Q9HP14 - HALSA - GREMLIN Contacts

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Q9HP14 - Uridine phosphorylase

UniProt:	Q9HP14	Sequences: MAKQPHLLVEDGDVNDVALLPGDPGRVDRIASHCDDSEVVAENREYKVVNATYEGVSLTICSTGIGCPSAAIAIEELAKVGVQTVIRVGTIGGLQAGVEVGDMIVANGAAKAEGTSKRYESATYPAVPAYSVLAELVDAAEATEGVGDHEQSAAADGPAGATVHVGPIVSDDAFYNESDDYVADWEAANLLGIEMEAATVFSLARRRGLAAGAICTVDGNLVAGTQKGADSDDELPEKAQNNVSRAIDIALDAVVALS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	258 (214)
Sequences:	5067 (3391)
Seq/√Len:	231.8

ECOLI - UDP DEOD MTNN
BACSU - DEOD MTNN
HALSA - Q9HP14 Q9HR25
SULSO - PNPH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
91_I	217_V	3.467	1.00
204_A	211_A	3.212	1.00
78_A	209_L	3.036	1.00
36_D	52_T	2.735	1.00
129_A	210_A	2.723	1.00
137_V	165_V	2.684	1.00
107_N	165_V	2.534	1.00
197_A	213_A	2.524	1.00
84_T	210_A	2.474	1.00
108_G	127_V	2.344	1.00
52_T	57_S	2.277	1.00
28_D	32_S	2.213	1.00
42_E	47_K	2.192	1.00
106_A	168_I	2.174	1.00
108_G	167_P	2.171	1.00
95_Q	191_L	2.134	1.00
137_V	141_E	2.110	1.00
183_A	187_A	2.059	1.00
134_A	138_D	1.991	1.00
17_V	84_T	1.937	1.00
169_V	190_L	1.933	1.00
108_G	125_P	1.868	1.00
105_V	133_L	1.835	1.00
75_E	207_R	1.789	1.00
39_V	50_N	1.786	1.00
83_Q	209_L	1.771	1.00
136_L	212_G	1.770	1.00
67_C	199_T	1.756	1.00
91_I	192_G	1.755	1.00
130_Y	134_A	1.676	1.00
99_E	102_D	1.664	1.00
132_V	212_G	1.662	1.00
79_K	207_R	1.646	1.00
74_I	203_L	1.636	1.00
29_R	244_S	1.618	1.00
75_E	79_K	1.605	1.00
133_L	165_V	1.594	1.00
46_Y	62_S	1.574	1.00
24_P	62_S	1.574	1.00
20_L	63_T	1.571	1.00
244_S	248_D	1.569	1.00
136_L	253_A	1.527	1.00
133_L	212_G	1.524	1.00
41_A	80_V	1.523	1.00
104_I	192_G	1.518	1.00
98_V	164_H	1.507	1.00
194_E	197_A	1.506	1.00
241_N	245_R	1.495	1.00
181_Y	184_D	1.489	1.00
20_L	85_V	1.471	1.00
97_G	164_H	1.466	1.00
67_C	170_S	1.465	1.00
39_V	42_E	1.450	1.00
111_K	202_S	1.420	1.00
168_I	192_G	1.399	1.00
168_I	215_C	1.373	1.00
192_G	217_V	1.357	1.00
74_I	85_V	1.350	1.00
181_Y	185_W	1.349	1.00
109_A	197_A	1.346	1.00
21_P	27_V	1.334	1.00
35_D	52_T	1.329	1.00
53_Y	251_L	1.300	1.00
139_A	142_A	1.298	1.00
105_V	137_V	1.292	1.00
220_N	223_A	1.289	1.00
140_A	163_V	1.273	1.00
41_A	50_N	1.252	1.00
184_D	187_A	1.250	1.00
22_G	26_R	1.245	1.00
105_V	163_V	1.243	1.00
50_N	59_T	1.238	1.00
109_A	201_F	1.238	1.00
166_G	191_L	1.237	1.00
30_I	60_I	1.223	1.00
54_E	252_D	1.217	1.00
48_V	61_C	1.217	1.00
115_T	119_Y	1.214	1.00
18_A	82_V	1.209	1.00
70_A	200_V	1.186	1.00
111_K	198_A	1.180	1.00
40_V	47_K	1.170	1.00
135_E	253_A	1.163	1.00
131_S	210_A	1.162	1.00
17_V	56_V	1.152	1.00
48_V	59_T	1.148	1.00
110_A	125_P	1.145	1.00
183_A	186_E	1.141	1.00
93_G	98_V	1.129	1.00
139_A	253_A	1.127	1.00
85_V	204_A	1.107	1.00
78_A	85_V	1.104	1.00
61_C	73_A	1.095	1.00
93_G	220_N	1.082	1.00
40_V	61_C	1.081	1.00
134_A	137_V	1.077	1.00
142_A	252_D	1.074	1.00
159_A	252_D	1.071	1.00
93_G	217_V	1.056	1.00
29_R	247_I	1.042	1.00
138_D	141_E	1.040	1.00
228_G	238_K	1.029	1.00
78_A	82_V	1.029	1.00
182_V	185_W	1.025	1.00
105_V	212_G	1.023	1.00
133_L	136_L	1.022	1.00
99_E	225_T	1.016	1.00
104_I	191_L	1.014	1.00
180_D	184_D	1.012	1.00
70_A	74_I	1.002	1.00
245_R	248_D	1.001	1.00
135_E	139_A	0.995	1.00
139_A	252_D	0.984	1.00
180_D	183_A	0.983	1.00
27_V	60_I	0.981	1.00
31_A	49_V	0.980	1.00
99_E	223_A	0.979	1.00
132_V	136_L	0.978	1.00
128_P	133_L	0.977	1.00
109_A	213_A	0.974	1.00
78_A	83_Q	0.971	1.00
237_E	241_N	0.961	1.00
33_H	251_L	0.960	1.00
228_G	237_E	0.957	1.00
164_H	191_L	0.957	1.00
50_N	57_S	0.950	1.00
44_R	76_E	0.949	1.00
78_A	207_R	0.945	1.00
112_A	171_D	0.934	1.00
95_Q	98_V	0.930	1.00
116_S	121_S	0.926	1.00
116_S	202_S	0.926	1.00
29_R	32_S	0.925	1.00
125_P	167_P	0.923	1.00
110_A	169_V	0.921	1.00
112_A	173_A	0.921	1.00
128_P	201_F	0.918	1.00
137_V	163_V	0.915	1.00
24_P	31_A	0.914	1.00
70_A	199_T	0.911	1.00
21_P	88_V	0.907	1.00
131_S	135_E	0.906	1.00
34_C	51_A	0.906	1.00
106_A	128_P	0.903	0.99
133_L	137_V	0.903	0.99
84_T	132_V	0.901	0.99
102_D	164_H	0.899	0.99
72_I	203_L	0.899	0.99
87_R	200_V	0.897	0.99
52_T	55_G	0.893	0.99
134_A	141_E	0.892	0.99
241_N	244_S	0.888	0.99
227_K	238_K	0.884	0.99
159_A	248_D	0.880	0.99
54_E	251_L	0.877	0.99
17_V	254_V	0.874	0.99
138_D	142_A	0.871	0.99
85_V	209_L	0.867	0.99
101_G	242_N	0.863	0.99
53_Y	58_L	0.862	0.99
106_A	215_C	0.862	0.99
71_A	203_L	0.847	0.99
170_S	197_A	0.846	0.99
182_V	186_E	0.844	0.99
106_A	192_G	0.836	0.99
103_M	249_I	0.836	0.99
135_E	138_D	0.835	0.99
99_E	220_N	0.831	0.99
201_F	211_A	0.824	0.99
27_V	49_V	0.818	0.99
248_D	252_D	0.815	0.99
25_G	42_E	0.813	0.99
35_D	55_G	0.809	0.99
25_G	28_D	0.808	0.99
140_A	249_I	0.806	0.99
131_S	134_A	0.805	0.99
114_G	119_Y	0.803	0.99
71_A	75_E	0.797	0.99
212_G	253_A	0.794	0.99
90_T	218_D	0.790	0.99
94_L	190_L	0.789	0.99
101_G	227_K	0.787	0.99
115_T	203_L	0.787	0.99
67_C	115_T	0.786	0.99
78_A	81_G	0.786	0.99
194_E	213_A	0.783	0.99
67_C	198_A	0.781	0.99
111_K	114_G	0.776	0.98
130_Y	133_L	0.773	0.98
161_A	249_I	0.769	0.98
23_D	26_R	0.756	0.98
94_L	193_I	0.754	0.98
72_I	75_E	0.752	0.98
46_Y	73_A	0.748	0.98
142_A	159_A	0.746	0.98
34_C	37_S	0.745	0.98
112_A	169_V	0.745	0.98
122_A	126_A	0.740	0.98
243_V	247_I	0.739	0.98
199_T	203_L	0.737	0.98
104_I	217_V	0.726	0.98
240_Q	244_S	0.724	0.98
30_I	88_V	0.715	0.97
99_E	162_T	0.713	0.97
216_T	238_K	0.711	0.97
67_C	113_E	0.710	0.97
37_S	49_V	0.709	0.97
94_L	221_L	0.700	0.97
18_A	59_T	0.699	0.97
96_A	186_E	0.699	0.97
33_H	248_D	0.697	0.97
75_E	203_L	0.697	0.97
106_A	109_A	0.694	0.97
100_V	228_G	0.681	0.97
48_V	76_E	0.679	0.96
110_A	124_Y	0.679	0.96
46_Y	65_I	0.675	0.96
96_A	222_V	0.674	0.96
71_A	199_T	0.673	0.96
115_T	120_E	0.667	0.96
139_A	249_I	0.667	0.96
48_V	80_V	0.665	0.96
61_C	77_L	0.665	0.96
127_V	205_R	0.660	0.96
134_A	165_V	0.660	0.96
33_H	244_S	0.659	0.96
37_S	40_V	0.658	0.96
72_I	76_E	0.653	0.96
193_I	219_G	0.651	0.96
123_T	127_V	0.649	0.95
41_A	48_V	0.647	0.95
98_V	217_V	0.644	0.95
21_P	30_I	0.643	0.95
127_V	130_Y	0.641	0.95
225_T	229_A	0.639	0.95
27_V	62_S	0.638	0.95
244_S	247_I	0.637	0.95
110_A	190_L	0.637	0.95
237_E	240_Q	0.637	0.95
179_D	183_A	0.636	0.95
126_A	202_S	0.634	0.95
46_Y	61_C	0.632	0.95
197_A	215_C	0.630	0.95
93_G	100_V	0.628	0.95
225_T	228_G	0.627	0.95
31_A	60_I	0.626	0.94
95_Q	164_H	0.626	0.94
90_T	243_V	0.623	0.94
117_K	123_T	0.623	0.94
107_N	127_V	0.623	0.94
29_R	33_H	0.622	0.94
193_I	221_L	0.622	0.94
77_L	82_V	0.619	0.94
25_G	240_Q	0.615	0.94
129_A	132_V	0.615	0.94
249_I	253_A	0.615	0.94
240_Q	243_V	0.610	0.94
81_G	209_L	0.608	0.94
20_L	74_I	0.607	0.94
63_T	74_I	0.607	0.94
139_A	159_A	0.603	0.93
107_N	133_L	0.603	0.93
106_A	201_F	0.603	0.93
130_Y	165_V	0.603	0.93
177_E	206_R	0.602	0.93
124_Y	202_S	0.600	0.93
44_R	207_R	0.596	0.93
107_N	167_P	0.593	0.93
116_S	119_Y	0.593	0.93
136_L	139_A	0.593	0.93
90_T	239_A	0.591	0.93
161_A	245_R	0.590	0.93
115_T	199_T	0.585	0.92
114_G	121_S	0.585	0.92
176_N	194_E	0.585	0.92
91_I	215_C	0.585	0.92
65_I	72_I	0.583	0.92
120_E	188_A	0.577	0.92
132_V	253_A	0.575	0.92
130_Y	137_V	0.571	0.91
87_R	90_T	0.570	0.91
125_P	189_N	0.570	0.91
101_G	238_K	0.570	0.91
86_I	132_V	0.569	0.91
218_D	243_V	0.569	0.91
42_E	45_E	0.568	0.91
181_Y	186_E	0.568	0.91
91_I	104_I	0.560	0.91
22_G	87_R	0.560	0.91
32_S	37_S	0.560	0.91
161_A	248_D	0.558	0.90
69_S	72_I	0.556	0.90
118_R	121_S	0.552	0.90
105_V	214_I	0.551	0.90
26_R	90_T	0.549	0.90
141_E	162_T	0.549	0.90
105_V	140_A	0.547	0.89
24_P	28_D	0.546	0.89
116_S	123_T	0.545	0.89
30_I	34_C	0.544	0.89
103_M	245_R	0.541	0.89
67_C	172_D	0.539	0.89
123_T	126_A	0.538	0.89
161_A	164_H	0.536	0.89
103_M	216_T	0.535	0.88
117_K	120_E	0.535	0.88
110_A	127_V	0.530	0.88
72_I	206_R	0.530	0.88
26_R	87_R	0.528	0.88
222_V	225_T	0.523	0.87
28_D	47_K	0.521	0.87
114_G	117_K	0.516	0.87
113_E	116_S	0.512	0.86
76_E	79_K	0.512	0.86
201_F	212_G	0.506	0.86
174_F	195_M	0.504	0.85
94_L	182_V	0.503	0.85
109_A	211_A	0.502	0.85
216_T	242_N	0.501	0.85
136_L	140_A	0.500	0.85
32_S	35_D	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3phcA	5	0.9147	100	0.225	Contact Map
3bjeA	2	0.9419	100	0.23	Contact Map
3mb8A	4	0.9225	100	0.241	Contact Map
2b94A	4	0.8798	100	0.25	Contact Map
4tymA	5	0.8953	100	0.265	Contact Map
3eufA	2	0.9031	100	0.268	Contact Map
4m3nA	3	0.8837	100	0.269	Contact Map
4mchA	3	0.9031	100	0.269	Contact Map
4m7wA	5	0.8953	100	0.27	Contact Map
4ldnA	3	0.907	100	0.27	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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