GREMLIN Database
Q9HP03 - Methionine aminopeptidase
UniProt: Q9HP03 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (224)
Sequences: 7554 (4406)
Seq/√Len: 294.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_Q147_E3.0341.00
48_E52_E2.7891.00
32_R45_F2.7721.00
112_P116_E2.6701.00
124_A127_D2.6181.00
124_A145_V2.5611.00
47_E51_R2.5451.00
38_T80_T2.4911.00
186_V230_D2.4811.00
146_V196_V2.3951.00
83_G110_G2.2741.00
117_A149_Y2.2631.00
24_T53_L2.2241.00
107_D115_V2.1851.00
28_E31_D2.1601.00
116_E120_E2.1561.00
25_V49_R2.1291.00
22_L102_A2.0291.00
15_Y189_V2.0131.00
14_Q96_D1.9981.00
17_E20_D1.9731.00
157_L211_I1.9661.00
197_T219_T1.9141.00
119_E123_A1.9061.00
49_R53_L1.9031.00
28_E49_R1.8851.00
186_V213_E1.8821.00
140_A144_D1.8421.00
129_V228_L1.8171.00
44_S48_E1.8131.00
49_R52_E1.8051.00
120_E124_A1.7921.00
121_S146_V1.7341.00
158_T172_T1.7271.00
22_L100_A1.6821.00
145_V149_Y1.6761.00
16_V217_S1.6511.00
113_E149_Y1.6481.00
28_E45_F1.6411.00
121_S145_V1.6161.00
12_Y210_E1.6161.00
28_E32_R1.6051.00
29_A46_A1.5831.00
17_E95_V1.5821.00
140_A177_G1.5661.00
40_L44_S1.5411.00
156_N201_G1.5171.00
45_F48_E1.5071.00
43_A47_E1.5071.00
20_D24_T1.4871.00
17_E96_D1.4801.00
26_L102_A1.4761.00
63_I87_V1.4751.00
67_E212_Y1.4731.00
131_P186_V1.4731.00
94_H99_I1.4621.00
35_V83_G1.4491.00
40_L76_A1.4431.00
128_M133_V1.4281.00
7_V169_T1.4271.00
8_G11_A1.4061.00
22_L93_V1.4001.00
66_N85_D1.3891.00
34_T37_A1.3871.00
157_L205_E1.3841.00
83_G109_S1.3821.00
46_A61_V1.3821.00
98_H164_V1.3821.00
152_N197_T1.3801.00
30_A106_V1.3761.00
113_E117_A1.3511.00
198_T217_S1.3271.00
38_T41_E1.3241.00
18_A100_A1.3121.00
11_A164_V1.3091.00
111_T198_T1.3051.00
154_V197_T1.3041.00
184_L190_V1.3001.00
120_E145_V1.2911.00
136_G181_G1.2811.00
68_E79_D1.2771.00
144_D148_A1.2741.00
65_V79_D1.2711.00
45_F49_R1.2671.00
116_E119_E1.2641.00
128_M141_E1.2541.00
13_E17_E1.2501.00
125_A141_E1.2461.00
69_A203_V1.2451.00
115_V222_D1.2411.00
24_T49_R1.2381.00
21_I93_V1.2131.00
9_S13_E1.2091.00
123_A127_D1.1841.00
88_C103_A1.1731.00
30_A104_T1.1501.00
134_Q137_A1.1421.00
68_E207_A1.1401.00
21_I95_V1.1181.00
198_T218_G1.1151.00
14_Q17_E1.1121.00
130_E133_V1.1101.00
21_I55_G1.1041.00
129_V192_I1.1031.00
61_V87_V1.0991.00
75_G79_D1.0871.00
26_L106_V1.0801.00
33_V42_V1.0781.00
177_G181_G1.0771.00
56_E94_H1.0761.00
136_G177_G1.0651.00
205_E211_I1.0591.00
189_V227_Q1.0531.00
21_I53_L1.0511.00
10_D13_E1.0491.00
124_A128_M1.0361.00
33_V108_L1.0361.00
151_Y198_T1.0291.00
81_E108_L1.0271.00
125_A128_M1.0051.00
113_E116_E1.0031.00
41_E44_S0.9971.00
37_A41_E0.9921.00
134_Q183_E0.9881.00
82_F85_D0.9851.00
92_G167_A0.9831.00
135_T184_L0.9801.00
11_A98_H0.9781.00
15_Y19_G0.9761.00
21_I97_G0.9761.00
114_L118_A0.9671.00
65_V87_V0.9641.00
122_L126_I0.9631.00
90_D101_D0.9611.00
28_E52_E0.9551.00
117_A145_V0.9501.00
51_R56_E0.9491.00
16_V20_D0.9451.00
135_T182_A0.9441.00
24_T28_E0.9411.00
99_I167_A0.9291.00
111_T151_Y0.9231.00
125_A138_L0.9231.00
50_I93_V0.9111.00
42_V61_V0.9101.00
10_D14_Q0.9041.00
27_S104_T0.9041.00
107_D112_P0.8991.00
122_L224_R0.8931.00
12_Y227_Q0.8891.00
25_V93_V0.8741.00
120_E149_Y0.8721.00
84_E108_L0.8701.00
37_A45_F0.8671.00
161_G171_P0.8661.00
105_T222_D0.8631.00
200_T217_S0.8391.00
158_T174_P0.8281.00
60_P73_A0.8251.00
6_T185_A0.8251.00
28_E53_L0.8251.00
71_H168_H0.8171.00
139_G143_Q0.8151.00
124_A144_D0.8131.00
114_L201_G0.8121.00
192_I209_T0.8101.00
155_V176_R0.8101.00
107_D110_G0.8091.00
146_V153_P0.8091.00
114_L151_Y0.8031.00
75_G78_D0.8011.00
205_E224_R0.7900.99
46_A50_I0.7840.99
44_S76_A0.7810.99
9_S186_V0.7790.99
204_T212_Y0.7760.99
13_E16_V0.7710.99
15_Y162_M0.7670.99
141_E145_V0.7660.99
144_D177_G0.7630.99
35_V108_L0.7620.99
138_L184_L0.7610.99
129_V211_I0.7600.99
162_M191_A0.7560.99
40_L43_A0.7550.99
40_L75_G0.7500.99
92_G100_A0.7490.99
15_Y164_V0.7490.99
117_A120_E0.7470.99
124_A141_E0.7450.99
67_E216_S0.7430.99
199_G202_K0.7420.99
75_G80_T0.7370.99
32_R37_A0.7370.99
84_E109_S0.7360.99
22_L26_L0.7300.99
90_D160_H0.7290.99
48_E51_R0.7280.99
166_D169_T0.7270.99
114_L198_T0.7260.99
50_I91_V0.7220.99
133_V137_A0.7220.99
135_T173_V0.7200.99
115_V224_R0.7200.99
140_A181_G0.7160.99
133_V141_E0.7160.99
12_Y189_V0.7150.99
26_L91_V0.7130.99
14_Q98_H0.7110.99
27_S31_D0.7110.99
136_G179_D0.7110.99
19_G23_T0.7110.99
155_V201_G0.7070.99
37_A42_V0.7030.99
118_A220_V0.7020.99
191_A208_A0.7020.99
156_N203_V0.7010.99
58_A99_I0.6990.99
32_R49_R0.6930.99
29_A89_L0.6880.98
47_E57_P0.6870.98
118_A196_V0.6870.98
175_N191_A0.6860.98
25_V29_A0.6830.98
23_T27_S0.6810.98
120_E148_A0.6810.98
55_G95_V0.6750.98
182_A188_D0.6740.98
129_V184_L0.6720.98
86_M105_T0.6700.98
29_A42_V0.6700.98
136_G180_S0.6670.98
42_V89_L0.6670.98
202_K206_G0.6650.98
70_S157_L0.6630.98
39_H81_E0.6630.98
191_A221_R0.6540.98
42_V46_A0.6540.98
39_H75_G0.6530.98
61_V91_V0.6430.98
204_T216_S0.6420.98
137_A141_E0.6410.98
202_K205_E0.6380.98
6_T188_D0.6370.98
128_M131_P0.6360.97
177_G180_S0.6350.97
18_A95_V0.6330.97
137_A177_G0.6320.97
22_L91_V0.6270.97
113_E151_Y0.6260.97
29_A45_F0.6250.97
136_G178_V0.6230.97
7_V189_V0.6200.97
7_V15_Y0.6170.97
44_S47_E0.6150.97
122_L192_I0.6150.97
55_G93_V0.6140.97
101_D193_E0.6130.97
42_V81_E0.6110.97
151_Y196_V0.6090.97
117_A151_Y0.6060.97
7_V163_D0.6050.97
33_V37_A0.6040.97
212_Y215_V0.6040.97
35_V80_T0.6020.97
7_V11_A0.6010.96
162_M225_A0.6000.96
135_T174_P0.5910.96
62_N67_E0.5910.96
42_V87_V0.5900.96
117_A196_V0.5900.96
40_L47_E0.5890.96
54_G95_V0.5890.96
99_I162_M0.5880.96
175_N221_R0.5870.96
63_I89_L0.5860.96
51_R57_P0.5810.96
125_A142_I0.5790.96
27_S30_A0.5790.96
162_M189_V0.5760.96
25_V46_A0.5750.95
54_G57_P0.5730.95
117_A146_V0.5720.95
19_G100_A0.5680.95
137_A179_D0.5680.95
18_A93_V0.5680.95
32_R42_V0.5680.95
137_A140_A0.5670.95
104_T115_V0.5670.95
92_G103_A0.5650.95
90_D193_E0.5610.95
39_H63_I0.5600.95
63_I85_D0.5530.94
126_I192_I0.5530.94
33_V89_L0.5500.94
104_T224_R0.5480.94
125_A133_V0.5480.94
17_E21_I0.5480.94
69_A195_F0.5470.94
24_T52_E0.5460.94
182_A185_A0.5460.94
204_T214_V0.5450.94
41_E45_F0.5400.94
26_L30_A0.5400.94
122_L222_D0.5350.93
29_A32_R0.5340.93
9_S187_G0.5330.93
15_Y99_I0.5330.93
32_R41_E0.5310.93
37_A81_E0.5310.93
94_H167_A0.5290.93
135_T138_L0.5270.93
68_E212_Y0.5250.93
132_G183_E0.5240.93
71_H90_D0.5230.93
63_I81_E0.5220.93
134_Q182_A0.5200.92
138_L141_E0.5200.92
79_D82_F0.5200.92
146_V152_N0.5190.92
164_V169_T0.5170.92
199_G205_E0.5160.92
145_V148_A0.5150.92
160_H193_E0.5150.92
129_V138_L0.5140.92
157_L203_V0.5130.92
126_I224_R0.5130.92
136_G140_A0.5120.92
79_D85_D0.5100.92
33_V106_V0.5080.92
7_V12_Y0.5070.91
153_P196_V0.5070.91
161_G169_T0.5040.91
101_D160_H0.5000.91
163_D169_T0.5000.91
19_G225_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fm3A 1 1 100 0.168 Contact Map
1xgsA 2 0.9696 100 0.169 Contact Map
4ipaA 1 0.9966 100 0.171 Contact Map
1b6aA 1 0.9696 100 0.182 Contact Map
2q8kA 1 0.9899 100 0.246 Contact Map
4b6at 1 0.8919 100 0.255 Contact Map
3ctzA 2 0.9257 100 0.362 Contact Map
4s2rP 2 0.9223 100 0.362 Contact Map
4fo7A 3 0.7905 100 0.388 Contact Map
1wn1A 2 0.7534 100 0.39 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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