Q9HP05 - HALSA - GREMLIN Contacts

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Q9HP05 - Histidine triad protein

UniProt:	Q9HP05	Sequences: MEQVFAPWRIEWVERDDTTDDDVDCVFCAFPGREHARQHLVVARTDHAAVMLNNYPYNPGHCMVIPDVHTGDYGDLDADTLLDHARLKQATLDALDAALGPDAFNTGLNLGGGAAGGSIGDHLHTHVVPRWNGDTNFMPVISDTKVIVEALDDTYDRLHDAFLARPDATEAPTGAVFVDFN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	181 (139)
Sequences:	1983 (1386)
Seq/√Len:	117.5

ECOLI - HINT
BACSU - HIT
HALSA - Q9HP05 Q9HNA0
SULSO - Q980P0 YHIT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
25_C	28_C	4.410	1.00
28_C	69_H	3.846	1.00
25_C	69_H	3.795	1.00
68_V	80_T	3.435	1.00
48_A	87_L	3.433	1.00
45_T	83_D	3.092	1.00
88_K	125_T	2.773	1.00
77_D	80_T	2.589	1.00
78_A	86_R	2.532	1.00
44_R	67_D	2.395	1.00
78_A	89_Q	2.198	1.00
155_Y	159_H	2.077	1.00
82_L	86_R	1.971	1.00
68_V	77_D	1.956	1.00
47_H	83_D	1.939	1.00
62_C	91_T	1.882	1.00
40_L	152_D	1.647	1.00
105_N	130_R	1.611	1.00
64_V	127_V	1.566	1.00
76_L	123_L	1.550	1.00
81_L	89_Q	1.541	1.00
149_E	157_R	1.538	1.00
72_D	75_D	1.531	1.00
94_A	98_A	1.490	1.00
42_V	62_C	1.485	1.00
27_F	119_I	1.483	1.00
88_K	106_T	1.443	1.00
64_V	88_K	1.432	1.00
73_Y	85_A	1.426	1.00
84_H	125_T	1.407	1.00
51_M	65_I	1.381	1.00
41_V	49_A	1.366	1.00
74_G	96_D	1.360	1.00
70_T	77_D	1.358	1.00
108_L	125_T	1.357	1.00
50_V	87_L	1.352	1.00
48_A	84_H	1.315	1.00
105_N	109_N	1.313	1.00
96_D	104_F	1.307	1.00
62_C	95_L	1.293	1.00
30_F	39_H	1.293	1.00
95_L	158_L	1.284	1.00
43_A	87_L	1.266	0.99
98_A	161_A	1.255	0.99
146_V	151_L	1.247	0.99
58_N	131_W	1.234	0.99
85_A	125_T	1.232	0.99
105_N	115_A	1.194	0.99
26_V	119_I	1.188	0.99
73_Y	106_T	1.184	0.99
111_G	115_A	1.182	0.99
49_A	67_D	1.164	0.99
102_D	132_N	1.160	0.99
156_D	160_D	1.156	0.99
49_A	65_I	1.144	0.99
153_D	157_R	1.134	0.99
33_R	41_V	1.104	0.99
89_Q	93_D	1.101	0.98
35_H	38_Q	1.084	0.98
33_R	39_H	1.079	0.98
81_L	85_A	1.077	0.98
52_L	151_L	1.057	0.98
153_D	156_D	1.036	0.98
97_A	161_A	1.035	0.98
40_L	148_V	1.033	0.98
91_T	162_F	1.032	0.98
48_A	83_D	1.020	0.98
83_D	87_L	1.008	0.97
31_P	67_D	0.995	0.97
43_A	90_A	0.991	0.97
101_P	111_G	0.979	0.97
29_A	34_E	0.970	0.97
72_D	96_D	0.968	0.97
99_L	154_T	0.967	0.97
92_L	106_T	0.963	0.96
39_H	49_A	0.956	0.96
71_G	111_G	0.949	0.96
41_V	67_D	0.943	0.96
114_A	132_N	0.940	0.96
52_L	62_C	0.924	0.96
71_G	75_D	0.900	0.95
92_L	96_D	0.897	0.95
50_V	62_C	0.897	0.95
71_G	121_D	0.893	0.95
70_T	76_L	0.887	0.94
57_Y	107_G	0.885	0.94
30_F	65_I	0.883	0.94
72_D	111_G	0.879	0.94
30_F	51_M	0.876	0.94
74_G	92_L	0.875	0.94
110_L	117_G	0.865	0.94
43_A	162_F	0.861	0.94
47_H	79_D	0.858	0.93
41_V	44_R	0.856	0.93
136_N	141_I	0.853	0.93
138_M	141_I	0.851	0.93
106_T	125_T	0.844	0.93
57_Y	118_S	0.835	0.92
130_R	134_D	0.834	0.92
50_V	91_T	0.825	0.92
59_P	150_A	0.825	0.92
29_A	32_G	0.818	0.92
102_D	114_A	0.812	0.91
84_H	123_L	0.810	0.91
94_A	162_F	0.805	0.91
45_T	87_L	0.805	0.91
151_L	155_Y	0.801	0.91
26_V	29_A	0.794	0.90
138_M	146_V	0.793	0.90
146_V	154_T	0.783	0.90
96_D	111_G	0.783	0.90
52_L	99_L	0.780	0.90
78_A	82_L	0.779	0.90
152_D	156_D	0.767	0.89
40_L	54_N	0.764	0.89
150_A	153_D	0.761	0.88
35_H	39_H	0.754	0.88
52_L	154_T	0.753	0.88
76_L	84_H	0.748	0.88
76_L	81_L	0.746	0.87
70_T	75_D	0.741	0.87
117_G	121_D	0.739	0.87
137_F	140_V	0.738	0.87
149_E	153_D	0.732	0.87
58_N	128_V	0.728	0.86
30_F	33_R	0.724	0.86
40_L	52_L	0.721	0.86
95_L	127_V	0.710	0.85
34_E	38_Q	0.708	0.85
23_V	29_A	0.705	0.84
107_G	136_N	0.700	0.84
26_V	30_F	0.697	0.84
85_A	89_Q	0.696	0.84
97_A	160_D	0.691	0.83
29_A	33_R	0.685	0.83
155_Y	158_L	0.669	0.81
31_P	35_H	0.667	0.81
92_L	110_L	0.661	0.80
103_A	114_A	0.658	0.80
74_G	93_D	0.653	0.80
70_T	80_T	0.653	0.80
85_A	108_L	0.652	0.79
107_G	128_V	0.649	0.79
115_A	118_S	0.645	0.79
63_M	138_M	0.639	0.78
76_L	80_T	0.638	0.78
159_H	163_L	0.631	0.77
70_T	123_L	0.630	0.77
90_A	94_A	0.626	0.77
42_V	159_H	0.621	0.76
113_G	132_N	0.621	0.76
152_D	159_H	0.620	0.76
52_L	109_N	0.618	0.76
90_A	163_L	0.616	0.76
108_L	123_L	0.614	0.75
22_D	29_A	0.611	0.75
59_P	99_L	0.610	0.75
42_V	155_Y	0.607	0.74
43_A	48_A	0.605	0.74
35_H	44_R	0.600	0.74
86_R	90_A	0.595	0.73
99_L	157_R	0.592	0.73
157_R	160_D	0.586	0.72
88_K	95_L	0.585	0.72
85_A	88_K	0.581	0.71
128_V	140_V	0.579	0.71
103_A	117_G	0.578	0.71
116_G	139_P	0.578	0.71
64_V	87_L	0.574	0.70
136_N	139_P	0.572	0.70
92_L	104_F	0.571	0.70
50_V	162_F	0.569	0.70
142_S	145_K	0.566	0.69
23_V	34_E	0.565	0.69
57_Y	134_D	0.564	0.69
21_D	24_D	0.564	0.69
104_F	114_A	0.558	0.68
42_V	160_D	0.554	0.68
71_G	74_G	0.552	0.67
47_H	80_T	0.547	0.67
40_L	151_L	0.545	0.66
22_D	33_R	0.544	0.66
53_N	109_N	0.543	0.66
94_A	158_L	0.540	0.66
31_P	65_I	0.537	0.65
26_V	35_H	0.537	0.65
43_A	91_T	0.534	0.65
29_A	35_H	0.530	0.64
114_A	133_G	0.526	0.64
130_R	136_N	0.525	0.64
87_L	90_A	0.524	0.63
90_A	162_F	0.523	0.63
31_P	41_V	0.523	0.63
133_G	136_N	0.522	0.63
30_F	54_N	0.520	0.63
27_F	65_I	0.520	0.63
24_D	32_G	0.518	0.63
97_A	100_G	0.516	0.62
101_P	131_W	0.514	0.62
106_T	123_L	0.511	0.61
131_W	134_D	0.510	0.61
135_T	138_M	0.509	0.61
84_H	87_L	0.507	0.61
26_V	51_M	0.505	0.61
118_S	136_N	0.504	0.60
63_M	146_V	0.504	0.60
47_H	73_Y	0.504	0.60
90_A	160_D	0.500	0.60

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3anoA	4	0.9227	100	0.28	Contact Map
3l7xA	2	0.8619	100	0.356	Contact Map
3ksvA	2	0.779	100	0.37	Contact Map
3lb5A	2	0.7569	100	0.392	Contact Map
3imiA	2	0.779	100	0.4	Contact Map
1y23A	2	0.768	100	0.409	Contact Map
2eo4A	2	0.8011	100	0.417	Contact Map
3o0mA	2	0.7624	100	0.421	Contact Map
1emsA	3	0.8066	100	0.432	Contact Map
3r6fA	2	0.7182	100	0.436	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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