GREMLIN Database
Q9HP28 - Monooxygenase
UniProt: Q9HP28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (169)
Sequences: 5541 (2971)
Seq/√Len: 228.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_A137_F3.8001.00
97_P187_D3.5261.00
43_E54_R3.2961.00
159_D165_R2.7671.00
165_R171_S2.6561.00
88_Q122_T2.6061.00
43_E56_G2.5531.00
91_R95_C2.5531.00
65_R100_A2.5461.00
44_L126_L2.5231.00
45_P54_R2.4851.00
99_L186_I2.2881.00
38_R163_V2.2881.00
93_F96_T2.1671.00
95_C100_A2.1121.00
75_D112_H2.0961.00
132_A136_A2.0601.00
90_A180_G2.0491.00
56_G59_D2.0451.00
41_A58_T2.0441.00
103_G125_L1.9421.00
187_D205_H1.9411.00
76_F114_A1.9221.00
41_A56_G1.8731.00
90_A93_F1.8641.00
204_A207_D1.8611.00
166_Y185_A1.8591.00
66_A160_A1.8361.00
44_L133_I1.7751.00
34_C37_A1.7291.00
92_W96_T1.6651.00
141_Q152_E1.6291.00
159_D163_V1.6201.00
68_V157_L1.6141.00
67_V102_W1.5861.00
86_A89_N1.5581.00
45_P109_T1.5121.00
165_R193_T1.5051.00
91_R122_T1.5041.00
33_R164_I1.4931.00
133_I137_F1.4851.00
92_W95_C1.4611.00
60_A102_W1.4201.00
113_E117_D1.4171.00
49_D53_T1.3971.00
114_A117_D1.3551.00
106_P134_A1.3431.00
181_A184_A1.3241.00
85_C89_N1.3131.00
60_A67_V1.2901.00
111_A114_A1.2881.00
131_G140_L1.2821.00
71_F104_I1.2571.00
86_A202_S1.2491.00
106_P151_P1.2391.00
68_V99_L1.2271.00
42_F137_F1.2261.00
161_D193_T1.2241.00
131_G135_D1.1991.00
66_A99_L1.1991.00
93_F183_K1.1841.00
109_T112_H1.1711.00
94_D183_K1.1611.00
92_W122_T1.1421.00
84_L115_F1.1351.00
174_S188_D1.1271.00
41_A57_L1.1241.00
157_L166_Y1.1241.00
108_S111_A1.1221.00
84_L123_F1.1201.00
88_Q91_R1.1121.00
39_A133_I1.1061.00
158_I164_I1.0911.00
93_F187_D1.0761.00
164_I167_A1.0671.00
135_D142_A1.0611.00
39_A57_L1.0561.00
108_S112_H1.0551.00
150_V172_D1.0541.00
106_P129_H1.0531.00
49_D55_L1.0201.00
154_A169_A1.0151.00
134_A140_L1.0081.00
87_I101_V0.9871.00
177_P181_A0.9871.00
87_I182_V0.9791.00
168_W185_A0.9751.00
155_V182_V0.9661.00
68_V155_V0.9651.00
86_A201_I0.9631.00
141_Q148_D0.9581.00
180_G204_A0.9561.00
86_A90_A0.9351.00
183_K187_D0.9291.00
40_P136_A0.9261.00
135_D140_L0.9221.00
72_Y103_G0.9221.00
39_A42_F0.9211.00
39_A158_I0.9211.00
139_V156_F0.9121.00
67_V100_A0.9070.99
84_L121_L0.8930.99
157_L182_V0.8920.99
93_F97_P0.8910.99
91_R101_V0.8770.99
109_T127_S0.8760.99
63_D162_R0.8630.99
152_E172_D0.8600.99
191_P209_T0.8560.99
45_P52_Q0.8510.99
97_P186_I0.8510.99
157_L186_I0.8500.99
174_S189_L0.8480.99
105_S127_S0.8480.99
152_E170_S0.8410.99
85_C88_Q0.8320.99
184_A188_D0.8310.99
34_C138_G0.8310.99
39_A164_I0.8170.99
45_P129_H0.8150.99
132_A135_D0.8140.99
197_A209_T0.8090.99
55_L60_A0.8060.99
84_L103_G0.7940.99
90_A179_L0.7930.99
49_D52_Q0.7910.99
147_H150_V0.7850.99
159_D193_T0.7830.98
79_V176_S0.7680.98
67_V162_R0.7650.98
50_G116_A0.7640.98
98_G190_Q0.7600.98
141_Q147_H0.7590.98
191_P197_A0.7590.98
35_E164_I0.7560.98
95_C122_T0.7470.98
66_A190_Q0.7470.98
64_N162_R0.7430.98
70_F103_G0.7430.98
70_F155_V0.7350.98
58_T63_D0.7270.98
165_R189_L0.7270.98
115_F119_Y0.7220.97
139_V154_A0.7150.97
77_S153_R0.7150.97
67_V158_I0.7150.97
68_V182_V0.7110.97
110_Y114_A0.7080.97
91_R100_A0.7070.97
113_E116_A0.7070.97
187_D204_A0.7050.97
74_F150_V0.7040.97
168_W182_V0.7040.97
112_H125_L0.7010.97
116_A125_L0.7010.97
105_S112_H0.7010.97
33_R37_A0.6990.97
74_F108_S0.6960.97
33_R40_P0.6950.97
69_L137_F0.6940.97
52_Q109_T0.6900.97
57_L67_V0.6900.97
90_A183_K0.6890.97
75_D125_L0.6830.96
32_M167_A0.6820.96
187_D190_Q0.6810.96
60_A69_L0.6780.96
103_G121_L0.6770.96
87_I179_L0.6750.96
69_L158_I0.6720.96
57_L137_F0.6690.96
116_A120_A0.6630.96
131_G134_A0.6620.96
190_Q194_A0.6620.96
109_T129_H0.6600.96
58_T162_R0.6550.95
104_I126_L0.6530.95
177_P184_A0.6530.95
134_A151_P0.6530.95
72_Y75_D0.6420.95
157_L185_A0.6400.95
68_V186_I0.6400.95
106_P131_G0.6380.95
155_V202_S0.6350.95
70_F83_E0.6350.95
198_P210_T0.6340.95
166_Y170_S0.6270.94
148_D172_D0.6270.94
115_F121_L0.6220.94
108_S129_H0.6180.94
42_F133_I0.6130.94
57_L60_A0.6080.93
36_G152_E0.6080.93
194_A205_H0.6050.93
191_P195_G0.6030.93
191_P194_A0.5900.92
142_A149_R0.5880.92
135_D149_R0.5880.92
64_N100_A0.5870.92
73_P77_S0.5860.92
192_D197_A0.5860.92
135_D147_H0.5860.92
75_D105_S0.5860.92
49_D124_P0.5860.92
180_G184_A0.5830.92
68_V101_V0.5830.92
109_T113_E0.5820.92
94_D101_V0.5810.92
192_D198_P0.5760.91
178_D182_V0.5730.91
67_V71_F0.5710.91
91_R123_F0.5700.91
72_Y80_C0.5700.91
114_A118_E0.5690.91
174_S199_R0.5660.91
156_F164_I0.5650.91
204_A208_G0.5630.90
81_A119_Y0.5600.90
86_A179_L0.5580.90
69_L126_L0.5570.90
155_V168_W0.5560.90
157_L168_W0.5520.90
84_L119_Y0.5500.89
205_H208_G0.5470.89
83_E155_V0.5460.89
49_D126_L0.5450.89
60_A100_A0.5450.89
75_D115_F0.5410.89
154_A167_A0.5370.88
63_D100_A0.5360.88
141_Q172_D0.5360.88
45_P127_S0.5360.88
52_Q113_E0.5330.88
71_F139_V0.5320.88
83_E170_S0.5320.88
178_D202_S0.5270.87
74_F107_D0.5270.87
189_L193_T0.5230.87
73_P115_F0.5210.87
94_D186_I0.5210.87
140_L200_T0.5190.87
141_Q149_R0.5170.86
75_D111_A0.5160.86
185_A189_L0.5150.86
73_P153_R0.5140.86
74_F110_Y0.5140.86
80_C153_R0.5130.86
97_P183_K0.5120.86
84_L88_Q0.5110.86
35_E152_E0.5100.86
161_D165_R0.5050.85
87_I123_F0.5020.85
69_L72_Y0.5010.85
71_F137_F0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v2gA 2 0.8208 100 0.276 Contact Map
1xccA 2 0.8208 100 0.284 Contact Map
1prxA 2 0.8302 100 0.285 Contact Map
3a2vA 5 0.8302 100 0.3 Contact Map
3w6gA 6 0.7972 100 0.302 Contact Map
3tjjA 3 0.7547 100 0.335 Contact Map
2i81A 3 0.8019 100 0.359 Contact Map
2pn8A 4 0.816 100 0.36 Contact Map
4rqxA 3 0.75 100 0.364 Contact Map
3zl5A 3 0.7406 100 0.364 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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