GREMLIN Database
Q9HP18 - Uncharacterized protein
UniProt: Q9HP18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (221)
Sequences: 9262 (6774)
Seq/√Len: 455.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_A85_A3.3551.00
203_H229_D2.9411.00
23_G26_D2.5141.00
91_A132_S2.4891.00
95_D136_A2.4891.00
71_T74_A2.4841.00
11_G235_Y2.4491.00
22_R96_A2.3951.00
215_D234_D2.3261.00
72_P76_A2.2961.00
21_V33_V2.2841.00
220_A239_V2.2361.00
72_P89_T2.1831.00
76_A92_A2.1771.00
18_L88_P2.1221.00
12_V237_G2.0631.00
46_F67_V2.0431.00
66_A69_D2.0111.00
104_H145_S2.0051.00
91_A135_A1.9801.00
42_T72_P1.9541.00
51_L78_A1.9421.00
33_V93_I1.9041.00
39_R71_T1.8551.00
22_R26_D1.8501.00
38_A44_V1.8341.00
91_A136_A1.8211.00
13_A23_G1.7781.00
235_Y238_V1.7651.00
17_T80_V1.7601.00
25_V101_T1.7281.00
63_A78_A1.7261.00
4_L30_G1.7071.00
45_V93_I1.6991.00
30_G102_T1.6861.00
33_V45_V1.6621.00
89_T92_A1.6571.00
165_A185_A1.6391.00
42_T89_T1.6391.00
190_V219_D1.6141.00
5_A20_A1.6011.00
52_D64_T1.5951.00
44_V72_P1.5921.00
210_N230_G1.5741.00
51_L70_A1.5361.00
65_G70_A1.5191.00
90_L105_V1.5101.00
216_T219_D1.5051.00
128_P131_D1.5021.00
61_T65_G1.4821.00
222_R226_A1.4741.00
144_F155_A1.4711.00
211_A228_V1.4531.00
219_D222_R1.4501.00
130_V159_A1.4391.00
44_V67_V1.4201.00
79_D84_G1.4181.00
21_V93_I1.4031.00
10_A20_A1.4011.00
38_A42_T1.3921.00
132_S136_A1.3911.00
127_Q158_A1.3911.00
37_P128_P1.3821.00
18_L96_A1.3731.00
154_A158_A1.3711.00
37_P43_P1.3651.00
134_A159_A1.3601.00
46_F60_I1.3571.00
9_F12_V1.3411.00
61_T80_V1.3361.00
7_R15_E1.3361.00
75_L87_V1.3321.00
156_R164_R1.3271.00
15_E53_D1.3271.00
144_F162_V1.3071.00
9_F23_G1.2821.00
91_A95_D1.2791.00
42_T91_A1.2481.00
188_P211_A1.2341.00
70_A74_A1.2341.00
38_A75_L1.2241.00
196_T200_A1.2121.00
50_R66_A1.2051.00
131_D135_A1.1961.00
145_S232_L1.1941.00
130_V155_A1.1881.00
35_V43_P1.1881.00
221_T225_R1.1711.00
154_A157_D1.1621.00
53_D60_I1.1521.00
107_L129_F1.1511.00
126_W151_A1.1451.00
41_G128_P1.1381.00
46_F87_V1.1341.00
202_A209_V1.1121.00
199_V209_V1.1061.00
152_L164_R1.1001.00
43_P129_F1.0931.00
127_Q131_D1.0911.00
18_L22_R1.0871.00
38_A72_P1.0811.00
70_A75_L1.0801.00
132_S135_A1.0781.00
156_R184_A1.0701.00
21_V31_I1.0671.00
202_A207_L1.0661.00
79_D86_G1.0661.00
145_S187_H1.0601.00
36_Q49_H1.0591.00
208_T229_D1.0581.00
25_V96_A1.0561.00
74_A77_D1.0551.00
44_V75_L1.0531.00
48_D53_D1.0421.00
35_V90_L1.0391.00
200_A204_D1.0351.00
4_L230_G1.0341.00
4_L104_H1.0291.00
133_V144_F1.0261.00
94_A133_V1.0231.00
19_A23_G1.0211.00
199_V203_H1.0051.00
198_L202_A0.9951.00
10_A234_D0.9901.00
52_D65_G0.9891.00
220_A231_V0.9891.00
50_R53_D0.9861.00
98_T138_A0.9791.00
76_A86_G0.9791.00
214_V220_A0.9731.00
70_A78_A0.9631.00
9_F237_G0.9631.00
159_A162_V0.9621.00
185_A208_T0.9611.00
107_L151_A0.9571.00
138_A141_P0.9571.00
35_V105_V0.9551.00
39_R69_D0.9401.00
214_V223_C0.9381.00
94_A136_A0.9381.00
104_H210_N0.9371.00
3_L239_V0.9301.00
94_A103_L0.9291.00
97_V103_L0.9211.00
126_W154_A0.9211.00
43_P128_P0.9171.00
52_D62_D0.9151.00
21_V45_V0.9111.00
43_P132_S0.9071.00
76_A89_T0.9061.00
138_A142_V0.9061.00
201_R205_A0.9061.00
32_E47_H0.9051.00
217_W221_T0.9051.00
90_L94_A0.9011.00
62_D65_G0.8991.00
212_W232_L0.8971.00
203_H209_V0.8901.00
130_V134_A0.8891.00
187_H210_N0.8871.00
104_H232_L0.8851.00
88_P93_I0.8831.00
127_Q154_A0.8821.00
5_A28_A0.8801.00
16_N21_V0.8791.00
60_I63_A0.8781.00
35_V129_F0.8701.00
104_H143_M0.8621.00
9_F236_P0.8581.00
98_T136_A0.8581.00
134_A139_D0.8531.00
13_A19_A0.8521.00
5_A9_F0.8501.00
79_D82_G0.8431.00
106_E147_F0.8431.00
147_F167_L0.8281.00
139_D159_A0.8111.00
145_S165_A0.8051.00
8_G21_V0.8011.00
148_F151_A0.7941.00
79_D83_S0.7931.00
5_A10_A0.7911.00
134_A161_G0.7901.00
33_V103_L0.7851.00
179_A205_A0.7801.00
201_R204_D0.7791.00
130_V158_A0.7741.00
128_P132_S0.7731.00
104_H187_H0.7721.00
37_P41_G0.7681.00
22_R97_V0.7681.00
211_A223_C0.7661.00
28_A236_P0.7621.00
197_S201_R0.7611.00
220_A238_V0.7601.00
189_P192_R0.7521.00
163_P184_A0.7511.00
199_V226_A0.7461.00
200_A203_H0.7451.00
145_S167_L0.7431.00
185_A210_N0.7401.00
6_H47_H0.7371.00
139_D142_V0.7331.00
224_R239_V0.7291.00
22_R85_A0.7241.00
36_Q68_W0.7221.00
149_D166_A0.7211.00
217_W238_V0.7201.00
42_T128_P0.7151.00
16_N88_P0.7131.00
176_A180_A0.7121.00
9_F13_A0.7121.00
12_V235_Y0.7111.00
107_L125_R0.7061.00
60_I65_G0.7041.00
219_D223_C0.7031.00
24_A28_A0.7001.00
92_A95_D0.7001.00
51_L75_L0.7001.00
112_C115_T0.6961.00
149_D153_A0.6881.00
165_A187_H0.6881.00
31_I101_T0.6801.00
93_I103_L0.6801.00
6_H32_E0.6791.00
4_L232_L0.6761.00
50_R64_T0.6711.00
106_E146_S0.6701.00
129_F133_V0.6701.00
51_L63_A0.6661.00
231_V239_V0.6621.00
133_V142_V0.6601.00
12_V23_G0.6581.00
34_D47_H0.6571.00
93_I97_V0.6531.00
196_T226_A0.6521.00
165_A210_N0.6521.00
49_H66_A0.6511.00
233_A239_V0.6501.00
33_V105_V0.6481.00
73_D77_D0.6461.00
155_A164_R0.6421.00
90_L129_F0.6421.00
3_L28_A0.6390.99
177_R180_A0.6370.99
36_Q67_V0.6370.99
220_A224_R0.6330.99
9_F28_A0.6280.99
133_V139_D0.6270.99
14_P85_A0.6260.99
39_R74_A0.6250.99
193_I211_A0.6240.99
37_P125_R0.6200.99
147_F212_W0.6180.99
61_T64_T0.6170.99
52_D61_T0.6160.99
215_D233_A0.6140.99
216_T238_V0.6130.99
98_T141_P0.6120.99
178_A181_A0.6120.99
100_D141_P0.6080.99
129_F144_F0.6080.99
80_V88_P0.6050.99
223_C226_A0.6020.99
198_L201_R0.6010.99
52_D63_A0.5980.99
25_V100_D0.5980.99
4_L210_N0.5960.99
44_V89_T0.5930.99
75_L78_A0.5890.99
105_V142_V0.5850.99
213_T233_A0.5830.99
31_I97_V0.5810.99
63_A70_A0.5790.99
174_G177_R0.5760.99
218_L221_T0.5750.99
178_A183_C0.5720.99
153_A157_D0.5650.99
99_G141_P0.5590.99
21_V96_A0.5590.99
126_W130_V0.5590.99
211_A214_V0.5580.99
150_G153_A0.5570.99
66_A70_A0.5560.99
94_A132_S0.5480.98
146_S152_L0.5460.98
199_V228_V0.5460.98
224_R231_V0.5460.98
73_D76_A0.5450.98
106_E167_L0.5450.98
178_A207_L0.5450.98
94_A138_A0.5440.98
36_Q109_S0.5440.98
169_V189_P0.5430.98
163_P208_T0.5420.98
3_L236_P0.5410.98
187_H190_V0.5400.98
80_V87_V0.5400.98
30_G104_H0.5400.98
179_A182_D0.5390.98
19_A22_R0.5390.98
196_T199_V0.5380.98
175_L178_A0.5360.98
152_L156_R0.5340.98
175_L179_A0.5340.98
43_P125_R0.5330.98
60_I80_V0.5320.98
102_T163_P0.5300.98
190_V214_V0.5290.98
90_L132_S0.5280.98
31_I103_L0.5280.98
143_M210_N0.5280.98
29_D102_T0.5260.98
176_A179_A0.5260.98
51_L65_G0.5240.98
18_L21_V0.5240.98
178_A182_D0.5240.98
222_R225_R0.5240.98
35_V45_V0.5240.98
195_D226_A0.5210.98
102_T143_M0.5200.98
175_L205_A0.5190.98
189_P212_W0.5180.98
17_T20_A0.5150.98
98_T103_L0.5130.98
210_N232_L0.5110.98
51_L61_T0.5110.98
32_E108_K0.5100.98
155_A162_V0.5050.97
151_A154_A0.5030.97
9_F24_A0.5000.97
89_T93_I0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pz0A 2 0.9383 100 0.129 Contact Map
4r7oA 4 0.93 100 0.133 Contact Map
3l12A 2 0.9835 100 0.134 Contact Map
3ks6A 1 0.9465 100 0.135 Contact Map
4oecA 1 0.9053 100 0.143 Contact Map
2oogA 4 0.93 100 0.143 Contact Map
3ch0A 1 0.9794 100 0.144 Contact Map
3qvqA 4 0.9383 100 0.144 Contact Map
2o55A 1 0.9424 100 0.146 Contact Map
2otdA 1 0.9342 100 0.148 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.