GREMLIN Database
GATD - Glutamyl-tRNA(Gln) amidotransferase subunit D
UniProt: Q9HP20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 427 (325)
Sequences: 1271 (853)
Seq/√Len: 47.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_S188_F6.7821.00
307_K329_E6.3551.00
180_L186_V6.2321.00
405_D408_A4.3371.00
86_S92_A4.2601.00
81_T123_N4.1901.00
176_L188_F4.0981.00
345_G349_D3.8641.00
236_H241_V3.7631.00
222_V241_V3.2641.00
355_V410_M3.1821.00
318_A343_T3.1401.00
125_R157_A2.9831.00
405_D409_A2.9661.00
219_E237_R2.9301.00
129_V148_A2.8441.00
147_A297_S2.7031.00
306_V317_L2.6701.00
150_R295_V2.5011.00
219_E260_L2.4481.00
177_S239_T2.4381.00
318_A346_S2.3701.00
329_E389_P2.3661.00
368_R373_G2.3291.00
85_I129_V2.3051.00
143_Q179_M2.2911.00
356_M381_V2.2901.00
330_G356_M2.2691.00
246_T358_S2.2091.00
300_E324_A2.1901.00
101_A104_A2.1631.00
325_G396_L2.1311.00
161_V213_A2.0891.00
146_A295_V2.0721.00
355_V384_A2.0701.00
132_I141_I2.0511.00
235_L261_G1.9870.99
188_F238_G1.9650.99
399_A403_A1.9480.99
96_D102_V1.9480.99
356_M367_D1.9020.99
153_I160_V1.8210.99
183_P293_L1.7750.99
348_V379_A1.7710.99
399_A409_A1.7680.99
169_M222_V1.7580.99
91_I202_N1.7390.98
353_T406_P1.7350.98
305_L389_P1.7220.98
181_E415_A1.7160.98
149_V162_V1.7110.98
181_E296_A1.7110.98
138_E339_D1.7040.98
153_I184_V1.6990.98
136_N372_T1.6950.98
353_T382_V1.6940.98
152_E156_G1.6650.98
83_A157_A1.6590.98
178_F417_A1.6370.98
223_C235_L1.6340.98
161_V210_V1.6280.98
150_R297_S1.5970.97
303_V327_V1.5310.96
357_T384_A1.5290.96
398_W402_N1.5030.96
221_M260_L1.4740.96
170_Q390_G1.4720.95
346_S350_D1.4420.95
186_V351_G1.4420.95
109_E113_R1.4400.95
256_G386_D1.4320.95
127_R148_A1.4270.95
181_E294_D1.4200.94
96_D103_T1.3830.94
164_H172_S1.3830.94
201_D243_K1.3810.94
140_S301_P1.3750.93
374_R377_L1.3740.93
95_V197_R1.3630.93
357_T389_P1.3620.93
189_T224_M1.3620.93
187_V221_M1.3500.93
139_P311_G1.3470.93
91_I191_S1.3260.92
242_R389_P1.3220.92
307_K389_P1.3180.92
241_V358_S1.3140.92
173_A241_V1.3020.91
167_D370_Y1.2960.91
296_A402_N1.2930.91
236_H254_T1.2870.91
385_G418_L1.2770.91
193_R249_R1.2710.90
208_C223_C1.2680.90
406_P409_A1.2680.90
141_I144_D1.2640.90
81_T125_R1.2480.90
117_D203_V1.2420.89
325_G357_T1.2340.89
142_W394_V1.2300.89
223_C263_V1.2130.88
312_M337_H1.2120.88
209_A212_A1.2100.88
243_K332_G1.2070.88
240_R310_P1.2060.88
221_M261_G1.2000.88
136_N339_D1.1990.88
92_A108_A1.1900.87
149_V153_I1.1750.87
317_L344_I1.1720.86
200_S203_V1.1700.86
343_T346_S1.1670.86
409_A412_E1.1650.86
398_W415_A1.1610.86
285_H288_R1.1520.85
245_H362_E1.1500.85
304_E326_V1.1500.85
374_R378_A1.1460.85
80_P122_A1.1460.85
174_S239_T1.1420.85
387_T418_L1.1260.84
138_E141_I1.1220.84
136_N338_S1.1170.84
84_L111_V1.1110.83
235_L260_L1.1100.83
174_S394_V1.1090.83
166_T236_H1.1080.83
413_S418_L1.1070.83
187_V212_A1.1000.83
314_E318_A1.0880.82
411_Q418_L1.0870.82
316_L320_C1.0840.82
286_A289_G1.0790.81
192_Q249_R1.0790.81
180_L295_V1.0700.81
132_I137_M1.0620.80
325_G392_A1.0580.80
179_M299_L1.0570.80
85_I162_V1.0540.80
82_I214_K1.0490.80
234_A262_Y1.0420.79
286_A293_L1.0420.79
389_P392_A1.0410.79
85_I127_R1.0400.79
153_I182_T1.0390.79
244_T253_E1.0150.77
308_F354_V1.0120.77
173_A392_A1.0090.77
79_L123_N1.0070.77
201_D332_G1.0070.77
149_V176_L1.0030.76
160_V184_V1.0020.76
225_H250_D0.9990.76
125_R152_E0.9820.75
391_T394_V0.9780.75
212_A267_A0.9550.73
237_R260_L0.9430.72
88_G165_G0.9430.72
159_G185_P0.9430.72
212_A223_C0.9430.72
193_R199_S0.9410.72
404_D407_E0.9370.71
312_M317_L0.9300.71
262_Y270_E0.9200.70
222_V236_H0.9190.70
182_T291_A0.9110.69
212_A235_L0.9080.69
118_L207_V0.9060.69
318_A345_G0.9050.69
91_I163_M0.9040.69
393_K397_M0.8990.68
181_E398_W0.8970.68
302_A324_A0.8950.68
135_E335_H0.8940.68
86_S108_A0.8930.68
142_W176_L0.8920.68
83_A127_R0.8900.67
182_T290_D0.8860.67
150_R154_E0.8840.67
342_D349_D0.8790.66
135_E331_T0.8790.66
223_C226_A0.8770.66
223_C265_Y0.8760.66
355_V396_L0.8730.66
106_F128_V0.8710.66
356_M376_L0.8690.66
84_L406_P0.8640.65
190_G201_D0.8570.65
190_G243_K0.8560.64
137_M188_F0.8540.64
373_G377_L0.8540.64
143_Q298_A0.8510.64
356_M365_V0.8470.64
282_E378_A0.8340.62
317_L343_T0.8300.62
199_S265_Y0.8270.62
305_L393_K0.8260.62
221_M235_L0.8170.61
142_W310_P0.8160.61
142_W164_H0.8130.60
157_A184_V0.8130.60
211_E215_S0.8110.60
284_A288_R0.8100.60
328_I344_I0.8100.60
133_L251_A0.8050.60
344_I381_V0.8040.60
191_S246_T0.8040.60
178_F239_T0.8010.59
162_V344_I0.7990.59
250_D336_V0.7960.59
303_V392_A0.7910.58
212_A330_G0.7900.58
342_D346_S0.7890.58
306_V320_C0.7880.58
303_V393_K0.7820.57
302_A315_S0.7790.57
286_A291_A0.7750.57
135_E189_T0.7750.57
285_H291_A0.7650.56
137_M245_H0.7620.55
348_V351_G0.7590.55
248_R340_L0.7550.55
308_F328_I0.7540.55
304_E323_S0.7540.55
173_A222_V0.7520.54
122_A214_K0.7510.54
298_A401_A0.7500.54
225_H241_V0.7490.54
89_G165_G0.7490.54
84_L210_V0.7480.54
179_M297_S0.7480.54
366_C369_V0.7470.54
204_M208_C0.7450.54
133_L224_M0.7440.54
147_A150_R0.7420.53
294_D324_A0.7420.53
174_S238_G0.7420.53
304_E347_L0.7420.53
137_M172_S0.7390.53
330_G365_V0.7380.53
135_E224_M0.7370.53
380_G383_E0.7350.53
191_S196_D0.7340.53
283_G286_A0.7330.53
317_L340_L0.7310.52
202_N267_A0.7280.52
306_V354_V0.7270.52
158_D184_V0.7250.52
86_S93_S0.7230.52
303_V337_H0.7210.51
87_T358_S0.7200.51
84_L129_V0.7190.51
190_G332_G0.7180.51
199_S330_G0.7170.51
378_A408_A0.7170.51
170_Q241_V0.7170.51
83_A152_E0.7160.51
93_S108_A0.7150.51
91_I164_H0.7130.51
336_V341_T0.7100.50
162_V351_G0.7090.50
84_L206_A0.7080.50
143_Q401_A0.7060.50
113_R419_T0.7060.50
171_F245_H0.7040.50
149_V160_V0.7030.50
284_A289_G0.7020.49
169_M190_G0.7000.49
310_P390_G0.6990.49
133_L238_G0.6990.49
240_R386_D0.6990.49
282_E286_A0.6990.49
359_Q390_G0.6980.49
357_T387_T0.6960.49
322_G328_I0.6890.48
81_T304_E0.6890.48
112_L115_V0.6860.48
122_A225_H0.6860.48
145_L172_S0.6850.48
106_F195_A0.6850.48
172_S175_A0.6840.48
302_A313_N0.6830.48
314_E343_T0.6820.47
344_I379_A0.6820.47
335_H356_M0.6780.47
365_V384_A0.6760.47
309_T393_K0.6720.46
311_G336_V0.6700.46
377_L415_A0.6640.46
126_G129_V0.6640.46
317_L349_D0.6620.46
389_P400_L0.6590.45
82_I262_Y0.6570.45
399_A406_P0.6570.45
147_A151_E0.6520.45
312_M340_L0.6520.45
331_T335_H0.6510.44
201_D224_M0.6510.44
360_C390_G0.6480.44
224_M332_G0.6470.44
136_N193_R0.6460.44
357_T392_A0.6450.44
347_L354_V0.6430.44
326_V347_L0.6430.44
376_L381_V0.6420.44
94_T107_D0.6410.43
244_T361_L0.6400.43
343_T413_S0.6400.43
367_D373_G0.6400.43
254_T311_G0.6400.43
287_A290_D0.6390.43
113_R287_A0.6380.43
289_G346_S0.6380.43
413_S417_A0.6380.43
115_V122_A0.6380.43
192_Q332_G0.6350.43
152_E157_A0.6350.43
166_T190_G0.6340.43
178_F391_T0.6330.43
112_L407_E0.6330.43
308_F336_V0.6320.43
85_I389_P0.6310.42
353_T400_L0.6310.42
121_R214_K0.6290.42
309_T323_S0.6250.42
219_E235_L0.6240.42
162_V188_F0.6230.42
140_S187_V0.6230.42
166_T332_G0.6220.42
289_G292_T0.6210.41
173_A413_S0.6200.41
94_T104_A0.6190.41
140_S404_D0.6180.41
187_V213_A0.6160.41
171_F307_K0.6160.41
298_A412_E0.6140.41
354_V385_G0.6130.41
242_R361_L0.6120.41
154_E186_V0.6110.41
146_A297_S0.6110.41
371_D397_M0.6110.41
121_R124_Y0.6090.40
132_I331_T0.6080.40
310_P386_D0.6070.40
150_R180_L0.6060.40
222_V374_R0.6060.40
408_A412_E0.6060.40
409_A415_A0.6060.40
325_G353_T0.6040.40
166_T250_D0.6040.40
95_V225_H0.6030.40
134_S165_G0.6020.40
296_A299_L0.6020.40
316_L319_A0.6010.40
132_I329_E0.5980.39
162_V411_Q0.5980.39
108_A111_V0.5970.39
175_A299_L0.5970.39
409_A413_S0.5960.39
328_I356_M0.5950.39
324_A403_A0.5940.39
292_T296_A0.5940.39
324_A407_E0.5940.39
133_L157_A0.5930.39
82_I226_A0.5920.39
359_Q370_Y0.5910.39
284_A287_A0.5890.38
101_A193_R0.5890.38
164_H238_G0.5890.38
224_M243_K0.5880.38
391_T395_K0.5870.38
127_R248_R0.5840.38
187_V235_L0.5840.38
404_D409_A0.5830.38
327_V355_V0.5830.38
303_V412_E0.5820.38
199_S249_R0.5820.38
254_T261_G0.5810.38
235_L239_T0.5800.38
122_A226_A0.5790.37
306_V323_S0.5780.37
162_V404_D0.5780.37
325_G400_L0.5770.37
285_H342_D0.5770.37
138_E191_S0.5760.37
85_I148_A0.5760.37
324_A401_A0.5750.37
124_Y191_S0.5740.37
151_E362_E0.5730.37
109_E124_Y0.5720.37
306_V312_M0.5720.37
202_N413_S0.5710.37
191_S343_T0.5700.37
88_G166_T0.5690.37
127_R326_V0.5690.37
215_S269_S0.5680.36
144_D414_V0.5660.36
317_L347_L0.5640.36
124_Y161_V0.5630.36
330_G333_L0.5630.36
199_S267_A0.5620.36
82_I218_A0.5590.36
180_L238_G0.5580.36
263_V267_A0.5570.35
250_D378_A0.5560.35
332_G335_H0.5560.35
85_I144_D0.5560.35
298_A419_T0.5540.35
384_A392_A0.5530.35
310_P395_K0.5520.35
354_V382_V0.5500.35
264_D267_A0.5480.35
288_R291_A0.5480.35
300_E306_V0.5480.35
335_H370_Y0.5480.35
240_R395_K0.5450.34
313_N326_V0.5450.34
198_P222_V0.5440.34
240_R419_T0.5440.34
117_D207_V0.5440.34
96_D101_A0.5430.34
251_A397_M0.5430.34
351_G355_V0.5430.34
130_A141_I0.5420.34
302_A323_S0.5410.34
126_G270_E0.5410.34
141_I179_M0.5390.34
404_D408_A0.5380.34
142_W188_F0.5380.34
139_P142_W0.5370.34
242_R382_V0.5360.34
148_A349_D0.5360.34
268_A317_L0.5360.34
174_S178_F0.5360.34
370_Y376_L0.5350.33
128_V141_I0.5340.33
90_T134_S0.5330.33
297_S396_L0.5320.33
160_V330_G0.5320.33
370_Y373_G0.5320.33
171_F359_Q0.5310.33
249_R333_L0.5310.33
166_T243_K0.5310.33
183_P287_A0.5300.33
200_S358_S0.5300.33
191_S265_Y0.5300.33
147_A301_P0.5270.33
304_E319_A0.5260.33
287_A291_A0.5260.33
327_V384_A0.5260.33
299_L401_A0.5230.32
142_W175_A0.5230.32
236_H358_S0.5220.32
336_V340_L0.5210.32
320_C343_T0.5200.32
174_S177_S0.5190.32
207_V211_E0.5190.32
150_R172_S0.5180.32
196_D245_H0.5180.32
341_T375_D0.5170.32
290_D355_V0.5170.32
262_Y381_V0.5160.32
81_T158_D0.5160.32
204_M327_V0.5160.32
169_M264_D0.5150.32
348_V404_D0.5140.32
292_T405_D0.5130.32
382_V399_A0.5110.31
114_A339_D0.5100.31
82_I127_R0.5090.31
111_V188_F0.5090.31
215_S387_T0.5080.31
187_V239_T0.5080.31
158_D352_T0.5080.31
99_T103_T0.5070.31
127_R152_E0.5070.31
390_G395_K0.5060.31
395_K417_A0.5040.31
144_D151_E0.5030.31
149_V186_V0.5030.31
372_T418_L0.5020.31
143_Q299_L0.5020.31
245_H364_R0.5010.31
210_V384_A0.5010.31
84_L162_V0.5010.31
257_A362_E0.5010.31
178_F310_P0.5000.30
151_E297_S0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d6fA 2 0.9461 100 0.137 Contact Map
1zq1A 2 0.9649 100 0.142 Contact Map
4q0mA 2 0.7447 100 0.302 Contact Map
1wlsA 2 0.7471 100 0.303 Contact Map
2himA 4 0.7541 100 0.312 Contact Map
4r8kA 3 0.7541 100 0.318 Contact Map
2wltA 4 0.7307 100 0.336 Contact Map
1nnsA 4 0.7377 100 0.338 Contact Map
3nxkA 4 0.7377 100 0.338 Contact Map
1wsaA 4 0.7237 100 0.338 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.