Q9HP13 - HALSA - GREMLIN Contacts

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Q9HP13 - Sugar kinase

UniProt:	Q9HP13	Sequences: MSRVVAAGHVNWDVTLRVDALPEPDGEAEIVSQRRSGGGSAANVACALAGFDIDAGLVGSVGDDEHGLLAQRELQAAGVDLAGLRVVDGLETSVKYLLVDSRGEVMVLGNDGANEAVAPGDLDPAVVGADCEHVHLTSQRPATAARLTALAREHDATVSFDPGRRLRDRDYGDALARTDILFVNDNEAGAVLDDDGGPTAPDSDRVVVVKHGSEGATVHTPSGSVTHPGFAVDPVDTTGAGDAFAAGFVAVVLDGGDHERALEFGNACGALAAQHEGARTAPTRADAASFLDSQF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	295 (274)
Sequences:	22460 (16782)
Seq/√Len:	1013.8

ECOLI - SQUV RBSK YDJH YEGV PSUK YEII K1PF FRLD KDGK PFKB INGK HLDE
BACSU - RBSK IOLC KDGK YDJE FRLD K1PF
HALSA - Q9HP13 Q9HMJ3 Q9HSM7
SULSO - KDGK Q981E2 Q97W01 Q980X6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_I	250_A	3.129	1.00
135_H	159_S	2.838	1.00
71_Q	86_V	2.609	1.00
218_V	262_L	2.535	1.00
211_H	217_T	2.522	1.00
56_G	80_D	2.511	1.00
257_D	260_R	2.391	1.00
5_V	131_C	2.360	1.00
251_V	256_G	2.327	1.00
63_D	88_D	2.313	1.00
216_A	244_F	2.283	1.00
149_A	177_R	2.168	1.00
68_L	86_V	2.156	1.00
48_L	53_I	2.121	1.00
60_S	87_V	2.024	1.00
50_G	77_A	1.998	1.00
6_A	45_A	1.984	1.00
185_D	211_H	1.961	1.00
159_S	249_V	1.946	1.00
151_A	156_A	1.946	1.00
225_V	259_E	1.943	1.00
251_V	264_F	1.929	1.00
243_A	268_C	1.912	1.00
283_T	286_D	1.894	1.00
133_H	157_T	1.865	1.00
60_S	121_D	1.858	1.00
148_T	158_V	1.855	1.00
46_C	77_A	1.841	1.00
157_T	179_D	1.825	1.00
182_F	245_A	1.814	1.00
179_D	205_R	1.804	1.00
47_A	246_A	1.797	1.00
196_G	199_T	1.767	1.00
256_G	260_R	1.762	1.00
75_Q	81_L	1.750	1.00
218_V	225_V	1.736	1.00
216_A	266_N	1.722	1.00
133_H	159_S	1.706	1.00
254_D	284_R	1.692	1.00
240_A	273_A	1.690	1.00
72_R	76_A	1.686	1.00
217_T	226_T	1.674	1.00
248_F	261_A	1.662	1.00
73_E	76_A	1.662	1.00
275_H	286_D	1.661	1.00
71_Q	75_Q	1.656	1.00
180_I	206_V	1.652	1.00
145_A	173_D	1.645	1.00
211_H	226_T	1.644	1.00
247_G	268_C	1.639	1.00
259_E	263_E	1.632	1.00
269_G	273_A	1.617	1.00
109_G	112_G	1.584	1.00
230_F	267_A	1.580	1.00
146_R	149_A	1.579	1.00
236_D	277_G	1.544	1.00
48_L	250_A	1.535	1.00
208_V	248_F	1.528	1.00
63_D	68_L	1.524	1.00
10_V	59_G	1.520	1.00
189_G	195_D	1.515	1.00
218_V	258_H	1.505	1.00
133_H	249_V	1.503	1.00
68_L	72_R	1.502	1.00
206_V	220_T	1.498	1.00
227_H	262_L	1.494	1.00
150_L	154_H	1.474	1.00
220_T	223_G	1.467	1.00
146_R	150_L	1.461	1.00
211_H	214_E	1.460	1.00
161_D	210_K	1.452	1.00
145_A	149_A	1.449	1.00
35_R	69_L	1.444	1.00
247_G	264_F	1.441	1.00
37_G	70_A	1.440	1.00
4_V	48_L	1.439	1.00
152_R	179_D	1.411	1.00
150_L	153_E	1.407	1.00
162_P	183_V	1.400	1.00
178_T	181_L	1.386	1.00
67_G	92_T	1.360	1.00
42_A	74_L	1.357	1.00
230_F	263_E	1.356	1.00
90_L	116_A	1.355	1.00
227_H	266_N	1.347	1.00
63_D	86_V	1.342	1.00
157_T	180_I	1.338	1.00
129_A	154_H	1.334	1.00
12_W	69_L	1.326	1.00
14_V	33_Q	1.324	1.00
71_Q	84_L	1.324	1.00
54_D	80_D	1.312	1.00
17_R	32_S	1.306	1.00
118_A	121_D	1.299	1.00
232_V	274_Q	1.291	1.00
152_R	177_R	1.277	1.00
216_A	262_L	1.265	1.00
248_F	252_V	1.239	1.00
119_P	146_R	1.233	1.00
247_G	265_G	1.232	1.00
251_V	261_A	1.223	1.00
182_F	210_K	1.210	1.00
206_V	252_V	1.209	1.00
206_V	248_F	1.205	1.00
73_E	77_A	1.202	1.00
248_F	265_G	1.202	1.00
230_F	266_N	1.201	1.00
260_R	263_E	1.188	1.00
49_A	79_V	1.187	1.00
206_V	258_H	1.186	1.00
157_T	205_R	1.178	1.00
234_P	273_A	1.176	1.00
232_V	273_A	1.176	1.00
211_H	215_G	1.170	1.00
210_K	244_F	1.168	1.00
188_A	209_V	1.167	1.00
51_F	247_G	1.167	1.00
37_G	73_E	1.162	1.00
69_L	72_R	1.155	1.00
134_V	151_A	1.150	1.00
53_I	253_L	1.143	1.00
68_L	71_Q	1.138	1.00
14_V	35_R	1.130	1.00
72_R	75_Q	1.127	1.00
48_L	55_A	1.124	1.00
149_A	153_E	1.118	1.00
65_E	68_L	1.118	1.00
44_V	135_H	1.117	1.00
250_A	254_D	1.110	1.00
136_L	158_V	1.108	1.00
271_L	275_H	1.104	1.00
271_L	274_Q	1.100	1.00
180_I	248_F	1.099	1.00
45_A	55_A	1.095	1.00
230_F	270_A	1.077	1.00
135_H	249_V	1.062	1.00
185_D	214_E	1.062	1.00
234_P	237_T	1.060	1.00
46_C	50_G	1.056	1.00
206_V	218_V	1.056	1.00
219_H	224_S	1.050	1.00
87_V	116_A	1.044	1.00
182_F	248_F	1.031	1.00
134_V	156_A	1.030	1.00
266_N	269_G	1.028	1.00
250_A	284_R	1.024	1.00
160_F	178_T	1.024	1.00
180_I	252_V	1.023	1.00
205_R	221_P	1.012	1.00
47_A	243_A	1.008	1.00
56_G	131_C	1.003	1.00
243_A	272_A	1.002	1.00
194_D	199_T	1.001	1.00
123_D	146_R	1.000	1.00
64_D	92_T	0.999	1.00
10_V	70_A	0.999	1.00
49_A	78_G	0.990	1.00
248_F	258_H	0.987	1.00
135_H	245_A	0.985	1.00
48_L	246_A	0.982	1.00
53_I	254_D	0.981	1.00
17_R	34_R	0.977	1.00
6_A	41_A	0.977	1.00
61_V	67_G	0.974	1.00
263_E	267_A	0.973	1.00
69_L	73_E	0.970	1.00
56_G	126_V	0.967	1.00
51_F	268_C	0.963	1.00
61_V	71_Q	0.963	1.00
37_G	69_L	0.962	1.00
62_G	92_T	0.962	1.00
261_A	265_G	0.962	1.00
142_A	146_R	0.960	1.00
56_G	83_G	0.953	1.00
131_C	156_A	0.951	1.00
7_A	134_V	0.950	1.00
16_L	96_Y	0.949	1.00
199_T	202_D	0.947	1.00
234_P	274_Q	0.947	1.00
251_V	254_D	0.947	1.00
229_G	266_N	0.946	1.00
136_L	148_T	0.941	1.00
106_M	109_G	0.936	1.00
15_T	36_S	0.933	1.00
250_A	264_F	0.932	1.00
223_G	259_E	0.930	1.00
215_G	229_G	0.927	1.00
61_V	84_L	0.924	1.00
214_E	226_T	0.917	1.00
185_D	189_G	0.916	1.00
184_N	187_E	0.915	1.00
127_V	131_C	0.915	1.00
10_V	42_A	0.913	1.00
87_V	90_L	0.912	1.00
5_V	58_V	0.903	1.00
256_G	264_F	0.902	1.00
14_V	66_H	0.895	1.00
81_L	84_L	0.894	1.00
49_A	54_D	0.893	1.00
71_Q	81_L	0.891	1.00
10_V	57_L	0.887	1.00
14_V	94_V	0.883	1.00
183_V	188_A	0.881	1.00
252_V	261_A	0.881	1.00
107_V	112_G	0.880	1.00
197_G	200_A	0.880	1.00
70_A	92_T	0.877	1.00
108_L	112_G	0.877	1.00
30_I	108_L	0.875	1.00
233_D	274_Q	0.875	1.00
257_D	261_A	0.873	1.00
42_A	279_R	0.870	1.00
61_V	86_V	0.853	1.00
221_P	224_S	0.852	1.00
235_V	276_E	0.849	1.00
44_V	245_A	0.844	1.00
161_D	182_F	0.844	1.00
149_A	173_D	0.841	1.00
4_V	253_L	0.841	1.00
225_V	262_L	0.831	1.00
107_V	111_D	0.829	1.00
244_F	266_N	0.828	1.00
143_T	147_L	0.828	1.00
227_H	263_E	0.828	1.00
11_N	93_S	0.823	1.00
227_H	259_E	0.817	1.00
161_D	183_V	0.816	1.00
136_L	144_A	0.813	1.00
85_R	121_D	0.812	1.00
60_S	85_R	0.811	1.00
243_A	247_G	0.810	1.00
247_G	251_V	0.800	1.00
175_L	178_T	0.798	1.00
159_S	182_F	0.797	1.00
243_A	269_G	0.797	1.00
138_S	160_F	0.793	1.00
71_Q	85_R	0.787	1.00
173_D	176_A	0.786	1.00
12_W	66_H	0.782	1.00
220_T	258_H	0.780	1.00
56_G	82_A	0.778	1.00
64_D	67_G	0.776	1.00
7_A	147_L	0.776	1.00
24_P	104_E	0.768	1.00
133_H	253_L	0.767	1.00
13_D	38_G	0.764	1.00
49_A	55_A	0.758	1.00
267_A	271_L	0.756	1.00
148_T	177_R	0.755	1.00
45_A	57_L	0.755	1.00
232_V	270_A	0.752	1.00
266_N	270_A	0.748	1.00
5_V	56_G	0.735	1.00
46_C	279_R	0.733	1.00
208_V	218_V	0.733	1.00
264_F	284_R	0.729	1.00
220_T	225_V	0.726	1.00
35_R	66_H	0.722	1.00
271_L	286_D	0.722	1.00
213_S	231_A	0.720	1.00
66_H	94_V	0.719	1.00
159_S	180_I	0.718	1.00
176_A	203_S	0.714	1.00
244_F	262_L	0.712	1.00
73_E	279_R	0.711	1.00
198_P	202_D	0.711	1.00
203_S	207_V	0.709	1.00
23_E	26_G	0.709	1.00
54_D	132_E	0.708	1.00
12_W	35_R	0.708	1.00
51_F	250_A	0.706	1.00
269_G	272_A	0.701	1.00
142_A	145_A	0.697	1.00
117_V	121_D	0.691	1.00
40_S	163_G	0.689	1.00
120_G	123_D	0.688	1.00
97_L	238_T	0.685	1.00
147_L	151_A	0.685	1.00
38_G	43_N	0.682	1.00
34_R	276_E	0.679	1.00
63_D	89_G	0.678	1.00
121_D	124_P	0.675	1.00
114_N	117_V	0.670	1.00
256_G	261_A	0.670	1.00
215_G	226_T	0.669	1.00
134_V	147_L	0.668	1.00
198_P	224_S	0.666	1.00
145_A	177_R	0.662	1.00
51_F	264_F	0.661	1.00
127_V	156_A	0.657	1.00
83_G	126_V	0.655	1.00
9_H	139_Q	0.654	1.00
172_G	176_A	0.647	1.00
100_D	104_E	0.647	1.00
244_F	265_G	0.645	1.00
45_A	79_V	0.642	1.00
65_E	69_L	0.640	1.00
27_E	40_S	0.638	1.00
59_G	84_L	0.638	1.00
262_L	266_N	0.638	1.00
159_S	245_A	0.636	1.00
107_V	110_N	0.632	1.00
132_E	156_A	0.632	1.00
151_A	158_V	0.630	1.00
97_L	107_V	0.630	1.00
119_P	142_A	0.629	1.00
105_V	109_G	0.629	1.00
244_F	269_G	0.628	1.00
16_L	33_Q	0.627	1.00
197_G	201_P	0.625	1.00
124_P	150_L	0.622	1.00
158_V	178_T	0.618	1.00
145_A	148_T	0.615	1.00
77_A	283_T	0.614	1.00
120_G	124_P	0.610	1.00
42_A	57_L	0.610	1.00
117_V	122_L	0.607	1.00
246_A	250_A	0.607	1.00
170_D	173_D	0.604	1.00
173_D	177_R	0.600	1.00
260_R	264_F	0.599	1.00
216_A	227_H	0.596	1.00
133_H	180_I	0.594	1.00
68_L	75_Q	0.593	1.00
181_L	207_V	0.593	1.00
17_R	276_E	0.593	1.00
220_T	224_S	0.592	1.00
24_P	100_D	0.591	1.00
9_H	163_G	0.591	1.00
16_L	30_I	0.590	1.00
208_V	244_F	0.590	1.00
151_A	154_H	0.590	1.00
204_D	207_V	0.589	1.00
182_F	208_V	0.587	1.00
40_S	139_Q	0.587	1.00
65_E	72_R	0.586	1.00
93_S	114_N	0.583	1.00
144_A	147_L	0.581	1.00
74_L	79_V	0.579	1.00
48_L	249_V	0.579	1.00
106_M	112_G	0.572	1.00
4_V	53_I	0.568	1.00
133_H	252_V	0.567	1.00
37_G	279_R	0.567	1.00
106_M	110_N	0.567	1.00
252_V	255_G	0.566	1.00
188_A	219_H	0.566	1.00
161_D	242_D	0.565	1.00
51_F	246_A	0.565	1.00
198_P	226_T	0.564	1.00
44_V	249_V	0.564	1.00
227_H	230_F	0.564	1.00
238_T	278_A	0.559	1.00
17_R	99_V	0.559	1.00
98_L	108_L	0.558	1.00
208_V	262_L	0.557	1.00
119_P	123_D	0.554	1.00
98_L	106_M	0.554	1.00
89_G	116_A	0.553	1.00
198_P	201_P	0.552	1.00
213_S	234_P	0.551	1.00
54_D	253_L	0.551	1.00
258_H	261_A	0.549	1.00
189_G	194_D	0.548	1.00
108_L	111_D	0.545	1.00
186_N	190_A	0.545	1.00
175_L	204_D	0.542	1.00
187_E	192_L	0.541	1.00
188_A	207_V	0.541	1.00
52_D	55_A	0.540	1.00
49_A	77_A	0.540	1.00
192_L	195_D	0.537	1.00
111_D	115_E	0.534	1.00
17_R	101_S	0.533	1.00
55_A	79_V	0.533	1.00
44_V	246_A	0.532	1.00
148_T	174_A	0.531	1.00
46_C	79_V	0.530	1.00
5_V	126_V	0.530	1.00
165_R	190_A	0.530	1.00
126_V	129_A	0.529	1.00
83_G	86_V	0.529	1.00
258_H	262_L	0.528	1.00
42_A	46_C	0.527	1.00
113_A	116_A	0.523	1.00
119_P	143_T	0.521	1.00
121_D	125_A	0.519	1.00
179_D	206_V	0.519	1.00
74_L	81_L	0.518	1.00
202_D	219_H	0.517	1.00
185_D	212_G	0.517	1.00
113_A	121_D	0.516	1.00
132_E	157_T	0.516	1.00
44_V	48_L	0.515	1.00
44_V	137_T	0.514	1.00
178_T	204_D	0.513	1.00
41_A	45_A	0.511	1.00
126_V	131_C	0.511	1.00
95_K	107_V	0.510	1.00
152_R	155_D	0.507	1.00
43_N	278_A	0.507	1.00
160_F	171_Y	0.506	1.00
217_T	224_S	0.505	1.00
151_A	155_D	0.505	1.00
174_A	177_R	0.505	1.00
95_K	98_L	0.504	1.00
210_K	242_D	0.504	1.00
159_S	252_V	0.501	1.00
163_G	245_A	0.500	1.00
4_V	133_H	0.500	1.00
183_V	210_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rbcA	2	0.9932	100	0.17	Contact Map
4xdaA	2	0.9898	100	0.204	Contact Map
3vasA	1	0.9661	100	0.204	Contact Map
3ikhA	2	0.9492	100	0.205	Contact Map
2c4eA	2	0.9797	100	0.208	Contact Map
1rkdA	2	0.9898	100	0.209	Contact Map
3ry7A	2	0.9729	100	0.21	Contact Map
2fv7A	2	0.9831	100	0.212	Contact Map
3go6A	4	0.9492	100	0.215	Contact Map
2pkfA	2	0.9898	100	0.217	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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