Q9HP24 - HALSA - GREMLIN Contacts

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Q9HP24 - Uncharacterized protein

UniProt:	Q9HP24	Sequences: MRVALLAHGQFPDRAKTAVGVLRYADYDVAAVLDRDTAGTQVADHITGTQDAPIVASMAAVDAAVDALIIGIAPIGGGFDPSWRPDVRAALERGADVSAGLHAFLADDEEFASLAAEHGCELHDIRRPPDDLGVADGTARDVDATVVTTVGTDCSVGKMTATRELYAAARDVGLDAGFVATGQTGILIESDGVPVDRVVADFAAGAVEDAVTAAAANHDYVFVEGQASIVHPAYSGVTTSVLHGSAPDHLVLCHEAGRGSVHGYDTTLPPIESFPARYERLAAPVSDSDVVGGMLNTRHIDADADAHDAVADYATAIDAPATDPVRFGPDAVLEAIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	337 (321)
Sequences:	582 (401)
Seq/√Len:	22.4

HALSA - Q9HP24

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_L	120_C	6.679	1.00
172_V	334_E	5.590	1.00
322_T	327_F	4.474	1.00
301_D	305_D	3.940	1.00
203_A	240_S	3.752	1.00
314_A	331_A	3.748	1.00
293_G	317_I	3.733	1.00
166_Y	176_A	3.518	1.00
272_E	316_A	3.363	1.00
168_A	330_D	3.154	1.00
87_V	97_V	3.042	1.00
91_L	118_H	2.968	0.99
84_R	108_D	2.929	0.99
169_A	174_L	2.872	0.99
179_V	211_V	2.861	0.99
303_D	307_H	2.843	0.99
32_V	54_I	2.780	0.99
34_D	54_I	2.766	0.99
88_R	114_L	2.682	0.99
21_V	69_I	2.667	0.99
297_T	306_A	2.606	0.99
8_H	35_R	2.594	0.99
282_A	288_S	2.569	0.98
250_L	278_Y	2.520	0.98
233_A	264_Y	2.506	0.98
55_V	63_A	2.423	0.98
277_R	281_L	2.272	0.97
31_A	55_V	2.143	0.95
308_D	312_D	2.130	0.95
250_L	282_A	2.118	0.95
290_V	319_A	2.082	0.94
149_T	162_T	2.074	0.94
235_S	238_T	2.027	0.94
260_S	265_D	2.027	0.94
17_T	184_T	2.014	0.93
207_V	245_S	1.980	0.93
147_V	249_H	1.967	0.93
193_V	198_V	1.951	0.92
169_A	222_F	1.945	0.92
274_F	278_Y	1.880	0.91
161_A	294_M	1.872	0.90
89_A	93_R	1.864	0.90
310_V	321_A	1.860	0.90
270_P	273_S	1.841	0.90
84_R	110_E	1.787	0.88
146_V	223_V	1.780	0.88
92_E	118_H	1.767	0.88
4_A	31_A	1.758	0.87
295_L	310_V	1.757	0.87
179_V	221_V	1.711	0.86
61_V	95_A	1.709	0.86
309_A	313_Y	1.705	0.86
168_A	172_V	1.704	0.86
271_I	313_Y	1.696	0.85
311_A	315_T	1.639	0.83
236_G	240_S	1.613	0.82
119_G	318_D	1.593	0.82
91_L	97_V	1.586	0.81
147_V	251_V	1.564	0.80
168_A	171_D	1.563	0.80
312_D	316_A	1.560	0.80
236_G	243_H	1.554	0.80
174_L	220_Y	1.521	0.78
57_S	95_A	1.519	0.78
249_H	291_V	1.518	0.78
33_L	57_S	1.516	0.78
256_A	300_I	1.511	0.78
275_P	290_V	1.501	0.77
166_Y	222_F	1.489	0.77
252_L	274_F	1.483	0.77
114_L	118_H	1.461	0.75
250_L	279_E	1.457	0.75
77_G	100_G	1.421	0.73
304_A	308_D	1.409	0.73
67_A	98_S	1.404	0.72
147_V	220_Y	1.401	0.72
87_V	111_F	1.348	0.69
32_V	41_Q	1.347	0.69
250_L	274_F	1.341	0.69
6_L	86_D	1.339	0.69
52_A	314_A	1.307	0.67
159_M	250_L	1.301	0.66
252_L	282_A	1.293	0.66
133_G	209_D	1.293	0.66
163_R	178_F	1.287	0.66
84_R	111_F	1.283	0.65
162_T	222_F	1.279	0.65
204_A	235_S	1.278	0.65
125_I	184_T	1.276	0.65
76_G	201_D	1.271	0.65
24_Y	164_E	1.266	0.64
200_A	203_A	1.250	0.63
88_R	110_E	1.249	0.63
279_E	290_V	1.238	0.63
194_P	234_Y	1.233	0.62
132_L	193_V	1.228	0.62
238_T	278_Y	1.219	0.61
165_L	222_F	1.202	0.60
180_A	185_G	1.201	0.60
295_L	309_A	1.201	0.60
119_G	311_A	1.192	0.60
222_F	333_L	1.175	0.58
200_A	240_S	1.174	0.58
130_D	247_P	1.173	0.58
146_V	195_V	1.166	0.58
275_P	325_V	1.157	0.57
179_V	214_A	1.155	0.57
306_A	326_R	1.154	0.57
114_L	293_G	1.147	0.57
303_D	308_D	1.146	0.56
30_A	65_V	1.143	0.56
152_T	254_H	1.143	0.56
251_V	292_G	1.134	0.56
112_A	116_A	1.134	0.56
25_A	98_S	1.128	0.55
92_E	117_E	1.116	0.54
117_E	187_L	1.102	0.53
295_L	321_A	1.097	0.53
5_L	334_E	1.090	0.53
154_C	200_A	1.077	0.52
282_A	290_V	1.068	0.51
97_V	171_D	1.059	0.51
135_A	261_V	1.059	0.51
194_P	198_V	1.059	0.51
235_S	285_V	1.058	0.50
240_S	244_G	1.053	0.50
237_V	240_S	1.050	0.50
154_C	237_V	1.049	0.50
170_R	177_G	1.049	0.50
20_G	184_T	1.047	0.50
60_A	265_D	1.038	0.49
61_V	65_V	1.027	0.48
68_L	86_D	1.024	0.48
205_G	208_E	1.020	0.48
207_V	247_P	1.019	0.48
129_P	132_L	1.019	0.48
309_A	321_A	1.018	0.48
159_M	282_A	1.015	0.48
33_L	86_D	1.011	0.47
128_P	199_V	1.011	0.47
322_T	331_A	1.005	0.47
154_C	234_Y	1.001	0.47
68_L	125_I	1.000	0.46
250_L	290_V	0.998	0.46
304_A	315_T	0.993	0.46
199_V	206_A	0.992	0.46
195_V	240_S	0.992	0.46
155_S	262_H	0.984	0.45
21_V	189_E	0.984	0.45
83_W	218_H	0.982	0.45
86_D	89_A	0.979	0.45
293_G	313_Y	0.964	0.44
98_S	187_L	0.963	0.44
278_Y	282_A	0.959	0.44
79_F	82_S	0.958	0.44
81_P	310_V	0.956	0.43
99_A	181_T	0.956	0.43
200_A	237_V	0.955	0.43
321_A	327_F	0.952	0.43
98_S	123_H	0.950	0.43
187_L	236_G	0.947	0.43
17_T	189_E	0.947	0.43
162_T	270_P	0.946	0.43
59_A	330_D	0.945	0.43
272_E	276_A	0.944	0.43
89_A	167_A	0.943	0.43
88_R	111_F	0.943	0.43
303_D	327_F	0.943	0.43
250_L	288_S	0.942	0.43
176_A	222_F	0.936	0.42
305_D	330_D	0.933	0.42
230_V	274_F	0.932	0.42
6_L	83_W	0.928	0.42
152_T	161_A	0.918	0.41
11_F	39_G	0.916	0.41
30_A	308_D	0.913	0.41
277_R	280_R	0.908	0.40
126_R	196_D	0.903	0.40
73_A	126_R	0.892	0.39
69_I	187_L	0.891	0.39
309_A	312_D	0.884	0.39
56_A	97_V	0.879	0.38
77_G	105_L	0.879	0.38
307_H	327_F	0.879	0.38
272_E	317_I	0.877	0.38
307_H	311_A	0.872	0.38
74_P	233_A	0.869	0.38
91_L	114_L	0.868	0.38
15_A	253_C	0.867	0.38
294_M	325_V	0.867	0.38
181_T	226_Q	0.859	0.37
203_A	332_V	0.859	0.37
30_A	306_A	0.853	0.37
220_Y	249_H	0.851	0.37
79_F	194_P	0.849	0.36
56_A	59_A	0.849	0.36
147_V	329_P	0.841	0.36
264_Y	282_A	0.840	0.36
247_P	314_A	0.838	0.36
214_A	218_H	0.837	0.36
308_D	311_A	0.834	0.36
112_A	304_A	0.830	0.35
247_P	288_S	0.829	0.35
171_D	276_A	0.828	0.35
132_L	194_P	0.826	0.35
23_R	160_T	0.826	0.35
97_V	221_V	0.821	0.35
154_C	198_V	0.819	0.35
254_H	295_L	0.817	0.34
295_L	313_Y	0.809	0.34
310_V	327_F	0.804	0.34
125_I	218_H	0.803	0.34
70_I	268_L	0.800	0.33
17_T	187_L	0.800	0.33
14_R	262_H	0.800	0.33
117_E	304_A	0.799	0.33
69_I	98_S	0.796	0.33
41_Q	52_A	0.795	0.33
186_I	194_P	0.794	0.33
238_T	242_L	0.793	0.33
79_F	97_V	0.793	0.33
17_T	103_A	0.792	0.33
171_D	308_D	0.792	0.33
74_P	78_G	0.790	0.33
165_L	334_E	0.788	0.33
244_G	323_D	0.788	0.33
111_F	242_L	0.786	0.33
137_G	205_G	0.784	0.32
174_L	333_L	0.782	0.32
104_F	107_D	0.782	0.32
229_I	278_Y	0.781	0.32
162_T	252_L	0.777	0.32
93_R	175_D	0.776	0.32
102_H	201_D	0.775	0.32
106_A	127_R	0.774	0.32
223_V	247_P	0.772	0.32
256_A	261_V	0.771	0.32
138_T	141_D	0.770	0.32
186_I	244_G	0.769	0.32
189_E	251_V	0.758	0.31
126_R	182_G	0.756	0.31
159_M	278_Y	0.754	0.31
273_S	277_R	0.752	0.31
137_G	208_E	0.750	0.30
186_I	235_S	0.749	0.30
139_A	142_V	0.748	0.30
159_M	207_V	0.747	0.30
153_D	183_Q	0.743	0.30
175_D	214_A	0.739	0.30
106_A	112_A	0.739	0.30
251_V	291_V	0.737	0.30
74_P	262_H	0.736	0.30
193_V	325_V	0.736	0.30
237_V	243_H	0.732	0.29
168_A	322_T	0.730	0.29
203_A	285_V	0.729	0.29
154_C	258_R	0.728	0.29
5_L	13_D	0.728	0.29
77_G	126_R	0.727	0.29
134_V	261_V	0.725	0.29
34_D	39_G	0.724	0.29
169_A	220_Y	0.720	0.29
99_A	255_E	0.717	0.29
159_M	162_T	0.715	0.28
234_Y	262_H	0.715	0.28
97_V	120_C	0.714	0.28
121_E	267_T	0.710	0.28
58_M	89_A	0.710	0.28
146_V	248_D	0.709	0.28
179_V	231_H	0.708	0.28
5_L	22_L	0.708	0.28
87_V	136_D	0.706	0.28
106_A	298_R	0.705	0.28
305_D	308_D	0.704	0.28
276_A	280_R	0.703	0.28
131_D	222_F	0.702	0.28
68_L	72_I	0.700	0.28
267_T	287_D	0.699	0.28
147_V	174_L	0.699	0.28
87_V	134_V	0.697	0.27
234_Y	237_V	0.695	0.27
73_A	76_G	0.694	0.27
153_D	196_D	0.693	0.27
146_V	246_A	0.691	0.27
102_H	202_F	0.691	0.27
300_I	305_D	0.690	0.27
140_R	246_A	0.690	0.27
70_I	103_A	0.690	0.27
170_R	304_A	0.689	0.27
129_P	333_L	0.687	0.27
76_G	100_G	0.687	0.27
62_D	268_L	0.686	0.27
165_L	168_A	0.684	0.27
175_D	215_A	0.683	0.27
251_V	307_H	0.681	0.27
122_L	329_P	0.680	0.27
301_D	304_A	0.680	0.27
162_T	251_V	0.679	0.26
129_P	295_L	0.679	0.26
184_T	256_A	0.678	0.26
100_G	202_F	0.678	0.26
43_A	330_D	0.676	0.26
4_A	55_V	0.675	0.26
56_A	245_S	0.673	0.26
295_L	333_L	0.672	0.26
60_A	93_R	0.667	0.26
220_Y	336_I	0.665	0.26
174_L	249_H	0.661	0.26
183_Q	196_D	0.661	0.26
69_I	105_L	0.660	0.25
102_H	154_C	0.659	0.25
235_S	244_G	0.659	0.25
12_P	37_T	0.657	0.25
250_L	275_P	0.655	0.25
216_A	330_D	0.654	0.25
171_D	311_A	0.652	0.25
178_F	185_G	0.652	0.25
73_A	77_G	0.650	0.25
203_A	262_H	0.648	0.25
34_D	57_S	0.648	0.25
62_D	304_A	0.648	0.25
155_S	162_T	0.647	0.25
271_I	319_A	0.646	0.25
200_A	236_G	0.644	0.25
279_E	288_S	0.644	0.25
165_L	172_V	0.643	0.25
119_G	334_E	0.643	0.25
15_A	87_V	0.643	0.25
162_T	275_P	0.642	0.25
113_S	125_I	0.640	0.24
11_F	32_V	0.639	0.24
11_F	54_I	0.638	0.24
252_L	278_Y	0.638	0.24
159_M	290_V	0.636	0.24
32_V	292_G	0.635	0.24
215_A	276_A	0.634	0.24
61_V	93_R	0.633	0.24
33_L	175_D	0.633	0.24
182_G	196_D	0.631	0.24
72_I	271_I	0.631	0.24
87_V	101_L	0.631	0.24
179_V	210_A	0.630	0.24
230_V	268_L	0.629	0.24
274_F	281_L	0.629	0.24
306_A	313_Y	0.628	0.24
203_A	236_G	0.626	0.24
255_E	258_R	0.626	0.24
113_S	276_A	0.625	0.24
183_Q	208_E	0.625	0.24
67_A	123_H	0.618	0.23
7_A	160_T	0.617	0.23
204_A	228_S	0.617	0.23
180_A	244_G	0.615	0.23
273_S	280_R	0.614	0.23
275_P	293_G	0.614	0.23
131_D	216_A	0.614	0.23
101_L	321_A	0.613	0.23
126_R	183_Q	0.612	0.23
117_E	120_C	0.611	0.23
116_A	318_D	0.611	0.23
178_F	188_I	0.611	0.23
141_D	223_V	0.610	0.23
70_I	83_W	0.608	0.23
102_H	183_Q	0.608	0.23
161_A	332_V	0.607	0.23
161_A	166_Y	0.606	0.23
147_V	291_V	0.606	0.23
59_A	307_H	0.601	0.23
90_A	147_V	0.599	0.22
192_G	244_G	0.598	0.22
147_V	332_V	0.597	0.22
80_D	103_A	0.595	0.22
139_A	295_L	0.595	0.22
25_A	29_V	0.594	0.22
39_G	54_I	0.593	0.22
163_R	324_P	0.593	0.22
29_V	52_A	0.593	0.22
142_V	212_T	0.592	0.22
31_A	93_R	0.592	0.22
252_L	290_V	0.591	0.22
195_V	243_H	0.589	0.22
25_A	186_I	0.589	0.22
93_R	312_D	0.588	0.22
100_G	201_D	0.587	0.22
74_P	101_L	0.587	0.22
107_D	136_D	0.586	0.22
80_D	108_D	0.585	0.22
100_G	126_R	0.585	0.22
192_G	224_E	0.585	0.22
176_A	251_V	0.584	0.22
187_L	202_F	0.581	0.22
150_V	253_C	0.580	0.22
172_V	324_P	0.580	0.22
86_D	309_A	0.579	0.21
215_A	335_A	0.579	0.21
134_V	231_H	0.578	0.21
63_A	223_V	0.577	0.21
68_L	222_F	0.577	0.21
75_I	79_F	0.574	0.21
89_A	304_A	0.573	0.21
184_T	291_V	0.573	0.21
214_A	231_H	0.572	0.21
313_Y	321_A	0.572	0.21
100_G	183_Q	0.571	0.21
79_F	135_A	0.571	0.21
6_L	24_Y	0.571	0.21
92_E	114_L	0.570	0.21
183_Q	205_G	0.568	0.21
185_G	190_S	0.565	0.21
69_I	332_V	0.562	0.21
240_S	243_H	0.562	0.21
163_R	336_I	0.561	0.21
303_D	316_A	0.561	0.21
275_P	332_V	0.560	0.21
188_I	191_D	0.559	0.21
252_L	321_A	0.557	0.20
190_S	194_P	0.557	0.20
56_A	165_L	0.557	0.20
252_L	265_D	0.557	0.20
193_V	265_D	0.556	0.20
293_G	305_D	0.556	0.20
33_L	199_V	0.550	0.20
58_M	179_V	0.548	0.20
62_D	167_A	0.546	0.20
8_H	160_T	0.545	0.20
81_P	170_R	0.545	0.20
91_L	122_L	0.544	0.20
278_Y	288_S	0.543	0.20
79_F	87_V	0.542	0.20
319_A	332_V	0.542	0.20
126_R	137_G	0.540	0.20
329_P	332_V	0.539	0.20
104_F	127_R	0.539	0.20
10_Q	129_P	0.538	0.20
22_L	52_A	0.536	0.20
332_V	336_I	0.536	0.20
251_V	332_V	0.536	0.20
235_S	240_S	0.535	0.20
272_E	334_E	0.533	0.19
97_V	307_H	0.533	0.19
170_R	293_G	0.533	0.19
211_V	221_V	0.532	0.19
174_L	332_V	0.532	0.19
155_S	333_L	0.532	0.19
25_A	67_A	0.531	0.19
194_P	236_G	0.531	0.19
15_A	321_A	0.531	0.19
207_V	336_I	0.529	0.19
193_V	231_H	0.528	0.19
17_T	77_G	0.527	0.19
7_A	11_F	0.527	0.19
82_S	113_S	0.524	0.19
168_A	329_P	0.524	0.19
97_V	331_A	0.522	0.19
122_L	276_A	0.522	0.19
77_G	102_H	0.521	0.19
165_L	169_A	0.518	0.19
204_A	233_A	0.516	0.19
14_R	155_S	0.516	0.19
235_S	243_H	0.516	0.19
72_I	256_A	0.515	0.19
323_D	326_R	0.515	0.19
180_A	240_S	0.515	0.19
126_R	184_T	0.513	0.19
89_A	305_D	0.513	0.19
88_R	118_H	0.511	0.19
153_D	205_G	0.510	0.18
109_E	272_E	0.508	0.18
71_G	202_F	0.508	0.18
152_T	277_R	0.507	0.18
167_A	223_V	0.507	0.18
119_G	222_F	0.506	0.18
68_L	187_L	0.505	0.18
87_V	251_V	0.505	0.18
61_V	289_D	0.504	0.18
134_V	234_Y	0.503	0.18
116_A	330_D	0.502	0.18
264_Y	281_L	0.502	0.18
186_I	301_D	0.502	0.18
149_T	298_R	0.500	0.18
252_L	300_I	0.500	0.18
61_V	136_D	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2obnA	2	0.9911	100	0.333	Contact Map
2g0tA	3	0.9407	100	0.452	Contact Map
1byiA	2	0.5371	98.9	0.912	Contact Map
3of5A	2	0.543	98.8	0.913	Contact Map
1vcoA	4	0.543	98.5	0.923	Contact Map
1wcv1	2	0.5252	98.4	0.924	Contact Map
4pfsA	1	0.5074	98.3	0.926	Contact Map
2ph1A	2	0.5638	98.3	0.926	Contact Map
2ozeA	2	0.5846	98.3	0.927	Contact Map
4wzaE	2	0.5282	98.2	0.929	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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