GREMLIN Database
Q9HP14 - Uridine phosphorylase
UniProt: Q9HP14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (214)
Sequences: 5067 (3391)
Seq/√Len: 231.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_I217_V3.4671.00
204_A211_A3.2121.00
78_A209_L3.0361.00
36_D52_T2.7351.00
129_A210_A2.7231.00
137_V165_V2.6841.00
107_N165_V2.5341.00
197_A213_A2.5241.00
84_T210_A2.4741.00
108_G127_V2.3441.00
52_T57_S2.2771.00
28_D32_S2.2131.00
42_E47_K2.1921.00
106_A168_I2.1741.00
108_G167_P2.1711.00
95_Q191_L2.1341.00
137_V141_E2.1101.00
183_A187_A2.0591.00
134_A138_D1.9911.00
17_V84_T1.9371.00
169_V190_L1.9331.00
108_G125_P1.8681.00
105_V133_L1.8351.00
75_E207_R1.7891.00
39_V50_N1.7861.00
83_Q209_L1.7711.00
136_L212_G1.7701.00
67_C199_T1.7561.00
91_I192_G1.7551.00
130_Y134_A1.6761.00
99_E102_D1.6641.00
132_V212_G1.6621.00
79_K207_R1.6461.00
74_I203_L1.6361.00
29_R244_S1.6181.00
75_E79_K1.6051.00
133_L165_V1.5941.00
46_Y62_S1.5741.00
24_P62_S1.5741.00
20_L63_T1.5711.00
244_S248_D1.5691.00
136_L253_A1.5271.00
133_L212_G1.5241.00
41_A80_V1.5231.00
104_I192_G1.5181.00
98_V164_H1.5071.00
194_E197_A1.5061.00
241_N245_R1.4951.00
181_Y184_D1.4891.00
20_L85_V1.4711.00
97_G164_H1.4661.00
67_C170_S1.4651.00
39_V42_E1.4501.00
111_K202_S1.4201.00
168_I192_G1.3991.00
168_I215_C1.3731.00
192_G217_V1.3571.00
74_I85_V1.3501.00
181_Y185_W1.3491.00
109_A197_A1.3461.00
21_P27_V1.3341.00
35_D52_T1.3291.00
53_Y251_L1.3001.00
139_A142_A1.2981.00
105_V137_V1.2921.00
220_N223_A1.2891.00
140_A163_V1.2731.00
41_A50_N1.2521.00
184_D187_A1.2501.00
22_G26_R1.2451.00
105_V163_V1.2431.00
50_N59_T1.2381.00
109_A201_F1.2381.00
166_G191_L1.2371.00
30_I60_I1.2231.00
54_E252_D1.2171.00
48_V61_C1.2171.00
115_T119_Y1.2141.00
18_A82_V1.2091.00
70_A200_V1.1861.00
111_K198_A1.1801.00
40_V47_K1.1701.00
135_E253_A1.1631.00
131_S210_A1.1621.00
17_V56_V1.1521.00
48_V59_T1.1481.00
110_A125_P1.1451.00
183_A186_E1.1411.00
93_G98_V1.1291.00
139_A253_A1.1271.00
85_V204_A1.1071.00
78_A85_V1.1041.00
61_C73_A1.0951.00
93_G220_N1.0821.00
40_V61_C1.0811.00
134_A137_V1.0771.00
142_A252_D1.0741.00
159_A252_D1.0711.00
93_G217_V1.0561.00
29_R247_I1.0421.00
138_D141_E1.0401.00
228_G238_K1.0291.00
78_A82_V1.0291.00
182_V185_W1.0251.00
105_V212_G1.0231.00
133_L136_L1.0221.00
99_E225_T1.0161.00
104_I191_L1.0141.00
180_D184_D1.0121.00
70_A74_I1.0021.00
245_R248_D1.0011.00
135_E139_A0.9951.00
139_A252_D0.9841.00
180_D183_A0.9831.00
27_V60_I0.9811.00
31_A49_V0.9801.00
99_E223_A0.9791.00
132_V136_L0.9781.00
128_P133_L0.9771.00
109_A213_A0.9741.00
78_A83_Q0.9711.00
237_E241_N0.9611.00
33_H251_L0.9601.00
228_G237_E0.9571.00
164_H191_L0.9571.00
50_N57_S0.9501.00
44_R76_E0.9491.00
78_A207_R0.9451.00
112_A171_D0.9341.00
95_Q98_V0.9301.00
116_S121_S0.9261.00
116_S202_S0.9261.00
29_R32_S0.9251.00
125_P167_P0.9231.00
110_A169_V0.9211.00
112_A173_A0.9211.00
128_P201_F0.9181.00
137_V163_V0.9151.00
24_P31_A0.9141.00
70_A199_T0.9111.00
21_P88_V0.9071.00
131_S135_E0.9061.00
34_C51_A0.9061.00
106_A128_P0.9030.99
133_L137_V0.9030.99
84_T132_V0.9010.99
102_D164_H0.8990.99
72_I203_L0.8990.99
87_R200_V0.8970.99
52_T55_G0.8930.99
134_A141_E0.8920.99
241_N244_S0.8880.99
227_K238_K0.8840.99
159_A248_D0.8800.99
54_E251_L0.8770.99
17_V254_V0.8740.99
138_D142_A0.8710.99
85_V209_L0.8670.99
101_G242_N0.8630.99
53_Y58_L0.8620.99
106_A215_C0.8620.99
71_A203_L0.8470.99
170_S197_A0.8460.99
182_V186_E0.8440.99
106_A192_G0.8360.99
103_M249_I0.8360.99
135_E138_D0.8350.99
99_E220_N0.8310.99
201_F211_A0.8240.99
27_V49_V0.8180.99
248_D252_D0.8150.99
25_G42_E0.8130.99
35_D55_G0.8090.99
25_G28_D0.8080.99
140_A249_I0.8060.99
131_S134_A0.8050.99
114_G119_Y0.8030.99
71_A75_E0.7970.99
212_G253_A0.7940.99
90_T218_D0.7900.99
94_L190_L0.7890.99
101_G227_K0.7870.99
115_T203_L0.7870.99
67_C115_T0.7860.99
78_A81_G0.7860.99
194_E213_A0.7830.99
67_C198_A0.7810.99
111_K114_G0.7760.98
130_Y133_L0.7730.98
161_A249_I0.7690.98
23_D26_R0.7560.98
94_L193_I0.7540.98
72_I75_E0.7520.98
46_Y73_A0.7480.98
142_A159_A0.7460.98
34_C37_S0.7450.98
112_A169_V0.7450.98
122_A126_A0.7400.98
243_V247_I0.7390.98
199_T203_L0.7370.98
104_I217_V0.7260.98
240_Q244_S0.7240.98
30_I88_V0.7150.97
99_E162_T0.7130.97
216_T238_K0.7110.97
67_C113_E0.7100.97
37_S49_V0.7090.97
94_L221_L0.7000.97
18_A59_T0.6990.97
96_A186_E0.6990.97
33_H248_D0.6970.97
75_E203_L0.6970.97
106_A109_A0.6940.97
100_V228_G0.6810.97
48_V76_E0.6790.96
110_A124_Y0.6790.96
46_Y65_I0.6750.96
96_A222_V0.6740.96
71_A199_T0.6730.96
115_T120_E0.6670.96
139_A249_I0.6670.96
48_V80_V0.6650.96
61_C77_L0.6650.96
127_V205_R0.6600.96
134_A165_V0.6600.96
33_H244_S0.6590.96
37_S40_V0.6580.96
72_I76_E0.6530.96
193_I219_G0.6510.96
123_T127_V0.6490.95
41_A48_V0.6470.95
98_V217_V0.6440.95
21_P30_I0.6430.95
127_V130_Y0.6410.95
225_T229_A0.6390.95
27_V62_S0.6380.95
244_S247_I0.6370.95
110_A190_L0.6370.95
237_E240_Q0.6370.95
179_D183_A0.6360.95
126_A202_S0.6340.95
46_Y61_C0.6320.95
197_A215_C0.6300.95
93_G100_V0.6280.95
225_T228_G0.6270.95
31_A60_I0.6260.94
95_Q164_H0.6260.94
90_T243_V0.6230.94
117_K123_T0.6230.94
107_N127_V0.6230.94
29_R33_H0.6220.94
193_I221_L0.6220.94
77_L82_V0.6190.94
25_G240_Q0.6150.94
129_A132_V0.6150.94
249_I253_A0.6150.94
240_Q243_V0.6100.94
81_G209_L0.6080.94
20_L74_I0.6070.94
63_T74_I0.6070.94
139_A159_A0.6030.93
107_N133_L0.6030.93
106_A201_F0.6030.93
130_Y165_V0.6030.93
177_E206_R0.6020.93
124_Y202_S0.6000.93
44_R207_R0.5960.93
107_N167_P0.5930.93
116_S119_Y0.5930.93
136_L139_A0.5930.93
90_T239_A0.5910.93
161_A245_R0.5900.93
115_T199_T0.5850.92
114_G121_S0.5850.92
176_N194_E0.5850.92
91_I215_C0.5850.92
65_I72_I0.5830.92
120_E188_A0.5770.92
132_V253_A0.5750.92
130_Y137_V0.5710.91
87_R90_T0.5700.91
125_P189_N0.5700.91
101_G238_K0.5700.91
86_I132_V0.5690.91
218_D243_V0.5690.91
42_E45_E0.5680.91
181_Y186_E0.5680.91
91_I104_I0.5600.91
22_G87_R0.5600.91
32_S37_S0.5600.91
161_A248_D0.5580.90
69_S72_I0.5560.90
118_R121_S0.5520.90
105_V214_I0.5510.90
26_R90_T0.5490.90
141_E162_T0.5490.90
105_V140_A0.5470.89
24_P28_D0.5460.89
116_S123_T0.5450.89
30_I34_C0.5440.89
103_M245_R0.5410.89
67_C172_D0.5390.89
123_T126_A0.5380.89
161_A164_H0.5360.89
103_M216_T0.5350.88
117_K120_E0.5350.88
110_A127_V0.5300.88
72_I206_R0.5300.88
26_R87_R0.5280.88
222_V225_T0.5230.87
28_D47_K0.5210.87
114_G117_K0.5160.87
113_E116_S0.5120.86
76_E79_K0.5120.86
201_F212_G0.5060.86
174_F195_M0.5040.85
94_L182_V0.5030.85
109_A211_A0.5020.85
216_T242_N0.5010.85
136_L140_A0.5000.85
32_S35_D0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3phcA 5 0.9147 100 0.225 Contact Map
3bjeA 2 0.9419 100 0.23 Contact Map
3mb8A 4 0.9225 100 0.241 Contact Map
2b94A 4 0.8798 100 0.25 Contact Map
4tymA 5 0.8953 100 0.265 Contact Map
3eufA 2 0.9031 100 0.268 Contact Map
4m3nA 3 0.8837 100 0.269 Contact Map
4mchA 3 0.9031 100 0.269 Contact Map
4m7wA 5 0.8953 100 0.27 Contact Map
4ldnA 3 0.907 100 0.27 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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