Q9HP21 - HALSA - GREMLIN Contacts

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Q9HP21 - Uncharacterized protein

UniProt:	Q9HP21	Sequences: MDSGALLDLLGNENRRRILQLLARKPCYVTEISEYIGVSPKAVIDHLQQLDDAGLVESRVDDQRRKYFHIAENLRLEVQLSPFGYGAKSAYPASTDLDLARCQYVSVRIEERDSNAEVNELAAKLKELNELERELSMAQRWVQGQLADVQAALGDAIGDGPDRLYADVLAALADDSRTARDVAEALEAPVPLIDGVLQTLADRGLVVERADGEYAIAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	218 (200)
Sequences:	116 (76)
Seq/√Len:	5.4

HALSA - Q9HP21

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_L	53_A	3.591	0.86
31_E	41_K	3.397	0.83
70_I	82_P	2.670	0.64
108_R	172_L	2.335	0.53
27_C	39_S	2.328	0.53
32_I	40_P	2.236	0.50
29_V	139_Q	2.209	0.49
182_V	195_G	2.192	0.49
14_N	61_D	2.171	0.48
25_K	41_K	2.169	0.48
22_L	46_H	2.135	0.47
14_N	40_P	2.117	0.46
180_R	198_Q	2.110	0.46
7_L	26_P	2.071	0.45
25_K	31_E	2.052	0.44
11_G	67_Y	2.042	0.44
125_L	129_N	1.955	0.41
88_K	138_A	1.854	0.37
78_V	135_L	1.807	0.36
75_R	139_Q	1.805	0.36
29_V	41_K	1.785	0.35
40_P	44_I	1.777	0.35
66_K	135_L	1.767	0.35
67_Y	70_I	1.742	0.34
128_L	142_V	1.737	0.34
176_S	182_V	1.714	0.33
8_D	26_P	1.684	0.32
31_E	40_P	1.678	0.32
103_Q	198_Q	1.664	0.32
168_V	174_D	1.613	0.30
2_D	201_A	1.541	0.28
173_A	202_D	1.535	0.28
10_L	46_H	1.525	0.28
10_L	22_L	1.525	0.28
19_L	183_A	1.515	0.28
30_T	33_S	1.492	0.27
55_L	78_V	1.483	0.27
59_R	182_V	1.471	0.26
23_A	143_Q	1.454	0.26
56_V	120_E	1.451	0.26
27_C	30_T	1.445	0.26
11_G	29_V	1.424	0.25
94_S	155_D	1.422	0.25
114_S	182_V	1.420	0.25
11_G	30_T	1.419	0.25
159_D	172_L	1.418	0.25
30_T	44_I	1.418	0.25
48_Q	52_D	1.402	0.25
33_S	58_S	1.398	0.24
9_L	132_E	1.366	0.24
32_I	139_Q	1.362	0.24
101_R	154_G	1.361	0.24
30_T	34_E	1.356	0.23
157_I	189_P	1.353	0.23
119_N	130_E	1.349	0.23
71_A	79_Q	1.347	0.23
105_V	155_D	1.331	0.23
108_R	116_A	1.324	0.23
54_G	85_Y	1.318	0.23
121_L	140_R	1.317	0.23
120_E	183_A	1.315	0.22
54_G	57_E	1.308	0.22
14_N	32_I	1.307	0.22
19_L	85_Y	1.297	0.22
8_D	11_G	1.292	0.22
53_A	77_E	1.285	0.22
126_K	130_E	1.275	0.22
13_E	23_A	1.269	0.21
169_L	176_S	1.263	0.21
3_S	57_E	1.260	0.21
14_N	44_I	1.242	0.21
20_Q	85_Y	1.237	0.21
25_K	40_P	1.233	0.21
111_E	118_V	1.232	0.21
17_R	21_L	1.225	0.20
168_V	182_V	1.212	0.20
18_I	26_P	1.206	0.20
131_L	134_E	1.203	0.20
31_E	64_R	1.203	0.20
157_I	187_E	1.192	0.20
40_P	139_Q	1.189	0.20
2_D	125_L	1.181	0.19
118_V	130_E	1.177	0.19
100_A	103_Q	1.176	0.19
44_I	61_D	1.170	0.19
124_K	199_T	1.160	0.19
108_R	127_E	1.153	0.19
117_E	130_E	1.141	0.19
33_S	149_V	1.141	0.19
29_V	33_S	1.132	0.18
29_V	40_P	1.131	0.18
29_V	32_I	1.126	0.18
36_I	111_E	1.120	0.18
95_T	152_A	1.119	0.18
28_Y	183_A	1.108	0.18
91_Y	188_A	1.094	0.18
180_R	194_D	1.084	0.18
13_E	36_I	1.082	0.17
39_S	66_K	1.078	0.17
31_E	44_I	1.075	0.17
107_V	129_N	1.060	0.17
133_R	147_A	1.060	0.17
11_G	44_I	1.053	0.17
28_Y	54_G	1.044	0.17
7_L	18_I	1.043	0.17
37_G	134_E	1.032	0.17
32_I	61_D	1.026	0.16
65_R	128_L	1.021	0.16
24_R	187_E	1.015	0.16
41_K	172_L	1.004	0.16
98_D	141_W	1.000	0.16
58_S	85_Y	0.997	0.16
160_G	183_A	0.995	0.16
107_V	150_Q	0.995	0.16
82_P	85_Y	0.989	0.16
178_T	196_V	0.989	0.16
164_L	169_L	0.981	0.16
29_V	75_R	0.980	0.16
40_P	64_R	0.978	0.16
55_L	90_A	0.975	0.15
25_K	39_S	0.975	0.15
80_L	147_A	0.971	0.15
108_R	113_D	0.971	0.15
21_L	32_I	0.966	0.15
46_H	66_K	0.965	0.15
22_L	66_K	0.965	0.15
8_D	41_K	0.964	0.15
14_N	66_K	0.958	0.15
12_N	15_R	0.942	0.15
12_N	47_L	0.942	0.15
15_R	47_L	0.942	0.15
16_R	47_L	0.942	0.15
12_N	16_R	0.942	0.15
5_A	28_Y	0.939	0.15
129_N	181_D	0.929	0.15
80_L	156_A	0.929	0.15
110_E	182_V	0.926	0.15
80_L	184_E	0.923	0.15
23_A	28_Y	0.922	0.15
95_T	107_V	0.920	0.15
25_K	29_V	0.910	0.14
31_E	61_D	0.901	0.14
11_G	41_K	0.900	0.14
74_L	176_S	0.899	0.14
108_R	152_A	0.898	0.14
36_I	160_G	0.897	0.14
172_L	178_T	0.897	0.14
153_L	173_A	0.896	0.14
41_K	44_I	0.893	0.14
110_E	198_Q	0.892	0.14
82_P	186_L	0.890	0.14
52_D	149_V	0.889	0.14
14_N	41_K	0.889	0.14
21_L	41_K	0.889	0.14
19_L	166_A	0.884	0.14
39_S	58_S	0.879	0.14
100_A	202_D	0.879	0.14
14_N	30_T	0.873	0.14
56_V	168_V	0.845	0.13
5_A	13_E	0.844	0.13
32_I	41_K	0.844	0.13
25_K	167_D	0.843	0.13
29_V	45_D	0.843	0.13
186_L	192_L	0.840	0.13
197_L	200_L	0.839	0.13
11_G	27_C	0.834	0.13
62_D	202_D	0.832	0.13
130_E	176_S	0.830	0.13
143_Q	149_V	0.829	0.13
70_I	141_W	0.820	0.13
98_D	144_G	0.816	0.13
92_P	98_D	0.816	0.13
107_V	200_L	0.813	0.13
19_L	54_G	0.800	0.13
133_R	168_V	0.797	0.13
55_L	65_R	0.795	0.13
28_Y	186_L	0.790	0.13
175_D	182_V	0.786	0.12
55_L	135_L	0.782	0.12
30_T	45_D	0.776	0.12
68_F	76_L	0.773	0.12
31_E	172_L	0.772	0.12
28_Y	136_S	0.769	0.12
13_E	25_K	0.765	0.12
20_Q	144_G	0.764	0.12
44_I	135_L	0.758	0.12
41_K	45_D	0.757	0.12
40_P	61_D	0.752	0.12
5_A	48_Q	0.750	0.12
171_A	194_D	0.747	0.12
8_D	31_E	0.745	0.12
52_D	123_A	0.741	0.12
9_L	102_C	0.736	0.12
28_Y	85_Y	0.731	0.12
118_V	196_V	0.723	0.12
26_P	36_I	0.723	0.12
19_L	28_Y	0.722	0.12
31_E	36_I	0.716	0.11
65_R	75_R	0.714	0.11
11_G	31_E	0.714	0.11
83_F	200_L	0.713	0.11
104_Y	133_R	0.711	0.11
18_I	36_I	0.695	0.11
22_L	67_Y	0.694	0.11
46_H	67_Y	0.694	0.11
10_L	67_Y	0.684	0.11
19_L	186_L	0.684	0.11
29_V	44_I	0.683	0.11
7_L	36_I	0.680	0.11
30_T	39_S	0.680	0.11
34_E	162_D	0.678	0.11
111_E	183_A	0.678	0.11
36_I	41_K	0.675	0.11
153_L	160_G	0.671	0.11
59_R	190_V	0.671	0.11
21_L	31_E	0.669	0.11
95_T	111_E	0.668	0.11
2_D	44_I	0.668	0.11
8_D	44_I	0.660	0.11
27_C	41_K	0.659	0.11
143_Q	153_L	0.654	0.11
177_R	182_V	0.652	0.11
95_T	117_E	0.650	0.11
24_R	143_Q	0.650	0.11
33_S	39_S	0.649	0.11
103_Q	154_G	0.648	0.11
38_V	66_K	0.646	0.11
124_K	127_E	0.640	0.10
14_N	31_E	0.639	0.10
27_C	139_Q	0.638	0.10
30_T	61_D	0.637	0.10
37_G	85_Y	0.637	0.10
78_V	121_L	0.636	0.10
169_L	187_E	0.634	0.10
102_C	137_M	0.628	0.10
34_E	39_S	0.619	0.10
158_G	199_T	0.619	0.10
105_V	109_I	0.616	0.10
39_S	132_E	0.615	0.10
170_A	190_V	0.608	0.10
181_D	198_Q	0.606	0.10
113_D	180_R	0.603	0.10
11_G	70_I	0.601	0.10
13_E	53_A	0.597	0.10
61_D	128_L	0.596	0.10
74_L	166_A	0.594	0.10
125_L	175_D	0.590	0.10
177_R	181_D	0.587	0.10
119_N	123_A	0.586	0.10
194_D	202_D	0.578	0.10
29_V	67_Y	0.577	0.10
72_E	145_Q	0.576	0.10
79_Q	168_V	0.573	0.10
14_N	166_A	0.573	0.10
75_R	134_E	0.572	0.10
61_D	66_K	0.570	0.10
57_E	66_K	0.570	0.10
63_Q	92_P	0.569	0.10
19_L	42_A	0.568	0.10
29_V	146_L	0.565	0.10
65_R	152_A	0.565	0.10
123_A	155_D	0.564	0.10
126_K	168_V	0.564	0.10
6_L	131_L	0.564	0.10
6_L	134_E	0.564	0.10
196_V	200_L	0.562	0.10
95_T	198_Q	0.558	0.09
111_E	178_T	0.555	0.09
5_A	125_L	0.554	0.09
6_L	135_L	0.545	0.09
87_A	154_G	0.545	0.09
84_G	162_D	0.544	0.09
23_A	107_V	0.541	0.09
63_Q	190_V	0.540	0.09
157_I	180_R	0.538	0.09
25_K	32_I	0.537	0.09
30_T	70_I	0.535	0.09
27_C	34_E	0.535	0.09
11_G	66_K	0.534	0.09
130_E	156_A	0.533	0.09
38_V	144_G	0.532	0.09
130_E	142_V	0.532	0.09
27_C	40_P	0.527	0.09
94_S	122_A	0.524	0.09
93_A	108_R	0.524	0.09
87_A	101_R	0.523	0.09
78_V	93_A	0.517	0.09
18_I	41_K	0.517	0.09
117_E	127_E	0.515	0.09
31_E	45_D	0.515	0.09
61_D	64_R	0.513	0.09
156_A	181_D	0.512	0.09
5_A	79_Q	0.510	0.09
57_E	121_L	0.509	0.09
26_P	41_K	0.508	0.09
7_L	135_L	0.504	0.09
80_L	84_G	0.504	0.09
14_N	38_V	0.503	0.09
71_A	120_E	0.501	0.09
195_G	201_A	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qlzA	2	0.9679	100	0.606	Contact Map
2p4wA	2	0.8716	99.5	0.789	Contact Map
3f6vA	2	0.4358	99.2	0.822	Contact Map
1r1tA	2	0.4037	99.2	0.823	Contact Map
2kkoA	2	0.4404	99.2	0.823	Contact Map
1u2wA	2	0.4083	99.2	0.828	Contact Map
3f6oA	2	0.4083	99.1	0.829	Contact Map
4k2eA	2	0.3945	99.1	0.829	Contact Map
3pqkA	2	0.4174	99.1	0.83	Contact Map
1r1uA	2	0.4128	99.1	0.83	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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