GREMLIN Database
Q9HP26 - Cold shock protein
UniProt: Q9HP26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 69 (58)
Sequences: 511 (308)
Seq/√Len: 40.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_T27_D2.7361.00
50_E66_V2.7061.00
4_G62_A2.5041.00
17_F34_H2.3471.00
18_I62_A2.2661.00
5_K28_D2.1050.99
56_S59_G1.9860.99
6_V43_L1.8290.98
46_G65_L1.7920.98
52_D64_N1.5860.95
5_K27_D1.5750.95
18_I49_V1.5640.95
8_F13_G1.5030.94
12_T33_F1.4830.93
47_Q51_F1.4290.92
7_D30_D1.3620.90
17_F32_F1.3380.89
40_G64_N1.3290.89
9_F13_G1.2890.87
33_F43_L1.2860.87
32_F37_D1.2530.86
26_D50_E1.1510.80
21_D28_D1.0940.77
9_F33_F1.0870.76
4_G35_M1.0850.76
3_S47_Q1.0810.76
20_T51_F1.0750.76
7_D13_G1.0510.74
6_V42_D1.0370.73
15_Y61_R1.0190.72
21_D48_E0.9880.69
42_D53_I0.9770.68
42_D64_N0.9660.67
33_F47_Q0.9460.66
9_F35_M0.9430.66
40_G43_L0.9190.63
49_V60_P0.9030.62
15_Y34_H0.8700.59
55_S60_P0.8690.59
15_Y65_L0.8680.59
15_Y53_I0.8630.59
52_D58_K0.8360.56
14_G38_V0.8290.56
61_R65_L0.8280.55
38_V53_I0.7980.53
9_F19_S0.7960.52
18_I37_D0.7920.52
14_G28_D0.7880.52
6_V16_G0.7590.49
48_E63_T0.7560.49
5_K48_E0.7560.49
39_G43_L0.7510.48
18_I61_R0.7410.47
33_F51_F0.7370.47
21_D27_D0.7180.45
3_S36_E0.7100.45
8_F33_F0.6900.43
3_S21_D0.6780.42
17_F36_E0.6730.41
4_G18_I0.6690.41
15_Y32_F0.6630.40
52_D63_T0.6620.40
58_K61_R0.6420.39
31_V37_D0.6360.38
15_Y36_E0.6280.37
20_T31_V0.6220.37
4_G33_F0.6200.37
13_G33_F0.6180.36
44_E63_T0.6100.36
17_F46_G0.6060.35
20_T28_D0.5980.35
12_T29_E0.5870.34
3_S18_I0.5870.34
21_D39_G0.5860.34
4_G21_D0.5830.34
49_V62_A0.5810.33
32_F51_F0.5650.32
20_T48_E0.5570.31
19_S49_V0.5500.31
29_E63_T0.5360.30
18_I53_I0.5300.29
54_E60_P0.5290.29
14_G39_G0.5160.28
39_G42_D0.5120.28
16_G43_L0.5090.28
5_K19_S0.5020.27
29_E65_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3camA 2 0.9275 99.6 0.258 Contact Map
3aqqA 4 0.942 99.6 0.272 Contact Map
1c9oA 2 0.913 99.5 0.274 Contact Map
2lxjA 1 0.913 99.5 0.278 Contact Map
3i2zB 2 0.9275 99.5 0.279 Contact Map
1g6pA 1 0.913 99.5 0.289 Contact Map
3a0jA 1 0.9275 99.5 0.289 Contact Map
2k5nA 1 0.9275 99.5 0.292 Contact Map
2kcmA 1 0.913 99.5 0.297 Contact Map
1wfqA 1 0.913 99.5 0.298 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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