5630.95
191_A194_V0.5630.95
162_V166_A0.5620.95
139_L169_D0.5610.95
126_T129_L0.5590.94
20_E26_A0.5580.94
128_E134_D0.5550.94
119_A198_L0.5520.94
31_V96_V0.5520.94
58_D192_A0.5500.94
186_K189_T0.5470.94
107_A165_A0.5450.94
27_T93_H0.5420.93
139_L146_V0.5370.93
118_W145_P0.5360.93
88_G118_W0.5360.93
156_T183_F0.5330.93
131_A157_A0.5320.93
194_V198_L0.5320.93
40_R44_G0.5300.93
110_A144_A0.5290.93
104_S107_A0.5240.92
82_N86_W0.5230.92
41_G48_L0.5230.92
67_Y76_E0.5200.92
39_H45_D0.5190.92
29_C91_Y0.5190.92
90_R93_H0.5180.92
150_Y157_A0.5170.92
120_A144_A0.5150.92
52_A62_C0.5140.92
70_W76_E0.5110.91
41_G182_F0.5100.91
33_C105_I0.5090.91
60_L198_L0.5080.91
75_G78_E0.5080.91
48_L123_L0.5060.91
188_G191_A0.5040.91
76_E83_A0.5020.91
101_F105_I0.5020.91
84_I88_G0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wtmA 2 0.9707 100 0.395 Contact Map
2i3dA 2 0.961 100 0.4 Contact Map
3o4hA 2 0.9805 100 0.404 Contact Map
4wjlA 2 0.9902 100 0.421 Contact Map
3bxpA 2 0.9756 100 0.422 Contact Map
4q3kA 3 0.9854 100 0.424 Contact Map
1xfdA 2 0.9902 100 0.425 Contact Map
3pfbA 2 0.9512 100 0.432 Contact Map
1zi8A 1 0.9317 100 0.433 Contact Map
4q1vA 2 0.9707 100 0.433 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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