GREMLIN Database
Q9HP11 - Translation initiation factor eIF-2B subunit alpha
UniProt: Q9HP11 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (289)
Sequences: 3201 (2144)
Seq/√Len: 126.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
204_V280_V3.5151.00
211_S220_R3.2971.00
74_Y94_A3.0741.00
11_D15_D2.8061.00
214_A279_Y2.7941.00
10_A61_T2.7881.00
239_T242_T2.6241.00
126_H151_K2.6041.00
137_K169_W2.5761.00
16_M156_R2.4991.00
5_D8_A2.4921.00
35_Q54_A2.4851.00
55_A72_L2.4451.00
219_E279_Y2.4161.00
55_A76_L2.4081.00
117_L190_H2.3871.00
121_D190_H2.3841.00
109_L227_A2.3771.00
182_R212_M2.2891.00
32_L55_A2.2681.00
147_E174_T2.2681.00
74_Y101_Q2.2601.00
118_R121_D2.2351.00
219_E278_R2.2341.00
192_L227_A2.1381.00
150_V173_V2.1211.00
59_R73_R2.1161.00
193_V210_T2.1111.00
177_V180_A2.0561.00
175_L265_P2.0411.00
33_E92_T2.0341.00
83_T86_A1.9651.00
10_A57_H1.9611.00
59_R69_P1.9601.00
30_D99_R1.9311.00
191_V217_A1.8881.00
75_V91_V1.8831.00
7_R57_H1.8821.00
198_I228_A1.8691.00
124_M151_K1.8561.00
43_S46_A1.8551.00
52_R76_L1.8511.00
89_A93_D1.8481.00
163_A175_L1.8251.00
11_D17_E1.8111.00
173_V265_P1.7791.00
114_A142_D1.7721.00
124_M188_V1.7271.00
180_A270_P1.7011.00
205_I243_V1.7011.00
122_T189_D1.6951.00
111_A138_A1.6891.00
225_M282_A1.6751.00
122_T147_E1.6651.00
149_V188_V1.6631.00
175_L261_Q1.6531.00
100_Q104_R1.6471.00
193_V224_V1.6381.00
203_S277_P1.6361.00
104_R108_D1.6241.00
238_L242_T1.6201.00
223_P281_D1.6031.00
30_D96_D1.5971.00
94_A97_A1.5861.00
122_T149_V1.5851.00
195_A228_A1.5491.00
69_P73_R1.5331.00
108_D111_A1.5301.00
51_L79_T1.5181.00
177_V253_V1.4961.00
204_V226_V1.4881.00
247_M268_E1.4871.00
135_C227_A1.4821.00
119_D145_H1.4711.00
233_L290_F1.4601.00
184_Y268_E1.4511.00
195_A198_I1.4371.00
147_E172_P1.4271.00
193_V226_V1.4141.00
14_A57_H1.4031.00
56_R60_D1.3841.00
251_T254_L1.3721.00
121_D189_D1.3721.00
9_T27_A1.3661.00
210_T275_T1.3551.00
138_A141_D1.3491.00
93_D97_A1.3191.00
52_R80_D1.3181.00
59_R72_L1.3081.00
138_A142_D1.2911.00
124_M213_L1.2841.00
172_P266_D1.2801.00
114_A144_K1.2781.00
250_E267_V1.2771.00
156_R160_H1.2741.00
254_L264_A1.2691.00
140_L145_H1.2601.00
111_A115_N1.2581.00
230_T286_E1.2521.00
115_N142_D1.2391.00
119_D144_K1.2381.00
141_D169_W1.2220.99
102_L106_Q1.2190.99
78_N94_A1.2060.99
199_A237_T1.2020.99
32_L75_V1.1970.99
185_L217_A1.1940.99
181_G213_L1.1860.99
211_S276_P1.1840.99
185_L191_V1.1780.99
50_E53_A1.1600.99
72_L76_L1.1570.99
49_A53_A1.1510.99
39_S50_E1.1490.99
251_T255_A1.1480.99
176_I184_Y1.1370.99
107_D111_A1.1350.99
148_A166_L1.1320.99
197_S234_H1.1300.99
139_A146_I1.1170.99
215_V219_E1.1170.99
70_N231_L1.1150.99
46_A50_E1.1000.99
110_G138_A1.0990.99
151_K181_G1.0930.99
139_A190_H1.0880.99
114_A138_A1.0850.99
10_A60_D1.0840.99
69_P72_L1.0790.99
107_D138_A1.0750.99
260_H263_G1.0740.99
167_R265_P1.0680.99
164_D168_E1.0650.99
181_G212_M1.0650.99
96_D99_R1.0600.98
203_S274_V1.0580.98
282_A289_Q1.0400.98
182_R215_V1.0370.98
26_R99_R1.0370.98
156_R271_A1.0370.98
151_K213_L1.0310.98
105_A230_T1.0300.98
107_D141_D1.0260.98
190_H282_A1.0230.98
92_T96_D1.0180.98
218_R221_G1.0070.98
52_R56_R1.0070.98
32_L76_L0.9990.98
253_V267_V0.9920.98
112_I115_N0.9920.98
116_R282_A0.9920.98
120_G145_H0.9900.98
57_H60_D0.9800.97
237_T242_T0.9720.97
126_H213_L0.9720.97
40_D88_R0.9680.97
182_R216_V0.9640.97
136_V146_I0.9630.97
47_F88_R0.9630.97
182_R220_R0.9620.97
97_A100_Q0.9610.97
84_V88_R0.9600.97
230_T287_R0.9600.97
115_N289_Q0.9580.97
183_R268_E0.9570.97
6_V57_H0.9540.97
94_A98_F0.9510.97
96_D100_Q0.9500.97
150_V162_T0.9490.97
61_T69_P0.9490.97
129_S232_K0.9490.97
198_I283_I0.9470.97
37_T92_T0.9410.97
156_R180_A0.9370.97
10_A14_A0.9350.97
110_G134_A0.9320.97
140_L172_P0.9310.97
26_R106_Q0.9290.96
225_M281_D0.9260.96
122_T146_I0.9230.96
212_M216_V0.9130.96
6_V54_A0.9060.96
254_L267_V0.9030.96
147_E173_V0.8960.96
129_S173_V0.8920.96
113_G135_C0.8880.95
82_E86_A0.8860.95
290_F293_E0.8790.95
36_A47_F0.8750.95
9_T31_A0.8740.95
108_D112_I0.8680.95
121_D144_K0.8600.95
184_Y188_V0.8600.95
134_A138_A0.8570.94
191_V213_L0.8510.94
148_A171_V0.8480.94
28_A68_L0.8480.94
152_E178_D0.8450.94
22_A131_D0.8420.94
218_R278_R0.8340.94
185_L222_V0.8310.94
179_N253_V0.8290.93
11_D14_A0.8260.93
248_R271_A0.8240.93
182_R211_S0.8210.93
132_A136_V0.8200.93
203_S240_G0.8130.93
225_M284_V0.8110.93
135_C192_L0.8100.93
149_V187_A0.7990.92
167_R173_V0.7980.92
109_L135_C0.7930.92
174_T266_D0.7930.92
94_A101_Q0.7930.92
226_V280_V0.7900.92
185_L220_R0.7900.92
73_R77_G0.7890.92
112_I288_G0.7860.92
123_V145_H0.7850.91
117_L123_V0.7780.91
187_A268_E0.7760.91
120_G146_I0.7760.91
88_R92_T0.7730.91
136_V148_A0.7670.91
10_A72_L0.7630.90
134_A137_K0.7630.90
74_Y98_F0.7620.90
39_S47_F0.7610.90
201_D238_L0.7610.90
158_Q207_K0.7610.90
32_L79_T0.7540.90
201_D240_G0.7530.90
248_R252_E0.7520.90
229_Q232_K0.7510.90
77_G80_D0.7500.90
155_P159_G0.7500.90
117_L146_I0.7470.89
117_L121_D0.7470.89
76_L79_T0.7450.89
9_T34_S0.7450.89
7_R11_D0.7420.89
32_L72_L0.7380.89
129_S135_C0.7380.89
31_A34_S0.7370.89
195_A204_V0.7350.89
33_E88_R0.7340.89
24_I71_A0.7300.88
136_V171_V0.7290.88
257_A260_H0.7280.88
85_A89_A0.7270.88
251_T260_H0.7240.88
76_L80_D0.7190.87
8_A11_D0.7160.87
133_L165_Q0.7160.87
49_A52_R0.7100.87
33_E38_D0.7090.87
195_A283_I0.7090.87
111_A142_D0.7080.87
191_V224_V0.7070.87
133_L136_V0.7030.86
48_R79_T0.7030.86
133_L137_K0.7030.86
116_R225_M0.7020.86
123_V190_H0.7020.86
121_D146_I0.7000.86
61_T72_L0.6960.86
150_V175_L0.6940.86
190_H225_M0.6940.86
119_D146_I0.6940.86
6_V35_Q0.6930.86
215_V220_R0.6920.85
99_R103_D0.6920.85
14_A60_D0.6860.85
128_H161_I0.6860.85
137_K171_V0.6850.85
123_V136_V0.6850.85
70_N74_Y0.6800.84
105_A109_L0.6790.84
121_D139_A0.6780.84
211_S215_V0.6780.84
149_V176_I0.6740.84
28_A71_A0.6720.84
196_D272_F0.6700.84
23_T27_A0.6700.84
139_A145_H0.6680.83
175_L270_P0.6640.83
48_R80_D0.6620.83
78_N90_S0.6600.83
214_A224_V0.6580.82
204_V283_I0.6560.82
233_L285_T0.6550.82
41_A46_A0.6540.82
181_G216_V0.6530.82
82_E90_S0.6520.82
250_E266_D0.6510.82
71_A75_V0.6500.82
124_M191_V0.6470.81
71_A98_F0.6470.81
127_C207_K0.6460.81
127_C158_Q0.6450.81
48_R52_R0.6450.81
113_G227_A0.6450.81
163_A262_L0.6440.81
156_R269_N0.6430.81
18_I27_A0.6410.81
202_G277_P0.6400.81
216_V220_R0.6360.80
54_A61_T0.6360.80
255_A260_H0.6360.80
47_F84_V0.6350.80
8_A17_E0.6340.80
40_D85_A0.6320.80
135_C138_A0.6320.80
84_V87_L0.6310.80
122_T187_A0.6280.79
259_R263_G0.6280.79
73_R236_D0.6240.79
140_L171_V0.6240.79
255_A263_G0.6230.79
117_L144_K0.6200.79
104_R107_D0.6200.79
24_I28_A0.6150.78
218_R279_Y0.6150.78
136_V140_L0.6140.78
32_L51_L0.6130.78
33_E37_T0.6130.78
196_D207_K0.6110.78
155_P178_D0.6090.77
58_L72_L0.6090.77
113_G284_V0.6080.77
46_A250_E0.6060.77
228_A283_I0.6060.77
62_R246_E0.6060.77
28_A58_L0.6050.77
163_A265_P0.6040.77
118_R190_H0.6020.77
127_C153_T0.6000.76
129_S204_V0.6000.76
75_V79_T0.5970.76
284_V289_Q0.5970.76
127_C206_N0.5970.76
205_I274_V0.5960.76
36_A39_S0.5960.76
207_K272_F0.5930.75
9_T24_I0.5930.75
25_A70_N0.5930.75
81_G86_A0.5930.75
41_A50_E0.5870.75
133_L166_L0.5870.75
55_A59_R0.5850.74
116_R291_P0.5850.74
274_V277_P0.5840.74
139_A144_K0.5840.74
26_R98_F0.5830.74
133_L162_T0.5830.74
154_R157_K0.5790.74
47_F87_L0.5780.74
44_P48_R0.5730.73
230_T233_L0.5730.73
116_R289_Q0.5730.73
223_P292_P0.5710.73
150_V163_A0.5710.73
86_A89_A0.5690.72
33_E96_D0.5680.72
50_E54_A0.5680.72
30_D33_E0.5670.72
6_V10_A0.5660.72
198_I204_V0.5650.72
129_S134_A0.5650.72
31_A35_Q0.5630.72
46_A49_A0.5620.72
199_A238_L0.5610.71
212_M215_V0.5610.71
201_D277_P0.5610.71
105_A286_E0.5600.71
56_R59_R0.5590.71
22_A130_T0.5580.71
199_A203_S0.5560.71
117_L139_A0.5560.71
90_S93_D0.5550.71
199_A240_G0.5550.71
190_H223_P0.5530.70
200_A237_T0.5520.70
261_Q265_P0.5510.70
25_A231_L0.5500.70
36_A88_R0.5490.70
283_I292_P0.5470.70
235_P290_F0.5470.70
106_Q130_T0.5470.70
184_Y187_A0.5450.69
44_P81_G0.5440.69
14_A61_T0.5430.69
153_T207_K0.5430.69
47_F176_I0.5420.69
35_Q39_S0.5410.69
116_R284_V0.5400.69
163_A173_V0.5390.68
182_R219_E0.5370.68
39_S88_R0.5360.68
39_S54_A0.5340.68
196_D206_N0.5330.68
157_K179_N0.5300.67
28_A69_P0.5300.67
193_V275_T0.5300.67
105_A231_L0.5290.67
230_T290_F0.5280.67
17_E27_A0.5260.67
159_G178_D0.5230.66
6_V38_D0.5230.66
220_R279_Y0.5220.66
59_R76_L0.5210.66
81_G87_L0.5200.66
249_D254_L0.5200.66
118_R189_D0.5200.66
42_D46_A0.5190.66
21_A196_D0.5140.65
83_T87_L0.5130.65
10_A54_A0.5110.64
129_S174_T0.5110.64
152_E155_P0.5110.64
116_R139_A0.5090.64
9_T35_Q0.5080.64
207_K246_E0.5070.64
103_D107_D0.5070.64
53_A56_R0.5070.64
154_R159_G0.5070.64
183_R187_A0.5040.63
145_H172_P0.5040.63
166_L171_V0.5030.63
167_R262_L0.5020.63
50_E251_T0.5020.63
179_N213_L0.5020.63
225_M289_Q0.5010.63
204_V275_T0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a11A 4 0.9968 100 0.103 Contact Map
4ldrA 2 0.965 100 0.164 Contact Map
2yvkA 2 0.9682 100 0.166 Contact Map
1t5oA 2 0.9618 100 0.177 Contact Map
1t9kA 2 0.9554 100 0.188 Contact Map
2a0uA 2 0.9809 100 0.19 Contact Map
3ecsA 4 0.9204 100 0.224 Contact Map
1vb5A 3 0.8726 100 0.301 Contact Map
1w2wB 2 0.5159 100 0.46 Contact Map
1w2wA 1 0.4745 99.8 0.752 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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