SYT - HALSA - GREMLIN Contacts

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SYT - Threonine--tRNA ligase

UniProt:	Q9HP27	Sequences: MSSVTVTLPDGSTLEVASGATVEDVAHEIGPGLGRDTVAGKIDHELVAKEEPISEDCEIEIVTDQSDEYLDVLRHTAAHVLAQAIRRHHPDAKLTIGPYTDEGFYYDIANVELDADDLDEIQAEAASIIDDDLDVERVEYDRADAREHYADNEFKREILDAEAAGDGPVSFYTQGDFEDLCKGPHVDSTGEIGGFEVLETSAAYWRGDEERETLTRVYGTAFPTESDLQEYLARREEAKERDHRKLGREMDLFSIPDVTGPGLPLYHPNGKTVLRELSEYVRGLNSEMGYDEVETPHLFRTELWKQSGHYDNYVDDMFLLDVNDEEYGLKPMNCPGHATIFNEGSWSYRDLPVRYFEDGKVYRKEQRGELSGLSRVWAFTIDDGHVFARADQIEAEVRRLMDTITEVLDTFDLDYEVALATRPEKSVGSDDIWEQSERQLREVLDQQGVDYDVEPGDGAFYGPKIDFGFEDALGRSWDGPTVQLDFNMPDRFDLEYTGSDNDAHQPVMIHRALYGSYERFFMVLIEHYNGRFPTWLAPEQVRILPVTDDNLGYAHRVKNELGDYRVEVEDRDWTVGKKIQQAHDDNVPYMLVVGDDEEDADAVSVRDRQEREGKGVDLAEFRAHLDSEVDGKRTEPDFLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	640 (623)
Sequences:	3567 (1628)
Seq/√Len:	65.2

ECOLI - SYT
BACSU - SYT1 SYT2
HALSA - SYT
SULSO - SYT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
498_G	504_H	5.964	1.00
550_N	595_D	4.121	1.00
556_R	601_D	3.846	1.00
394_E	442_E	3.828	1.00
124_E	127_S	3.471	1.00
87_R	124_E	3.415	1.00
441_R	445_D	3.353	1.00
132_D	188_S	3.265	1.00
394_E	446_Q	3.233	1.00
43_D	55_E	3.176	1.00
139_E	168_P	3.130	1.00
77_A	221_A	3.115	1.00
251_D	344_G	3.006	1.00
41_K	60_E	2.952	1.00
493_D	505_Q	2.906	1.00
301_T	305_K	2.892	1.00
138_V	173_T	2.889	1.00
22_V	40_G	2.842	1.00
293_V	340_I	2.832	1.00
490_D	505_Q	2.800	1.00
109_A	212_E	2.729	1.00
37_T	61_I	2.690	1.00
147_E	150_A	2.673	1.00
146_R	160_D	2.620	1.00
558_K	566_V	2.612	1.00
525_I	532_F	2.596	1.00
500_D	504_H	2.592	1.00
109_A	154_F	2.586	1.00
85_I	108_I	2.517	1.00
254_S	267_H	2.499	1.00
87_R	131_D	2.471	1.00
225_E	229_Q	2.444	1.00
80_V	129_I	2.413	1.00
41_K	68_E	2.370	1.00
560_E	619_A	2.341	1.00
80_V	192_I	2.321	1.00
42_I	57_C	2.306	1.00
498_G	502_D	2.297	1.00
146_R	156_R	2.265	1.00
136_E	173_T	2.256	1.00
422_R	426_S	2.224	1.00
76_T	135_V	2.187	1.00
591_L	603_V	2.143	1.00
429_S	432_I	2.140	1.00
544_L	575_V	2.134	1.00
595_D	599_D	2.127	1.00
414_D	470_E	2.123	1.00
80_V	128_I	2.111	1.00
224_T	227_D	2.109	1.00
571_R	581_Q	2.105	1.00
302_E	305_K	2.098	1.00
423_P	458_G	2.084	1.00
223_P	227_D	2.081	1.00
445_D	451_Y	2.070	1.00
627_S	631_G	2.056	1.00
83_Q	174_Q	2.050	1.00
539_E	567_E	2.032	1.00
76_T	186_V	2.019	1.00
557_V	618_L	2.001	1.00
284_L	406_E	1.984	1.00
284_L	288_M	1.983	1.00
173_T	178_E	1.981	1.00
150_A	160_D	1.980	1.00
438_R	442_E	1.962	1.00
558_K	568_V	1.944	1.00
142_R	164_A	1.943	1.00
24_D	27_H	1.939	1.00
251_D	267_H	1.933	1.00
543_I	558_K	1.925	1.00
284_L	287_E	1.914	1.00
549_D	595_D	1.901	1.00
547_T	550_N	1.890	1.00
398_R	446_Q	1.889	1.00
280_Y	410_T	1.855	1.00
86_R	177_F	1.855	1.00
438_R	441_R	1.854	1.00
299_F	336_G	1.853	1.00
426_S	430_D	1.851	1.00
620_E	623_A	1.842	1.00
86_R	152_N	1.839	1.00
39_A	72_V	1.787	1.00
196_E	232_L	1.778	1.00
269_N	585_D	1.777	1.00
441_R	453_V	1.771	1.00
132_D	190_G	1.768	1.00
122_Q	196_E	1.763	1.00
402_D	447_Q	1.756	1.00
16_V	20_A	1.741	1.00
60_E	66_S	1.736	1.00
87_R	176_D	1.734	1.00
74_R	220_T	1.733	1.00
427_V	487_N	1.725	0.99
564_Y	629_V	1.717	0.99
231_Y	235_R	1.712	0.99
187_D	191_E	1.709	0.99
338_A	508_M	1.694	0.99
276_E	279_E	1.694	0.99
147_E	151_D	1.679	0.99
555_H	558_K	1.676	0.99
546_V	575_V	1.675	0.99
81_L	121_I	1.670	0.99
47_V	51_E	1.669	0.99
154_F	212_E	1.660	0.99
16_V	28_E	1.649	0.99
552_G	555_H	1.633	0.99
32_G	36_D	1.610	0.99
280_Y	406_E	1.604	0.99
87_R	127_S	1.601	0.99
390_A	435_Q	1.600	0.99
273_V	521_F	1.596	0.99
70_L	74_R	1.593	0.99
454_E	457_D	1.578	0.99
556_R	560_E	1.570	0.99
534_T	625_L	1.569	0.99
269_N	567_E	1.568	0.99
83_Q	133_L	1.561	0.99
198_L	235_R	1.554	0.99
37_T	49_K	1.550	0.99
31_P	35_R	1.550	0.99
401_M	467_F	1.543	0.99
416_E	476_S	1.539	0.99
534_T	628_E	1.535	0.99
236_E	239_K	1.521	0.99
531_R	586_N	1.518	0.99
14_L	28_E	1.513	0.99
86_R	91_D	1.498	0.99
564_Y	625_L	1.497	0.99
23_E	27_H	1.479	0.98
583_H	586_N	1.479	0.98
142_R	165_G	1.475	0.98
245_K	249_E	1.469	0.98
73_L	223_P	1.468	0.98
43_D	57_C	1.467	0.98
626_D	630_D	1.456	0.98
444_L	465_I	1.455	0.98
123_A	126_A	1.443	0.98
555_H	570_D	1.441	0.98
343_E	346_W	1.439	0.98
208_D	211_R	1.437	0.98
149_Y	171_F	1.434	0.98
30_G	36_D	1.430	0.98
297_H	362_Y	1.429	0.98
596_D	599_D	1.426	0.98
143_A	147_E	1.423	0.98
561_L	622_R	1.422	0.98
260_G	263_L	1.419	0.98
582_A	590_M	1.409	0.98
25_V	59_I	1.408	0.98
202_A	213_T	1.406	0.98
495_E	503_A	1.404	0.98
102_E	234_R	1.402	0.98
591_L	621_F	1.401	0.98
134_D	188_S	1.397	0.98
468_G	476_S	1.397	0.98
161_A	206_R	1.388	0.98
544_L	590_M	1.386	0.98
397_V	465_I	1.384	0.98
366_Q	369_E	1.382	0.98
543_I	554_A	1.380	0.98
583_H	590_M	1.373	0.97
22_V	47_V	1.369	0.97
32_G	35_R	1.356	0.97
26_A	61_I	1.356	0.97
138_V	144_D	1.356	0.97
541_V	625_L	1.350	0.97
7_T	58_E	1.349	0.97
94_L	152_N	1.348	0.97
553_Y	593_V	1.343	0.97
623_A	627_S	1.341	0.97
592_V	604_S	1.340	0.97
278_S	294_E	1.338	0.97
171_F	178_E	1.338	0.97
269_N	539_E	1.335	0.97
135_V	174_Q	1.335	0.97
96_I	158_I	1.334	0.97
157_E	206_R	1.326	0.97
301_T	326_E	1.325	0.97
346_W	350_D	1.320	0.97
40_G	61_I	1.320	0.97
560_E	601_D	1.319	0.97
312_N	425_K	1.318	0.97
542_R	582_A	1.316	0.97
29_I	33_L	1.310	0.97
25_V	53_I	1.309	0.97
550_N	598_E	1.307	0.97
148_H	178_E	1.305	0.97
305_K	311_D	1.298	0.96
91_D	110_N	1.297	0.96
93_K	109_A	1.293	0.96
46_L	62_V	1.278	0.96
227_D	230_E	1.278	0.96
541_V	564_Y	1.273	0.96
266_Y	521_F	1.273	0.96
246_L	250_M	1.272	0.96
127_S	131_D	1.267	0.96
69_Y	223_P	1.261	0.96
497_T	503_A	1.260	0.96
140_Y	171_F	1.254	0.96
53_I	57_C	1.252	0.96
64_D	70_L	1.252	0.96
38_V	72_V	1.251	0.96
542_R	585_D	1.250	0.96
421_T	453_V	1.242	0.95
163_A	166_D	1.239	0.95
114_D	118_L	1.238	0.95
17_A	20_A	1.234	0.95
70_L	73_L	1.225	0.95
240_E	529_N	1.224	0.95
7_T	13_T	1.221	0.95
41_K	46_L	1.221	0.95
144_D	147_E	1.218	0.95
140_Y	148_H	1.217	0.95
141_D	144_D	1.214	0.95
198_L	220_T	1.213	0.95
281_V	407_V	1.213	0.95
146_R	159_L	1.212	0.95
21_T	24_D	1.210	0.95
589_Y	628_E	1.210	0.95
622_R	626_D	1.208	0.95
391_D	499_S	1.207	0.95
393_I	484_L	1.203	0.94
560_E	622_R	1.201	0.94
421_T	441_R	1.200	0.94
272_T	565_R	1.200	0.94
379_F	516_S	1.192	0.94
617_D	620_E	1.190	0.94
51_E	170_S	1.188	0.94
346_W	353_V	1.187	0.94
321_D	324_D	1.186	0.94
288_M	406_E	1.184	0.94
51_E	137_R	1.182	0.94
624_H	628_E	1.182	0.94
201_S	213_T	1.178	0.94
555_H	568_V	1.175	0.94
539_E	542_R	1.172	0.94
26_A	29_I	1.164	0.93
556_R	559_N	1.164	0.93
360_K	378_A	1.163	0.93
94_L	108_I	1.162	0.93
272_T	276_E	1.160	0.93
75_H	98_P	1.158	0.93
274_L	294_E	1.157	0.93
96_I	100_T	1.157	0.93
354_R	396_E	1.155	0.93
288_M	403_T	1.154	0.93
133_L	189_T	1.153	0.93
163_A	169_V	1.150	0.93
281_V	285_N	1.149	0.93
562_G	626_D	1.145	0.93
577_K	581_Q	1.144	0.93
256_P	339_T	1.143	0.93
64_D	73_L	1.140	0.93
27_H	31_P	1.140	0.93
164_A	167_G	1.139	0.93
338_A	494_L	1.130	0.92
251_D	254_S	1.127	0.92
36_D	65_Q	1.125	0.92
40_G	47_V	1.122	0.92
546_V	576_G	1.120	0.92
552_G	556_R	1.118	0.92
560_E	618_L	1.118	0.92
75_H	79_H	1.112	0.92
430_D	434_E	1.109	0.92
42_I	59_I	1.109	0.92
607_D	610_E	1.108	0.92
605_V	621_F	1.106	0.92
71_D	99_Y	1.104	0.92
531_R	608_R	1.101	0.91
135_V	186_V	1.101	0.91
274_L	278_S	1.093	0.91
402_D	406_E	1.091	0.91
113_L	217_V	1.091	0.91
344_G	350_D	1.088	0.91
616_V	624_H	1.088	0.91
398_R	447_Q	1.088	0.91
310_Y	328_G	1.087	0.91
275_R	279_E	1.082	0.91
133_L	176_D	1.079	0.91
60_E	68_E	1.078	0.91
551_L	570_D	1.077	0.90
226_S	229_Q	1.075	0.90
7_T	56_D	1.073	0.90
405_T	409_D	1.070	0.90
279_E	283_G	1.069	0.90
100_T	105_Y	1.069	0.90
73_L	77_A	1.069	0.90
297_H	360_K	1.067	0.90
85_I	92_A	1.066	0.90
432_I	487_N	1.066	0.90
426_S	434_E	1.063	0.90
22_V	61_I	1.062	0.90
134_D	190_G	1.062	0.90
254_S	343_E	1.060	0.90
616_V	621_F	1.059	0.90
237_E	240_E	1.057	0.90
554_A	568_V	1.056	0.90
137_R	170_S	1.055	0.90
293_V	337_H	1.054	0.90
236_E	240_E	1.054	0.90
256_P	267_H	1.050	0.89
64_D	223_P	1.048	0.89
277_L	514_Y	1.047	0.89
321_D	326_E	1.045	0.89
76_T	80_V	1.044	0.89
92_A	108_I	1.043	0.89
277_L	411_F	1.042	0.89
260_G	299_F	1.039	0.89
23_E	34_G	1.039	0.89
230_E	233_A	1.034	0.89
276_E	565_R	1.034	0.89
159_L	169_V	1.033	0.89
611_R	614_K	1.031	0.88
118_L	219_G	1.030	0.88
338_A	387_F	1.029	0.88
591_L	605_V	1.025	0.88
543_I	557_V	1.024	0.88
95_T	152_N	1.020	0.88
469_F	479_G	1.019	0.88
548_D	551_L	1.019	0.88
285_N	358_D	1.015	0.88
300_R	325_E	1.014	0.88
418_A	468_G	1.012	0.88
6_V	25_V	1.012	0.88
131_D	176_D	1.009	0.87
42_I	53_I	1.007	0.87
133_L	174_Q	1.005	0.87
10_D	29_I	1.005	0.87
312_N	427_V	1.005	0.87
80_V	135_V	1.004	0.87
386_V	400_L	1.004	0.87
88_H	121_I	0.999	0.87
22_V	59_I	0.998	0.87
233_A	236_E	0.994	0.87
376_V	379_F	0.993	0.86
442_E	446_Q	0.991	0.86
555_H	559_N	0.989	0.86
62_V	72_V	0.988	0.86
226_S	230_E	0.988	0.86
27_H	34_G	0.987	0.86
596_D	600_A	0.985	0.86
301_T	310_Y	0.982	0.86
42_I	47_V	0.980	0.86
73_L	221_A	0.979	0.86
224_T	229_Q	0.978	0.86
43_D	58_E	0.971	0.85
619_A	623_A	0.966	0.85
42_I	51_E	0.966	0.85
531_R	583_H	0.964	0.85
70_L	223_P	0.963	0.85
33_L	61_I	0.961	0.85
545_P	554_A	0.959	0.85
389_R	499_S	0.958	0.84
574_T	577_K	0.951	0.84
122_Q	126_A	0.951	0.84
273_V	276_E	0.948	0.84
6_V	59_I	0.945	0.84
132_D	189_T	0.943	0.84
163_A	167_G	0.943	0.84
271_K	294_E	0.942	0.83
20_A	24_D	0.940	0.83
304_W	336_G	0.939	0.83
26_A	30_G	0.936	0.83
417_V	449_V	0.936	0.83
21_T	52_P	0.936	0.83
488_M	491_R	0.933	0.83
361_V	514_Y	0.931	0.83
159_L	163_A	0.928	0.83
98_P	185_H	0.928	0.83
30_G	33_L	0.927	0.82
93_K	153_E	0.926	0.82
74_R	221_A	0.924	0.82
439_Q	484_L	0.923	0.82
108_I	113_L	0.922	0.82
155_K	179_D	0.921	0.82
293_V	355_Y	0.920	0.82
62_V	66_S	0.919	0.82
39_A	62_V	0.919	0.82
115_A	119_D	0.916	0.82
545_P	550_N	0.913	0.81
143_A	165_G	0.912	0.81
96_I	206_R	0.912	0.81
89_H	111_V	0.911	0.81
138_V	171_F	0.910	0.81
79_H	185_H	0.908	0.81
79_H	98_P	0.907	0.81
282_R	292_E	0.906	0.81
434_E	438_R	0.906	0.81
188_S	191_E	0.905	0.81
8_L	30_G	0.904	0.81
562_G	622_R	0.902	0.81
541_V	591_L	0.901	0.81
595_D	598_E	0.900	0.81
610_E	613_G	0.898	0.80
275_R	278_S	0.898	0.80
534_T	629_V	0.896	0.80
601_D	618_L	0.896	0.80
26_A	34_G	0.895	0.80
20_A	53_I	0.895	0.80
19_G	52_P	0.893	0.80
96_I	152_N	0.890	0.80
22_V	25_V	0.889	0.80
10_D	33_L	0.886	0.80
75_H	185_H	0.885	0.79
133_L	175_G	0.884	0.79
355_Y	384_G	0.884	0.79
418_A	454_E	0.883	0.79
8_L	59_I	0.883	0.79
113_L	119_D	0.882	0.79
73_L	129_I	0.880	0.79
601_D	619_A	0.878	0.79
181_C	185_H	0.875	0.79
146_R	150_A	0.874	0.79
16_V	25_V	0.874	0.79
401_M	447_Q	0.872	0.78
575_V	578_K	0.871	0.78
457_D	466_D	0.870	0.78
564_Y	626_D	0.868	0.78
374_S	522_M	0.866	0.78
8_L	12_S	0.866	0.78
421_T	458_G	0.866	0.78
548_D	572_D	0.860	0.77
616_V	620_E	0.860	0.77
543_I	593_V	0.859	0.77
86_R	92_A	0.858	0.77
233_A	240_E	0.858	0.77
233_A	237_E	0.858	0.77
142_R	163_A	0.857	0.77
419_L	484_L	0.857	0.77
53_I	56_D	0.856	0.77
281_V	358_D	0.854	0.77
118_L	197_V	0.854	0.77
401_M	465_I	0.854	0.77
263_L	378_A	0.850	0.77
471_D	475_R	0.848	0.76
531_R	609_Q	0.847	0.76
553_Y	557_V	0.847	0.76
545_P	568_V	0.846	0.76
357_E	380_T	0.844	0.76
543_I	568_V	0.843	0.76
285_N	356_F	0.842	0.76
542_R	567_E	0.838	0.76
20_A	25_V	0.836	0.75
602_A	617_D	0.836	0.75
306_Q	492_F	0.835	0.75
288_M	402_D	0.834	0.75
209_E	366_Q	0.832	0.75
605_V	616_V	0.832	0.75
416_E	452_D	0.832	0.75
285_N	400_L	0.829	0.75
291_D	355_Y	0.828	0.75
78_A	182_K	0.827	0.75
106_Y	155_K	0.826	0.75
232_L	235_R	0.826	0.75
246_L	249_E	0.825	0.74
266_Y	518_E	0.824	0.74
252_L	525_I	0.824	0.74
543_I	618_L	0.819	0.74
382_D	477_W	0.819	0.74
255_I	264_P	0.818	0.74
87_R	128_I	0.818	0.74
276_E	629_V	0.818	0.74
142_R	146_R	0.817	0.74
41_K	62_V	0.817	0.74
209_E	212_E	0.817	0.74
573_W	581_Q	0.816	0.74
413_L	486_F	0.814	0.73
85_I	121_I	0.814	0.73
75_H	181_C	0.813	0.73
73_L	186_V	0.811	0.73
417_V	467_F	0.811	0.73
604_S	612_E	0.810	0.73
102_E	231_Y	0.808	0.73
154_F	211_R	0.806	0.73
98_P	181_C	0.803	0.72
397_V	482_V	0.802	0.72
157_E	211_R	0.800	0.72
554_A	593_V	0.799	0.72
400_L	509_I	0.798	0.72
471_D	478_D	0.798	0.72
26_A	33_L	0.797	0.72
389_R	392_Q	0.796	0.72
106_Y	179_D	0.793	0.72
357_E	361_V	0.792	0.71
149_Y	159_L	0.792	0.71
395_A	399_R	0.790	0.71
551_L	555_H	0.789	0.71
612_E	615_G	0.789	0.71
422_R	430_D	0.787	0.71
382_D	471_D	0.787	0.71
381_I	512_A	0.787	0.71
302_E	306_Q	0.786	0.71
584_D	608_R	0.786	0.71
74_R	223_P	0.785	0.71
18_S	54_S	0.785	0.71
304_W	423_P	0.782	0.70
22_V	49_K	0.782	0.70
45_E	51_E	0.780	0.70
621_F	625_L	0.780	0.70
627_S	630_D	0.780	0.70
553_Y	598_E	0.777	0.70
111_V	117_D	0.777	0.70
421_T	454_E	0.775	0.70
77_A	195_F	0.774	0.70
97_G	183_G	0.774	0.70
569_E	578_K	0.773	0.70
252_L	532_F	0.771	0.69
198_L	232_L	0.771	0.69
6_V	57_C	0.769	0.69
419_L	441_R	0.768	0.69
534_T	589_Y	0.768	0.69
51_E	54_S	0.768	0.69
117_D	120_E	0.767	0.69
280_Y	284_L	0.767	0.69
79_H	97_G	0.767	0.69
419_L	444_L	0.766	0.69
79_H	181_C	0.765	0.69
8_L	33_L	0.763	0.69
111_V	120_E	0.762	0.68
250_M	531_R	0.760	0.68
246_L	586_N	0.758	0.68
250_M	585_D	0.757	0.68
82_A	177_F	0.755	0.68
288_M	399_R	0.752	0.67
532_F	537_A	0.750	0.67
110_N	212_E	0.749	0.67
203_A	213_T	0.749	0.67
39_A	46_L	0.748	0.67
16_V	19_G	0.748	0.67
437_E	455_P	0.748	0.67
345_S	503_A	0.748	0.67
66_S	69_Y	0.745	0.67
339_T	342_N	0.742	0.66
29_I	32_G	0.740	0.66
97_G	106_Y	0.740	0.66
234_R	473_L	0.738	0.66
299_F	328_G	0.737	0.66
95_T	214_L	0.734	0.66
512_A	516_S	0.733	0.65
157_E	161_A	0.733	0.65
284_L	410_T	0.732	0.65
78_A	99_Y	0.730	0.65
407_V	512_A	0.730	0.65
264_P	378_A	0.728	0.65
142_R	169_V	0.728	0.65
75_H	97_G	0.728	0.65
342_N	494_L	0.725	0.65
404_I	413_L	0.724	0.65
604_S	615_G	0.723	0.64
83_Q	176_D	0.723	0.64
541_V	566_V	0.723	0.64
545_P	551_L	0.723	0.64
155_K	185_H	0.722	0.64
434_E	437_E	0.721	0.64
557_V	561_L	0.720	0.64
128_I	131_D	0.720	0.64
405_T	415_Y	0.719	0.64
77_A	80_V	0.718	0.64
287_E	406_E	0.717	0.64
31_P	34_G	0.717	0.64
98_P	106_Y	0.717	0.64
113_L	152_N	0.717	0.64
345_S	497_T	0.717	0.64
16_V	53_I	0.716	0.64
124_E	131_D	0.715	0.64
81_L	85_I	0.715	0.64
382_D	478_D	0.715	0.64
291_D	353_V	0.715	0.64
230_E	234_R	0.715	0.64
142_R	167_G	0.713	0.63
342_N	493_D	0.713	0.63
589_Y	621_F	0.713	0.63
29_I	34_G	0.710	0.63
561_L	618_L	0.709	0.63
70_L	220_T	0.708	0.63
546_V	550_N	0.708	0.63
131_D	189_T	0.706	0.63
85_I	113_L	0.706	0.63
545_P	575_V	0.705	0.62
304_W	458_G	0.705	0.62
315_D	425_K	0.705	0.62
263_L	299_F	0.705	0.62
38_V	64_D	0.705	0.62
163_A	168_P	0.704	0.62
471_D	477_W	0.704	0.62
358_D	512_A	0.702	0.62
274_L	380_T	0.702	0.62
140_Y	146_R	0.699	0.62
534_T	621_F	0.697	0.62
65_Q	227_D	0.697	0.62
292_E	408_L	0.696	0.61
64_D	74_R	0.695	0.61
420_A	454_E	0.694	0.61
613_G	616_V	0.694	0.61
301_T	319_L	0.694	0.61
285_N	514_Y	0.693	0.61
33_L	63_T	0.691	0.61
247_G	253_F	0.689	0.61
40_G	59_I	0.688	0.61
567_E	587_V	0.688	0.61
33_L	37_T	0.688	0.61
395_A	398_R	0.687	0.60
361_V	400_L	0.687	0.60
148_H	173_T	0.687	0.60
177_F	180_L	0.687	0.60
165_G	169_V	0.685	0.60
179_D	185_H	0.685	0.60
310_Y	408_L	0.684	0.60
618_L	622_R	0.682	0.60
534_T	564_Y	0.679	0.60
97_G	179_D	0.678	0.59
97_G	185_H	0.678	0.59
418_A	476_S	0.676	0.59
126_A	130_D	0.676	0.59
319_L	328_G	0.673	0.59
82_A	106_Y	0.673	0.59
95_T	158_I	0.672	0.59
283_G	563_D	0.670	0.59
62_V	68_E	0.670	0.59
462_G	486_F	0.667	0.58
8_L	34_G	0.667	0.58
361_V	380_T	0.666	0.58
400_L	482_V	0.666	0.58
138_V	178_E	0.664	0.58
564_Y	622_R	0.664	0.58
421_T	457_D	0.664	0.58
30_G	34_G	0.664	0.58
268_P	355_Y	0.662	0.58
354_R	399_R	0.661	0.57
313_Y	466_D	0.661	0.57
54_S	57_C	0.660	0.57
362_Y	408_L	0.659	0.57
36_D	63_T	0.659	0.57
547_T	595_D	0.658	0.57
109_A	153_E	0.657	0.57
396_E	399_R	0.656	0.57
561_L	564_Y	0.654	0.57
102_E	220_T	0.654	0.57
119_D	123_A	0.654	0.57
436_S	486_F	0.653	0.57
154_F	213_T	0.653	0.57
318_F	364_K	0.653	0.57
467_F	480_P	0.652	0.56
6_V	20_A	0.652	0.56
382_D	523_V	0.652	0.56
153_E	212_E	0.652	0.56
23_E	49_K	0.648	0.56
487_N	490_D	0.648	0.56
400_L	404_I	0.647	0.56
256_P	265_L	0.647	0.56
73_L	220_T	0.646	0.56
31_P	36_D	0.646	0.56
297_H	378_A	0.646	0.56
64_D	69_Y	0.646	0.56
96_I	105_Y	0.645	0.56
83_Q	128_I	0.645	0.56
453_V	458_G	0.644	0.56
427_V	491_R	0.643	0.55
547_T	572_D	0.642	0.55
106_Y	185_H	0.642	0.55
98_P	155_K	0.642	0.55
148_H	171_F	0.641	0.55
290_Y	400_L	0.641	0.55
157_E	205_W	0.640	0.55
592_V	615_G	0.640	0.55
432_I	490_D	0.640	0.55
46_L	72_V	0.639	0.55
423_P	479_G	0.638	0.55
209_E	213_T	0.638	0.55
172_Y	184_P	0.637	0.55
361_V	374_S	0.635	0.55
424_E	456_G	0.635	0.55
6_V	16_V	0.635	0.55
422_R	437_E	0.635	0.55
382_D	475_R	0.635	0.55
140_Y	144_D	0.634	0.54
75_H	106_Y	0.633	0.54
281_V	514_Y	0.632	0.54
284_L	403_T	0.631	0.54
602_A	615_G	0.631	0.54
100_T	218_Y	0.630	0.54
20_A	52_P	0.629	0.54
113_L	215_T	0.629	0.54
275_R	292_E	0.629	0.54
312_N	487_N	0.628	0.54
100_T	206_R	0.626	0.53
123_A	226_S	0.626	0.53
539_E	566_V	0.625	0.53
37_T	63_T	0.625	0.53
8_L	19_G	0.624	0.53
143_A	146_R	0.624	0.53
72_V	76_T	0.624	0.53
100_T	158_I	0.624	0.53
521_F	525_I	0.624	0.53
83_Q	135_V	0.624	0.53
404_I	467_F	0.623	0.53
229_Q	233_A	0.623	0.53
145_A	169_V	0.623	0.53
156_R	160_D	0.623	0.53
19_G	54_S	0.620	0.53
607_D	628_E	0.619	0.53
129_I	190_G	0.619	0.53
197_V	217_V	0.618	0.53
89_H	117_D	0.618	0.53
381_I	516_S	0.617	0.52
337_H	486_F	0.615	0.52
583_H	609_Q	0.614	0.52
556_R	598_E	0.613	0.52
489_P	508_M	0.613	0.52
603_V	621_F	0.612	0.52
328_G	336_G	0.612	0.52
360_K	380_T	0.612	0.52
80_V	194_G	0.612	0.52
454_E	468_G	0.611	0.52
48_A	184_P	0.610	0.52
129_I	195_F	0.609	0.51
623_A	626_D	0.608	0.51
298_L	320_L	0.606	0.51
272_T	275_R	0.606	0.51
458_G	479_G	0.605	0.51
79_H	106_Y	0.605	0.51
329_L	472_A	0.604	0.51
140_Y	145_A	0.604	0.51
453_V	457_D	0.602	0.51
197_V	219_G	0.601	0.51
421_T	444_L	0.601	0.51
523_V	527_H	0.600	0.50
97_G	181_C	0.598	0.50
431_D	434_E	0.596	0.50
98_P	183_G	0.596	0.50
120_E	123_A	0.595	0.50
482_V	509_I	0.595	0.50
522_M	525_I	0.594	0.50
278_S	337_H	0.593	0.50
74_R	195_F	0.593	0.50
239_K	245_K	0.593	0.50
101_D	470_E	0.592	0.49
77_A	192_I	0.592	0.49
313_Y	316_D	0.592	0.49
160_D	163_A	0.591	0.49
53_I	59_I	0.590	0.49
545_P	593_V	0.590	0.49
81_L	217_V	0.588	0.49
22_V	52_P	0.587	0.49
23_E	50_E	0.587	0.49
8_L	32_G	0.586	0.49
418_A	452_D	0.586	0.49
234_R	474_G	0.585	0.49
94_L	149_Y	0.585	0.49
557_V	560_E	0.585	0.49
275_R	286_S	0.584	0.49
88_H	124_E	0.583	0.48
194_G	225_E	0.582	0.48
319_L	488_M	0.582	0.48
79_H	183_G	0.581	0.48
26_A	40_G	0.581	0.48
251_D	269_N	0.581	0.48
12_S	28_E	0.581	0.48
137_R	172_Y	0.579	0.48
341_F	508_M	0.578	0.48
294_E	360_K	0.577	0.48
496_Y	504_H	0.577	0.48
8_L	11_G	0.577	0.48
589_Y	607_D	0.576	0.48
79_H	155_K	0.575	0.47
194_G	228_L	0.575	0.47
138_V	148_H	0.574	0.47
143_A	166_D	0.574	0.47
292_E	480_P	0.574	0.47
146_R	163_A	0.572	0.47
583_H	606_R	0.571	0.47
353_V	389_R	0.570	0.47
64_D	186_V	0.570	0.47
285_N	361_V	0.570	0.47
607_D	614_K	0.569	0.47
541_V	593_V	0.569	0.47
553_Y	602_A	0.569	0.47
444_L	451_Y	0.568	0.47
75_H	155_K	0.568	0.47
362_Y	378_A	0.568	0.47
109_A	213_T	0.568	0.47
250_M	532_F	0.567	0.47
45_E	147_E	0.566	0.46
306_Q	488_M	0.565	0.46
263_L	297_H	0.565	0.46
260_G	297_H	0.565	0.46
371_S	374_S	0.565	0.46
155_K	181_C	0.565	0.46
604_S	613_G	0.564	0.46
97_G	155_K	0.563	0.46
72_V	187_D	0.563	0.46
25_V	28_E	0.563	0.46
94_L	177_F	0.562	0.46
95_T	157_E	0.562	0.46
562_G	623_A	0.561	0.46
92_A	113_L	0.561	0.46
390_A	504_H	0.561	0.46
47_V	57_C	0.560	0.46
625_L	629_V	0.560	0.46
328_G	408_L	0.560	0.46
542_R	593_V	0.559	0.46
384_G	488_M	0.558	0.46
281_V	361_V	0.557	0.45
478_D	516_S	0.557	0.45
290_Y	511_R	0.557	0.45
341_F	346_W	0.556	0.45
571_R	574_T	0.556	0.45
484_L	509_I	0.556	0.45
96_I	182_K	0.555	0.45
478_D	523_V	0.555	0.45
305_K	326_E	0.555	0.45
110_N	113_L	0.555	0.45
361_V	492_F	0.554	0.45
582_A	587_V	0.554	0.45
14_L	33_L	0.554	0.45
439_Q	443_V	0.554	0.45
420_A	468_G	0.553	0.45
77_A	220_T	0.552	0.45
514_Y	517_Y	0.552	0.45
170_S	174_Q	0.552	0.45
237_E	241_R	0.551	0.45
138_V	141_D	0.551	0.45
275_R	282_R	0.550	0.45
301_T	328_G	0.549	0.44
391_D	435_Q	0.548	0.44
285_N	382_D	0.547	0.44
613_G	624_H	0.547	0.44
471_D	523_V	0.546	0.44
381_I	478_D	0.546	0.44
115_A	215_T	0.545	0.44
131_D	175_G	0.545	0.44
11_G	33_L	0.545	0.44
340_I	486_F	0.544	0.44
250_M	587_V	0.544	0.44
52_P	55_E	0.543	0.44
393_I	397_V	0.543	0.44
126_A	225_E	0.543	0.44
310_Y	314_V	0.543	0.44
20_A	28_E	0.543	0.44
229_Q	611_R	0.542	0.44
574_T	580_Q	0.542	0.44
44_H	60_E	0.542	0.44
12_S	29_I	0.541	0.44
208_D	212_E	0.541	0.44
542_R	587_V	0.540	0.43
100_T	182_K	0.539	0.43
274_L	361_V	0.538	0.43
281_V	356_F	0.536	0.43
299_F	320_L	0.536	0.43
361_V	517_Y	0.536	0.43
292_E	358_D	0.536	0.43
408_L	469_F	0.536	0.43
237_E	529_N	0.536	0.43
285_N	289_G	0.535	0.43
413_L	428_G	0.534	0.43
230_E	474_G	0.534	0.43
423_P	453_V	0.533	0.43
407_V	513_L	0.532	0.43
393_I	439_Q	0.532	0.43
209_E	369_E	0.532	0.43
411_F	520_F	0.531	0.42
67_D	452_D	0.531	0.42
310_Y	319_L	0.531	0.42
475_R	478_D	0.530	0.42
320_L	328_G	0.529	0.42
86_R	135_V	0.529	0.42
22_V	39_A	0.529	0.42
185_H	218_Y	0.529	0.42
173_T	177_F	0.528	0.42
421_T	437_E	0.528	0.42
123_A	127_S	0.528	0.42
158_I	161_A	0.527	0.42
298_L	327_Y	0.527	0.42
608_R	614_K	0.527	0.42
14_L	25_V	0.527	0.42
140_Y	156_R	0.527	0.42
45_E	55_E	0.526	0.42
278_S	517_Y	0.525	0.42
304_W	479_G	0.524	0.42
320_L	364_K	0.523	0.41
278_S	358_D	0.523	0.41
234_R	470_E	0.523	0.41
272_T	286_S	0.523	0.41
286_S	292_E	0.523	0.41
29_I	61_I	0.523	0.41
83_Q	87_R	0.522	0.41
282_R	358_D	0.522	0.41
398_R	402_D	0.522	0.41
83_Q	189_T	0.521	0.41
28_E	31_P	0.521	0.41
586_N	609_Q	0.521	0.41
477_W	480_P	0.520	0.41
106_Y	181_C	0.520	0.41
267_H	343_E	0.520	0.41
420_A	488_M	0.518	0.41
469_F	476_S	0.518	0.41
254_S	265_L	0.517	0.41
8_L	20_A	0.517	0.41
610_E	614_K	0.517	0.41
404_I	513_L	0.516	0.41
441_R	455_P	0.516	0.41
260_G	380_T	0.515	0.41
150_A	153_E	0.514	0.40
274_L	360_K	0.514	0.40
543_I	603_V	0.514	0.40
426_S	458_G	0.513	0.40
70_L	227_D	0.512	0.40
12_S	33_L	0.511	0.40
299_F	469_F	0.511	0.40
593_V	603_V	0.511	0.40
89_H	120_E	0.511	0.40
389_R	496_Y	0.511	0.40
197_V	200_T	0.511	0.40
401_M	419_L	0.510	0.40
471_D	516_S	0.510	0.40
134_D	189_T	0.509	0.40
251_D	346_W	0.508	0.40
413_L	469_F	0.507	0.40
141_D	170_S	0.506	0.40
48_A	51_E	0.506	0.40
316_D	366_Q	0.506	0.40
304_W	421_T	0.506	0.40
68_E	71_D	0.504	0.39
428_G	471_D	0.504	0.39
186_V	194_G	0.504	0.39
285_N	512_A	0.503	0.39
429_S	487_N	0.503	0.39
401_M	469_F	0.502	0.39
75_H	183_G	0.501	0.39
261_P	325_E	0.501	0.39
271_K	360_K	0.501	0.39
541_V	621_F	0.501	0.39
432_I	435_Q	0.500	0.39
241_R	529_N	0.500	0.39
70_L	221_A	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qf6A	1	0.9922	100	0.357	Contact Map
1nyrA	2	0.9906	100	0.368	Contact Map
3uh0A	2	0.6156	100	0.658	Contact Map
4hwtA	2	0.6188	100	0.66	Contact Map
1evlA	2	0.6188	100	0.661	Contact Map
3a32A	2	0.6234	100	0.671	Contact Map
3qneA	2	0.6547	100	0.721	Contact Map
2zt5A	2	0.5563	100	0.727	Contact Map
1atiA	2	0.5594	100	0.728	Contact Map
2j3lA	2	0.6281	100	0.73	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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