GREMLIN Database
Q9HP13 - Sugar kinase
UniProt: Q9HP13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 295 (274)
Sequences: 22460 (16782)
Seq/√Len: 1013.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_I250_A3.1291.00
135_H159_S2.8381.00
71_Q86_V2.6091.00
218_V262_L2.5351.00
211_H217_T2.5221.00
56_G80_D2.5111.00
257_D260_R2.3911.00
5_V131_C2.3601.00
251_V256_G2.3271.00
63_D88_D2.3131.00
216_A244_F2.2831.00
149_A177_R2.1681.00
68_L86_V2.1561.00
48_L53_I2.1211.00
60_S87_V2.0241.00
50_G77_A1.9981.00
6_A45_A1.9841.00
185_D211_H1.9611.00
159_S249_V1.9461.00
151_A156_A1.9461.00
225_V259_E1.9431.00
251_V264_F1.9291.00
243_A268_C1.9121.00
283_T286_D1.8941.00
133_H157_T1.8651.00
60_S121_D1.8581.00
148_T158_V1.8551.00
46_C77_A1.8411.00
157_T179_D1.8251.00
182_F245_A1.8141.00
179_D205_R1.8041.00
47_A246_A1.7971.00
196_G199_T1.7671.00
256_G260_R1.7621.00
75_Q81_L1.7501.00
218_V225_V1.7361.00
216_A266_N1.7221.00
133_H159_S1.7061.00
254_D284_R1.6921.00
240_A273_A1.6901.00
72_R76_A1.6861.00
217_T226_T1.6741.00
248_F261_A1.6621.00
73_E76_A1.6621.00
275_H286_D1.6611.00
71_Q75_Q1.6561.00
180_I206_V1.6521.00
145_A173_D1.6451.00
211_H226_T1.6441.00
247_G268_C1.6391.00
259_E263_E1.6321.00
269_G273_A1.6171.00
109_G112_G1.5841.00
230_F267_A1.5801.00
146_R149_A1.5791.00
236_D277_G1.5441.00
48_L250_A1.5351.00
208_V248_F1.5281.00
63_D68_L1.5241.00
10_V59_G1.5201.00
189_G195_D1.5151.00
218_V258_H1.5051.00
133_H249_V1.5031.00
68_L72_R1.5021.00
206_V220_T1.4981.00
227_H262_L1.4941.00
150_L154_H1.4741.00
220_T223_G1.4671.00
146_R150_L1.4611.00
211_H214_E1.4601.00
161_D210_K1.4521.00
145_A149_A1.4491.00
35_R69_L1.4441.00
247_G264_F1.4411.00
37_G70_A1.4401.00
4_V48_L1.4391.00
152_R179_D1.4111.00
150_L153_E1.4071.00
162_P183_V1.4001.00
178_T181_L1.3861.00
67_G92_T1.3601.00
42_A74_L1.3571.00
230_F263_E1.3561.00
90_L116_A1.3551.00
227_H266_N1.3471.00
63_D86_V1.3421.00
157_T180_I1.3381.00
129_A154_H1.3341.00
12_W69_L1.3261.00
14_V33_Q1.3241.00
71_Q84_L1.3241.00
54_D80_D1.3121.00
17_R32_S1.3061.00
118_A121_D1.2991.00
232_V274_Q1.2911.00
152_R177_R1.2771.00
216_A262_L1.2651.00
248_F252_V1.2391.00
119_P146_R1.2331.00
247_G265_G1.2321.00
251_V261_A1.2231.00
182_F210_K1.2101.00
206_V252_V1.2091.00
206_V248_F1.2051.00
73_E77_A1.2021.00
248_F265_G1.2021.00
230_F266_N1.2011.00
260_R263_E1.1881.00
49_A79_V1.1871.00
206_V258_H1.1861.00
157_T205_R1.1781.00
234_P273_A1.1761.00
232_V273_A1.1761.00
211_H215_G1.1701.00
210_K244_F1.1681.00
188_A209_V1.1671.00
51_F247_G1.1671.00
37_G73_E1.1621.00
69_L72_R1.1551.00
134_V151_A1.1501.00
53_I253_L1.1431.00
68_L71_Q1.1381.00
14_V35_R1.1301.00
72_R75_Q1.1271.00
48_L55_A1.1241.00
149_A153_E1.1181.00
65_E68_L1.1181.00
44_V135_H1.1171.00
250_A254_D1.1101.00
136_L158_V1.1081.00
271_L275_H1.1041.00
271_L274_Q1.1001.00
180_I248_F1.0991.00
45_A55_A1.0951.00
230_F270_A1.0771.00
135_H249_V1.0621.00
185_D214_E1.0621.00
234_P237_T1.0601.00
46_C50_G1.0561.00
206_V218_V1.0561.00
219_H224_S1.0501.00
87_V116_A1.0441.00
182_F248_F1.0311.00
134_V156_A1.0301.00
266_N269_G1.0281.00
250_A284_R1.0241.00
160_F178_T1.0241.00
180_I252_V1.0231.00
205_R221_P1.0121.00
47_A243_A1.0081.00
56_G131_C1.0031.00
243_A272_A1.0021.00
194_D199_T1.0011.00
123_D146_R1.0001.00
64_D92_T0.9991.00
10_V70_A0.9991.00
49_A78_G0.9901.00
248_F258_H0.9871.00
135_H245_A0.9851.00
48_L246_A0.9821.00
53_I254_D0.9811.00
17_R34_R0.9771.00
6_A41_A0.9771.00
61_V67_G0.9741.00
263_E267_A0.9731.00
69_L73_E0.9701.00
56_G126_V0.9671.00
51_F268_C0.9631.00
61_V71_Q0.9631.00
37_G69_L0.9621.00
62_G92_T0.9621.00
261_A265_G0.9621.00
142_A146_R0.9601.00
56_G83_G0.9531.00
131_C156_A0.9511.00
7_A134_V0.9501.00
16_L96_Y0.9491.00
199_T202_D0.9471.00
234_P274_Q0.9471.00
251_V254_D0.9471.00
229_G266_N0.9461.00
136_L148_T0.9411.00
106_M109_G0.9361.00
15_T36_S0.9331.00
250_A264_F0.9321.00
223_G259_E0.9301.00
215_G229_G0.9271.00
61_V84_L0.9241.00
214_E226_T0.9171.00
185_D189_G0.9161.00
184_N187_E0.9151.00
127_V131_C0.9151.00
10_V42_A0.9131.00
87_V90_L0.9121.00
5_V58_V0.9031.00
256_G264_F0.9021.00
14_V66_H0.8951.00
81_L84_L0.8941.00
49_A54_D0.8931.00
71_Q81_L0.8911.00
10_V57_L0.8871.00
14_V94_V0.8831.00
183_V188_A0.8811.00
252_V261_A0.8811.00
107_V112_G0.8801.00
197_G200_A0.8801.00
70_A92_T0.8771.00
108_L112_G0.8771.00
30_I108_L0.8751.00
233_D274_Q0.8751.00
257_D261_A0.8731.00
42_A279_R0.8701.00
61_V86_V0.8531.00
221_P224_S0.8521.00
235_V276_E0.8491.00
44_V245_A0.8441.00
161_D182_F0.8441.00
149_A173_D0.8411.00
4_V253_L0.8411.00
225_V262_L0.8311.00
107_V111_D0.8291.00
244_F266_N0.8281.00
143_T147_L0.8281.00
227_H263_E0.8281.00
11_N93_S0.8231.00
227_H259_E0.8171.00
161_D183_V0.8161.00
136_L144_A0.8131.00
85_R121_D0.8121.00
60_S85_R0.8111.00
243_A247_G0.8101.00
247_G251_V0.8001.00
175_L178_T0.7981.00
159_S182_F0.7971.00
243_A269_G0.7971.00
138_S160_F0.7931.00
71_Q85_R0.7871.00
173_D176_A0.7861.00
12_W66_H0.7821.00
220_T258_H0.7801.00
56_G82_A0.7781.00
64_D67_G0.7761.00
7_A147_L0.7761.00
24_P104_E0.7681.00
133_H253_L0.7671.00
13_D38_G0.7641.00
49_A55_A0.7581.00
267_A271_L0.7561.00
148_T177_R0.7551.00
45_A57_L0.7551.00
232_V270_A0.7521.00
266_N270_A0.7481.00
5_V56_G0.7351.00
46_C279_R0.7331.00
208_V218_V0.7331.00
264_F284_R0.7291.00
220_T225_V0.7261.00
35_R66_H0.7221.00
271_L286_D0.7221.00
213_S231_A0.7201.00
66_H94_V0.7191.00
159_S180_I0.7181.00
176_A203_S0.7141.00
244_F262_L0.7121.00
73_E279_R0.7111.00
198_P202_D0.7111.00
203_S207_V0.7091.00
23_E26_G0.7091.00
54_D132_E0.7081.00
12_W35_R0.7081.00
51_F250_A0.7061.00
269_G272_A0.7011.00
142_A145_A0.6971.00
117_V121_D0.6911.00
40_S163_G0.6891.00
120_G123_D0.6881.00
97_L238_T0.6851.00
147_L151_A0.6851.00
38_G43_N0.6821.00
34_R276_E0.6791.00
63_D89_G0.6781.00
121_D124_P0.6751.00
114_N117_V0.6701.00
256_G261_A0.6701.00
215_G226_T0.6691.00
134_V147_L0.6681.00
198_P224_S0.6661.00
145_A177_R0.6621.00
51_F264_F0.6611.00
127_V156_A0.6571.00
83_G126_V0.6551.00
9_H139_Q0.6541.00
172_G176_A0.6471.00
100_D104_E0.6471.00
244_F265_G0.6451.00
45_A79_V0.6421.00
65_E69_L0.6401.00
27_E40_S0.6381.00
59_G84_L0.6381.00
262_L266_N0.6381.00
159_S245_A0.6361.00
107_V110_N0.6321.00
132_E156_A0.6321.00
151_A158_V0.6301.00
97_L107_V0.6301.00
119_P142_A0.6291.00
105_V109_G0.6291.00
244_F269_G0.6281.00
16_L33_Q0.6271.00
197_G201_P0.6251.00
124_P150_L0.6221.00
158_V178_T0.6181.00
145_A148_T0.6151.00
77_A283_T0.6141.00
120_G124_P0.6101.00
42_A57_L0.6101.00
117_V122_L0.6071.00
246_A250_A0.6071.00
170_D173_D0.6041.00
173_D177_R0.6001.00
260_R264_F0.5991.00
216_A227_H0.5961.00
133_H180_I0.5941.00
68_L75_Q0.5931.00
181_L207_V0.5931.00
17_R276_E0.5931.00
220_T224_S0.5921.00
24_P100_D0.5911.00
9_H163_G0.5911.00
16_L30_I0.5901.00
208_V244_F0.5901.00
151_A154_H0.5901.00
204_D207_V0.5891.00
182_F208_V0.5871.00
40_S139_Q0.5871.00
65_E72_R0.5861.00
93_S114_N0.5831.00
144_A147_L0.5811.00
74_L79_V0.5791.00
48_L249_V0.5791.00
106_M112_G0.5721.00
4_V53_I0.5681.00
133_H252_V0.5671.00
37_G279_R0.5671.00
106_M110_N0.5671.00
252_V255_G0.5661.00
188_A219_H0.5661.00
161_D242_D0.5651.00
51_F246_A0.5651.00
198_P226_T0.5641.00
44_V249_V0.5641.00
227_H230_F0.5641.00
238_T278_A0.5591.00
17_R99_V0.5591.00
98_L108_L0.5581.00
208_V262_L0.5571.00
119_P123_D0.5541.00
98_L106_M0.5541.00
89_G116_A0.5531.00
198_P201_P0.5521.00
213_S234_P0.5511.00
54_D253_L0.5511.00
258_H261_A0.5491.00
189_G194_D0.5481.00
108_L111_D0.5451.00
186_N190_A0.5451.00
175_L204_D0.5421.00
187_E192_L0.5411.00
188_A207_V0.5411.00
52_D55_A0.5401.00
49_A77_A0.5401.00
192_L195_D0.5371.00
111_D115_E0.5341.00
17_R101_S0.5331.00
55_A79_V0.5331.00
44_V246_A0.5321.00
148_T174_A0.5311.00
46_C79_V0.5301.00
5_V126_V0.5301.00
165_R190_A0.5301.00
126_V129_A0.5291.00
83_G86_V0.5291.00
258_H262_L0.5281.00
42_A46_C0.5271.00
113_A116_A0.5231.00
119_P143_T0.5211.00
121_D125_A0.5191.00
179_D206_V0.5191.00
74_L81_L0.5181.00
202_D219_H0.5171.00
185_D212_G0.5171.00
113_A121_D0.5161.00
132_E157_T0.5161.00
44_V48_L0.5151.00
44_V137_T0.5141.00
178_T204_D0.5131.00
41_A45_A0.5111.00
126_V131_C0.5111.00
95_K107_V0.5101.00
152_R155_D0.5071.00
43_N278_A0.5071.00
160_F171_Y0.5061.00
217_T224_S0.5051.00
151_A155_D0.5051.00
174_A177_R0.5051.00
95_K98_L0.5041.00
210_K242_D0.5041.00
159_S252_V0.5011.00
163_G245_A0.5001.00
4_V133_H0.5001.00
183_V210_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rbcA 2 0.9932 100 0.17 Contact Map
4xdaA 2 0.9898 100 0.204 Contact Map
3vasA 1 0.9661 100 0.204 Contact Map
3ikhA 2 0.9492 100 0.205 Contact Map
2c4eA 2 0.9797 100 0.208 Contact Map
1rkdA 2 0.9898 100 0.209 Contact Map
3ry7A 2 0.9729 100 0.21 Contact Map
2fv7A 2 0.9831 100 0.212 Contact Map
3go6A 4 0.9492 100 0.215 Contact Map
2pkfA 2 0.9898 100 0.217 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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