GREMLIN Database
Q9HP07 - Uncharacterized protein
UniProt: Q9HP07 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 432 (408)
Sequences: 7283 (4324)
Seq/√Len: 214.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_S294_D3.6191.00
247_S297_A3.5901.00
127_L161_A3.5211.00
248_D261_S3.4361.00
165_V205_E3.3831.00
362_D401_T3.2271.00
306_R351_E3.1921.00
199_A232_H3.1661.00
264_R304_E3.0791.00
223_E269_T3.0731.00
249_D294_D3.0391.00
360_R401_T3.0131.00
403_E415_E3.0121.00
405_T415_E2.9241.00
227_A273_T2.8841.00
197_R201_E2.7601.00
336_D340_A2.6561.00
299_M344_L2.6421.00
249_D253_D2.4741.00
300_D304_E2.4551.00
303_R347_D2.4271.00
360_R403_E2.3141.00
196_E231_E2.3091.00
264_R305_T2.2901.00
161_A172_I2.2711.00
8_T18_S2.2421.00
99_D102_E2.2141.00
159_E162_R2.2021.00
270_F277_W2.1971.00
170_K206_F2.1961.00
333_T336_D2.1781.00
239_L277_W2.1781.00
161_A198_I2.1741.00
227_A231_E2.1371.00
265_D268_E2.1031.00
303_R344_L2.0771.00
365_V388_N2.0581.00
330_G333_T1.9981.00
292_D333_T1.9891.00
295_H340_A1.9821.00
300_D303_R1.9771.00
230_A273_T1.9571.00
162_R166_H1.9481.00
314_R338_S1.9471.00
199_A234_E1.9231.00
3_R31_H1.9201.00
260_V297_A1.9181.00
395_E398_D1.8811.00
299_M340_A1.8781.00
362_D399_F1.8651.00
165_V202_I1.8581.00
154_V197_R1.8551.00
199_A233_D1.8231.00
260_V264_R1.8191.00
35_T38_D1.8051.00
268_E304_E1.7741.00
28_A105_T1.7731.00
296_E300_D1.7681.00
350_G354_E1.7671.00
357_V407_H1.7651.00
317_K324_A1.7621.00
268_E272_D1.7621.00
331_G334_K1.7531.00
243_V301_L1.7531.00
245_S298_S1.7371.00
262_Q265_D1.7181.00
306_R348_V1.6881.00
259_E262_Q1.6801.00
136_N148_R1.6651.00
83_E87_D1.6631.00
6_I18_S1.6571.00
352_A355_S1.6531.00
296_E340_A1.6361.00
365_V400_A1.6071.00
248_D260_V1.5921.00
228_V232_H1.5841.00
356_M361_R1.5831.00
196_E232_H1.5651.00
206_F362_D1.5621.00
260_V300_D1.5601.00
291_D294_D1.5571.00
190_K193_E1.5491.00
190_K224_E1.5441.00
261_S265_D1.5321.00
196_E228_V1.5161.00
250_V253_D1.5081.00
292_D296_E1.4991.00
294_D297_A1.4921.00
4_Y32_K1.4911.00
237_N276_E1.4881.00
308_E352_A1.4641.00
199_A228_V1.4511.00
152_P160_K1.4381.00
226_A270_F1.4361.00
48_T145_A1.4261.00
239_L270_F1.4101.00
138_S255_R1.4051.00
21_I74_T1.3931.00
78_A91_D1.3891.00
153_P156_E1.3821.00
196_E224_E1.3811.00
72_I90_V1.3761.00
297_A300_D1.3741.00
43_I72_I1.3711.00
402_V414_A1.3671.00
223_E227_A1.3631.00
159_E163_A1.3601.00
183_G186_T1.3581.00
138_S287_F1.3581.00
260_V301_L1.3331.00
172_I205_E1.3291.00
163_A167_A1.3111.00
192_P228_V1.3091.00
229_F235_I1.3061.00
335_K339_K1.2981.00
94_V97_W1.2971.00
193_E224_E1.2951.00
237_N381_Y1.2941.00
48_T54_E1.2701.00
96_H99_D1.2691.00
302_L341_M1.2681.00
253_D326_L1.2681.00
136_N144_Q1.2631.00
65_A71_L1.2611.00
339_K343_E1.2601.00
158_V197_R1.2591.00
195_L235_I1.2551.00
306_R352_A1.2461.00
312_V338_S1.2411.00
253_D294_D1.2371.00
193_E197_R1.2361.00
152_P156_E1.2361.00
283_F302_L1.2331.00
293_D297_A1.2221.00
406_S413_F1.2141.00
314_R335_K1.2101.00
79_L93_Q1.2101.00
253_D287_F1.2081.00
276_E359_T1.2021.00
354_E357_V1.1971.00
158_V162_R1.1951.00
331_G335_K1.1901.00
356_M359_T1.1851.00
345_K348_V1.1771.00
344_L348_V1.1751.00
404_V412_A1.1721.00
55_R59_R1.1701.00
274_L277_W1.1641.00
253_D289_T1.1641.00
400_A416_P1.1621.00
61_A73_V1.1611.00
394_L398_D1.1591.00
46_T73_V1.1591.00
198_I208_V1.1551.00
163_A166_H1.1481.00
255_R322_D1.1401.00
314_R331_G1.1401.00
322_D325_E1.1351.00
269_T272_D1.1331.00
265_D269_T1.1311.00
3_R38_D1.1291.00
92_A103_A1.1211.00
228_V235_I1.1161.00
266_I269_T1.1161.00
141_I145_A1.1161.00
70_D107_G1.1141.00
152_P157_N1.1121.00
292_D340_A1.1091.00
343_E347_D1.1041.00
206_F234_E1.1041.00
296_E299_M1.1041.00
203_E234_E1.1021.00
51_E55_R1.0961.00
232_H235_I1.0921.00
165_V206_F1.0901.00
208_V234_E1.0831.00
90_V103_A1.0821.00
293_D296_E1.0791.00
7_E60_R1.0791.00
386_V404_V1.0771.00
90_V107_G1.0771.00
44_L64_L1.0761.00
81_Q84_A1.0731.00
248_D259_E1.0651.00
267_V279_L1.0651.00
306_R355_S1.0621.00
229_F274_L1.0591.00
138_S322_D1.0511.00
25_L104_V1.0501.00
6_I43_I1.0481.00
302_L310_I1.0451.00
312_V342_T1.0431.00
285_V295_H1.0421.00
289_T328_G1.0401.00
378_D384_V1.0381.00
74_T92_A1.0371.00
267_V305_T1.0311.00
42_A69_A1.0231.00
199_A235_I1.0221.00
179_T210_V1.0181.00
156_E159_E1.0161.00
378_D381_Y1.0161.00
134_M148_R1.0131.00
281_T307_P1.0131.00
248_D297_A1.0121.00
361_R404_V1.0111.00
283_F310_I1.0081.00
127_L157_N1.0081.00
80_A145_A1.0001.00
310_I345_K0.9921.00
125_G164_L0.9911.00
113_T116_A0.9891.00
357_V406_S0.9891.00
354_E407_H0.9861.00
299_M303_R0.9861.00
46_T57_M0.9851.00
271_N306_R0.9801.00
230_A274_L0.9791.00
347_D351_E0.9731.00
224_E227_A0.9681.00
154_V158_V0.9681.00
141_I144_Q0.9661.00
226_A273_T0.9641.00
42_A64_L0.9611.00
285_V338_S0.9601.00
84_A87_D0.9571.00
5_H36_A0.9561.00
344_L347_D0.9541.00
70_D108_E0.9441.00
281_T310_I0.9421.00
276_E355_S0.9400.99
113_T117_E0.9310.99
379_G383_Q0.9300.99
247_S250_V0.9270.99
229_F239_L0.9260.99
350_G407_H0.9240.99
130_A149_V0.9240.99
226_A274_L0.9210.99
6_I22_E0.9210.99
295_H341_M0.9190.99
350_G353_H0.9190.99
365_V386_V0.9130.99
4_Y30_H0.9120.99
60_R63_E0.9080.99
191_L225_L0.9060.99
380_A383_Q0.9060.99
338_S342_T0.9020.99
199_A208_V0.8990.99
161_A202_I0.8990.99
155_E159_E0.8920.99
292_D336_D0.8900.99
378_D386_V0.8890.99
195_L232_H0.8880.99
269_T273_T0.8870.99
127_L172_I0.8860.99
8_T45_N0.8830.99
165_V204_G0.8830.99
162_R203_E0.8820.99
154_V182_Y0.8820.99
164_L169_A0.8810.99
13_S177_Q0.8780.99
4_Y26_R0.8740.99
170_K399_F0.8720.99
378_D388_N0.8720.99
22_E32_K0.8710.99
375_K378_D0.8700.99
349_V353_H0.8650.99
170_K398_D0.8640.99
42_A68_T0.8640.99
302_L307_P0.8600.99
201_E232_H0.8600.99
381_Y384_V0.8590.99
111_T114_P0.8550.99
9_Y60_R0.8550.99
162_R197_R0.8540.99
135_S178_D0.8450.99
343_E346_M0.8450.99
384_V387_Q0.8440.99
192_P224_E0.8430.99
378_D382_R0.8430.99
89_D93_Q0.8420.99
4_Y22_E0.8410.99
151_S185_D0.8380.99
9_Y57_M0.8380.99
287_F326_L0.8340.99
54_E81_Q0.8330.99
408_Q413_F0.8330.99
378_D383_Q0.8320.99
364_L399_F0.8290.99
278_T308_E0.8200.99
253_D328_G0.8180.99
237_N274_L0.8180.99
192_P222_R0.8170.99
44_L61_A0.8170.99
3_R33_V0.8170.99
345_K349_V0.8170.99
262_Q266_I0.8160.99
33_V39_A0.8140.99
280_S309_K0.8130.99
384_V388_N0.8120.99
84_A88_A0.8060.98
285_V334_K0.8060.98
207_R236_Y0.8040.98
125_G169_A0.8040.98
238_F280_S0.8010.98
351_E354_E0.8010.98
307_P310_I0.8000.98
285_V341_M0.7980.98
249_D297_A0.7980.98
380_A384_V0.7980.98
404_V414_A0.7970.98
264_R268_E0.7940.98
112_T117_E0.7930.98
195_L225_L0.7930.98
301_L305_T0.7900.98
70_D90_V0.7890.98
136_N255_R0.7890.98
30_H41_V0.7890.98
328_G334_K0.7870.98
243_V283_F0.7870.98
79_L82_G0.7860.98
303_R348_V0.7860.98
317_K334_K0.7860.98
250_V294_D0.7850.98
376_C384_V0.7830.98
65_A89_D0.7830.98
149_V181_V0.7820.98
83_E86_A0.7800.98
41_V72_I0.7770.98
346_M410_V0.7770.98
28_A102_E0.7770.98
41_V70_D0.7770.98
348_V352_A0.7750.98
123_V366_V0.7750.98
368_E373_S0.7740.98
36_A42_A0.7730.98
158_V202_I0.7730.98
348_V351_E0.7710.98
192_P225_L0.7710.98
202_I205_E0.7690.98
340_A344_L0.7690.98
246_G297_A0.7670.98
362_D381_Y0.7670.98
377_Y383_Q0.7660.98
221_I266_I0.7650.98
127_L164_L0.7640.98
144_Q322_D0.7630.98
25_L43_I0.7620.98
369_G372_D0.7600.98
226_A269_T0.7600.98
263_Y307_P0.7570.98
134_M184_W0.7560.98
12_T382_R0.7560.98
114_P117_E0.7550.98
238_F383_Q0.7530.98
243_V263_Y0.7520.98
302_L348_V0.7510.98
283_F341_M0.7500.98
363_V402_V0.7500.98
295_H299_M0.7470.97
376_C381_Y0.7440.97
70_D104_V0.7430.97
310_I348_V0.7430.97
24_R101_P0.7430.97
111_T116_A0.7430.97
22_E26_R0.7420.97
210_V229_F0.7410.97
102_E106_N0.7410.97
158_V198_I0.7400.97
261_S264_R0.7400.97
58_L62_K0.7380.97
206_F399_F0.7370.97
296_E303_R0.7320.97
19_R23_R0.7320.97
377_Y381_Y0.7310.97
246_G263_Y0.7280.97
239_L279_L0.7230.97
36_A64_L0.7220.97
237_N379_G0.7220.97
33_V38_D0.7210.97
298_S341_M0.7180.97
18_S45_N0.7180.97
227_A230_A0.7130.97
188_E193_E0.7100.97
5_H33_V0.7100.97
85_F88_A0.7070.96
223_E226_A0.7070.96
130_A176_G0.7050.96
405_T414_A0.7050.96
18_S22_E0.7050.96
5_H39_A0.7050.96
299_M341_M0.7040.96
60_R64_L0.7010.96
93_Q97_W0.7000.96
21_I100_V0.6980.96
362_D379_G0.6970.96
329_L334_K0.6950.96
110_P115_D0.6940.96
181_V216_G0.6930.96
128_P131_R0.6900.96
100_V104_V0.6870.96
135_S181_V0.6870.96
250_V287_F0.6870.96
162_R202_I0.6860.96
178_D217_G0.6860.96
216_G257_Q0.6860.96
165_V203_E0.6860.96
16_G128_P0.6850.96
52_K55_R0.6850.96
155_E197_R0.6850.96
30_H105_T0.6830.96
350_G409_T0.6810.96
139_Y258_H0.6810.96
388_N402_V0.6790.96
124_V173_R0.6780.96
207_R399_F0.6780.96
356_M382_R0.6760.95
5_H42_A0.6760.95
72_I92_A0.6760.95
365_V402_V0.6740.95
302_L345_K0.6740.95
193_E196_E0.6730.95
342_T345_K0.6720.95
8_T15_R0.6720.95
126_I173_R0.6710.95
352_A356_M0.6700.95
222_R225_L0.6700.95
368_E393_G0.6670.95
346_M409_T0.6660.95
23_R27_D0.6650.95
376_C380_A0.6630.95
62_K65_A0.6560.95
181_V217_G0.6550.95
62_K88_A0.6520.94
355_S359_T0.6520.94
82_G86_A0.6490.94
127_L174_I0.6490.94
17_E131_R0.6470.94
340_A343_E0.6460.94
12_T175_T0.6460.94
129_I179_T0.6450.94
19_R120_L0.6440.94
138_S253_D0.6430.94
319_P324_A0.6420.94
223_E273_T0.6390.94
390_T394_L0.6380.94
264_R301_L0.6380.94
377_Y380_A0.6370.94
28_A101_P0.6360.94
113_T118_P0.6360.94
110_P114_P0.6340.94
395_E416_P0.6340.94
180_G242_P0.6310.93
144_Q320_G0.6300.93
379_G384_V0.6300.93
204_G234_E0.6300.93
246_G301_L0.6280.93
26_R32_K0.6280.93
180_G213_A0.6280.93
59_R62_K0.6250.93
205_E234_E0.6250.93
26_R31_H0.6230.93
221_I225_L0.6200.93
159_E166_H0.6200.93
114_P118_P0.6190.93
292_D337_R0.6180.93
381_Y388_N0.6170.93
165_V208_V0.6150.93
135_S257_Q0.6130.92
191_L210_V0.6120.92
112_T115_D0.6110.92
249_D252_A0.6100.92
48_T80_A0.6100.92
115_D156_E0.6100.92
356_M360_R0.6100.92
112_T116_A0.6090.92
239_L274_L0.6080.92
287_F323_A0.6060.92
246_G298_S0.6050.92
95_L98_D0.6040.92
111_T115_D0.6040.92
249_D293_D0.6040.92
246_G260_V0.6030.92
195_L199_A0.6020.92
13_S16_G0.6020.92
192_P196_E0.6010.92
353_H384_V0.6010.92
116_A119_I0.6000.92
9_Y44_L0.5990.92
379_G382_R0.5990.92
96_H103_A0.5970.91
56_N59_R0.5940.91
110_P113_T0.5940.91
52_K316_S0.5930.91
203_E206_F0.5930.91
360_R414_A0.5930.91
111_T117_E0.5920.91
49_V141_I0.5910.91
283_F298_S0.5910.91
129_I194_L0.5900.91
154_V193_E0.5900.91
387_Q411_Y0.5890.91
298_S302_L0.5890.91
24_R27_D0.5880.91
191_L195_L0.5860.91
357_V360_R0.5850.91
205_E208_V0.5850.91
309_K349_V0.5840.91
302_L344_L0.5840.91
205_E399_F0.5820.90
44_L57_M0.5820.90
376_C388_N0.5810.90
20_D24_R0.5780.90
5_H34_E0.5770.90
314_R334_K0.5770.90
33_V36_A0.5760.90
165_V234_E0.5750.90
249_D289_T0.5750.90
109_C117_E0.5700.89
394_L416_P0.5700.89
160_K164_L0.5690.89
52_K56_N0.5690.89
89_D94_V0.5690.89
157_N194_L0.5670.89
92_A96_H0.5650.89
154_V194_L0.5650.89
376_C383_Q0.5640.89
223_E266_I0.5630.89
295_H302_L0.5620.89
94_V98_D0.5610.89
383_Q388_N0.5600.89
332_Q336_D0.5600.89
369_G374_V0.5590.89
335_K338_S0.5580.88
377_Y384_V0.5580.88
180_G217_G0.5570.88
120_L167_A0.5550.88
363_V414_A0.5550.88
134_M149_V0.5540.88
4_Y25_L0.5540.88
302_L306_R0.5540.88
105_T108_E0.5540.88
212_M238_F0.5520.88
386_V414_A0.5490.88
312_V341_M0.5480.88
176_G179_T0.5480.88
202_I206_F0.5480.88
5_H35_T0.5480.88
249_D291_D0.5460.87
170_K364_L0.5450.87
92_A100_V0.5450.87
46_T61_A0.5440.87
402_V405_T0.5430.87
312_V345_K0.5390.87
139_Y255_R0.5360.86
296_E336_D0.5360.86
121_D169_A0.5360.86
317_K321_T0.5350.86
354_E406_S0.5340.86
174_I198_I0.5340.86
353_H407_H0.5320.86
370_T373_S0.5310.86
368_E372_D0.5300.86
104_V108_E0.5290.86
309_K378_D0.5270.86
101_P105_T0.5260.85
369_G373_S0.5250.85
394_L400_A0.5240.85
165_V172_I0.5240.85
165_V169_A0.5230.85
375_K389_A0.5230.85
136_N322_D0.5220.85
206_F233_D0.5220.85
102_E105_T0.5210.85
353_H412_A0.5200.85
393_G398_D0.5200.85
4_Y18_S0.5190.85
227_A269_T0.5190.85
211_G379_G0.5180.85
363_V366_V0.5180.85
405_T413_F0.5170.84
100_V103_A0.5170.84
333_T337_R0.5160.84
26_R29_G0.5160.84
135_S216_G0.5150.84
178_D191_L0.5150.84
134_M181_V0.5140.84
376_C379_G0.5130.84
162_R201_E0.5130.84
349_V409_T0.5130.84
278_T382_R0.5110.84
285_V314_R0.5110.84
315_F326_L0.5100.84
361_R379_G0.5100.84
73_V85_F0.5090.84
113_T119_I0.5070.83
315_F323_A0.5070.83
243_V307_P0.5070.83
336_D339_K0.5070.83
7_E64_L0.5060.83
248_D265_D0.5060.83
43_I90_V0.5060.83
54_E80_A0.5050.83
162_R204_G0.5050.83
181_V242_P0.5030.83
342_T346_M0.5020.83
93_Q100_V0.5010.83
15_R19_R0.5010.83
365_V395_E0.5010.83
64_L71_L0.5010.83
35_T42_A0.5000.82
86_A91_D0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jc0A 1 0.9444 100 0.359 Contact Map
2qgqA 1 0.6204 100 0.556 Contact Map
1oltA 1 0.7731 100 0.772 Contact Map
4u0oB 1 0.6019 99.9 0.808 Contact Map
3iixA 1 0.7616 99.9 0.832 Contact Map
4wcxA 1 0.7986 99.9 0.832 Contact Map
2yx0A 1 0.6713 99.9 0.837 Contact Map
3t7vA 1 0.7662 99.9 0.839 Contact Map
4rtbA 2 0.8032 99.8 0.843 Contact Map
4r33A 2 0.8032 99.8 0.843 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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