Q9HP11 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HP11 - Translation initiation factor eIF-2B subunit alpha

UniProt:	Q9HP11	Sequences: MVTEDVRATADDIADMEIRGAATIARAAADALESQATDSDADSPAAFRAELRAAARHLRDTRPTAVSLPNALRYVLGNTDGETVAALRASVTDAADAFRQQLDRAQDDLGAIGANRLRDGDTVMTHCHSTDALACVKAALDDGKHIEAVVKETRPRKQGHITADQLREWGVPVTLIVDNAGRRYLDAVDHVLVGADSIAADGSVINKIGTSMLAVVARERGVPVMVAAQTLKLHPDTLTGNTVEIEMRDETEVLAAADRHQLGAPDVENPAFDVTPPRYVDAIVTERGQFPPESIVTLMRELYGDGTTEPWAED	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	314 (289)
Sequences:	3201 (2144)
Seq/√Len:	126.1

BACSU - MTNA
HALSA - Q9HP11 Q9HPV9
SULSO - Q97UM6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
204_V	280_V	3.515	1.00
211_S	220_R	3.297	1.00
74_Y	94_A	3.074	1.00
11_D	15_D	2.806	1.00
214_A	279_Y	2.794	1.00
10_A	61_T	2.788	1.00
239_T	242_T	2.624	1.00
126_H	151_K	2.604	1.00
137_K	169_W	2.576	1.00
16_M	156_R	2.499	1.00
5_D	8_A	2.492	1.00
35_Q	54_A	2.485	1.00
55_A	72_L	2.445	1.00
219_E	279_Y	2.416	1.00
55_A	76_L	2.408	1.00
117_L	190_H	2.387	1.00
121_D	190_H	2.384	1.00
109_L	227_A	2.377	1.00
182_R	212_M	2.289	1.00
32_L	55_A	2.268	1.00
147_E	174_T	2.268	1.00
74_Y	101_Q	2.260	1.00
118_R	121_D	2.235	1.00
219_E	278_R	2.234	1.00
192_L	227_A	2.138	1.00
150_V	173_V	2.121	1.00
59_R	73_R	2.116	1.00
193_V	210_T	2.111	1.00
177_V	180_A	2.056	1.00
175_L	265_P	2.041	1.00
33_E	92_T	2.034	1.00
83_T	86_A	1.965	1.00
10_A	57_H	1.961	1.00
59_R	69_P	1.960	1.00
30_D	99_R	1.931	1.00
191_V	217_A	1.888	1.00
75_V	91_V	1.883	1.00
7_R	57_H	1.882	1.00
198_I	228_A	1.869	1.00
124_M	151_K	1.856	1.00
43_S	46_A	1.855	1.00
52_R	76_L	1.851	1.00
89_A	93_D	1.848	1.00
163_A	175_L	1.825	1.00
11_D	17_E	1.811	1.00
173_V	265_P	1.779	1.00
114_A	142_D	1.772	1.00
124_M	188_V	1.727	1.00
180_A	270_P	1.701	1.00
205_I	243_V	1.701	1.00
122_T	189_D	1.695	1.00
111_A	138_A	1.689	1.00
225_M	282_A	1.675	1.00
122_T	147_E	1.665	1.00
149_V	188_V	1.663	1.00
175_L	261_Q	1.653	1.00
100_Q	104_R	1.647	1.00
193_V	224_V	1.638	1.00
203_S	277_P	1.636	1.00
104_R	108_D	1.624	1.00
238_L	242_T	1.620	1.00
223_P	281_D	1.603	1.00
30_D	96_D	1.597	1.00
94_A	97_A	1.586	1.00
122_T	149_V	1.585	1.00
195_A	228_A	1.549	1.00
69_P	73_R	1.533	1.00
108_D	111_A	1.530	1.00
51_L	79_T	1.518	1.00
177_V	253_V	1.496	1.00
204_V	226_V	1.488	1.00
247_M	268_E	1.487	1.00
135_C	227_A	1.482	1.00
119_D	145_H	1.471	1.00
233_L	290_F	1.460	1.00
184_Y	268_E	1.451	1.00
195_A	198_I	1.437	1.00
147_E	172_P	1.427	1.00
193_V	226_V	1.414	1.00
14_A	57_H	1.403	1.00
56_R	60_D	1.384	1.00
251_T	254_L	1.372	1.00
121_D	189_D	1.372	1.00
9_T	27_A	1.366	1.00
210_T	275_T	1.355	1.00
138_A	141_D	1.349	1.00
93_D	97_A	1.319	1.00
52_R	80_D	1.318	1.00
59_R	72_L	1.308	1.00
138_A	142_D	1.291	1.00
124_M	213_L	1.284	1.00
172_P	266_D	1.280	1.00
114_A	144_K	1.278	1.00
250_E	267_V	1.277	1.00
156_R	160_H	1.274	1.00
254_L	264_A	1.269	1.00
140_L	145_H	1.260	1.00
111_A	115_N	1.258	1.00
230_T	286_E	1.252	1.00
115_N	142_D	1.239	1.00
119_D	144_K	1.238	1.00
141_D	169_W	1.222	0.99
102_L	106_Q	1.219	0.99
78_N	94_A	1.206	0.99
199_A	237_T	1.202	0.99
32_L	75_V	1.197	0.99
185_L	217_A	1.194	0.99
181_G	213_L	1.186	0.99
211_S	276_P	1.184	0.99
185_L	191_V	1.178	0.99
50_E	53_A	1.160	0.99
72_L	76_L	1.157	0.99
49_A	53_A	1.151	0.99
39_S	50_E	1.149	0.99
251_T	255_A	1.148	0.99
176_I	184_Y	1.137	0.99
107_D	111_A	1.135	0.99
148_A	166_L	1.132	0.99
197_S	234_H	1.130	0.99
139_A	146_I	1.117	0.99
215_V	219_E	1.117	0.99
70_N	231_L	1.115	0.99
46_A	50_E	1.100	0.99
110_G	138_A	1.099	0.99
151_K	181_G	1.093	0.99
139_A	190_H	1.088	0.99
114_A	138_A	1.085	0.99
10_A	60_D	1.084	0.99
69_P	72_L	1.079	0.99
107_D	138_A	1.075	0.99
260_H	263_G	1.074	0.99
167_R	265_P	1.068	0.99
164_D	168_E	1.065	0.99
181_G	212_M	1.065	0.99
96_D	99_R	1.060	0.98
203_S	274_V	1.058	0.98
282_A	289_Q	1.040	0.98
182_R	215_V	1.037	0.98
26_R	99_R	1.037	0.98
156_R	271_A	1.037	0.98
151_K	213_L	1.031	0.98
105_A	230_T	1.030	0.98
107_D	141_D	1.026	0.98
190_H	282_A	1.023	0.98
92_T	96_D	1.018	0.98
218_R	221_G	1.007	0.98
52_R	56_R	1.007	0.98
32_L	76_L	0.999	0.98
253_V	267_V	0.992	0.98
112_I	115_N	0.992	0.98
116_R	282_A	0.992	0.98
120_G	145_H	0.990	0.98
57_H	60_D	0.980	0.97
237_T	242_T	0.972	0.97
126_H	213_L	0.972	0.97
40_D	88_R	0.968	0.97
182_R	216_V	0.964	0.97
136_V	146_I	0.963	0.97
47_F	88_R	0.963	0.97
182_R	220_R	0.962	0.97
97_A	100_Q	0.961	0.97
84_V	88_R	0.960	0.97
230_T	287_R	0.960	0.97
115_N	289_Q	0.958	0.97
183_R	268_E	0.957	0.97
6_V	57_H	0.954	0.97
94_A	98_F	0.951	0.97
96_D	100_Q	0.950	0.97
150_V	162_T	0.949	0.97
61_T	69_P	0.949	0.97
129_S	232_K	0.949	0.97
198_I	283_I	0.947	0.97
37_T	92_T	0.941	0.97
156_R	180_A	0.937	0.97
10_A	14_A	0.935	0.97
110_G	134_A	0.932	0.97
140_L	172_P	0.931	0.97
26_R	106_Q	0.929	0.96
225_M	281_D	0.926	0.96
122_T	146_I	0.923	0.96
212_M	216_V	0.913	0.96
6_V	54_A	0.906	0.96
254_L	267_V	0.903	0.96
147_E	173_V	0.896	0.96
129_S	173_V	0.892	0.96
113_G	135_C	0.888	0.95
82_E	86_A	0.886	0.95
290_F	293_E	0.879	0.95
36_A	47_F	0.875	0.95
9_T	31_A	0.874	0.95
108_D	112_I	0.868	0.95
121_D	144_K	0.860	0.95
184_Y	188_V	0.860	0.95
134_A	138_A	0.857	0.94
191_V	213_L	0.851	0.94
148_A	171_V	0.848	0.94
28_A	68_L	0.848	0.94
152_E	178_D	0.845	0.94
22_A	131_D	0.842	0.94
218_R	278_R	0.834	0.94
185_L	222_V	0.831	0.94
179_N	253_V	0.829	0.93
11_D	14_A	0.826	0.93
248_R	271_A	0.824	0.93
182_R	211_S	0.821	0.93
132_A	136_V	0.820	0.93
203_S	240_G	0.813	0.93
225_M	284_V	0.811	0.93
135_C	192_L	0.810	0.93
149_V	187_A	0.799	0.92
167_R	173_V	0.798	0.92
109_L	135_C	0.793	0.92
174_T	266_D	0.793	0.92
94_A	101_Q	0.793	0.92
226_V	280_V	0.790	0.92
185_L	220_R	0.790	0.92
73_R	77_G	0.789	0.92
112_I	288_G	0.786	0.92
123_V	145_H	0.785	0.91
117_L	123_V	0.778	0.91
187_A	268_E	0.776	0.91
120_G	146_I	0.776	0.91
88_R	92_T	0.773	0.91
136_V	148_A	0.767	0.91
10_A	72_L	0.763	0.90
134_A	137_K	0.763	0.90
74_Y	98_F	0.762	0.90
39_S	47_F	0.761	0.90
201_D	238_L	0.761	0.90
158_Q	207_K	0.761	0.90
32_L	79_T	0.754	0.90
201_D	240_G	0.753	0.90
248_R	252_E	0.752	0.90
229_Q	232_K	0.751	0.90
77_G	80_D	0.750	0.90
155_P	159_G	0.750	0.90
117_L	146_I	0.747	0.89
117_L	121_D	0.747	0.89
76_L	79_T	0.745	0.89
9_T	34_S	0.745	0.89
7_R	11_D	0.742	0.89
32_L	72_L	0.738	0.89
129_S	135_C	0.738	0.89
31_A	34_S	0.737	0.89
195_A	204_V	0.735	0.89
33_E	88_R	0.734	0.89
24_I	71_A	0.730	0.88
136_V	171_V	0.729	0.88
257_A	260_H	0.728	0.88
85_A	89_A	0.727	0.88
251_T	260_H	0.724	0.88
76_L	80_D	0.719	0.87
8_A	11_D	0.716	0.87
133_L	165_Q	0.716	0.87
49_A	52_R	0.710	0.87
33_E	38_D	0.709	0.87
195_A	283_I	0.709	0.87
111_A	142_D	0.708	0.87
191_V	224_V	0.707	0.87
133_L	136_V	0.703	0.86
48_R	79_T	0.703	0.86
133_L	137_K	0.703	0.86
116_R	225_M	0.702	0.86
123_V	190_H	0.702	0.86
121_D	146_I	0.700	0.86
61_T	72_L	0.696	0.86
150_V	175_L	0.694	0.86
190_H	225_M	0.694	0.86
119_D	146_I	0.694	0.86
6_V	35_Q	0.693	0.86
215_V	220_R	0.692	0.85
99_R	103_D	0.692	0.85
14_A	60_D	0.686	0.85
128_H	161_I	0.686	0.85
137_K	171_V	0.685	0.85
123_V	136_V	0.685	0.85
70_N	74_Y	0.680	0.84
105_A	109_L	0.679	0.84
121_D	139_A	0.678	0.84
211_S	215_V	0.678	0.84
149_V	176_I	0.674	0.84
28_A	71_A	0.672	0.84
196_D	272_F	0.670	0.84
23_T	27_A	0.670	0.84
139_A	145_H	0.668	0.83
175_L	270_P	0.664	0.83
48_R	80_D	0.662	0.83
78_N	90_S	0.660	0.83
214_A	224_V	0.658	0.82
204_V	283_I	0.656	0.82
233_L	285_T	0.655	0.82
41_A	46_A	0.654	0.82
181_G	216_V	0.653	0.82
82_E	90_S	0.652	0.82
250_E	266_D	0.651	0.82
71_A	75_V	0.650	0.82
124_M	191_V	0.647	0.81
71_A	98_F	0.647	0.81
127_C	207_K	0.646	0.81
127_C	158_Q	0.645	0.81
48_R	52_R	0.645	0.81
113_G	227_A	0.645	0.81
163_A	262_L	0.644	0.81
156_R	269_N	0.643	0.81
18_I	27_A	0.641	0.81
202_G	277_P	0.640	0.81
216_V	220_R	0.636	0.80
54_A	61_T	0.636	0.80
255_A	260_H	0.636	0.80
47_F	84_V	0.635	0.80
8_A	17_E	0.634	0.80
40_D	85_A	0.632	0.80
135_C	138_A	0.632	0.80
84_V	87_L	0.631	0.80
122_T	187_A	0.628	0.79
259_R	263_G	0.628	0.79
73_R	236_D	0.624	0.79
140_L	171_V	0.624	0.79
255_A	263_G	0.623	0.79
117_L	144_K	0.620	0.79
104_R	107_D	0.620	0.79
24_I	28_A	0.615	0.78
218_R	279_Y	0.615	0.78
136_V	140_L	0.614	0.78
32_L	51_L	0.613	0.78
33_E	37_T	0.613	0.78
196_D	207_K	0.611	0.78
155_P	178_D	0.609	0.77
58_L	72_L	0.609	0.77
113_G	284_V	0.608	0.77
46_A	250_E	0.606	0.77
228_A	283_I	0.606	0.77
62_R	246_E	0.606	0.77
28_A	58_L	0.605	0.77
163_A	265_P	0.604	0.77
118_R	190_H	0.602	0.77
127_C	153_T	0.600	0.76
129_S	204_V	0.600	0.76
75_V	79_T	0.597	0.76
284_V	289_Q	0.597	0.76
127_C	206_N	0.597	0.76
205_I	274_V	0.596	0.76
36_A	39_S	0.596	0.76
207_K	272_F	0.593	0.75
9_T	24_I	0.593	0.75
25_A	70_N	0.593	0.75
81_G	86_A	0.593	0.75
41_A	50_E	0.587	0.75
133_L	166_L	0.587	0.75
55_A	59_R	0.585	0.74
116_R	291_P	0.585	0.74
274_V	277_P	0.584	0.74
139_A	144_K	0.584	0.74
26_R	98_F	0.583	0.74
133_L	162_T	0.583	0.74
154_R	157_K	0.579	0.74
47_F	87_L	0.578	0.74
44_P	48_R	0.573	0.73
230_T	233_L	0.573	0.73
116_R	289_Q	0.573	0.73
223_P	292_P	0.571	0.73
150_V	163_A	0.571	0.73
86_A	89_A	0.569	0.72
33_E	96_D	0.568	0.72
50_E	54_A	0.568	0.72
30_D	33_E	0.567	0.72
6_V	10_A	0.566	0.72
198_I	204_V	0.565	0.72
129_S	134_A	0.565	0.72
31_A	35_Q	0.563	0.72
46_A	49_A	0.562	0.72
199_A	238_L	0.561	0.71
212_M	215_V	0.561	0.71
201_D	277_P	0.561	0.71
105_A	286_E	0.560	0.71
56_R	59_R	0.559	0.71
22_A	130_T	0.558	0.71
199_A	203_S	0.556	0.71
117_L	139_A	0.556	0.71
90_S	93_D	0.555	0.71
199_A	240_G	0.555	0.71
190_H	223_P	0.553	0.70
200_A	237_T	0.552	0.70
261_Q	265_P	0.551	0.70
25_A	231_L	0.550	0.70
36_A	88_R	0.549	0.70
283_I	292_P	0.547	0.70
235_P	290_F	0.547	0.70
106_Q	130_T	0.547	0.70
184_Y	187_A	0.545	0.69
44_P	81_G	0.544	0.69
14_A	61_T	0.543	0.69
153_T	207_K	0.543	0.69
47_F	176_I	0.542	0.69
35_Q	39_S	0.541	0.69
116_R	284_V	0.540	0.69
163_A	173_V	0.539	0.68
182_R	219_E	0.537	0.68
39_S	88_R	0.536	0.68
39_S	54_A	0.534	0.68
196_D	206_N	0.533	0.68
157_K	179_N	0.530	0.67
28_A	69_P	0.530	0.67
193_V	275_T	0.530	0.67
105_A	231_L	0.529	0.67
230_T	290_F	0.528	0.67
17_E	27_A	0.526	0.67
159_G	178_D	0.523	0.66
6_V	38_D	0.523	0.66
220_R	279_Y	0.522	0.66
59_R	76_L	0.521	0.66
81_G	87_L	0.520	0.66
249_D	254_L	0.520	0.66
118_R	189_D	0.520	0.66
42_D	46_A	0.519	0.66
21_A	196_D	0.514	0.65
83_T	87_L	0.513	0.65
10_A	54_A	0.511	0.64
129_S	174_T	0.511	0.64
152_E	155_P	0.511	0.64
116_R	139_A	0.509	0.64
9_T	35_Q	0.508	0.64
207_K	246_E	0.507	0.64
103_D	107_D	0.507	0.64
53_A	56_R	0.507	0.64
154_R	159_G	0.507	0.64
183_R	187_A	0.504	0.63
145_H	172_P	0.504	0.63
166_L	171_V	0.503	0.63
167_R	262_L	0.502	0.63
50_E	251_T	0.502	0.63
179_N	213_L	0.502	0.63
225_M	289_Q	0.501	0.63
204_V	275_T	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a11A	4	0.9968	100	0.103	Contact Map
4ldrA	2	0.965	100	0.164	Contact Map
2yvkA	2	0.9682	100	0.166	Contact Map
1t5oA	2	0.9618	100	0.177	Contact Map
1t9kA	2	0.9554	100	0.188	Contact Map
2a0uA	2	0.9809	100	0.19	Contact Map
3ecsA	4	0.9204	100	0.224	Contact Map
1vb5A	3	0.8726	100	0.301	Contact Map
1w2wB	2	0.5159	100	0.46	Contact Map
1w2wA	1	0.4745	99.8	0.752	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.