GREMLIN Database
Q9HP24 - Uncharacterized protein
UniProt: Q9HP24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 337 (321)
Sequences: 582 (401)
Seq/√Len: 22.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_L120_C6.6791.00
172_V334_E5.5901.00
322_T327_F4.4741.00
301_D305_D3.9401.00
203_A240_S3.7521.00
314_A331_A3.7481.00
293_G317_I3.7331.00
166_Y176_A3.5181.00
272_E316_A3.3631.00
168_A330_D3.1541.00
87_V97_V3.0421.00
91_L118_H2.9680.99
84_R108_D2.9290.99
169_A174_L2.8720.99
179_V211_V2.8610.99
303_D307_H2.8430.99
32_V54_I2.7800.99
34_D54_I2.7660.99
88_R114_L2.6820.99
21_V69_I2.6670.99
297_T306_A2.6060.99
8_H35_R2.5940.99
282_A288_S2.5690.98
250_L278_Y2.5200.98
233_A264_Y2.5060.98
55_V63_A2.4230.98
277_R281_L2.2720.97
31_A55_V2.1430.95
308_D312_D2.1300.95
250_L282_A2.1180.95
290_V319_A2.0820.94
149_T162_T2.0740.94
235_S238_T2.0270.94
260_S265_D2.0270.94
17_T184_T2.0140.93
207_V245_S1.9800.93
147_V249_H1.9670.93
193_V198_V1.9510.92
169_A222_F1.9450.92
274_F278_Y1.8800.91
161_A294_M1.8720.90
89_A93_R1.8640.90
310_V321_A1.8600.90
270_P273_S1.8410.90
84_R110_E1.7870.88
146_V223_V1.7800.88
92_E118_H1.7670.88
4_A31_A1.7580.87
295_L310_V1.7570.87
179_V221_V1.7110.86
61_V95_A1.7090.86
309_A313_Y1.7050.86
168_A172_V1.7040.86
271_I313_Y1.6960.85
311_A315_T1.6390.83
236_G240_S1.6130.82
119_G318_D1.5930.82
91_L97_V1.5860.81
147_V251_V1.5640.80
168_A171_D1.5630.80
312_D316_A1.5600.80
236_G243_H1.5540.80
174_L220_Y1.5210.78
57_S95_A1.5190.78
249_H291_V1.5180.78
33_L57_S1.5160.78
256_A300_I1.5110.78
275_P290_V1.5010.77
166_Y222_F1.4890.77
252_L274_F1.4830.77
114_L118_H1.4610.75
250_L279_E1.4570.75
77_G100_G1.4210.73
304_A308_D1.4090.73
67_A98_S1.4040.72
147_V220_Y1.4010.72
87_V111_F1.3480.69
32_V41_Q1.3470.69
250_L274_F1.3410.69
6_L86_D1.3390.69
52_A314_A1.3070.67
159_M250_L1.3010.66
252_L282_A1.2930.66
133_G209_D1.2930.66
163_R178_F1.2870.66
84_R111_F1.2830.65
162_T222_F1.2790.65
204_A235_S1.2780.65
125_I184_T1.2760.65
76_G201_D1.2710.65
24_Y164_E1.2660.64
200_A203_A1.2500.63
88_R110_E1.2490.63
279_E290_V1.2380.63
194_P234_Y1.2330.62
132_L193_V1.2280.62
238_T278_Y1.2190.61
165_L222_F1.2020.60
180_A185_G1.2010.60
295_L309_A1.2010.60
119_G311_A1.1920.60
222_F333_L1.1750.58
200_A240_S1.1740.58
130_D247_P1.1730.58
146_V195_V1.1660.58
275_P325_V1.1570.57
179_V214_A1.1550.57
306_A326_R1.1540.57
114_L293_G1.1470.57
303_D308_D1.1460.56
30_A65_V1.1430.56
152_T254_H1.1430.56
251_V292_G1.1340.56
112_A116_A1.1340.56
25_A98_S1.1280.55
92_E117_E1.1160.54
117_E187_L1.1020.53
295_L321_A1.0970.53
5_L334_E1.0900.53
154_C200_A1.0770.52
282_A290_V1.0680.51
97_V171_D1.0590.51
135_A261_V1.0590.51
194_P198_V1.0590.51
235_S285_V1.0580.50
240_S244_G1.0530.50
237_V240_S1.0500.50
154_C237_V1.0490.50
170_R177_G1.0490.50
20_G184_T1.0470.50
60_A265_D1.0380.49
61_V65_V1.0270.48
68_L86_D1.0240.48
205_G208_E1.0200.48
207_V247_P1.0190.48
129_P132_L1.0190.48
309_A321_A1.0180.48
159_M282_A1.0150.48
33_L86_D1.0110.47
128_P199_V1.0110.47
322_T331_A1.0050.47
154_C234_Y1.0010.47
68_L125_I1.0000.46
250_L290_V0.9980.46
304_A315_T0.9930.46
199_V206_A0.9920.46
195_V240_S0.9920.46
155_S262_H0.9840.45
21_V189_E0.9840.45
83_W218_H0.9820.45
86_D89_A0.9790.45
293_G313_Y0.9640.44
98_S187_L0.9630.44
278_Y282_A0.9590.44
79_F82_S0.9580.44
81_P310_V0.9560.43
99_A181_T0.9560.43
200_A237_V0.9550.43
321_A327_F0.9520.43
98_S123_H0.9500.43
187_L236_G0.9470.43
17_T189_E0.9470.43
162_T270_P0.9460.43
59_A330_D0.9450.43
272_E276_A0.9440.43
89_A167_A0.9430.43
88_R111_F0.9430.43
303_D327_F0.9430.43
250_L288_S0.9420.43
176_A222_F0.9360.42
305_D330_D0.9330.42
230_V274_F0.9320.42
6_L83_W0.9280.42
152_T161_A0.9180.41
11_F39_G0.9160.41
30_A308_D0.9130.41
277_R280_R0.9080.40
126_R196_D0.9030.40
73_A126_R0.8920.39
69_I187_L0.8910.39
309_A312_D0.8840.39
56_A97_V0.8790.38
77_G105_L0.8790.38
307_H327_F0.8790.38
272_E317_I0.8770.38
307_H311_A0.8720.38
74_P233_A0.8690.38
91_L114_L0.8680.38
15_A253_C0.8670.38
294_M325_V0.8670.38
181_T226_Q0.8590.37
203_A332_V0.8590.37
30_A306_A0.8530.37
220_Y249_H0.8510.37
79_F194_P0.8490.36
56_A59_A0.8490.36
147_V329_P0.8410.36
264_Y282_A0.8400.36
247_P314_A0.8380.36
214_A218_H0.8370.36
308_D311_A0.8340.36
112_A304_A0.8300.35
247_P288_S0.8290.35
171_D276_A0.8280.35
132_L194_P0.8260.35
23_R160_T0.8260.35
97_V221_V0.8210.35
154_C198_V0.8190.35
254_H295_L0.8170.34
295_L313_Y0.8090.34
310_V327_F0.8040.34
125_I218_H0.8030.34
70_I268_L0.8000.33
17_T187_L0.8000.33
14_R262_H0.8000.33
117_E304_A0.7990.33
69_I98_S0.7960.33
41_Q52_A0.7950.33
186_I194_P0.7940.33
238_T242_L0.7930.33
79_F97_V0.7930.33
17_T103_A0.7920.33
171_D308_D0.7920.33
74_P78_G0.7900.33
165_L334_E0.7880.33
244_G323_D0.7880.33
111_F242_L0.7860.33
137_G205_G0.7840.32
174_L333_L0.7820.32
104_F107_D0.7820.32
229_I278_Y0.7810.32
162_T252_L0.7770.32
93_R175_D0.7760.32
102_H201_D0.7750.32
106_A127_R0.7740.32
223_V247_P0.7720.32
256_A261_V0.7710.32
138_T141_D0.7700.32
186_I244_G0.7690.32
189_E251_V0.7580.31
126_R182_G0.7560.31
159_M278_Y0.7540.31
273_S277_R0.7520.31
137_G208_E0.7500.30
186_I235_S0.7490.30
139_A142_V0.7480.30
159_M207_V0.7470.30
153_D183_Q0.7430.30
175_D214_A0.7390.30
106_A112_A0.7390.30
251_V291_V0.7370.30
74_P262_H0.7360.30
193_V325_V0.7360.30
237_V243_H0.7320.29
168_A322_T0.7300.29
203_A285_V0.7290.29
154_C258_R0.7280.29
5_L13_D0.7280.29
77_G126_R0.7270.29
134_V261_V0.7250.29
34_D39_G0.7240.29
169_A220_Y0.7200.29
99_A255_E0.7170.29
159_M162_T0.7150.28
234_Y262_H0.7150.28
97_V120_C0.7140.28
121_E267_T0.7100.28
58_M89_A0.7100.28
146_V248_D0.7090.28
179_V231_H0.7080.28
5_L22_L0.7080.28
87_V136_D0.7060.28
106_A298_R0.7050.28
305_D308_D0.7040.28
276_A280_R0.7030.28
131_D222_F0.7020.28
68_L72_I0.7000.28
267_T287_D0.6990.28
147_V174_L0.6990.28
87_V134_V0.6970.27
234_Y237_V0.6950.27
73_A76_G0.6940.27
153_D196_D0.6930.27
146_V246_A0.6910.27
102_H202_F0.6910.27
300_I305_D0.6900.27
140_R246_A0.6900.27
70_I103_A0.6900.27
170_R304_A0.6890.27
129_P333_L0.6870.27
76_G100_G0.6870.27
62_D268_L0.6860.27
165_L168_A0.6840.27
175_D215_A0.6830.27
251_V307_H0.6810.27
122_L329_P0.6800.27
301_D304_A0.6800.27
162_T251_V0.6790.26
129_P295_L0.6790.26
184_T256_A0.6780.26
100_G202_F0.6780.26
43_A330_D0.6760.26
4_A55_V0.6750.26
56_A245_S0.6730.26
295_L333_L0.6720.26
60_A93_R0.6670.26
220_Y336_I0.6650.26
174_L249_H0.6610.26
183_Q196_D0.6610.26
69_I105_L0.6600.25
102_H154_C0.6590.25
235_S244_G0.6590.25
12_P37_T0.6570.25
250_L275_P0.6550.25
216_A330_D0.6540.25
171_D311_A0.6520.25
178_F185_G0.6520.25
73_A77_G0.6500.25
203_A262_H0.6480.25
34_D57_S0.6480.25
62_D304_A0.6480.25
155_S162_T0.6470.25
271_I319_A0.6460.25
200_A236_G0.6440.25
279_E288_S0.6440.25
165_L172_V0.6430.25
119_G334_E0.6430.25
15_A87_V0.6430.25
162_T275_P0.6420.25
113_S125_I0.6400.24
11_F32_V0.6390.24
11_F54_I0.6380.24
252_L278_Y0.6380.24
159_M290_V0.6360.24
32_V292_G0.6350.24
215_A276_A0.6340.24
61_V93_R0.6330.24
33_L175_D0.6330.24
182_G196_D0.6310.24
72_I271_I0.6310.24
87_V101_L0.6310.24
179_V210_A0.6300.24
230_V268_L0.6290.24
274_F281_L0.6290.24
306_A313_Y0.6280.24
203_A236_G0.6260.24
255_E258_R0.6260.24
113_S276_A0.6250.24
183_Q208_E0.6250.24
67_A123_H0.6180.23
7_A160_T0.6170.23
204_A228_S0.6170.23
180_A244_G0.6150.23
273_S280_R0.6140.23
275_P293_G0.6140.23
131_D216_A0.6140.23
101_L321_A0.6130.23
126_R183_Q0.6120.23
117_E120_C0.6110.23
116_A318_D0.6110.23
178_F188_I0.6110.23
141_D223_V0.6100.23
70_I83_W0.6080.23
102_H183_Q0.6080.23
161_A332_V0.6070.23
161_A166_Y0.6060.23
147_V291_V0.6060.23
59_A307_H0.6010.23
90_A147_V0.5990.22
192_G244_G0.5980.22
147_V332_V0.5970.22
80_D103_A0.5950.22
139_A295_L0.5950.22
25_A29_V0.5940.22
39_G54_I0.5930.22
163_R324_P0.5930.22
29_V52_A0.5930.22
142_V212_T0.5920.22
31_A93_R0.5920.22
252_L290_V0.5910.22
195_V243_H0.5890.22
25_A186_I0.5890.22
93_R312_D0.5880.22
100_G201_D0.5870.22
74_P101_L0.5870.22
107_D136_D0.5860.22
80_D108_D0.5850.22
100_G126_R0.5850.22
192_G224_E0.5850.22
176_A251_V0.5840.22
187_L202_F0.5810.22
150_V253_C0.5800.22
172_V324_P0.5800.22
86_D309_A0.5790.21
215_A335_A0.5790.21
134_V231_H0.5780.21
63_A223_V0.5770.21
68_L222_F0.5770.21
75_I79_F0.5740.21
89_A304_A0.5730.21
184_T291_V0.5730.21
214_A231_H0.5720.21
313_Y321_A0.5720.21
100_G183_Q0.5710.21
79_F135_A0.5710.21
6_L24_Y0.5710.21
92_E114_L0.5700.21
183_Q205_G0.5680.21
185_G190_S0.5650.21
69_I332_V0.5620.21
240_S243_H0.5620.21
163_R336_I0.5610.21
303_D316_A0.5610.21
275_P332_V0.5600.21
188_I191_D0.5590.21
252_L321_A0.5570.20
190_S194_P0.5570.20
56_A165_L0.5570.20
252_L265_D0.5570.20
193_V265_D0.5560.20
293_G305_D0.5560.20
33_L199_V0.5500.20
58_M179_V0.5480.20
62_D167_A0.5460.20
8_H160_T0.5450.20
81_P170_R0.5450.20
91_L122_L0.5440.20
278_Y288_S0.5430.20
79_F87_V0.5420.20
319_A332_V0.5420.20
126_R137_G0.5400.20
329_P332_V0.5390.20
104_F127_R0.5390.20
10_Q129_P0.5380.20
22_L52_A0.5360.20
332_V336_I0.5360.20
251_V332_V0.5360.20
235_S240_S0.5350.20
272_E334_E0.5330.19
97_V307_H0.5330.19
170_R293_G0.5330.19
211_V221_V0.5320.19
174_L332_V0.5320.19
155_S333_L0.5320.19
25_A67_A0.5310.19
194_P236_G0.5310.19
15_A321_A0.5310.19
207_V336_I0.5290.19
193_V231_H0.5280.19
17_T77_G0.5270.19
7_A11_F0.5270.19
82_S113_S0.5240.19
168_A329_P0.5240.19
97_V331_A0.5220.19
122_L276_A0.5220.19
77_G102_H0.5210.19
165_L169_A0.5180.19
204_A233_A0.5160.19
14_R155_S0.5160.19
235_S243_H0.5160.19
72_I256_A0.5150.19
323_D326_R0.5150.19
180_A240_S0.5150.19
126_R184_T0.5130.19
89_A305_D0.5130.19
88_R118_H0.5110.19
153_D205_G0.5100.18
109_E272_E0.5080.18
71_G202_F0.5080.18
152_T277_R0.5070.18
167_A223_V0.5070.18
119_G222_F0.5060.18
68_L187_L0.5050.18
87_V251_V0.5050.18
61_V289_D0.5040.18
134_V234_Y0.5030.18
116_A330_D0.5020.18
264_Y281_L0.5020.18
186_I301_D0.5020.18
149_T298_R0.5000.18
252_L300_I0.5000.18
61_V136_D0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2obnA 2 0.9911 100 0.333 Contact Map
2g0tA 3 0.9407 100 0.452 Contact Map
1byiA 2 0.5371 98.9 0.912 Contact Map
3of5A 2 0.543 98.8 0.913 Contact Map
1vcoA 4 0.543 98.5 0.923 Contact Map
1wcv1 2 0.5252 98.4 0.924 Contact Map
4pfsA 1 0.5074 98.3 0.926 Contact Map
2ph1A 2 0.5638 98.3 0.926 Contact Map
2ozeA 2 0.5846 98.3 0.927 Contact Map
4wzaE 2 0.5282 98.2 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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