GREMLIN Database
Q9HP05 - Histidine triad protein
UniProt: Q9HP05 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (139)
Sequences: 1983 (1386)
Seq/√Len: 117.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_C28_C4.4101.00
28_C69_H3.8461.00
25_C69_H3.7951.00
68_V80_T3.4351.00
48_A87_L3.4331.00
45_T83_D3.0921.00
88_K125_T2.7731.00
77_D80_T2.5891.00
78_A86_R2.5321.00
44_R67_D2.3951.00
78_A89_Q2.1981.00
155_Y159_H2.0771.00
82_L86_R1.9711.00
68_V77_D1.9561.00
47_H83_D1.9391.00
62_C91_T1.8821.00
40_L152_D1.6471.00
105_N130_R1.6111.00
64_V127_V1.5661.00
76_L123_L1.5501.00
81_L89_Q1.5411.00
149_E157_R1.5381.00
72_D75_D1.5311.00
94_A98_A1.4901.00
42_V62_C1.4851.00
27_F119_I1.4831.00
88_K106_T1.4431.00
64_V88_K1.4321.00
73_Y85_A1.4261.00
84_H125_T1.4071.00
51_M65_I1.3811.00
41_V49_A1.3661.00
74_G96_D1.3601.00
70_T77_D1.3581.00
108_L125_T1.3571.00
50_V87_L1.3521.00
48_A84_H1.3151.00
105_N109_N1.3131.00
96_D104_F1.3071.00
62_C95_L1.2931.00
30_F39_H1.2931.00
95_L158_L1.2841.00
43_A87_L1.2660.99
98_A161_A1.2550.99
146_V151_L1.2470.99
58_N131_W1.2340.99
85_A125_T1.2320.99
105_N115_A1.1940.99
26_V119_I1.1880.99
73_Y106_T1.1840.99
111_G115_A1.1820.99
49_A67_D1.1640.99
102_D132_N1.1600.99
156_D160_D1.1560.99
49_A65_I1.1440.99
153_D157_R1.1340.99
33_R41_V1.1040.99
89_Q93_D1.1010.98
35_H38_Q1.0840.98
33_R39_H1.0790.98
81_L85_A1.0770.98
52_L151_L1.0570.98
153_D156_D1.0360.98
97_A161_A1.0350.98
40_L148_V1.0330.98
91_T162_F1.0320.98
48_A83_D1.0200.98
83_D87_L1.0080.97
31_P67_D0.9950.97
43_A90_A0.9910.97
101_P111_G0.9790.97
29_A34_E0.9700.97
72_D96_D0.9680.97
99_L154_T0.9670.97
92_L106_T0.9630.96
39_H49_A0.9560.96
71_G111_G0.9490.96
41_V67_D0.9430.96
114_A132_N0.9400.96
52_L62_C0.9240.96
71_G75_D0.9000.95
92_L96_D0.8970.95
50_V62_C0.8970.95
71_G121_D0.8930.95
70_T76_L0.8870.94
57_Y107_G0.8850.94
30_F65_I0.8830.94
72_D111_G0.8790.94
30_F51_M0.8760.94
74_G92_L0.8750.94
110_L117_G0.8650.94
43_A162_F0.8610.94
47_H79_D0.8580.93
41_V44_R0.8560.93
136_N141_I0.8530.93
138_M141_I0.8510.93
106_T125_T0.8440.93
57_Y118_S0.8350.92
130_R134_D0.8340.92
50_V91_T0.8250.92
59_P150_A0.8250.92
29_A32_G0.8180.92
102_D114_A0.8120.91
84_H123_L0.8100.91
94_A162_F0.8050.91
45_T87_L0.8050.91
151_L155_Y0.8010.91
26_V29_A0.7940.90
138_M146_V0.7930.90
146_V154_T0.7830.90
96_D111_G0.7830.90
52_L99_L0.7800.90
78_A82_L0.7790.90
152_D156_D0.7670.89
40_L54_N0.7640.89
150_A153_D0.7610.88
35_H39_H0.7540.88
52_L154_T0.7530.88
76_L84_H0.7480.88
76_L81_L0.7460.87
70_T75_D0.7410.87
117_G121_D0.7390.87
137_F140_V0.7380.87
149_E153_D0.7320.87
58_N128_V0.7280.86
30_F33_R0.7240.86
40_L52_L0.7210.86
95_L127_V0.7100.85
34_E38_Q0.7080.85
23_V29_A0.7050.84
107_G136_N0.7000.84
26_V30_F0.6970.84
85_A89_Q0.6960.84
97_A160_D0.6910.83
29_A33_R0.6850.83
155_Y158_L0.6690.81
31_P35_H0.6670.81
92_L110_L0.6610.80
103_A114_A0.6580.80
74_G93_D0.6530.80
70_T80_T0.6530.80
85_A108_L0.6520.79
107_G128_V0.6490.79
115_A118_S0.6450.79
63_M138_M0.6390.78
76_L80_T0.6380.78
159_H163_L0.6310.77
70_T123_L0.6300.77
90_A94_A0.6260.77
42_V159_H0.6210.76
113_G132_N0.6210.76
152_D159_H0.6200.76
52_L109_N0.6180.76
90_A163_L0.6160.76
108_L123_L0.6140.75
22_D29_A0.6110.75
59_P99_L0.6100.75
42_V155_Y0.6070.74
43_A48_A0.6050.74
35_H44_R0.6000.74
86_R90_A0.5950.73
99_L157_R0.5920.73
157_R160_D0.5860.72
88_K95_L0.5850.72
85_A88_K0.5810.71
128_V140_V0.5790.71
103_A117_G0.5780.71
116_G139_P0.5780.71
64_V87_L0.5740.70
136_N139_P0.5720.70
92_L104_F0.5710.70
50_V162_F0.5690.70
142_S145_K0.5660.69
23_V34_E0.5650.69
57_Y134_D0.5640.69
21_D24_D0.5640.69
104_F114_A0.5580.68
42_V160_D0.5540.68
71_G74_G0.5520.67
47_H80_T0.5470.67
40_L151_L0.5450.66
22_D33_R0.5440.66
53_N109_N0.5430.66
94_A158_L0.5400.66
31_P65_I0.5370.65
26_V35_H0.5370.65
43_A91_T0.5340.65
29_A35_H0.5300.64
114_A133_G0.5260.64
130_R136_N0.5250.64
87_L90_A0.5240.63
90_A162_F0.5230.63
31_P41_V0.5230.63
133_G136_N0.5220.63
30_F54_N0.5200.63
27_F65_I0.5200.63
24_D32_G0.5180.63
97_A100_G0.5160.62
101_P131_W0.5140.62
106_T123_L0.5110.61
131_W134_D0.5100.61
135_T138_M0.5090.61
84_H87_L0.5070.61
26_V51_M0.5050.61
118_S136_N0.5040.60
63_M146_V0.5040.60
47_H73_Y0.5040.60
90_A160_D0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3anoA 4 0.9227 100 0.28 Contact Map
3l7xA 2 0.8619 100 0.356 Contact Map
3ksvA 2 0.779 100 0.37 Contact Map
3lb5A 2 0.7569 100 0.392 Contact Map
3imiA 2 0.779 100 0.4 Contact Map
1y23A 2 0.768 100 0.409 Contact Map
2eo4A 2 0.8011 100 0.417 Contact Map
3o0mA 2 0.7624 100 0.421 Contact Map
1emsA 3 0.8066 100 0.432 Contact Map
3r6fA 2 0.7182 100 0.436 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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