GREMLIN Database
Q9HP12 - Uncharacterized protein
UniProt: Q9HP12 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 277 (255)
Sequences: 212 (156)
Seq/√Len: 9.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_P197_P6.4661.00
183_T194_E3.5880.97
12_A15_P2.9610.92
59_Y63_Q2.9070.91
107_A112_V2.6030.85
82_A86_A2.6020.85
222_V229_A2.3500.79
87_A113_A2.3120.77
94_A112_V2.2620.76
76_G195_Q2.1950.74
63_Q264_H2.1380.71
178_L235_L2.0820.69
87_A90_A2.0520.68
38_P252_G2.0500.68
46_L254_V2.0220.67
232_V255_A1.9870.66
59_Y195_Q1.9580.64
80_V268_L1.9450.64
59_Y264_H1.9430.64
187_V228_L1.9300.63
108_G116_V1.9090.62
132_T226_L1.8800.61
20_L147_T1.8620.60
60_A72_A1.8510.60
177_A226_L1.8500.60
10_G59_Y1.7960.57
119_T128_A1.7770.57
115_A118_I1.7660.56
251_L257_V1.7590.56
63_Q195_Q1.7580.56
48_L106_L1.7380.55
221_F224_V1.7300.54
90_A250_I1.7060.53
119_T127_T1.6940.53
178_L182_S1.6720.52
63_Q196_T1.6570.51
224_V233_V1.6350.50
226_L233_V1.6220.50
50_P55_G1.6210.50
262_G266_V1.6200.49
56_S182_S1.6130.49
10_G264_H1.6120.49
9_S14_P1.6060.49
10_G63_Q1.6050.49
182_S265_N1.5840.48
224_V229_A1.5710.47
67_Y266_V1.5700.47
32_G53_V1.5610.47
112_V145_V1.5570.47
22_V262_G1.5500.46
17_P197_P1.5350.46
149_G223_V1.5230.45
50_P110_G1.5210.45
52_M116_V1.5110.45
69_S72_A1.5080.44
165_V236_L1.5060.44
111_A170_V1.5050.44
151_W175_G1.4980.44
118_I205_L1.4950.44
140_V266_V1.4770.43
54_A57_S1.4630.42
60_A79_I1.4470.42
94_A145_V1.4450.42
41_D168_A1.4410.41
53_V114_A1.4380.41
75_F266_V1.4360.41
144_L174_F1.4340.41
50_P81_Y1.4230.41
115_A142_A1.3810.39
151_W262_G1.3790.39
252_G256_A1.3570.38
77_S234_V1.3500.38
75_F89_G1.3490.37
62_H195_Q1.3490.37
137_L226_L1.3480.37
74_V133_L1.3380.37
53_V107_A1.3290.37
55_G81_Y1.3280.37
16_L145_V1.3170.36
25_L149_G1.2970.35
169_G221_F1.2930.35
132_T228_L1.2860.35
75_F96_R1.2840.35
12_A233_V1.2720.34
87_A200_T1.2650.34
115_A145_V1.2590.34
244_P260_G1.2570.34
73_P79_I1.2550.34
10_G196_T1.2550.34
183_T220_L1.2440.33
136_P139_A1.2240.32
88_A267_V1.2230.32
72_A79_I1.2220.32
24_A71_V1.2140.32
191_G198_L1.2050.32
169_G219_W1.2010.31
62_H70_A1.1940.31
135_W189_A1.1890.31
64_L271_A1.1870.31
70_A195_Q1.1850.31
63_Q234_V1.1810.31
197_P221_F1.1770.30
132_T238_E1.1700.30
172_A240_V1.1680.30
181_T224_V1.1620.30
47_A91_T1.1540.30
116_V149_G1.1520.30
128_A200_T1.1510.30
80_V192_Y1.1500.29
202_I220_L1.1440.29
199_S251_L1.1200.28
37_P155_A1.1160.28
69_S79_I1.1070.28
188_D206_A1.0990.28
44_A186_G1.0860.27
94_A109_V1.0800.27
11_F77_S1.0760.27
41_D44_A1.0730.27
221_F256_A1.0720.27
195_Q262_G1.0600.26
49_A227_A1.0560.26
10_G15_P1.0540.26
64_L268_L1.0530.26
37_P67_Y1.0520.26
185_V241_R1.0500.26
57_S233_V1.0480.26
132_T173_V1.0450.26
111_A148_A1.0420.26
53_V237_A1.0390.25
47_A149_G1.0360.25
61_C79_I1.0360.25
199_S203_I1.0290.25
63_Q67_Y1.0290.25
65_G140_V1.0290.25
15_P19_L1.0260.25
100_A198_L1.0250.25
18_H262_G1.0250.25
108_G132_T1.0210.25
203_I217_G1.0160.25
20_L111_A1.0120.25
85_A241_R1.0120.25
95_V133_L1.0070.24
98_F165_V1.0040.24
196_T264_H1.0030.24
12_A197_P1.0030.24
92_W150_S1.0020.24
86_A153_L1.0000.24
183_T199_S0.9980.24
68_P71_V0.9880.24
82_A222_V0.9860.24
22_V249_A0.9850.24
44_A63_Q0.9740.23
67_Y95_V0.9690.23
37_P96_R0.9580.23
25_L113_A0.9550.23
118_I153_L0.9470.22
138_G141_G0.9440.22
112_V133_L0.9400.22
147_T187_V0.9350.22
18_H56_S0.9310.22
108_G118_I0.9270.22
142_A145_V0.9250.22
112_V116_V0.9150.21
43_R122_L0.9080.21
172_A247_G0.9030.21
62_H76_G0.9010.21
51_W227_A0.9000.21
206_A217_G0.8940.21
59_Y196_T0.8940.21
139_A224_V0.8900.21
119_T141_G0.8870.21
180_A225_K0.8810.20
14_P184_A0.8720.20
154_L197_P0.8710.20
54_A117_P0.8700.20
118_I254_V0.8660.20
107_A111_A0.8630.20
29_V233_V0.8630.20
23_A27_A0.8630.20
249_A253_L0.8580.20
152_R204_E0.8540.20
37_P82_A0.8460.19
165_V260_G0.8450.19
216_G226_L0.8410.19
15_P73_P0.8390.19
63_Q76_G0.8390.19
55_G110_G0.8360.19
199_S265_N0.8360.19
24_A157_I0.8350.19
77_S263_V0.8320.19
83_T120_A0.8230.19
233_V251_L0.8230.19
58_L138_G0.8220.19
108_G148_A0.8170.19
90_A227_A0.8130.18
81_Y267_V0.8120.18
170_V270_I0.8110.18
186_G190_L0.8090.18
14_P169_G0.8090.18
199_S254_V0.8060.18
111_A138_G0.8050.18
219_W260_G0.7980.18
168_A205_L0.7980.18
20_L148_A0.7970.18
147_T170_V0.7950.18
113_A254_V0.7940.18
12_A43_R0.7930.18
232_V252_G0.7930.18
51_W102_P0.7870.18
61_C105_L0.7840.18
108_G126_W0.7830.18
18_H57_S0.7810.18
175_G262_G0.7800.18
75_F193_G0.7790.18
194_E202_I0.7770.18
93_L270_I0.7750.17
61_C143_A0.7740.17
97_R113_A0.7740.17
60_A237_A0.7730.17
136_P227_A0.7730.17
120_A138_G0.7710.17
11_F14_P0.7640.17
37_P157_I0.7610.17
117_P233_V0.7600.17
52_M138_G0.7600.17
230_A236_L0.7590.17
18_H266_V0.7550.17
20_L232_V0.7500.17
116_V133_L0.7490.17
182_S268_L0.7470.17
67_Y99_G0.7390.17
59_Y76_G0.7380.17
123_A144_L0.7360.16
195_Q266_V0.7360.16
17_P186_G0.7360.16
151_W235_L0.7320.16
155_A250_I0.7270.16
16_L106_L0.7240.16
183_T265_N0.7240.16
138_G170_V0.7210.16
47_A50_P0.7180.16
65_G202_I0.7180.16
30_L54_A0.7170.16
151_W187_V0.7160.16
194_E199_S0.7150.16
30_L250_I0.7110.16
45_V171_L0.7030.16
9_S63_Q0.7000.16
92_W203_I0.7000.16
70_A237_A0.6970.16
83_T232_V0.6960.16
23_A95_V0.6950.15
71_V93_L0.6940.15
133_L259_L0.6930.15
84_T175_G0.6930.15
77_S242_D0.6900.15
176_H262_G0.6900.15
143_A177_A0.6890.15
56_S60_A0.6860.15
66_L230_A0.6850.15
232_V260_G0.6800.15
81_Y169_G0.6790.15
13_L82_A0.6760.15
179_D261_P0.6760.15
11_F222_V0.6720.15
24_A88_A0.6710.15
68_P235_L0.6680.15
40_V154_L0.6670.15
44_A196_T0.6660.15
122_L125_G0.6660.15
10_G14_P0.6650.15
149_G153_L0.6640.15
81_Y110_G0.6630.15
169_G265_N0.6630.15
139_A205_L0.6610.15
40_V194_E0.6600.15
52_M201_A0.6590.15
40_V183_T0.6560.15
233_V260_G0.6560.15
105_L148_A0.6530.15
77_S262_G0.6530.15
13_L86_A0.6510.14
94_A140_V0.6510.14
91_T115_A0.6490.14
16_L236_L0.6490.14
144_L152_R0.6480.14
22_V261_P0.6440.14
249_A257_V0.6420.14
144_L150_S0.6360.14
106_L250_I0.6360.14
127_T141_G0.6340.14
115_A152_R0.6340.14
34_R204_E0.6310.14
126_W170_V0.6310.14
27_A54_A0.6290.14
76_G102_P0.6280.14
32_G156_R0.6260.14
68_P72_A0.6260.14
72_A134_A0.6230.14
15_P269_F0.6220.14
153_L271_A0.6210.14
122_L130_T0.6200.14
19_L197_P0.6170.14
82_A116_V0.6160.14
45_V54_A0.6160.14
86_A233_V0.6150.14
36_D96_R0.6150.14
44_A94_A0.6140.14
194_E261_P0.6090.14
48_L176_H0.6090.14
176_H188_D0.6080.14
108_G145_V0.6060.13
63_Q75_F0.6060.13
60_A125_G0.6050.13
134_A173_V0.6010.13
16_L101_R0.5980.13
65_G127_T0.5980.13
142_A181_T0.5970.13
202_I257_V0.5970.13
197_P266_V0.5940.13
60_A119_T0.5920.13
151_W199_S0.5880.13
24_A152_R0.5860.13
9_S264_H0.5840.13
173_V252_G0.5830.13
131_L242_D0.5820.13
163_R254_V0.5810.13
86_A116_V0.5750.13
19_L194_E0.5750.13
123_A140_V0.5720.13
65_G239_S0.5720.13
52_M155_A0.5690.13
52_M115_A0.5680.13
56_S257_V0.5670.13
52_M204_E0.5660.13
86_A227_A0.5650.13
158_R241_R0.5610.13
152_R163_R0.5610.13
90_A136_P0.5580.12
137_L232_V0.5540.12
11_F264_H0.5540.12
24_A115_A0.5540.12
172_A233_V0.5530.12
16_L233_V0.5520.12
64_L233_V0.5510.12
35_R233_V0.5490.12
20_L42_G0.5480.12
154_L182_S0.5410.12
143_A174_F0.5410.12
20_L74_V0.5410.12
117_P144_L0.5380.12
8_P219_W0.5380.12
92_W264_H0.5360.12
180_A231_G0.5350.12
26_A175_G0.5330.12
184_A265_N0.5310.12
176_H261_P0.5310.12
106_L224_V0.5310.12
195_Q271_A0.5300.12
111_A131_L0.5260.12
86_A94_A0.5260.12
173_V180_A0.5250.12
20_L255_A0.5240.12
106_L221_F0.5240.12
20_L100_A0.5220.12
16_L255_A0.5210.12
64_L185_V0.5180.12
87_A108_G0.5180.12
10_G195_Q0.5170.12
221_F260_G0.5170.12
93_L108_G0.5170.12
21_A33_L0.5170.12
177_A223_V0.5150.12
57_S267_V0.5150.12
137_L168_A0.5150.12
264_H268_L0.5090.12
90_A100_A0.5050.11
147_T174_F0.5010.11
156_R159_P0.5010.11
174_F236_L0.5000.11
42_G167_V0.5000.11
17_P44_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jk0B 1 0.0361 3.9 0.976 Contact Map
4gx0A 3 0.4765 3.4 0.977 Contact Map
2m8fA 1 0.0758 3 0.978 Contact Map
4xnjA 1 0.769 2.8 0.978 Contact Map
4pedA 1 0.2058 2.7 0.978 Contact Map
1uf2K 1 0 2.4 0.979 Contact Map
1j6rA 1 0.1697 2.4 0.979 Contact Map
4c48C 1 0.1372 2.1 0.979 Contact Map
2lq1A 1 0.0614 1.6 0.981 Contact Map
1lddA 4 0.1444 1.6 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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