Q9HP06 - HALSA - GREMLIN Contacts

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Q9HP06 - Cation efflux system protein (Zinc/cadmium)

UniProt:	Q9HP06	Sequences: MERKRAVRRVGALVLAANLALVAAKGAAWWATGSLAVGSEAINSLADVAYSLVVLGGLYLTTQPPDFKHPHGHERIEPFVSLVVALGVLAAGGAVLWQATTTVAAGDYGPTPGLPAVGVLVGTAVAKYALYRYVLGVAADHRSPALRATALDNRNDILTASAALVGVLGSATGYPVLDPLAAFVVAAGILHTGYEIVRDNVNYLVGAAPPADLREQILGRALDNPDVEGAHDVVAHYVGPEIDVSLHVEVEGEMTLHEAHDIETDLILDLESIPEVDDVFVHVDPKELGEWKDADTAPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	299 (277)
Sequences:	10422 (7299)
Seq/√Len:	438.6

ECOLI - FIEF ZITB
BACSU - CZCD YEAB YDBO YDFM
HALSA - Q9HP06
SULSO - Q97WI8 Q97WH2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
176_V	180_L	3.596	1.00
191_H	195_E	3.136	1.00
246_L	281_V	3.060	1.00
202_N	207_A	3.003	1.00
231_H	247_H	2.995	1.00
221_A	246_L	2.792	1.00
218_L	222_L	2.723	1.00
28_A	119_V	2.441	1.00
26_G	41_A	2.365	1.00
221_A	266_L	2.336	1.00
96_L	183_F	2.330	1.00
66_D	73_H	2.301	1.00
97_W	101_T	2.298	1.00
138_A	147_R	2.187	1.00
224_N	269_D	2.173	1.00
85_A	197_V	2.139	1.00
228_E	251_E	2.094	1.00
76_I	205_V	2.085	1.00
118_G	122_G	2.064	1.00
198_R	202_N	2.062	1.00
29_W	38_G	2.056	1.00
220_R	274_P	2.056	1.00
117_V	164_L	1.953	1.00
255_T	258_E	1.943	1.00
69_H	73_H	1.898	1.00
215_E	219_G	1.889	1.00
224_N	265_D	1.869	1.00
220_R	269_D	1.868	1.00
96_L	186_A	1.864	1.00
216_Q	273_I	1.864	1.00
252_G	257_H	1.863	1.00
248_V	266_L	1.816	1.00
214_R	235_A	1.810	1.00
224_N	266_L	1.792	1.00
260_H	282_H	1.770	1.00
75_R	206_G	1.756	1.00
168_L	172_T	1.746	1.00
258_E	261_D	1.739	1.00
101_T	105_A	1.724	1.00
27_A	31_A	1.711	1.00
95_V	182_A	1.701	1.00
135_L	139_A	1.672	1.00
12_A	16_A	1.658	1.00
183_F	187_A	1.631	1.00
136_G	140_D	1.626	1.00
261_D	265_D	1.611	1.00
26_G	30_W	1.599	1.00
43_N	152_D	1.597	1.00
220_R	273_I	1.581	1.00
229_G	249_E	1.568	1.00
187_A	191_H	1.568	1.00
194_Y	198_R	1.562	1.00
219_G	223_D	1.561	1.00
166_G	181_A	1.554	1.00
52_L	56_G	1.540	1.00
256_L	259_A	1.537	1.00
93_G	97_W	1.536	1.00
100_T	104_A	1.502	1.00
231_H	284_D	1.501	1.00
12_A	55_L	1.497	1.00
259_A	283_V	1.472	1.00
17_A	126_A	1.443	1.00
147_R	199_D	1.440	1.00
128_Y	132_R	1.432	1.00
99_A	182_A	1.422	1.00
195_E	198_R	1.415	1.00
162_A	181_A	1.400	1.00
265_D	269_D	1.399	1.00
213_L	216_Q	1.399	1.00
19_L	48_V	1.398	1.00
235_A	244_V	1.391	1.00
32_T	116_A	1.366	1.00
121_V	125_V	1.359	1.00
71_H	245_S	1.352	1.00
250_V	256_L	1.338	1.00
268_L	272_S	1.329	1.00
222_L	229_G	1.328	1.00
129_A	132_R	1.322	1.00
25_K	44_S	1.319	1.00
135_L	150_A	1.318	1.00
117_V	167_V	1.316	1.00
176_V	179_P	1.311	1.00
250_V	262_I	1.305	1.00
13_L	133_Y	1.300	1.00
216_Q	220_R	1.298	1.00
209_P	235_A	1.285	1.00
247_H	284_D	1.283	1.00
94_A	97_W	1.265	1.00
149_T	152_D	1.265	1.00
234_V	278_D	1.246	1.00
244_V	276_V	1.242	1.00
210_P	213_L	1.233	1.00
103_V	179_P	1.230	1.00
206_G	243_D	1.218	1.00
92_G	190_L	1.215	1.00
66_D	69_H	1.210	1.00
89_L	193_G	1.201	1.00
121_V	164_L	1.200	1.00
224_N	262_I	1.197	1.00
254_M	258_E	1.196	1.00
215_E	218_L	1.196	1.00
57_G	80_V	1.185	1.00
137_V	140_D	1.179	1.00
29_W	41_A	1.175	1.00
233_V	246_L	1.175	1.00
263_E	282_H	1.169	1.00
169_G	177_L	1.167	1.00
137_V	141_H	1.161	1.00
35_L	99_A	1.159	1.00
125_V	129_A	1.155	1.00
124_A	164_L	1.154	1.00
216_Q	219_G	1.150	1.00
263_E	267_I	1.148	1.00
17_A	130_L	1.145	1.00
60_L	76_I	1.142	1.00
21_L	25_K	1.129	1.00
103_V	176_V	1.128	1.00
22_V	45_L	1.125	1.00
16_A	20_A	1.116	1.00
270_L	276_V	1.108	1.00
256_L	283_V	1.107	1.00
15_L	48_V	1.106	1.00
257_H	261_D	1.102	1.00
267_I	282_H	1.102	1.00
69_H	202_N	1.098	1.00
244_V	279_V	1.088	1.00
53_V	80_V	1.079	1.00
22_V	41_A	1.079	1.00
68_K	73_H	1.077	1.00
129_A	133_Y	1.077	1.00
78_P	203_Y	1.068	1.00
231_H	249_E	1.066	1.00
74_E	241_E	1.066	1.00
132_R	136_G	1.061	1.00
118_G	121_V	1.061	1.00
263_E	283_V	1.060	1.00
22_V	26_G	1.058	1.00
260_H	285_P	1.057	1.00
15_L	55_L	1.050	1.00
174_Y	177_L	1.049	1.00
98_Q	101_T	1.049	1.00
89_L	194_Y	1.049	1.00
169_G	172_T	1.045	1.00
85_A	196_I	1.040	1.00
217_I	235_A	1.030	1.00
132_R	135_L	1.028	1.00
161_S	165_V	1.017	1.00
14_V	130_L	1.015	1.00
113_G	118_G	1.013	1.00
116_A	167_V	1.013	1.00
206_G	238_V	1.012	1.00
59_Y	62_T	1.010	1.00
211_A	215_E	1.007	1.00
40_E	43_N	1.005	1.00
89_L	190_L	1.005	1.00
269_D	273_I	1.001	1.00
150_A	154_R	0.998	1.00
89_L	93_G	0.998	1.00
223_D	269_D	0.996	1.00
21_L	126_A	0.986	1.00
226_D	262_I	0.986	1.00
217_I	270_L	0.986	1.00
26_G	38_G	0.981	1.00
220_R	224_N	0.980	1.00
9_R	13_L	0.977	1.00
106_G	109_G	0.974	1.00
96_L	100_T	0.969	1.00
273_I	276_V	0.966	1.00
260_H	263_E	0.964	1.00
60_L	63_Q	0.955	1.00
136_G	139_A	0.950	1.00
107_D	110_P	0.948	1.00
264_T	268_L	0.946	1.00
56_G	60_L	0.945	1.00
120_L	164_L	0.944	1.00
30_W	38_G	0.943	1.00
226_D	258_E	0.942	1.00
117_V	170_S	0.937	1.00
103_V	183_F	0.936	1.00
54_V	148_A	0.931	1.00
35_L	102_T	0.927	1.00
253_E	257_H	0.925	1.00
70_P	208_A	0.921	1.00
79_F	205_V	0.920	1.00
99_A	183_F	0.917	1.00
54_V	145_A	0.917	1.00
23_A	27_A	0.909	1.00
15_L	52_L	0.909	1.00
35_L	182_A	0.908	1.00
40_E	160_A	0.897	1.00
68_K	207_A	0.893	1.00
226_D	265_D	0.884	1.00
222_L	230_A	0.884	1.00
270_L	279_V	0.879	1.00
206_G	236_H	0.876	1.00
131_Y	150_A	0.871	1.00
219_G	222_L	0.869	1.00
168_L	171_A	0.869	1.00
86_L	90_A	0.865	1.00
259_A	263_E	0.865	1.00
24_A	122_G	0.863	1.00
19_L	23_A	0.862	1.00
250_V	283_V	0.860	1.00
135_L	138_A	0.855	1.00
138_A	150_A	0.853	1.00
232_D	247_H	0.852	1.00
238_V	243_D	0.852	1.00
250_V	259_A	0.850	1.00
152_D	156_D	0.850	1.00
98_Q	102_T	0.846	1.00
213_L	242_I	0.844	1.00
203_Y	237_Y	0.843	1.00
260_H	284_D	0.842	1.00
43_N	47_D	0.841	1.00
10_V	133_Y	0.841	1.00
101_T	104_A	0.840	1.00
263_E	281_V	0.840	1.00
128_Y	154_R	0.831	1.00
112_P	170_S	0.830	1.00
117_V	121_V	0.829	1.00
166_G	177_L	0.826	1.00
209_P	242_I	0.825	1.00
227_V	248_V	0.823	1.00
18_N	44_S	0.822	1.00
209_P	213_L	0.820	1.00
214_R	218_L	0.820	1.00
249_E	286_K	0.815	1.00
82_L	197_V	0.814	1.00
71_H	236_H	0.813	1.00
130_L	134_V	0.805	1.00
169_G	173_G	0.805	1.00
254_M	262_I	0.794	1.00
230_A	233_V	0.794	1.00
208_A	214_R	0.789	1.00
24_A	119_V	0.788	1.00
218_L	230_A	0.785	1.00
94_A	98_Q	0.784	1.00
22_V	48_V	0.784	1.00
264_T	267_I	0.783	1.00
35_L	98_Q	0.782	1.00
232_D	278_D	0.781	1.00
75_R	236_H	0.779	1.00
100_T	183_F	0.778	1.00
130_L	153_N	0.775	1.00
230_A	246_L	0.771	1.00
177_L	181_A	0.768	1.00
127_K	130_L	0.766	1.00
30_W	41_A	0.761	1.00
276_V	279_V	0.760	1.00
114_L	118_G	0.753	1.00
180_L	184_V	0.753	1.00
220_R	223_D	0.751	1.00
34_S	178_D	0.747	1.00
220_R	272_S	0.744	1.00
251_E	254_M	0.743	1.00
228_E	286_K	0.743	1.00
25_K	41_A	0.740	1.00
90_A	97_W	0.738	1.00
82_L	86_L	0.738	1.00
266_L	281_V	0.736	1.00
90_A	94_A	0.734	1.00
269_D	272_S	0.730	1.00
181_A	185_V	0.729	1.00
56_G	59_Y	0.723	1.00
266_L	269_D	0.723	1.00
46_A	91_A	0.721	1.00
282_H	285_P	0.720	1.00
36_A	181_A	0.719	1.00
155_N	192_T	0.716	1.00
151_L	154_R	0.715	1.00
61_T	77_E	0.715	1.00
131_Y	154_R	0.713	1.00
268_L	271_E	0.713	1.00
217_I	244_V	0.711	1.00
234_V	245_S	0.710	1.00
58_L	145_A	0.709	1.00
123_T	127_K	0.707	1.00
22_V	44_S	0.707	1.00
79_F	83_V	0.702	1.00
148_A	196_I	0.701	1.00
137_V	143_S	0.698	1.00
14_V	134_V	0.698	1.00
26_G	45_L	0.697	1.00
18_N	47_D	0.697	1.00
221_A	230_A	0.697	1.00
138_A	141_H	0.692	1.00
188_G	192_T	0.691	1.00
101_T	107_D	0.689	1.00
270_L	281_V	0.688	1.00
68_K	202_N	0.684	1.00
226_D	251_E	0.683	1.00
170_S	173_G	0.683	1.00
141_H	144_P	0.681	1.00
111_T	114_L	0.678	1.00
267_I	279_V	0.672	1.00
29_W	32_T	0.671	1.00
124_A	161_S	0.671	1.00
254_M	259_A	0.671	1.00
252_G	286_K	0.668	1.00
134_V	149_T	0.668	1.00
212_D	235_A	0.668	1.00
237_Y	242_I	0.667	1.00
191_H	194_Y	0.666	1.00
14_V	149_T	0.662	1.00
43_N	88_V	0.662	1.00
202_N	210_P	0.660	1.00
50_Y	87_G	0.659	1.00
120_L	123_T	0.656	1.00
12_A	15_L	0.655	1.00
51_S	149_T	0.655	1.00
131_Y	135_L	0.653	0.99
10_V	137_V	0.652	0.99
50_Y	54_V	0.651	0.99
55_L	59_Y	0.649	0.99
259_A	285_P	0.646	0.99
81_S	145_A	0.646	0.99
245_S	278_D	0.641	0.99
271_E	277_D	0.641	0.99
92_G	193_G	0.636	0.99
82_L	200_N	0.633	0.99
147_R	151_L	0.631	0.99
14_V	153_N	0.627	0.99
126_A	130_L	0.626	0.99
77_E	143_S	0.625	0.99
14_V	51_S	0.624	0.99
265_D	268_L	0.622	0.99
127_K	134_V	0.617	0.99
99_A	186_A	0.616	0.99
267_I	271_E	0.615	0.99
81_S	196_I	0.613	0.99
227_V	230_A	0.609	0.99
16_A	19_L	0.609	0.99
27_A	30_W	0.606	0.99
259_A	262_I	0.606	0.99
10_V	136_G	0.606	0.99
108_Y	175_P	0.605	0.99
163_A	166_G	0.602	0.99
25_K	40_E	0.602	0.99
128_Y	157_I	0.602	0.99
127_K	153_N	0.600	0.99
45_L	49_A	0.600	0.99
21_L	130_L	0.595	0.99
130_L	133_Y	0.590	0.99
79_F	201_V	0.587	0.99
144_P	199_D	0.586	0.99
37_V	120_L	0.584	0.99
184_V	188_G	0.584	0.99
59_Y	63_Q	0.581	0.99
262_I	266_L	0.580	0.99
160_A	163_A	0.579	0.99
258_E	265_D	0.577	0.99
233_V	244_V	0.575	0.99
99_A	179_P	0.574	0.99
110_P	113_G	0.572	0.99
142_R	275_E	0.569	0.99
93_G	190_L	0.565	0.99
225_P	265_D	0.564	0.99
248_V	283_V	0.562	0.99
122_G	126_A	0.560	0.98
50_Y	152_D	0.559	0.98
261_D	264_T	0.558	0.98
260_H	264_T	0.556	0.98
237_Y	240_P	0.554	0.98
91_A	94_A	0.553	0.98
70_P	234_V	0.553	0.98
209_P	214_R	0.552	0.98
138_A	143_S	0.551	0.98
250_V	254_M	0.551	0.98
221_A	248_V	0.549	0.98
33_G	107_D	0.546	0.98
147_R	150_A	0.545	0.98
20_A	24_A	0.544	0.98
162_A	185_V	0.544	0.98
188_G	191_H	0.543	0.98
15_L	51_S	0.542	0.98
81_S	200_N	0.541	0.98
85_A	200_N	0.541	0.98
221_A	224_N	0.541	0.98
90_A	93_G	0.540	0.98
134_V	153_N	0.539	0.98
208_A	237_Y	0.537	0.98
113_G	170_S	0.537	0.98
208_A	235_A	0.537	0.98
13_L	16_A	0.536	0.98
21_L	24_A	0.536	0.98
152_D	155_N	0.536	0.98
18_N	127_K	0.533	0.98
168_L	177_L	0.531	0.98
133_Y	137_V	0.530	0.98
172_T	177_L	0.529	0.98
158_L	161_S	0.529	0.98
76_I	80_V	0.529	0.98
88_V	153_N	0.527	0.98
139_A	147_R	0.526	0.98
35_L	38_G	0.525	0.98
18_N	48_V	0.523	0.98
186_A	193_G	0.521	0.98
49_A	52_L	0.520	0.98
190_L	194_Y	0.520	0.98
226_D	266_L	0.517	0.97
71_H	234_V	0.517	0.97
64_P	73_H	0.516	0.97
11_G	15_L	0.516	0.97
25_K	123_T	0.516	0.97
131_Y	153_N	0.512	0.97
26_G	42_I	0.512	0.97
179_P	182_A	0.507	0.97
11_G	54_V	0.505	0.97
67_F	214_R	0.505	0.97
271_E	274_P	0.503	0.97
118_G	125_V	0.503	0.97
22_V	42_I	0.503	0.97
159_T	166_G	0.503	0.97
181_A	184_V	0.502	0.97
69_H	207_A	0.502	0.97
37_V	88_V	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j1zP	8	0.9766	100	0.102	Contact Map
3h90A	3	0.9465	100	0.129	Contact Map
3bypA	2	0.2676	99.5	0.759	Contact Map
2zztA	2	0.2676	99.5	0.761	Contact Map
3w61A	2	0.2642	99.3	0.779	Contact Map
3cq1A	2	0.3177	50.1	0.942	Contact Map
3lnoA	1	0.3043	46.6	0.944	Contact Map
2zbcA	6	0.2709	46.2	0.944	Contact Map
1uwdA	1	0.3211	37.6	0.947	Contact Map
2cviA	2	0.2776	34.4	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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