GREMLIN Database
Q9HP06 - Cation efflux system protein (Zinc/cadmium)
UniProt: Q9HP06 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (277)
Sequences: 10422 (7299)
Seq/√Len: 438.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_V180_L3.5961.00
191_H195_E3.1361.00
246_L281_V3.0601.00
202_N207_A3.0031.00
231_H247_H2.9951.00
221_A246_L2.7921.00
218_L222_L2.7231.00
28_A119_V2.4411.00
26_G41_A2.3651.00
221_A266_L2.3361.00
96_L183_F2.3301.00
66_D73_H2.3011.00
97_W101_T2.2981.00
138_A147_R2.1871.00
224_N269_D2.1731.00
85_A197_V2.1391.00
228_E251_E2.0941.00
76_I205_V2.0851.00
118_G122_G2.0641.00
198_R202_N2.0621.00
29_W38_G2.0561.00
220_R274_P2.0561.00
117_V164_L1.9531.00
255_T258_E1.9431.00
69_H73_H1.8981.00
215_E219_G1.8891.00
224_N265_D1.8691.00
220_R269_D1.8681.00
96_L186_A1.8641.00
216_Q273_I1.8641.00
252_G257_H1.8631.00
248_V266_L1.8161.00
214_R235_A1.8101.00
224_N266_L1.7921.00
260_H282_H1.7701.00
75_R206_G1.7561.00
168_L172_T1.7461.00
258_E261_D1.7391.00
101_T105_A1.7241.00
27_A31_A1.7111.00
95_V182_A1.7011.00
135_L139_A1.6721.00
12_A16_A1.6581.00
183_F187_A1.6311.00
136_G140_D1.6261.00
261_D265_D1.6111.00
26_G30_W1.5991.00
43_N152_D1.5971.00
220_R273_I1.5811.00
229_G249_E1.5681.00
187_A191_H1.5681.00
194_Y198_R1.5621.00
219_G223_D1.5611.00
166_G181_A1.5541.00
52_L56_G1.5401.00
256_L259_A1.5371.00
93_G97_W1.5361.00
100_T104_A1.5021.00
231_H284_D1.5011.00
12_A55_L1.4971.00
259_A283_V1.4721.00
17_A126_A1.4431.00
147_R199_D1.4401.00
128_Y132_R1.4321.00
99_A182_A1.4221.00
195_E198_R1.4151.00
162_A181_A1.4001.00
265_D269_D1.3991.00
213_L216_Q1.3991.00
19_L48_V1.3981.00
235_A244_V1.3911.00
32_T116_A1.3661.00
121_V125_V1.3591.00
71_H245_S1.3521.00
250_V256_L1.3381.00
268_L272_S1.3291.00
222_L229_G1.3281.00
129_A132_R1.3221.00
25_K44_S1.3191.00
135_L150_A1.3181.00
117_V167_V1.3161.00
176_V179_P1.3111.00
250_V262_I1.3051.00
13_L133_Y1.3001.00
216_Q220_R1.2981.00
209_P235_A1.2851.00
247_H284_D1.2831.00
94_A97_W1.2651.00
149_T152_D1.2651.00
234_V278_D1.2461.00
244_V276_V1.2421.00
210_P213_L1.2331.00
103_V179_P1.2301.00
206_G243_D1.2181.00
92_G190_L1.2151.00
66_D69_H1.2101.00
89_L193_G1.2011.00
121_V164_L1.2001.00
224_N262_I1.1971.00
254_M258_E1.1961.00
215_E218_L1.1961.00
57_G80_V1.1851.00
137_V140_D1.1791.00
29_W41_A1.1751.00
233_V246_L1.1751.00
263_E282_H1.1691.00
169_G177_L1.1671.00
137_V141_H1.1611.00
35_L99_A1.1591.00
125_V129_A1.1551.00
124_A164_L1.1541.00
216_Q219_G1.1501.00
263_E267_I1.1481.00
17_A130_L1.1451.00
60_L76_I1.1421.00
21_L25_K1.1291.00
103_V176_V1.1281.00
22_V45_L1.1251.00
16_A20_A1.1161.00
270_L276_V1.1081.00
256_L283_V1.1071.00
15_L48_V1.1061.00
257_H261_D1.1021.00
267_I282_H1.1021.00
69_H202_N1.0981.00
244_V279_V1.0881.00
53_V80_V1.0791.00
22_V41_A1.0791.00
68_K73_H1.0771.00
129_A133_Y1.0771.00
78_P203_Y1.0681.00
231_H249_E1.0661.00
74_E241_E1.0661.00
132_R136_G1.0611.00
118_G121_V1.0611.00
263_E283_V1.0601.00
22_V26_G1.0581.00
260_H285_P1.0571.00
15_L55_L1.0501.00
174_Y177_L1.0491.00
98_Q101_T1.0491.00
89_L194_Y1.0491.00
169_G172_T1.0451.00
85_A196_I1.0401.00
217_I235_A1.0301.00
132_R135_L1.0281.00
161_S165_V1.0171.00
14_V130_L1.0151.00
113_G118_G1.0131.00
116_A167_V1.0131.00
206_G238_V1.0121.00
59_Y62_T1.0101.00
211_A215_E1.0071.00
40_E43_N1.0051.00
89_L190_L1.0051.00
269_D273_I1.0011.00
150_A154_R0.9981.00
89_L93_G0.9981.00
223_D269_D0.9961.00
21_L126_A0.9861.00
226_D262_I0.9861.00
217_I270_L0.9861.00
26_G38_G0.9811.00
220_R224_N0.9801.00
9_R13_L0.9771.00
106_G109_G0.9741.00
96_L100_T0.9691.00
273_I276_V0.9661.00
260_H263_E0.9641.00
60_L63_Q0.9551.00
136_G139_A0.9501.00
107_D110_P0.9481.00
264_T268_L0.9461.00
56_G60_L0.9451.00
120_L164_L0.9441.00
30_W38_G0.9431.00
226_D258_E0.9421.00
117_V170_S0.9371.00
103_V183_F0.9361.00
54_V148_A0.9311.00
35_L102_T0.9271.00
253_E257_H0.9251.00
70_P208_A0.9211.00
79_F205_V0.9201.00
99_A183_F0.9171.00
54_V145_A0.9171.00
23_A27_A0.9091.00
15_L52_L0.9091.00
35_L182_A0.9081.00
40_E160_A0.8971.00
68_K207_A0.8931.00
226_D265_D0.8841.00
222_L230_A0.8841.00
270_L279_V0.8791.00
206_G236_H0.8761.00
131_Y150_A0.8711.00
219_G222_L0.8691.00
168_L171_A0.8691.00
86_L90_A0.8651.00
259_A263_E0.8651.00
24_A122_G0.8631.00
19_L23_A0.8621.00
250_V283_V0.8601.00
135_L138_A0.8551.00
138_A150_A0.8531.00
232_D247_H0.8521.00
238_V243_D0.8521.00
250_V259_A0.8501.00
152_D156_D0.8501.00
98_Q102_T0.8461.00
213_L242_I0.8441.00
203_Y237_Y0.8431.00
260_H284_D0.8421.00
43_N47_D0.8411.00
10_V133_Y0.8411.00
101_T104_A0.8401.00
263_E281_V0.8401.00
128_Y154_R0.8311.00
112_P170_S0.8301.00
117_V121_V0.8291.00
166_G177_L0.8261.00
209_P242_I0.8251.00
227_V248_V0.8231.00
18_N44_S0.8221.00
209_P213_L0.8201.00
214_R218_L0.8201.00
249_E286_K0.8151.00
82_L197_V0.8141.00
71_H236_H0.8131.00
130_L134_V0.8051.00
169_G173_G0.8051.00
254_M262_I0.7941.00
230_A233_V0.7941.00
208_A214_R0.7891.00
24_A119_V0.7881.00
218_L230_A0.7851.00
94_A98_Q0.7841.00
22_V48_V0.7841.00
264_T267_I0.7831.00
35_L98_Q0.7821.00
232_D278_D0.7811.00
75_R236_H0.7791.00
100_T183_F0.7781.00
130_L153_N0.7751.00
230_A246_L0.7711.00
177_L181_A0.7681.00
127_K130_L0.7661.00
30_W41_A0.7611.00
276_V279_V0.7601.00
114_L118_G0.7531.00
180_L184_V0.7531.00
220_R223_D0.7511.00
34_S178_D0.7471.00
220_R272_S0.7441.00
251_E254_M0.7431.00
228_E286_K0.7431.00
25_K41_A0.7401.00
90_A97_W0.7381.00
82_L86_L0.7381.00
266_L281_V0.7361.00
90_A94_A0.7341.00
269_D272_S0.7301.00
181_A185_V0.7291.00
56_G59_Y0.7231.00
266_L269_D0.7231.00
46_A91_A0.7211.00
282_H285_P0.7201.00
36_A181_A0.7191.00
155_N192_T0.7161.00
151_L154_R0.7151.00
61_T77_E0.7151.00
131_Y154_R0.7131.00
268_L271_E0.7131.00
217_I244_V0.7111.00
234_V245_S0.7101.00
58_L145_A0.7091.00
123_T127_K0.7071.00
22_V44_S0.7071.00
79_F83_V0.7021.00
148_A196_I0.7011.00
137_V143_S0.6981.00
14_V134_V0.6981.00
26_G45_L0.6971.00
18_N47_D0.6971.00
221_A230_A0.6971.00
138_A141_H0.6921.00
188_G192_T0.6911.00
101_T107_D0.6891.00
270_L281_V0.6881.00
68_K202_N0.6841.00
226_D251_E0.6831.00
170_S173_G0.6831.00
141_H144_P0.6811.00
111_T114_L0.6781.00
267_I279_V0.6721.00
29_W32_T0.6711.00
124_A161_S0.6711.00
254_M259_A0.6711.00
252_G286_K0.6681.00
134_V149_T0.6681.00
212_D235_A0.6681.00
237_Y242_I0.6671.00
191_H194_Y0.6661.00
14_V149_T0.6621.00
43_N88_V0.6621.00
202_N210_P0.6601.00
50_Y87_G0.6591.00
120_L123_T0.6561.00
12_A15_L0.6551.00
51_S149_T0.6551.00
131_Y135_L0.6530.99
10_V137_V0.6520.99
50_Y54_V0.6510.99
55_L59_Y0.6490.99
259_A285_P0.6460.99
81_S145_A0.6460.99
245_S278_D0.6410.99
271_E277_D0.6410.99
92_G193_G0.6360.99
82_L200_N0.6330.99
147_R151_L0.6310.99
14_V153_N0.6270.99
126_A130_L0.6260.99
77_E143_S0.6250.99
14_V51_S0.6240.99
265_D268_L0.6220.99
127_K134_V0.6170.99
99_A186_A0.6160.99
267_I271_E0.6150.99
81_S196_I0.6130.99
227_V230_A0.6090.99
16_A19_L0.6090.99
27_A30_W0.6060.99
259_A262_I0.6060.99
10_V136_G0.6060.99
108_Y175_P0.6050.99
163_A166_G0.6020.99
25_K40_E0.6020.99
128_Y157_I0.6020.99
127_K153_N0.6000.99
45_L49_A0.6000.99
21_L130_L0.5950.99
130_L133_Y0.5900.99
79_F201_V0.5870.99
144_P199_D0.5860.99
37_V120_L0.5840.99
184_V188_G0.5840.99
59_Y63_Q0.5810.99
262_I266_L0.5800.99
160_A163_A0.5790.99
258_E265_D0.5770.99
233_V244_V0.5750.99
99_A179_P0.5740.99
110_P113_G0.5720.99
142_R275_E0.5690.99
93_G190_L0.5650.99
225_P265_D0.5640.99
248_V283_V0.5620.99
122_G126_A0.5600.98
50_Y152_D0.5590.98
261_D264_T0.5580.98
260_H264_T0.5560.98
237_Y240_P0.5540.98
91_A94_A0.5530.98
70_P234_V0.5530.98
209_P214_R0.5520.98
138_A143_S0.5510.98
250_V254_M0.5510.98
221_A248_V0.5490.98
33_G107_D0.5460.98
147_R150_A0.5450.98
20_A24_A0.5440.98
162_A185_V0.5440.98
188_G191_H0.5430.98
15_L51_S0.5420.98
81_S200_N0.5410.98
85_A200_N0.5410.98
221_A224_N0.5410.98
90_A93_G0.5400.98
134_V153_N0.5390.98
208_A237_Y0.5370.98
113_G170_S0.5370.98
208_A235_A0.5370.98
13_L16_A0.5360.98
21_L24_A0.5360.98
152_D155_N0.5360.98
18_N127_K0.5330.98
168_L177_L0.5310.98
133_Y137_V0.5300.98
172_T177_L0.5290.98
158_L161_S0.5290.98
76_I80_V0.5290.98
88_V153_N0.5270.98
139_A147_R0.5260.98
35_L38_G0.5250.98
18_N48_V0.5230.98
186_A193_G0.5210.98
49_A52_L0.5200.98
190_L194_Y0.5200.98
226_D266_L0.5170.97
71_H234_V0.5170.97
64_P73_H0.5160.97
11_G15_L0.5160.97
25_K123_T0.5160.97
131_Y153_N0.5120.97
26_G42_I0.5120.97
179_P182_A0.5070.97
11_G54_V0.5050.97
67_F214_R0.5050.97
271_E274_P0.5030.97
118_G125_V0.5030.97
22_V42_I0.5030.97
159_T166_G0.5030.97
181_A184_V0.5020.97
69_H207_A0.5020.97
37_V88_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.9766 100 0.102 Contact Map
3h90A 3 0.9465 100 0.129 Contact Map
3bypA 2 0.2676 99.5 0.759 Contact Map
2zztA 2 0.2676 99.5 0.761 Contact Map
3w61A 2 0.2642 99.3 0.779 Contact Map
3cq1A 2 0.3177 50.1 0.942 Contact Map
3lnoA 1 0.3043 46.6 0.944 Contact Map
2zbcA 6 0.2709 46.2 0.944 Contact Map
1uwdA 1 0.3211 37.6 0.947 Contact Map
2cviA 2 0.2776 34.4 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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