GREMLIN Database
Q9HP16 - Potassium channel homolog
UniProt: Q9HP16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 411 (381)
Sequences: 2841 (2250)
Seq/√Len: 115.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
329_V346_V4.2011.00
226_A230_A4.1621.00
84_G88_V3.7391.00
226_A229_F3.6371.00
225_G229_F3.3751.00
225_G230_A3.3521.00
173_T176_L3.0651.00
172_G176_L2.8071.00
190_D193_Y2.6611.00
227_A230_A2.6401.00
85_F89_V2.5931.00
84_G87_L2.5031.00
171_V176_L2.3901.00
89_V92_G2.3511.00
76_A89_V2.3001.00
170_T176_L2.2651.00
331_A343_V2.2031.00
266_V277_L2.1881.00
223_V227_A2.1691.00
225_G228_S2.1371.00
87_L92_G2.1321.00
192_F196_L2.0561.00
347_R374_D2.0401.00
173_T177_R2.0371.00
76_A83_T2.0231.00
86_L89_V2.0071.00
83_T87_L1.9831.00
329_V353_V1.9801.00
193_Y196_L1.9571.00
75_A89_V1.9381.00
170_T173_T1.9041.00
84_G90_S1.8831.00
190_D194_Y1.8801.00
222_L226_A1.8531.00
85_F88_V1.8481.00
222_L225_G1.8321.00
343_V373_A1.8261.00
201_T205_G1.8201.00
72_V84_G1.8151.00
172_G177_R1.8101.00
227_A231_V1.8031.00
155_Q158_V1.7891.00
202_V206_D1.7801.00
85_F90_S1.7681.00
68_V72_V1.7581.00
202_V205_G1.7561.00
76_A84_G1.7541.00
226_A233_L1.7471.00
86_L90_S1.7421.00
224_S229_F1.7411.00
84_G89_V1.7271.00
83_T86_L1.7111.00
83_T88_V1.7051.00
160_T165_V1.7031.00
319_T324_D1.6861.00
224_S228_S1.6851.00
223_V229_F1.6651.00
26_G31_P1.6571.00
261_N325_R1.6561.00
323_V329_V1.6541.00
76_A88_V1.6501.00
88_V92_G1.6471.00
223_V226_A1.6321.00
83_T89_V1.6311.00
347_R355_V1.6301.00
87_L90_S1.6221.00
79_T83_T1.6181.00
188_V193_Y1.6101.00
155_Q162_L1.6031.00
155_Q165_V1.6001.00
7_T49_T1.5981.00
84_G92_G1.5941.00
201_T204_Y1.5921.00
161_G167_A1.5841.00
263_H327_R1.5741.00
346_V353_V1.5711.00
162_L165_V1.5701.00
191_A195_T1.5681.00
189_L193_Y1.5621.00
82_L85_F1.5581.00
224_S230_A1.5481.00
72_V88_V1.5431.00
167_A173_T1.5381.00
171_V175_A1.5251.00
170_T174_Y1.5211.00
331_A339_D1.5041.00
153_T156_L1.4931.00
71_W83_T1.4921.00
174_Y177_R1.4841.00
265_V323_V1.4781.00
262_D327_R1.4771.00
206_D209_P1.4771.00
171_V174_Y1.4721.00
167_A170_T1.4701.00
68_V71_W1.4691.00
323_V350_H1.4651.00
170_T177_R1.4591.00
230_A233_L1.4501.00
76_A87_L1.4371.00
167_A176_L1.4211.00
75_A88_V1.4101.00
192_F195_T1.4021.00
79_T87_L1.4011.00
93_G96_R1.3921.00
155_Q164_G1.3921.00
160_T164_G1.3891.00
82_L86_L1.3841.00
71_W84_G1.3801.00
224_S227_A1.3791.00
172_G179_D1.3781.00
188_V192_F1.3751.00
222_L227_A1.3701.00
158_V164_G1.3641.00
81_A85_F1.3411.00
167_A177_R1.3261.00
156_L164_G1.3241.00
158_V165_V1.3181.00
216_L220_S1.3151.00
190_D195_T1.3101.00
71_W88_V1.2991.00
75_A79_T1.2931.00
223_V230_A1.2890.99
205_G209_P1.2880.99
223_V228_S1.2870.99
160_T167_A1.2860.99
167_A172_G1.2860.99
229_F233_L1.2840.99
265_V326_A1.2780.99
221_V224_S1.2770.99
156_L162_L1.2750.99
85_F92_G1.2600.99
188_V194_Y1.2590.99
76_A90_S1.2580.99
194_Y197_V1.2540.99
155_Q160_T1.2510.99
172_G175_A1.2480.99
157_A165_V1.2450.99
75_A87_L1.2440.99
75_A92_G1.2430.99
93_G97_G1.2420.99
189_L192_F1.2330.99
81_A89_V1.2210.99
167_A174_Y1.2160.99
71_W75_A1.2150.99
190_D198_T1.2130.99
202_V208_T1.2120.99
229_F232_A1.1980.99
222_L229_F1.1920.99
227_A233_L1.1900.99
152_S157_A1.1850.99
228_S232_A1.1780.99
219_L222_L1.1770.99
158_V162_L1.1710.99
86_L92_G1.1660.99
193_Y197_V1.1660.99
83_T90_S1.1580.99
354_A374_D1.1560.99
161_G164_G1.1500.99
156_L165_V1.1500.99
69_P72_V1.1490.99
205_G208_T1.1460.99
75_A83_T1.1440.99
79_T84_G1.1380.99
158_V161_G1.1280.99
155_Q159_G1.1250.99
209_P212_Q1.1230.99
213_A216_L1.1210.99
323_V349_S1.1150.99
152_S158_V1.1120.98
80_G84_G1.1110.98
83_T92_G1.1110.98
76_A86_L1.1060.98
76_A92_G1.1040.98
228_S231_V1.1040.98
331_A342_V1.1030.98
75_A84_G1.0970.98
204_Y209_P1.0930.98
203_G206_D1.0930.98
190_D196_L1.0890.98
312_P342_V1.0830.98
333_T342_V1.0820.98
188_V195_T1.0780.98
153_T165_V1.0770.98
82_L88_V1.0710.98
154_S158_V1.0710.98
161_G165_V1.0590.98
172_G178_G1.0590.98
215_R218_S1.0580.98
77_G83_T1.0570.98
73_S85_F1.0550.98
157_A163_I1.0520.98
156_L160_T1.0510.98
217_F220_S1.0450.98
152_S155_Q1.0420.98
72_V75_A1.0380.98
74_Q78_F1.0350.98
269_Y277_L1.0330.98
81_A84_G1.0320.98
72_V89_V1.0290.97
236_L239_P1.0220.97
202_V207_I1.0150.97
80_G88_V1.0140.97
80_G86_L1.0120.97
171_V177_R1.0110.97
76_A80_G1.0110.97
72_V83_T1.0100.97
74_Q89_V1.0050.97
201_T206_D1.0020.97
72_V86_L1.0000.97
193_Y198_T0.9990.97
176_L180_D0.9980.97
72_V76_A0.9960.97
226_A232_A0.9960.97
79_T88_V0.9950.97
11_R49_T0.9940.97
203_G207_I0.9940.97
192_F197_V0.9930.97
221_V229_F0.9720.96
73_S88_V0.9690.96
226_A231_V0.9680.96
71_W79_T0.9640.96
153_T160_T0.9610.96
228_S233_L0.9590.96
154_S157_A0.9550.96
220_S226_A0.9490.96
212_Q215_R0.9490.96
216_L219_L0.9460.96
241_L244_R0.9460.96
182_F186_S0.9450.96
150_P156_L0.9420.96
153_T164_G0.9400.96
328_A391_A0.9290.95
240_A243_A0.9290.95
69_P88_V0.9250.95
157_A164_G0.9240.95
189_L196_L0.9240.95
373_A376_V0.9220.95
220_S225_G0.9200.95
79_T89_V0.9190.95
159_G162_L0.9180.95
172_G180_D0.9180.95
218_S223_V0.9150.95
217_F223_V0.9140.95
192_F198_T0.9120.95
202_V209_P0.9120.95
220_S223_V0.9080.95
78_F81_A0.9070.95
344_L371_A0.9060.95
160_T163_I0.9040.95
4_G8_A0.9030.95
153_T162_L0.9020.95
378_S381_V0.9020.95
323_V353_V0.9010.95
81_A87_L0.8980.95
153_T158_V0.8980.95
260_L263_H0.8940.94
218_S221_V0.8910.94
71_W87_L0.8890.94
69_P75_A0.8870.94
214_A217_F0.8870.94
72_V85_F0.8830.94
8_A199_A0.8730.94
167_A171_V0.8700.94
150_P153_T0.8700.94
189_L194_Y0.8680.93
239_P242_E0.8670.93
199_A202_V0.8660.93
212_Q216_L0.8660.93
330_V391_A0.8660.93
217_F222_L0.8610.93
75_A85_F0.8610.93
97_G295_R0.8580.93
153_T157_A0.8540.93
78_F84_G0.8540.93
225_G233_L0.8520.93
151_R158_V0.8510.93
176_L181_G0.8510.93
222_L228_S0.8500.93
225_G231_V0.8490.93
322_G325_R0.8480.93
235_T238_G0.8420.92
227_A235_T0.8410.92
148_R152_S0.8380.92
247_N250_G0.8370.92
69_P84_G0.8370.92
159_G165_V0.8340.92
217_F221_V0.8330.92
279_E388_A0.8320.92
75_A86_L0.8310.92
77_G84_G0.8300.92
49_T198_T0.8290.92
225_G232_A0.8270.92
86_L91_A0.8220.91
77_G81_A0.8220.91
291_T296_S0.8210.91
331_A357_A0.8210.91
153_T159_G0.8210.91
71_W76_A0.8200.91
78_F82_L0.8150.91
170_T175_A0.8140.91
203_G209_P0.8090.91
72_V79_T0.8080.91
251_R255_R0.7990.90
46_S50_G0.7930.90
71_W74_Q0.7910.90
239_P243_A0.7900.90
69_P89_V0.7890.90
68_V75_A0.7850.89
195_T199_A0.7820.89
70_A81_A0.7710.89
223_V233_L0.7710.89
128_V134_S0.7700.89
70_A74_Q0.7660.88
158_V166_L0.7660.88
190_D197_V0.7660.88
152_S156_L0.7650.88
151_R157_A0.7650.88
221_V225_G0.7630.88
150_P155_Q0.7620.88
6_A10_R0.7600.88
219_L223_V0.7600.88
344_L348_E0.7560.88
88_V91_A0.7520.87
191_A194_Y0.7490.87
156_L159_G0.7480.87
117_L124_S0.7470.87
340_A367_K0.7470.87
150_P157_A0.7450.87
347_R373_A0.7440.87
267_A329_V0.7440.87
296_S299_A0.7440.87
73_S76_A0.7430.87
267_A312_P0.7430.87
152_S162_L0.7420.87
83_T91_A0.7410.87
219_L228_S0.7410.87
271_D358_A0.7370.86
144_R301_R0.7350.86
221_V226_A0.7350.86
215_R219_L0.7330.86
277_L300_L0.7330.86
74_Q86_L0.7310.86
175_A178_G0.7290.86
188_V196_L0.7260.86
164_G167_A0.7240.85
154_S159_G0.7220.85
80_G85_F0.7200.85
151_R156_L0.7190.85
382_I386_L0.7170.85
230_A234_T0.7170.85
213_A217_F0.7170.85
152_S160_T0.7160.85
263_H326_A0.7150.85
70_A86_L0.7130.84
71_W85_F0.7110.84
300_L303_R0.7080.84
187_T193_Y0.7070.84
70_A77_G0.7060.84
159_G164_G0.7050.84
293_D296_S0.7050.84
153_T163_I0.7040.84
71_W78_F0.7040.84
333_T339_D0.7030.84
218_S225_G0.6990.83
315_D349_S0.6980.83
70_A85_F0.6980.83
173_T181_G0.6970.83
266_V330_V0.6960.83
140_V149_T0.6960.83
237_I240_A0.6950.83
388_A391_A0.6950.83
150_P162_L0.6920.83
42_V47_V0.6910.83
79_T92_G0.6910.83
12_R42_V0.6860.82
191_A199_A0.6850.82
114_A118_L0.6850.82
187_T190_D0.6840.82
204_Y208_T0.6830.82
297_V307_V0.6830.82
155_Q161_G0.6830.82
78_F88_V0.6810.82
175_A179_D0.6800.82
222_L230_A0.6790.81
74_Q84_G0.6790.81
80_G89_V0.6790.81
335_D338_E0.6760.81
208_T211_T0.6750.81
187_T192_F0.6750.81
92_G95_R0.6740.81
350_H353_V0.6740.81
180_D186_S0.6730.81
360_S379_P0.6700.81
379_P383_G0.6690.81
70_A89_V0.6680.80
214_A218_S0.6670.80
359_A365_E0.6660.80
53_G205_G0.6580.79
229_F235_T0.6580.79
187_T191_A0.6560.79
281_D287_Y0.6540.79
219_L227_A0.6530.79
214_A220_S0.6520.79
68_V83_T0.6520.79
211_T214_A0.6510.79
156_L161_G0.6510.79
69_P80_G0.6500.79
230_A238_G0.6480.78
170_T178_G0.6480.78
221_V228_S0.6460.78
72_V80_G0.6440.78
68_V87_L0.6440.78
154_S160_T0.6430.78
155_Q163_I0.6410.78
226_A234_T0.6410.78
76_A85_F0.6410.78
189_L195_T0.6400.78
68_V79_T0.6370.77
151_R155_Q0.6360.77
157_A160_T0.6360.77
81_A86_L0.6360.77
173_T180_D0.6310.77
237_I241_L0.6280.76
68_V74_Q0.6240.76
336_D364_N0.6220.76
82_L89_V0.6220.76
174_Y180_D0.6200.75
72_V87_L0.6190.75
315_D345_T0.6180.75
361_D364_N0.6140.75
167_A175_A0.6130.74
171_V180_D0.6120.74
173_T178_G0.6120.74
187_T196_L0.6120.74
342_V346_V0.6110.74
340_A371_A0.6110.74
269_Y305_L0.6110.74
69_P86_L0.6110.74
210_T213_A0.6100.74
151_R164_G0.6090.74
73_S84_G0.6080.74
227_A232_A0.6070.74
115_Q139_G0.6070.74
7_T52_V0.6060.74
70_A76_A0.6060.74
72_V78_F0.6030.73
38_L46_S0.6000.73
150_P158_V0.5990.73
336_D339_D0.5980.73
272_L387_I0.5970.73
154_S162_L0.5960.72
68_V84_G0.5960.72
227_A234_T0.5960.72
152_S165_V0.5960.72
71_W86_L0.5950.72
220_S233_L0.5950.72
153_T161_G0.5950.72
340_A364_N0.5950.72
71_W89_V0.5950.72
20_R24_M0.5950.72
327_R354_A0.5940.72
238_G242_E0.5940.72
143_G149_T0.5930.72
68_V89_V0.5930.72
158_V167_A0.5890.72
42_V46_S0.5870.71
87_L91_A0.5870.71
75_A81_A0.5860.71
203_G208_T0.5830.71
100_A104_S0.5820.71
323_V346_V0.5820.71
252_M255_R0.5820.71
341_L344_L0.5810.71
248_V251_R0.5810.71
79_T85_F0.5790.70
77_G88_V0.5790.70
201_T208_T0.5770.70
217_F225_G0.5770.70
249_L255_R0.5760.70
218_S230_A0.5760.70
70_A83_T0.5750.70
329_V342_V0.5740.70
218_S222_L0.5740.70
265_V329_V0.5730.69
151_R165_V0.5720.69
68_V88_V0.5720.69
72_V90_S0.5720.69
193_Y200_T0.5700.69
150_P165_V0.5700.69
112_T119_Q0.5680.69
215_R221_V0.5670.69
16_Y289_V0.5670.69
94_L98_L0.5660.69
207_I212_Q0.5630.68
69_P73_S0.5630.68
150_P154_S0.5620.68
379_P384_G0.5610.68
51_V54_I0.5600.68
11_R46_S0.5600.68
220_S224_S0.5590.68
290_V308_L0.5580.67
94_L97_G0.5580.67
152_S163_I0.5570.67
379_P385_R0.5550.67
173_T179_D0.5550.67
71_W92_G0.5550.67
75_A90_S0.5520.67
296_S300_L0.5520.67
150_P160_T0.5510.66
289_V305_L0.5510.66
150_P163_I0.5500.66
68_V81_A0.5490.66
53_G115_Q0.5470.66
224_S231_V0.5460.66
214_A219_L0.5430.65
132_V137_V0.5430.65
253_T256_D0.5430.65
244_R247_N0.5410.65
128_V133_G0.5410.65
4_G53_G0.5400.65
246_A249_L0.5380.65
35_A187_T0.5370.65
357_A372_G0.5370.65
152_S159_G0.5360.64
330_V356_V0.5360.64
15_Y38_L0.5350.64
177_R181_G0.5350.64
343_V355_V0.5330.64
272_L332_A0.5330.64
74_Q81_A0.5310.64
68_V86_L0.5300.64
174_Y179_D0.5300.64
73_S89_V0.5300.64
197_V200_T0.5290.63
264_V280_L0.5270.63
277_L287_Y0.5270.63
217_F224_S0.5260.63
206_D211_T0.5260.63
156_L163_I0.5260.63
79_T82_L0.5240.63
235_T239_P0.5220.62
21_R26_G0.5210.62
216_L226_A0.5200.62
103_Y111_V0.5190.62
336_D367_K0.5190.62
81_A90_S0.5180.62
273_T291_T0.5170.62
297_V309_V0.5160.61
70_A88_V0.5140.61
72_V77_G0.5130.61
75_A78_F0.5120.61
12_R15_Y0.5120.61
214_A223_V0.5110.61
221_V227_A0.5100.61
266_V276_I0.5080.60
218_S229_F0.5080.60
265_V322_G0.5080.60
222_L233_L0.5080.60
265_V353_V0.5070.60
12_R17_V0.5070.60
163_I170_T0.5070.60
71_W90_S0.5050.60
290_V317_A0.5050.60
28_E33_R0.5040.60
96_R104_S0.5030.60
107_V111_V0.5010.59
264_V328_A0.5010.59
241_L245_L0.5010.59
106_V114_A0.5010.59
80_G83_T0.5000.59
264_V330_V0.5000.59
281_D305_L0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lnqA 6 0.5499 100 0.55 Contact Map
4gx0A 3 0.6204 100 0.583 Contact Map
3nafA 3 0.3917 100 0.627 Contact Map
2r9rB 3 0.601 100 0.673 Contact Map
3mt5A 5 0.3625 100 0.687 Contact Map
4hpfA 3 0.3479 100 0.697 Contact Map
2aefA 2 0.3552 99.9 0.726 Contact Map
3l9wA 2 0.3674 99.9 0.752 Contact Map
1orqC 4 0.5158 99.8 0.766 Contact Map
4bgnA 3 0.5061 99.8 0.766 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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