GREMLIN Database
Q9HP09 - Uncharacterized protein
UniProt: Q9HP09 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (330)
Sequences: 15178 (11004)
Seq/√Len: 605.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_E300_A3.9771.00
33_P78_V3.8821.00
35_T78_V3.5101.00
199_A209_S3.2741.00
106_A317_A3.2271.00
56_Q60_D3.2091.00
82_K97_T3.1861.00
180_T205_D2.9611.00
295_R299_D2.9431.00
127_A151_F2.9061.00
66_A318_L2.8891.00
33_P75_R2.8671.00
319_L322_S2.7751.00
319_L323_Y2.7661.00
85_E90_V2.7361.00
292_R296_A2.6831.00
65_H296_A2.6411.00
64_E68_R2.6351.00
91_A115_V2.5931.00
86_A112_L2.5591.00
298_S302_P2.4171.00
210_V225_D2.4151.00
37_G98_L2.3721.00
171_D202_L2.3231.00
168_K172_D2.2161.00
33_P76_D2.0671.00
318_L322_S2.0331.00
65_H311_Y2.0171.00
291_K295_R2.0101.00
185_Y211_P2.0001.00
63_V314_A1.9591.00
107_I123_A1.9351.00
182_T208_A1.9231.00
32_Q75_R1.9181.00
82_K94_R1.9031.00
39_L94_R1.8981.00
60_D64_E1.8891.00
39_L84_T1.8881.00
63_V79_H1.8871.00
368_N373_N1.8831.00
179_D232_D1.8811.00
314_A318_L1.8401.00
59_I314_A1.7571.00
65_H315_A1.7361.00
296_A299_D1.6731.00
56_Q81_S1.6611.00
178_A233_A1.6211.00
87_D90_V1.5911.00
65_H69_G1.5591.00
312_D369_G1.5431.00
366_N373_N1.5241.00
270_S274_W1.5221.00
168_K202_L1.5211.00
57_R297_L1.5131.00
35_T80_V1.5071.00
57_R60_D1.5021.00
77_V318_L1.5021.00
95_Y123_A1.4891.00
354_R357_D1.4701.00
295_R298_S1.4491.00
66_A315_A1.4481.00
249_E252_G1.4471.00
163_A167_A1.4371.00
223_V249_E1.4281.00
294_R298_S1.4261.00
317_A321_A1.4231.00
97_T102_E1.4211.00
41_P84_T1.4111.00
187_D213_Q1.4061.00
178_A232_D1.4041.00
82_K98_L1.4021.00
181_A233_A1.3931.00
90_V94_R1.3911.00
288_V292_R1.3861.00
169_I173_D1.3771.00
292_R295_R1.3721.00
212_Y238_G1.3721.00
180_T230_D1.3681.00
57_R301_T1.3631.00
110_P116_T1.3531.00
113_S137_A1.3501.00
215_G242_S1.3381.00
174_M178_A1.3351.00
180_T232_D1.3281.00
171_D204_A1.3201.00
170_V260_A1.3151.00
121_E125_A1.3061.00
124_A150_K1.3051.00
223_V250_L1.2981.00
38_S59_I1.2971.00
99_A128_Q1.2921.00
356_T360_D1.2901.00
192_A211_P1.2891.00
250_L255_Y1.2861.00
366_N375_D1.2841.00
60_D81_S1.2841.00
183_I195_A1.2801.00
223_V253_R1.2801.00
53_A57_R1.2701.00
43_S83_D1.2641.00
62_A318_L1.2541.00
185_Y195_A1.2541.00
61_T65_H1.2521.00
286_S291_K1.2511.00
182_T231_P1.2501.00
131_V317_A1.2501.00
123_A130_L1.2451.00
58_A310_A1.2421.00
200_D205_D1.2331.00
116_T135_T1.2291.00
82_K102_E1.2281.00
138_P160_S1.2271.00
261_L265_L1.2261.00
136_T159_D1.2181.00
80_V102_E1.2151.00
62_A311_Y1.2031.00
110_P119_L1.2001.00
100_A126_D1.1971.00
182_T210_V1.1931.00
116_T130_L1.1811.00
141_A154_R1.1811.00
97_T101_D1.1801.00
110_P130_L1.1791.00
357_D360_D1.1711.00
360_D364_E1.1621.00
180_T207_L1.1551.00
187_D192_A1.1541.00
37_G104_P1.1391.00
59_I79_H1.1381.00
359_I363_R1.1381.00
42_L81_S1.1371.00
166_M235_A1.1291.00
55_H310_A1.1291.00
35_T104_P1.1281.00
84_T115_V1.1271.00
95_Y107_I1.1191.00
58_A307_T1.1161.00
62_A314_A1.1151.00
59_I310_A1.1111.00
220_G249_E1.1091.00
73_N322_S1.1091.00
293_L307_T1.1071.00
39_L119_L1.0991.00
60_D79_H1.0931.00
184_L246_V1.0911.00
227_L255_Y1.0891.00
288_V291_K1.0881.00
281_T284_S1.0861.00
99_A122_Q1.0841.00
195_A199_A1.0831.00
62_A315_A1.0801.00
216_T222_P1.0791.00
194_L237_I1.0741.00
361_A364_E1.0671.00
59_I108_V1.0671.00
16_T19_T1.0661.00
90_V93_D1.0621.00
66_A314_A1.0621.00
139_A142_T1.0591.00
271_P275_N1.0591.00
315_A318_L1.0581.00
224_D253_R1.0431.00
132_S135_T1.0241.00
117_T139_A1.0191.00
182_T226_A1.0081.00
38_S79_H0.9971.00
39_L95_Y0.9961.00
225_D229_P0.9911.00
169_I278_Y0.9891.00
72_I318_L0.9831.00
67_N71_G0.9811.00
53_A56_Q0.9781.00
17_A20_G0.9781.00
95_Y119_L0.9751.00
92_A96_A0.9741.00
36_V106_A0.9691.00
233_A260_A0.9691.00
249_E253_R0.9671.00
171_D179_D0.9671.00
153_A363_R0.9661.00
272_P275_N0.9651.00
250_L259_I0.9641.00
207_L231_P0.9631.00
195_A209_S0.9581.00
18_A21_L0.9551.00
143_A149_Q0.9521.00
323_Y365_L0.9511.00
155_T316_L0.9501.00
99_A126_D0.9431.00
96_A100_A0.9401.00
15_A18_A0.9381.00
238_G246_V0.9361.00
294_R299_D0.9361.00
61_T296_A0.9291.00
164_A168_K0.9271.00
60_D300_A0.9271.00
132_S152_V0.9181.00
94_R97_T0.9181.00
224_D228_A0.9161.00
270_S273_S0.9091.00
104_P107_I0.9081.00
61_T297_L0.9061.00
185_Y209_S0.9041.00
139_A143_A0.9041.00
169_I174_M0.9031.00
38_S81_S0.9031.00
96_A122_Q0.8941.00
315_A319_L0.8921.00
323_Y361_A0.8911.00
193_A196_D0.8891.00
153_A359_I0.8891.00
38_S63_V0.8891.00
223_V255_Y0.8881.00
27_V30_A0.8871.00
63_V67_N0.8821.00
322_S325_G0.8801.00
153_A376_L0.8801.00
192_A196_D0.8781.00
289_G292_R0.8721.00
124_A149_Q0.8711.00
227_L253_R0.8701.00
65_H68_R0.8691.00
20_G23_G0.8671.00
323_Y364_E0.8671.00
182_T207_L0.8671.00
213_Q216_T0.8671.00
319_L365_L0.8661.00
287_T290_T0.8641.00
42_L56_Q0.8641.00
120_T152_V0.8631.00
226_A231_P0.8621.00
127_A356_T0.8611.00
58_A62_A0.8601.00
108_V313_A0.8601.00
293_L297_L0.8591.00
208_A225_D0.8581.00
95_Y126_D0.8571.00
95_Y99_A0.8561.00
312_D371_T0.8561.00
130_L152_V0.8501.00
142_T148_G0.8501.00
182_T229_P0.8471.00
62_A66_A0.8451.00
310_A314_A0.8421.00
84_T110_P0.8421.00
181_A204_A0.8411.00
21_L24_C0.8381.00
296_A300_A0.8381.00
66_A77_V0.8371.00
24_C27_V0.8371.00
54_D304_Q0.8361.00
120_T149_Q0.8351.00
61_T64_E0.8351.00
133_P310_A0.8351.00
276_G279_T0.8261.00
287_T291_K0.8231.00
92_A122_Q0.8161.00
357_D361_A0.8161.00
136_T156_C0.8161.00
55_H111_V0.8131.00
198_L235_A0.8081.00
290_T294_R0.8061.00
163_A194_L0.8061.00
108_V131_V0.8001.00
31_G75_R0.7991.00
227_L230_D0.7971.00
281_T285_A0.7931.00
196_D199_A0.7871.00
367_Y374_V0.7871.00
172_D202_L0.7851.00
25_A29_G0.7841.00
29_G32_Q0.7831.00
132_S140_I0.7831.00
184_L222_P0.7811.00
39_L110_P0.7751.00
34_V321_A0.7691.00
26_G29_G0.7661.00
35_T102_E0.7661.00
218_T221_G0.7661.00
25_A28_G0.7641.00
99_A123_A0.7621.00
324_S361_A0.7611.00
110_P123_A0.7601.00
36_V314_A0.7591.00
153_A362_G0.7581.00
245_G249_E0.7581.00
26_G30_A0.7551.00
275_N279_T0.7551.00
188_N191_G0.7521.00
167_A198_L0.7501.00
248_D252_G0.7501.00
208_A229_P0.7501.00
200_D203_G0.7481.00
34_V75_R0.7421.00
122_Q125_A0.7381.00
61_T300_A0.7381.00
19_T22_A0.7361.00
236_F246_V0.7341.00
105_L128_Q0.7331.00
155_T313_A0.7321.00
94_R98_L0.7311.00
24_C28_G0.7291.00
167_A171_D0.7271.00
276_G280_A0.7271.00
51_L111_V0.7251.00
129_L151_F0.7241.00
170_V174_M0.7211.00
183_I206_L0.7201.00
289_G368_N0.7201.00
28_G31_G0.7191.00
220_G252_G0.7171.00
227_L257_G0.7171.00
73_N76_D0.7161.00
247_I259_I0.7141.00
297_L300_A0.7141.00
129_L355_A0.7101.00
106_A129_L0.7081.00
77_V314_A0.7061.00
359_I362_G0.7041.00
282_V285_A0.7041.00
290_T293_L0.7031.00
159_D193_A0.6991.00
316_L362_G0.6971.00
195_A211_P0.6961.00
212_Y242_S0.6941.00
86_A115_V0.6921.00
39_L123_A0.6921.00
41_P52_A0.6911.00
143_A148_G0.6911.00
84_T91_A0.6851.00
261_L264_A0.6851.00
320_A324_S0.6851.00
171_D174_M0.6851.00
140_I152_V0.6851.00
271_P276_G0.6811.00
207_L229_P0.6801.00
112_L115_V0.6801.00
96_A126_D0.6801.00
266_A269_S0.6781.00
96_A125_A0.6771.00
286_S290_T0.6771.00
369_G372_G0.6771.00
263_S266_A0.6761.00
69_G322_S0.6741.00
30_A75_R0.6711.00
39_L98_L0.6701.00
246_V250_L0.6681.00
156_C309_N0.6671.00
360_D363_R0.6651.00
210_V222_P0.6641.00
316_L376_L0.6641.00
117_T140_I0.6631.00
187_D211_P0.6601.00
281_T290_T0.6591.00
48_L112_L0.6581.00
67_N76_D0.6581.00
167_A202_L0.6541.00
274_W277_A0.6521.00
98_L104_P0.6481.00
218_T249_E0.6461.00
138_P193_A0.6451.00
68_R71_G0.6451.00
265_L269_S0.6451.00
361_A365_L0.6421.00
37_G82_K0.6401.00
223_V246_V0.6401.00
99_A107_I0.6371.00
131_V155_T0.6331.00
116_T140_I0.6321.00
225_D228_A0.6311.00
13_I16_T0.6301.00
91_A119_L0.6291.00
315_A367_Y0.6291.00
95_Y122_Q0.6291.00
168_K171_D0.6281.00
72_I77_V0.6271.00
80_V104_P0.6241.00
126_D129_L0.6221.00
36_V317_A0.6191.00
223_V227_L0.6181.00
291_K294_R0.6151.00
294_R300_A0.6151.00
206_L209_S0.6111.00
66_A72_I0.6111.00
183_I198_L0.6101.00
219_P249_E0.6101.00
216_T219_P0.6091.00
61_T311_Y0.6081.00
65_H292_R0.6081.00
251_V272_P0.6081.00
188_N214_G0.6071.00
13_I17_A0.6071.00
61_T293_L0.6031.00
251_V273_S0.6031.00
93_D96_A0.6011.00
27_V31_G0.6001.00
129_L359_I0.5991.00
286_S289_G0.5981.00
24_C29_G0.5981.00
243_S265_L0.5961.00
42_L53_A0.5951.00
159_D162_Q0.5891.00
89_S93_D0.5881.00
277_A280_A0.5871.00
134_S306_Y0.5861.00
14_G19_T0.5841.00
67_N72_I0.5841.00
62_A65_H0.5841.00
185_Y192_A0.5841.00
275_N280_A0.5831.00
14_G20_G0.5811.00
41_P86_A0.5801.00
260_A266_A0.5801.00
274_W278_Y0.5801.00
119_L123_A0.5791.00
162_Q263_S0.5781.00
271_P274_W0.5771.00
264_A268_A0.5751.00
14_G17_A0.5751.00
55_H133_P0.5741.00
170_V178_A0.5731.00
362_G365_L0.5721.00
234_V257_G0.5711.00
167_A204_A0.5711.00
173_D178_A0.5681.00
71_G74_G0.5661.00
35_T103_S0.5661.00
236_F243_S0.5651.00
183_I199_A0.5621.00
259_I262_S0.5621.00
191_G237_I0.5591.00
106_A358_L0.5591.00
188_N239_S0.5571.00
189_A192_A0.5571.00
92_A118_A0.5561.00
105_L129_L0.5561.00
121_E124_A0.5551.00
178_A204_A0.5541.00
289_G315_A0.5541.00
44_G52_A0.5541.00
199_A206_L0.5541.00
356_T359_I0.5530.99
174_M179_D0.5530.99
196_D209_S0.5510.99
265_L268_A0.5490.99
220_G253_R0.5470.99
234_V255_Y0.5470.99
308_E370_A0.5450.99
275_N278_Y0.5450.99
133_P313_A0.5450.99
118_A121_E0.5440.99
316_L367_Y0.5440.99
129_L133_P0.5420.99
122_Q126_D0.5400.99
221_G224_D0.5390.99
73_N321_A0.5380.99
325_G328_T0.5370.99
116_T152_V0.5370.99
57_R61_T0.5360.99
31_G76_D0.5350.99
274_W279_T0.5320.99
105_L321_A0.5320.99
71_G75_R0.5320.99
116_T132_S0.5300.99
321_A327_P0.5280.99
135_T140_I0.5280.99
59_I63_V0.5260.99
262_S267_S0.5260.99
66_A322_S0.5250.99
15_A19_T0.5230.99
189_A193_A0.5220.99
298_S301_T0.5190.99
164_A201_R0.5170.99
63_V318_L0.5170.99
138_P159_D0.5170.99
308_E312_D0.5150.99
266_A279_T0.5140.99
261_L267_S0.5140.99
245_G248_D0.5140.99
251_V256_G0.5130.99
117_T137_A0.5120.99
41_P111_V0.5110.99
24_C30_A0.5090.99
70_G73_N0.5090.99
30_A33_P0.5070.99
312_D315_A0.5060.99
25_A30_A0.5060.99
311_Y315_A0.5060.99
35_T38_S0.5050.99
119_L130_L0.5050.99
138_P197_V0.5040.99
109_G130_L0.5030.99
297_L301_T0.5010.99
319_L367_Y0.5010.99
312_D370_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xaqA 2 0.891 100 0.3 Contact Map
1dp4A 2 0.845 100 0.314 Contact Map
4ms4B 1 0.8765 100 0.323 Contact Map
3sm9A 2 0.8886 100 0.323 Contact Map
4ms4A 1 0.845 100 0.327 Contact Map
2e4uA 2 0.9031 100 0.329 Contact Map
1jdpA 2 0.8499 100 0.337 Contact Map
3ks9A 2 0.8814 100 0.344 Contact Map
5c5cA 1 0.8765 100 0.365 Contact Map
4uqqA 3 0.8499 100 0.365 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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