GREMLIN Database
DEOC - Deoxyribose-phosphate aldolase
UniProt: Q9HP08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (202)
Sequences: 3199 (2058)
Seq/√Len: 144.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
183_T186_D3.6271.00
107_T144_D2.9741.00
80_H84_D2.8541.00
99_K134_E2.8331.00
102_D105_A2.7791.00
143_A173_L2.7241.00
114_N121_V2.6821.00
103_H137_A2.6711.00
174_P196_V2.5811.00
9_R191_F2.3621.00
135_K165_D2.3431.00
107_T111_A2.2551.00
129_V157_T2.2291.00
98_L103_H2.2191.00
25_L47_D2.1821.00
97_R102_D2.1251.00
97_R105_A2.1181.00
37_N59_A2.0521.00
167_S171_E1.9421.00
71_T75_V1.8711.00
137_A140_E1.8611.00
14_V19_T1.8511.00
25_L51_H1.8291.00
91_L110_I1.8131.00
57_T87_D1.8011.00
93_I98_L1.7871.00
163_V189_A1.7491.00
29_D33_A1.7411.00
136_H172_Y1.7301.00
14_V24_V1.7191.00
70_A80_H1.6591.00
184_Y188_A1.6491.00
79_E83_A1.6041.00
78_A117_T1.5901.00
114_N118_P1.5891.00
111_A115_D1.5561.00
188_A192_D1.5541.00
187_A198_I1.5531.00
29_D51_H1.5291.00
132_D164_P1.4941.00
109_E113_V1.4841.00
41_P66_H1.4761.00
128_P157_T1.4741.00
123_V147_A1.4581.00
87_D119_L1.4511.00
73_V76_A1.4501.00
46_A84_D1.4441.00
72_S80_H1.4241.00
49_R87_D1.4171.00
78_A89_L1.4051.00
98_L138_A1.3831.00
10_I203_G1.3811.00
80_H83_A1.3701.00
70_A84_D1.3691.00
25_L29_D1.3681.00
21_R100_G1.3681.00
41_P68_T1.3641.00
131_T134_E1.3581.00
45_V58_I1.3331.00
98_L141_A1.3291.00
93_I138_A1.2951.00
166_V175_V1.2901.00
125_I135_K1.2901.00
186_D189_A1.2871.00
43_C94_P1.2861.00
139_C169_M1.2801.00
182_G186_D1.2801.00
186_D190_M1.2761.00
36_M203_G1.2731.00
69_Q73_V1.2551.00
107_T141_A1.2431.00
82_H116_A1.2421.00
163_V193_A1.2421.00
128_P158_D1.2291.00
21_R47_D1.2261.00
35_G55_D1.2221.00
127_T178_S1.2131.00
20_T23_D1.2011.00
47_D51_H1.1781.00
22_A25_L1.1671.00
136_H171_E1.1651.00
21_R44_Y1.1601.00
170_S174_P1.1561.00
42_P69_Q1.1551.00
185_A189_A1.1511.00
182_G202_S1.1480.99
117_T121_V1.1440.99
37_N57_T1.1320.99
132_D135_K1.1300.99
45_V60_T1.1270.99
69_Q77_A1.1260.99
23_D26_S1.1240.99
42_P60_T1.1230.99
125_I150_V1.1140.99
12_H203_G1.1110.99
32_E54_A1.1070.99
14_V23_D1.0950.99
159_G162_T1.0910.99
82_H119_L1.0760.99
48_A58_I1.0750.99
108_A112_A1.0680.99
71_T109_E1.0590.99
170_S196_V1.0530.99
8_A35_G1.0220.99
120_P148_A1.0170.99
28_V38_V1.0030.99
21_R25_L0.9950.99
136_H140_E0.9950.99
114_N117_T0.9890.98
114_N148_A0.9870.98
127_T165_D0.9840.98
34_H204_V0.9820.98
108_A111_A0.9760.98
139_C150_V0.9710.98
62_I89_L0.9680.98
49_R58_I0.9660.98
163_V190_M0.9650.98
94_P109_E0.9460.98
28_V51_H0.9440.98
185_A188_A0.9430.98
7_A35_G0.9420.98
112_A115_D0.9360.98
164_P167_S0.9360.98
52_A56_R0.9320.98
46_A50_D0.9310.98
21_R102_D0.9290.98
118_P148_A0.9280.98
18_T129_V0.9230.98
17_P66_H0.9200.98
8_A55_D0.9180.98
125_I138_A0.9180.98
39_C61_V0.9040.97
142_A147_A0.9020.97
106_V109_E0.9010.97
36_M204_V0.9010.97
75_V116_A0.9010.97
135_K168_L0.8920.97
107_T145_A0.8900.97
150_V169_M0.8820.97
103_H141_A0.8800.97
39_C59_A0.8740.97
104_E107_T0.8710.97
29_D32_E0.8710.97
74_K109_E0.8620.96
136_H168_L0.8620.96
42_P70_A0.8570.96
142_A145_A0.8550.96
6_L9_R0.8440.96
169_M175_V0.8410.96
63_G69_Q0.8340.96
140_E172_Y0.8320.96
163_V167_S0.8260.95
24_V44_Y0.8220.95
104_E108_A0.8200.95
11_D37_N0.8200.95
76_A79_E0.8200.95
159_G165_D0.8170.95
189_A193_A0.8060.95
142_A169_M0.8000.95
66_H156_F0.7990.95
45_V84_D0.7990.95
26_S30_D0.7970.94
189_A192_D0.7940.94
121_V148_A0.7930.94
127_T159_G0.7930.94
125_I142_A0.7920.94
32_E53_S0.7910.94
13_T27_V0.7890.94
6_L187_A0.7850.94
12_H30_D0.7850.94
70_A73_V0.7810.94
128_P153_A0.7730.94
129_V158_D0.7720.93
5_T8_A0.7700.93
143_A150_V0.7700.93
110_I147_A0.7680.93
200_A203_G0.7670.93
14_V27_V0.7670.93
149_M174_P0.7660.93
75_V113_V0.7600.93
44_Y100_G0.7570.93
75_V112_A0.7550.93
202_S205_D0.7500.92
110_I142_A0.7490.92
153_A160_G0.7470.92
75_V79_E0.7360.92
97_R100_G0.7320.92
32_E55_D0.7290.91
40_I45_V0.7280.91
60_T81_A0.7240.91
89_L117_T0.7180.91
143_A172_Y0.7170.91
135_K162_T0.7090.90
40_I48_A0.7070.90
91_L113_V0.7050.90
9_R196_V0.6980.90
43_C105_A0.6960.89
63_G77_A0.6950.89
94_P97_R0.6910.89
81_A86_A0.6910.89
81_A84_D0.6870.89
43_C97_R0.6860.89
135_K139_C0.6840.89
153_A161_A0.6810.88
167_S192_D0.6770.88
24_V27_V0.6730.88
28_V52_A0.6700.88
187_A191_F0.6660.87
184_Y206_I0.6540.86
66_H69_Q0.6530.86
76_A80_H0.6530.86
62_I81_A0.6510.86
72_S76_A0.6490.86
141_A145_A0.6480.86
135_K169_M0.6480.86
26_S29_D0.6430.85
125_I169_M0.6410.85
127_T135_K0.6360.85
200_A206_I0.6350.85
181_V202_S0.6320.84
140_E144_D0.6270.84
135_K159_G0.6260.84
90_D151_K0.6260.84
91_L109_E0.6260.84
6_L184_Y0.6260.84
91_L147_A0.6240.84
22_A26_S0.6230.83
170_S173_L0.6220.83
78_A113_V0.6210.83
137_A141_A0.6180.83
11_D59_A0.6170.83
99_K131_T0.6110.82
32_E51_H0.6110.82
25_L28_V0.6040.82
177_A181_V0.6010.81
79_E115_D0.5980.81
105_A108_A0.5960.81
118_P121_V0.5950.81
71_T108_A0.5940.80
170_S175_V0.5910.80
45_V48_A0.5900.80
91_L123_V0.5900.80
40_I60_T0.5880.80
63_G74_K0.5880.80
82_H89_L0.5870.80
10_I36_M0.5870.80
113_V121_V0.5840.79
96_G100_G0.5830.79
17_P158_D0.5810.79
140_E143_A0.5810.79
93_I106_V0.5790.79
78_A82_H0.5730.78
7_A10_I0.5720.78
187_A206_I0.5700.78
101_G106_V0.5700.78
71_T105_A0.5670.77
75_V109_E0.5640.77
72_S84_D0.5620.77
31_A56_R0.5580.76
72_S112_A0.5580.76
57_T120_P0.5570.76
128_P159_G0.5560.76
166_V195_A0.5560.76
18_T23_D0.5560.76
15_L156_F0.5500.75
20_T100_G0.5460.75
82_H117_T0.5410.74
170_S193_A0.5400.74
19_T23_D0.5400.74
165_D168_L0.5370.73
95_I98_L0.5340.73
91_L121_V0.5330.73
81_A89_L0.5310.73
93_I123_V0.5300.73
141_A144_D0.5290.72
58_I87_D0.5280.72
89_L121_V0.5250.72
42_P73_V0.5250.72
25_L50_D0.5240.72
125_I139_C0.5230.72
160_G178_S0.5210.71
95_I129_V0.5210.71
184_Y187_A0.5210.71
110_I123_V0.5180.71
101_G134_E0.5180.71
203_G206_I0.5170.71
42_P62_I0.5140.70
9_R149_M0.5110.70
28_V48_A0.5110.70
93_I125_I0.5100.70
181_V190_M0.5090.70
136_H143_A0.5090.70
82_H113_V0.5090.70
44_Y47_D0.5090.70
60_T89_L0.5080.69
166_V190_M0.5070.69
68_T94_P0.5060.69
98_L137_A0.5050.69
17_P95_I0.5020.68
5_T35_G0.5010.68
138_A145_A0.5010.68
139_C172_Y0.5010.68
32_E56_R0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a4aA 2 0.9906 100 0.17 Contact Map
4eivA 2 0.9906 100 0.181 Contact Map
1p1xA 1 1 100 0.207 Contact Map
3r12A 2 1 100 0.215 Contact Map
3oa3A 2 0.9953 100 0.221 Contact Map
1vcvA 2 0.9434 100 0.226 Contact Map
3ngjA 4 0.9953 100 0.24 Contact Map
3ndoA 2 0.9953 100 0.275 Contact Map
1ub3A 3 0.967 100 0.331 Contact Map
1n7kA 3 0.9717 100 0.368 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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