Q9HP09 - HALSA - GREMLIN Contacts

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Q9HP09 - Uncharacterized protein

UniProt:	Q9HP09	Sequences: MHSTTRREWLGAIGATAATGLAGCAGVGGAGQPVTVGSLLPLSGPGSLGALAADHQRAIDTAVEHANRGGGINGRDVVHVSKDTEADPSVAADRYATLAADESPLAIVGPVLSGVTTALTEQAAADAQLLVSPSTTAPAIATAGRSDGQKFVARTCPNDSQQAAVMAKIVDDDMYAAADTATILYVDNAFGAALADVLADRLGADLLASVPYQGGTDTPGGPVDDALAPDPDAVAFIGSPGSSSGVIDELVGREYGGEIALSSALASASSPPSWNGAYTATVNSASTVGTKRLRRALSDATPLQPYTENAYDAAALALLAASYSGDPTPRAVAGALQSVSGGVGHSITVGDFGRATDLIDAGRELNYNGATGNVDLTAALEPVTGYLIQQLTDAGIETRELLKSGYFTDGGDA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	413 (330)
Sequences:	15178 (11004)
Seq/√Len:	605.8

ECOLI - LIVJ LIVK
HALSA - Q9HP09
SULSO - Q97V02

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
64_E	300_A	3.977	1.00
33_P	78_V	3.882	1.00
35_T	78_V	3.510	1.00
199_A	209_S	3.274	1.00
106_A	317_A	3.227	1.00
56_Q	60_D	3.209	1.00
82_K	97_T	3.186	1.00
180_T	205_D	2.961	1.00
295_R	299_D	2.943	1.00
127_A	151_F	2.906	1.00
66_A	318_L	2.889	1.00
33_P	75_R	2.867	1.00
319_L	322_S	2.775	1.00
319_L	323_Y	2.766	1.00
85_E	90_V	2.736	1.00
292_R	296_A	2.683	1.00
65_H	296_A	2.641	1.00
64_E	68_R	2.635	1.00
91_A	115_V	2.593	1.00
86_A	112_L	2.559	1.00
298_S	302_P	2.417	1.00
210_V	225_D	2.415	1.00
37_G	98_L	2.372	1.00
171_D	202_L	2.323	1.00
168_K	172_D	2.216	1.00
33_P	76_D	2.067	1.00
318_L	322_S	2.033	1.00
65_H	311_Y	2.017	1.00
291_K	295_R	2.010	1.00
185_Y	211_P	2.000	1.00
63_V	314_A	1.959	1.00
107_I	123_A	1.935	1.00
182_T	208_A	1.923	1.00
32_Q	75_R	1.918	1.00
82_K	94_R	1.903	1.00
39_L	94_R	1.898	1.00
60_D	64_E	1.889	1.00
39_L	84_T	1.888	1.00
63_V	79_H	1.887	1.00
368_N	373_N	1.883	1.00
179_D	232_D	1.881	1.00
314_A	318_L	1.840	1.00
59_I	314_A	1.757	1.00
65_H	315_A	1.736	1.00
296_A	299_D	1.673	1.00
56_Q	81_S	1.661	1.00
178_A	233_A	1.621	1.00
87_D	90_V	1.591	1.00
65_H	69_G	1.559	1.00
312_D	369_G	1.543	1.00
366_N	373_N	1.524	1.00
270_S	274_W	1.522	1.00
168_K	202_L	1.521	1.00
57_R	297_L	1.513	1.00
35_T	80_V	1.507	1.00
57_R	60_D	1.502	1.00
77_V	318_L	1.502	1.00
95_Y	123_A	1.489	1.00
354_R	357_D	1.470	1.00
295_R	298_S	1.449	1.00
66_A	315_A	1.448	1.00
249_E	252_G	1.447	1.00
163_A	167_A	1.437	1.00
223_V	249_E	1.428	1.00
294_R	298_S	1.426	1.00
317_A	321_A	1.423	1.00
97_T	102_E	1.421	1.00
41_P	84_T	1.411	1.00
187_D	213_Q	1.406	1.00
178_A	232_D	1.404	1.00
82_K	98_L	1.402	1.00
181_A	233_A	1.393	1.00
90_V	94_R	1.391	1.00
288_V	292_R	1.386	1.00
169_I	173_D	1.377	1.00
292_R	295_R	1.372	1.00
212_Y	238_G	1.372	1.00
180_T	230_D	1.368	1.00
57_R	301_T	1.363	1.00
110_P	116_T	1.353	1.00
113_S	137_A	1.350	1.00
215_G	242_S	1.338	1.00
174_M	178_A	1.335	1.00
180_T	232_D	1.328	1.00
171_D	204_A	1.320	1.00
170_V	260_A	1.315	1.00
121_E	125_A	1.306	1.00
124_A	150_K	1.305	1.00
223_V	250_L	1.298	1.00
38_S	59_I	1.297	1.00
99_A	128_Q	1.292	1.00
356_T	360_D	1.290	1.00
192_A	211_P	1.289	1.00
250_L	255_Y	1.286	1.00
366_N	375_D	1.284	1.00
60_D	81_S	1.284	1.00
183_I	195_A	1.280	1.00
223_V	253_R	1.280	1.00
53_A	57_R	1.270	1.00
43_S	83_D	1.264	1.00
62_A	318_L	1.254	1.00
185_Y	195_A	1.254	1.00
61_T	65_H	1.252	1.00
286_S	291_K	1.251	1.00
182_T	231_P	1.250	1.00
131_V	317_A	1.250	1.00
123_A	130_L	1.245	1.00
58_A	310_A	1.242	1.00
200_D	205_D	1.233	1.00
116_T	135_T	1.229	1.00
82_K	102_E	1.228	1.00
138_P	160_S	1.227	1.00
261_L	265_L	1.226	1.00
136_T	159_D	1.218	1.00
80_V	102_E	1.215	1.00
62_A	311_Y	1.203	1.00
110_P	119_L	1.200	1.00
100_A	126_D	1.197	1.00
182_T	210_V	1.193	1.00
116_T	130_L	1.181	1.00
141_A	154_R	1.181	1.00
97_T	101_D	1.180	1.00
110_P	130_L	1.179	1.00
357_D	360_D	1.171	1.00
360_D	364_E	1.162	1.00
180_T	207_L	1.155	1.00
187_D	192_A	1.154	1.00
37_G	104_P	1.139	1.00
59_I	79_H	1.138	1.00
359_I	363_R	1.138	1.00
42_L	81_S	1.137	1.00
166_M	235_A	1.129	1.00
55_H	310_A	1.129	1.00
35_T	104_P	1.128	1.00
84_T	115_V	1.127	1.00
95_Y	107_I	1.119	1.00
58_A	307_T	1.116	1.00
62_A	314_A	1.115	1.00
59_I	310_A	1.111	1.00
220_G	249_E	1.109	1.00
73_N	322_S	1.109	1.00
293_L	307_T	1.107	1.00
39_L	119_L	1.099	1.00
60_D	79_H	1.093	1.00
184_L	246_V	1.091	1.00
227_L	255_Y	1.089	1.00
288_V	291_K	1.088	1.00
281_T	284_S	1.086	1.00
99_A	122_Q	1.084	1.00
195_A	199_A	1.083	1.00
62_A	315_A	1.080	1.00
216_T	222_P	1.079	1.00
194_L	237_I	1.074	1.00
361_A	364_E	1.067	1.00
59_I	108_V	1.067	1.00
16_T	19_T	1.066	1.00
90_V	93_D	1.062	1.00
66_A	314_A	1.062	1.00
139_A	142_T	1.059	1.00
271_P	275_N	1.059	1.00
315_A	318_L	1.058	1.00
224_D	253_R	1.043	1.00
132_S	135_T	1.024	1.00
117_T	139_A	1.019	1.00
182_T	226_A	1.008	1.00
38_S	79_H	0.997	1.00
39_L	95_Y	0.996	1.00
225_D	229_P	0.991	1.00
169_I	278_Y	0.989	1.00
72_I	318_L	0.983	1.00
67_N	71_G	0.981	1.00
53_A	56_Q	0.978	1.00
17_A	20_G	0.978	1.00
95_Y	119_L	0.975	1.00
92_A	96_A	0.974	1.00
36_V	106_A	0.969	1.00
233_A	260_A	0.969	1.00
249_E	253_R	0.967	1.00
171_D	179_D	0.967	1.00
153_A	363_R	0.966	1.00
272_P	275_N	0.965	1.00
250_L	259_I	0.964	1.00
207_L	231_P	0.963	1.00
195_A	209_S	0.958	1.00
18_A	21_L	0.955	1.00
143_A	149_Q	0.952	1.00
323_Y	365_L	0.951	1.00
155_T	316_L	0.950	1.00
99_A	126_D	0.943	1.00
96_A	100_A	0.940	1.00
15_A	18_A	0.938	1.00
238_G	246_V	0.936	1.00
294_R	299_D	0.936	1.00
61_T	296_A	0.929	1.00
164_A	168_K	0.927	1.00
60_D	300_A	0.927	1.00
132_S	152_V	0.918	1.00
94_R	97_T	0.918	1.00
224_D	228_A	0.916	1.00
270_S	273_S	0.909	1.00
104_P	107_I	0.908	1.00
61_T	297_L	0.906	1.00
185_Y	209_S	0.904	1.00
139_A	143_A	0.904	1.00
169_I	174_M	0.903	1.00
38_S	81_S	0.903	1.00
96_A	122_Q	0.894	1.00
315_A	319_L	0.892	1.00
323_Y	361_A	0.891	1.00
193_A	196_D	0.889	1.00
153_A	359_I	0.889	1.00
38_S	63_V	0.889	1.00
223_V	255_Y	0.888	1.00
27_V	30_A	0.887	1.00
63_V	67_N	0.882	1.00
322_S	325_G	0.880	1.00
153_A	376_L	0.880	1.00
192_A	196_D	0.878	1.00
289_G	292_R	0.872	1.00
124_A	149_Q	0.871	1.00
227_L	253_R	0.870	1.00
65_H	68_R	0.869	1.00
20_G	23_G	0.867	1.00
323_Y	364_E	0.867	1.00
182_T	207_L	0.867	1.00
213_Q	216_T	0.867	1.00
319_L	365_L	0.866	1.00
287_T	290_T	0.864	1.00
42_L	56_Q	0.864	1.00
120_T	152_V	0.863	1.00
226_A	231_P	0.862	1.00
127_A	356_T	0.861	1.00
58_A	62_A	0.860	1.00
108_V	313_A	0.860	1.00
293_L	297_L	0.859	1.00
208_A	225_D	0.858	1.00
95_Y	126_D	0.857	1.00
95_Y	99_A	0.856	1.00
312_D	371_T	0.856	1.00
130_L	152_V	0.850	1.00
142_T	148_G	0.850	1.00
182_T	229_P	0.847	1.00
62_A	66_A	0.845	1.00
310_A	314_A	0.842	1.00
84_T	110_P	0.842	1.00
181_A	204_A	0.841	1.00
21_L	24_C	0.838	1.00
296_A	300_A	0.838	1.00
66_A	77_V	0.837	1.00
24_C	27_V	0.837	1.00
54_D	304_Q	0.836	1.00
120_T	149_Q	0.835	1.00
61_T	64_E	0.835	1.00
133_P	310_A	0.835	1.00
276_G	279_T	0.826	1.00
287_T	291_K	0.823	1.00
92_A	122_Q	0.816	1.00
357_D	361_A	0.816	1.00
136_T	156_C	0.816	1.00
55_H	111_V	0.813	1.00
198_L	235_A	0.808	1.00
290_T	294_R	0.806	1.00
163_A	194_L	0.806	1.00
108_V	131_V	0.800	1.00
31_G	75_R	0.799	1.00
227_L	230_D	0.797	1.00
281_T	285_A	0.793	1.00
196_D	199_A	0.787	1.00
367_Y	374_V	0.787	1.00
172_D	202_L	0.785	1.00
25_A	29_G	0.784	1.00
29_G	32_Q	0.783	1.00
132_S	140_I	0.783	1.00
184_L	222_P	0.781	1.00
39_L	110_P	0.775	1.00
34_V	321_A	0.769	1.00
26_G	29_G	0.766	1.00
35_T	102_E	0.766	1.00
218_T	221_G	0.766	1.00
25_A	28_G	0.764	1.00
99_A	123_A	0.762	1.00
324_S	361_A	0.761	1.00
110_P	123_A	0.760	1.00
36_V	314_A	0.759	1.00
153_A	362_G	0.758	1.00
245_G	249_E	0.758	1.00
26_G	30_A	0.755	1.00
275_N	279_T	0.755	1.00
188_N	191_G	0.752	1.00
167_A	198_L	0.750	1.00
248_D	252_G	0.750	1.00
208_A	229_P	0.750	1.00
200_D	203_G	0.748	1.00
34_V	75_R	0.742	1.00
122_Q	125_A	0.738	1.00
61_T	300_A	0.738	1.00
19_T	22_A	0.736	1.00
236_F	246_V	0.734	1.00
105_L	128_Q	0.733	1.00
155_T	313_A	0.732	1.00
94_R	98_L	0.731	1.00
24_C	28_G	0.729	1.00
167_A	171_D	0.727	1.00
276_G	280_A	0.727	1.00
51_L	111_V	0.725	1.00
129_L	151_F	0.724	1.00
170_V	174_M	0.721	1.00
183_I	206_L	0.720	1.00
289_G	368_N	0.720	1.00
28_G	31_G	0.719	1.00
220_G	252_G	0.717	1.00
227_L	257_G	0.717	1.00
73_N	76_D	0.716	1.00
247_I	259_I	0.714	1.00
297_L	300_A	0.714	1.00
129_L	355_A	0.710	1.00
106_A	129_L	0.708	1.00
77_V	314_A	0.706	1.00
359_I	362_G	0.704	1.00
282_V	285_A	0.704	1.00
290_T	293_L	0.703	1.00
159_D	193_A	0.699	1.00
316_L	362_G	0.697	1.00
195_A	211_P	0.696	1.00
212_Y	242_S	0.694	1.00
86_A	115_V	0.692	1.00
39_L	123_A	0.692	1.00
41_P	52_A	0.691	1.00
143_A	148_G	0.691	1.00
84_T	91_A	0.685	1.00
261_L	264_A	0.685	1.00
320_A	324_S	0.685	1.00
171_D	174_M	0.685	1.00
140_I	152_V	0.685	1.00
271_P	276_G	0.681	1.00
207_L	229_P	0.680	1.00
112_L	115_V	0.680	1.00
96_A	126_D	0.680	1.00
266_A	269_S	0.678	1.00
96_A	125_A	0.677	1.00
286_S	290_T	0.677	1.00
369_G	372_G	0.677	1.00
263_S	266_A	0.676	1.00
69_G	322_S	0.674	1.00
30_A	75_R	0.671	1.00
39_L	98_L	0.670	1.00
246_V	250_L	0.668	1.00
156_C	309_N	0.667	1.00
360_D	363_R	0.665	1.00
210_V	222_P	0.664	1.00
316_L	376_L	0.664	1.00
117_T	140_I	0.663	1.00
187_D	211_P	0.660	1.00
281_T	290_T	0.659	1.00
48_L	112_L	0.658	1.00
67_N	76_D	0.658	1.00
167_A	202_L	0.654	1.00
274_W	277_A	0.652	1.00
98_L	104_P	0.648	1.00
218_T	249_E	0.646	1.00
138_P	193_A	0.645	1.00
68_R	71_G	0.645	1.00
265_L	269_S	0.645	1.00
361_A	365_L	0.642	1.00
37_G	82_K	0.640	1.00
223_V	246_V	0.640	1.00
99_A	107_I	0.637	1.00
131_V	155_T	0.633	1.00
116_T	140_I	0.632	1.00
225_D	228_A	0.631	1.00
13_I	16_T	0.630	1.00
91_A	119_L	0.629	1.00
315_A	367_Y	0.629	1.00
95_Y	122_Q	0.629	1.00
168_K	171_D	0.628	1.00
72_I	77_V	0.627	1.00
80_V	104_P	0.624	1.00
126_D	129_L	0.622	1.00
36_V	317_A	0.619	1.00
223_V	227_L	0.618	1.00
291_K	294_R	0.615	1.00
294_R	300_A	0.615	1.00
206_L	209_S	0.611	1.00
66_A	72_I	0.611	1.00
183_I	198_L	0.610	1.00
219_P	249_E	0.610	1.00
216_T	219_P	0.609	1.00
61_T	311_Y	0.608	1.00
65_H	292_R	0.608	1.00
251_V	272_P	0.608	1.00
188_N	214_G	0.607	1.00
13_I	17_A	0.607	1.00
61_T	293_L	0.603	1.00
251_V	273_S	0.603	1.00
93_D	96_A	0.601	1.00
27_V	31_G	0.600	1.00
129_L	359_I	0.599	1.00
286_S	289_G	0.598	1.00
24_C	29_G	0.598	1.00
243_S	265_L	0.596	1.00
42_L	53_A	0.595	1.00
159_D	162_Q	0.589	1.00
89_S	93_D	0.588	1.00
277_A	280_A	0.587	1.00
134_S	306_Y	0.586	1.00
14_G	19_T	0.584	1.00
67_N	72_I	0.584	1.00
62_A	65_H	0.584	1.00
185_Y	192_A	0.584	1.00
275_N	280_A	0.583	1.00
14_G	20_G	0.581	1.00
41_P	86_A	0.580	1.00
260_A	266_A	0.580	1.00
274_W	278_Y	0.580	1.00
119_L	123_A	0.579	1.00
162_Q	263_S	0.578	1.00
271_P	274_W	0.577	1.00
264_A	268_A	0.575	1.00
14_G	17_A	0.575	1.00
55_H	133_P	0.574	1.00
170_V	178_A	0.573	1.00
362_G	365_L	0.572	1.00
234_V	257_G	0.571	1.00
167_A	204_A	0.571	1.00
173_D	178_A	0.568	1.00
71_G	74_G	0.566	1.00
35_T	103_S	0.566	1.00
236_F	243_S	0.565	1.00
183_I	199_A	0.562	1.00
259_I	262_S	0.562	1.00
191_G	237_I	0.559	1.00
106_A	358_L	0.559	1.00
188_N	239_S	0.557	1.00
189_A	192_A	0.557	1.00
92_A	118_A	0.556	1.00
105_L	129_L	0.556	1.00
121_E	124_A	0.555	1.00
178_A	204_A	0.554	1.00
289_G	315_A	0.554	1.00
44_G	52_A	0.554	1.00
199_A	206_L	0.554	1.00
356_T	359_I	0.553	0.99
174_M	179_D	0.553	0.99
196_D	209_S	0.551	0.99
265_L	268_A	0.549	0.99
220_G	253_R	0.547	0.99
234_V	255_Y	0.547	0.99
308_E	370_A	0.545	0.99
275_N	278_Y	0.545	0.99
133_P	313_A	0.545	0.99
118_A	121_E	0.544	0.99
316_L	367_Y	0.544	0.99
129_L	133_P	0.542	0.99
122_Q	126_D	0.540	0.99
221_G	224_D	0.539	0.99
73_N	321_A	0.538	0.99
325_G	328_T	0.537	0.99
116_T	152_V	0.537	0.99
57_R	61_T	0.536	0.99
31_G	76_D	0.535	0.99
274_W	279_T	0.532	0.99
105_L	321_A	0.532	0.99
71_G	75_R	0.532	0.99
116_T	132_S	0.530	0.99
321_A	327_P	0.528	0.99
135_T	140_I	0.528	0.99
59_I	63_V	0.526	0.99
262_S	267_S	0.526	0.99
66_A	322_S	0.525	0.99
15_A	19_T	0.523	0.99
189_A	193_A	0.522	0.99
298_S	301_T	0.519	0.99
164_A	201_R	0.517	0.99
63_V	318_L	0.517	0.99
138_P	159_D	0.517	0.99
308_E	312_D	0.515	0.99
266_A	279_T	0.514	0.99
261_L	267_S	0.514	0.99
245_G	248_D	0.514	0.99
251_V	256_G	0.513	0.99
117_T	137_A	0.512	0.99
41_P	111_V	0.511	0.99
24_C	30_A	0.509	0.99
70_G	73_N	0.509	0.99
30_A	33_P	0.507	0.99
312_D	315_A	0.506	0.99
25_A	30_A	0.506	0.99
311_Y	315_A	0.506	0.99
35_T	38_S	0.505	0.99
119_L	130_L	0.505	0.99
138_P	197_V	0.504	0.99
109_G	130_L	0.503	0.99
297_L	301_T	0.501	0.99
319_L	367_Y	0.501	0.99
312_D	370_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xaqA	2	0.891	100	0.3	Contact Map
1dp4A	2	0.845	100	0.314	Contact Map
4ms4B	1	0.8765	100	0.323	Contact Map
3sm9A	2	0.8886	100	0.323	Contact Map
4ms4A	1	0.845	100	0.327	Contact Map
2e4uA	2	0.9031	100	0.329	Contact Map
1jdpA	2	0.8499	100	0.337	Contact Map
3ks9A	2	0.8814	100	0.344	Contact Map
5c5cA	1	0.8765	100	0.365	Contact Map
4uqqA	3	0.8499	100	0.365	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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