GREMLIN Database
Q9HP21 - Uncharacterized protein
UniProt: Q9HP21 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (200)
Sequences: 116 (76)
Seq/√Len: 5.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_L53_A3.5910.86
31_E41_K3.3970.83
70_I82_P2.6700.64
108_R172_L2.3350.53
27_C39_S2.3280.53
32_I40_P2.2360.50
29_V139_Q2.2090.49
182_V195_G2.1920.49
14_N61_D2.1710.48
25_K41_K2.1690.48
22_L46_H2.1350.47
14_N40_P2.1170.46
180_R198_Q2.1100.46
7_L26_P2.0710.45
25_K31_E2.0520.44
11_G67_Y2.0420.44
125_L129_N1.9550.41
88_K138_A1.8540.37
78_V135_L1.8070.36
75_R139_Q1.8050.36
29_V41_K1.7850.35
40_P44_I1.7770.35
66_K135_L1.7670.35
67_Y70_I1.7420.34
128_L142_V1.7370.34
176_S182_V1.7140.33
8_D26_P1.6840.32
31_E40_P1.6780.32
103_Q198_Q1.6640.32
168_V174_D1.6130.30
2_D201_A1.5410.28
173_A202_D1.5350.28
10_L46_H1.5250.28
10_L22_L1.5250.28
19_L183_A1.5150.28
30_T33_S1.4920.27
55_L78_V1.4830.27
59_R182_V1.4710.26
23_A143_Q1.4540.26
56_V120_E1.4510.26
27_C30_T1.4450.26
11_G29_V1.4240.25
94_S155_D1.4220.25
114_S182_V1.4200.25
11_G30_T1.4190.25
159_D172_L1.4180.25
30_T44_I1.4180.25
48_Q52_D1.4020.25
33_S58_S1.3980.24
9_L132_E1.3660.24
32_I139_Q1.3620.24
101_R154_G1.3610.24
30_T34_E1.3560.23
157_I189_P1.3530.23
119_N130_E1.3490.23
71_A79_Q1.3470.23
105_V155_D1.3310.23
108_R116_A1.3240.23
54_G85_Y1.3180.23
121_L140_R1.3170.23
120_E183_A1.3150.22
54_G57_E1.3080.22
14_N32_I1.3070.22
19_L85_Y1.2970.22
8_D11_G1.2920.22
53_A77_E1.2850.22
126_K130_E1.2750.22
13_E23_A1.2690.21
169_L176_S1.2630.21
3_S57_E1.2600.21
14_N44_I1.2420.21
20_Q85_Y1.2370.21
25_K40_P1.2330.21
111_E118_V1.2320.21
17_R21_L1.2250.20
168_V182_V1.2120.20
18_I26_P1.2060.20
131_L134_E1.2030.20
31_E64_R1.2030.20
157_I187_E1.1920.20
40_P139_Q1.1890.20
2_D125_L1.1810.19
118_V130_E1.1770.19
100_A103_Q1.1760.19
44_I61_D1.1700.19
124_K199_T1.1600.19
108_R127_E1.1530.19
117_E130_E1.1410.19
33_S149_V1.1410.19
29_V33_S1.1320.18
29_V40_P1.1310.18
29_V32_I1.1260.18
36_I111_E1.1200.18
95_T152_A1.1190.18
28_Y183_A1.1080.18
91_Y188_A1.0940.18
180_R194_D1.0840.18
13_E36_I1.0820.17
39_S66_K1.0780.17
31_E44_I1.0750.17
107_V129_N1.0600.17
133_R147_A1.0600.17
11_G44_I1.0530.17
28_Y54_G1.0440.17
7_L18_I1.0430.17
37_G134_E1.0320.17
32_I61_D1.0260.16
65_R128_L1.0210.16
24_R187_E1.0150.16
41_K172_L1.0040.16
98_D141_W1.0000.16
58_S85_Y0.9970.16
160_G183_A0.9950.16
107_V150_Q0.9950.16
82_P85_Y0.9890.16
178_T196_V0.9890.16
164_L169_L0.9810.16
29_V75_R0.9800.16
40_P64_R0.9780.16
55_L90_A0.9750.15
25_K39_S0.9750.15
80_L147_A0.9710.15
108_R113_D0.9710.15
21_L32_I0.9660.15
46_H66_K0.9650.15
22_L66_K0.9650.15
8_D41_K0.9640.15
14_N66_K0.9580.15
12_N15_R0.9420.15
12_N47_L0.9420.15
15_R47_L0.9420.15
16_R47_L0.9420.15
12_N16_R0.9420.15
5_A28_Y0.9390.15
129_N181_D0.9290.15
80_L156_A0.9290.15
110_E182_V0.9260.15
80_L184_E0.9230.15
23_A28_Y0.9220.15
95_T107_V0.9200.15
25_K29_V0.9100.14
31_E61_D0.9010.14
11_G41_K0.9000.14
74_L176_S0.8990.14
108_R152_A0.8980.14
36_I160_G0.8970.14
172_L178_T0.8970.14
153_L173_A0.8960.14
41_K44_I0.8930.14
110_E198_Q0.8920.14
82_P186_L0.8900.14
52_D149_V0.8890.14
14_N41_K0.8890.14
21_L41_K0.8890.14
19_L166_A0.8840.14
39_S58_S0.8790.14
100_A202_D0.8790.14
14_N30_T0.8730.14
56_V168_V0.8450.13
5_A13_E0.8440.13
32_I41_K0.8440.13
25_K167_D0.8430.13
29_V45_D0.8430.13
186_L192_L0.8400.13
197_L200_L0.8390.13
11_G27_C0.8340.13
62_D202_D0.8320.13
130_E176_S0.8300.13
143_Q149_V0.8290.13
70_I141_W0.8200.13
98_D144_G0.8160.13
92_P98_D0.8160.13
107_V200_L0.8130.13
19_L54_G0.8000.13
133_R168_V0.7970.13
55_L65_R0.7950.13
28_Y186_L0.7900.13
175_D182_V0.7860.12
55_L135_L0.7820.12
30_T45_D0.7760.12
68_F76_L0.7730.12
31_E172_L0.7720.12
28_Y136_S0.7690.12
13_E25_K0.7650.12
20_Q144_G0.7640.12
44_I135_L0.7580.12
41_K45_D0.7570.12
40_P61_D0.7520.12
5_A48_Q0.7500.12
171_A194_D0.7470.12
8_D31_E0.7450.12
52_D123_A0.7410.12
9_L102_C0.7360.12
28_Y85_Y0.7310.12
118_V196_V0.7230.12
26_P36_I0.7230.12
19_L28_Y0.7220.12
31_E36_I0.7160.11
65_R75_R0.7140.11
11_G31_E0.7140.11
83_F200_L0.7130.11
104_Y133_R0.7110.11
18_I36_I0.6950.11
22_L67_Y0.6940.11
46_H67_Y0.6940.11
10_L67_Y0.6840.11
19_L186_L0.6840.11
29_V44_I0.6830.11
7_L36_I0.6800.11
30_T39_S0.6800.11
34_E162_D0.6780.11
111_E183_A0.6780.11
36_I41_K0.6750.11
153_L160_G0.6710.11
59_R190_V0.6710.11
21_L31_E0.6690.11
95_T111_E0.6680.11
2_D44_I0.6680.11
8_D44_I0.6600.11
27_C41_K0.6590.11
143_Q153_L0.6540.11
177_R182_V0.6520.11
95_T117_E0.6500.11
24_R143_Q0.6500.11
33_S39_S0.6490.11
103_Q154_G0.6480.11
38_V66_K0.6460.11
124_K127_E0.6400.10
14_N31_E0.6390.10
27_C139_Q0.6380.10
30_T61_D0.6370.10
37_G85_Y0.6370.10
78_V121_L0.6360.10
169_L187_E0.6340.10
102_C137_M0.6280.10
34_E39_S0.6190.10
158_G199_T0.6190.10
105_V109_I0.6160.10
39_S132_E0.6150.10
170_A190_V0.6080.10
181_D198_Q0.6060.10
113_D180_R0.6030.10
11_G70_I0.6010.10
13_E53_A0.5970.10
61_D128_L0.5960.10
74_L166_A0.5940.10
125_L175_D0.5900.10
177_R181_D0.5870.10
119_N123_A0.5860.10
194_D202_D0.5780.10
29_V67_Y0.5770.10
72_E145_Q0.5760.10
79_Q168_V0.5730.10
14_N166_A0.5730.10
75_R134_E0.5720.10
61_D66_K0.5700.10
57_E66_K0.5700.10
63_Q92_P0.5690.10
19_L42_A0.5680.10
29_V146_L0.5650.10
65_R152_A0.5650.10
123_A155_D0.5640.10
126_K168_V0.5640.10
6_L131_L0.5640.10
6_L134_E0.5640.10
196_V200_L0.5620.10
95_T198_Q0.5580.09
111_E178_T0.5550.09
5_A125_L0.5540.09
6_L135_L0.5450.09
87_A154_G0.5450.09
84_G162_D0.5440.09
23_A107_V0.5410.09
63_Q190_V0.5400.09
157_I180_R0.5380.09
25_K32_I0.5370.09
30_T70_I0.5350.09
27_C34_E0.5350.09
11_G66_K0.5340.09
130_E156_A0.5330.09
38_V144_G0.5320.09
130_E142_V0.5320.09
27_C40_P0.5270.09
94_S122_A0.5240.09
93_A108_R0.5240.09
87_A101_R0.5230.09
78_V93_A0.5170.09
18_I41_K0.5170.09
117_E127_E0.5150.09
31_E45_D0.5150.09
61_D64_R0.5130.09
156_A181_D0.5120.09
5_A79_Q0.5100.09
57_E121_L0.5090.09
26_P41_K0.5080.09
7_L135_L0.5040.09
80_L84_G0.5040.09
14_N38_V0.5030.09
71_A120_E0.5010.09
195_G201_A0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qlzA 2 0.9679 100 0.606 Contact Map
2p4wA 2 0.8716 99.5 0.789 Contact Map
3f6vA 2 0.4358 99.2 0.822 Contact Map
1r1tA 2 0.4037 99.2 0.823 Contact Map
2kkoA 2 0.4404 99.2 0.823 Contact Map
1u2wA 2 0.4083 99.2 0.828 Contact Map
3f6oA 2 0.4083 99.1 0.829 Contact Map
4k2eA 2 0.3945 99.1 0.829 Contact Map
3pqkA 2 0.4174 99.1 0.83 Contact Map
1r1uA 2 0.4128 99.1 0.83 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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