GREMLIN Database
Q9HP02 - Spermidine/putrescine ABC transporter permease
UniProt: Q9HP02 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (251)
Sequences: 69136 (44678)
Seq/√Len: 2820.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_V185_D3.9661.00
70_A74_T3.1811.00
173_R182_A3.0661.00
158_S162_A2.9711.00
67_G70_A2.6161.00
68_S226_E2.5901.00
37_S56_Y2.5461.00
96_R169_A2.5341.00
178_S181_V2.5021.00
172_A182_A2.4871.00
160_R194_A2.4841.00
82_L146_A2.4721.00
78_L142_V2.4581.00
169_A187_T2.4101.00
221_D229_A2.3931.00
57_Q61_Q2.3891.00
66_L70_A2.3541.00
54_A57_Q2.3111.00
179_P182_A2.2991.00
80_S199_F2.2751.00
180_L184_R2.2141.00
235_T238_K2.2031.00
157_V195_V2.1951.00
54_A58_A2.1911.00
177_A181_V2.0241.00
181_V184_R2.0081.00
88_V183_F1.9511.00
74_T138_F1.9091.00
35_V39_A1.9051.00
95_V162_A1.8981.00
153_V198_G1.8921.00
161_L191_I1.8851.00
168_L190_A1.8711.00
172_A177_A1.8671.00
88_V191_I1.7921.00
106_R158_S1.7881.00
99_V102_S1.7871.00
84_T199_F1.7491.00
31_V35_V1.7421.00
67_G71_N1.7311.00
173_R179_P1.7291.00
169_A182_A1.6971.00
58_A238_K1.6841.00
76_A203_W1.6791.00
255_A259_T1.6721.00
87_G153_V1.6441.00
74_T78_L1.6301.00
79_A206_S1.6201.00
226_E230_L1.6061.00
90_A154_V1.5991.00
169_A173_R1.5901.00
88_V157_V1.5871.00
138_F220_T1.5381.00
34_I244_T1.5141.00
94_L154_V1.5081.00
166_D169_A1.4701.00
58_A61_Q1.4561.00
16_S20_V1.4481.00
101_L104_A1.4331.00
153_V202_A1.4261.00
28_L32_V1.4251.00
64_A67_G1.3861.00
210_F214_Y1.3841.00
75_I222_V1.3721.00
85_A89_P1.3651.00
32_V36_L1.3651.00
188_L195_V1.3631.00
95_V158_S1.3581.00
98_D102_S1.3491.00
52_T55_H1.3481.00
53_L57_Q1.3421.00
91_S157_V1.3391.00
197_S201_F1.3351.00
161_L187_T1.3341.00
83_A202_A1.3291.00
217_S220_T1.3271.00
221_D226_E1.3121.00
166_D170_D1.2841.00
157_V198_G1.2751.00
96_R166_D1.2561.00
172_A186_V1.2561.00
210_F228_Y1.2391.00
230_L233_Y1.2331.00
167_T170_D1.2311.00
144_T216_V1.2311.00
88_V195_V1.2271.00
104_A107_V1.1991.00
92_V161_L1.1961.00
128_I140_P1.1931.00
20_V24_A1.1791.00
81_V85_A1.1701.00
212_R216_V1.1701.00
178_S182_A1.1621.00
137_G220_T1.1601.00
43_A50_G1.1581.00
84_T195_V1.1571.00
71_N74_T1.1521.00
78_L81_V1.1501.00
164_V190_A1.1451.00
230_L235_T1.1351.00
11_L15_L1.1281.00
33_I244_T1.1211.00
192_A196_A1.1171.00
72_S223_L1.1041.00
150_L154_V1.0911.00
104_A108_A1.0881.00
13_H17_A1.0781.00
157_V194_A1.0571.00
141_T213_A1.0571.00
142_V146_A1.0531.00
40_E43_A1.0441.00
259_T262_D1.0411.00
222_V225_T1.0401.00
82_L142_V1.0381.00
60_L66_L1.0311.00
13_H16_S1.0281.00
169_A179_P1.0271.00
32_V35_V1.0251.00
95_V161_L1.0231.00
256_V260_A1.0211.00
78_L82_L1.0191.00
92_V183_F1.0111.00
139_V143_L1.0061.00
156_L198_G1.0061.00
126_I130_T1.0021.00
190_A193_P0.9991.00
79_A83_A0.9981.00
213_A222_V0.9971.00
79_A145_H0.9941.00
73_A77_T0.9851.00
92_V179_P0.9831.00
89_P93_A0.9811.00
138_F142_V0.9801.00
221_D225_T0.9741.00
209_E212_R0.9731.00
177_A182_A0.9711.00
102_S162_A0.9591.00
182_A185_D0.9561.00
226_E242_I0.9531.00
55_H237_P0.9491.00
56_Y244_T0.9481.00
81_V199_F0.9381.00
69_V223_L0.9371.00
58_A62_D0.9371.00
74_T139_V0.9261.00
226_E229_A0.9251.00
79_A142_V0.9221.00
209_E213_A0.9201.00
12_G16_S0.9191.00
71_N138_F0.9191.00
74_T77_T0.9151.00
134_I139_V0.9071.00
124_V216_V0.9061.00
77_T81_V0.9031.00
23_L27_W0.9011.00
36_L240_N0.8981.00
65_L242_I0.8971.00
91_S95_V0.8951.00
231_L239_L0.8951.00
191_I194_A0.8881.00
100_P103_N0.8871.00
214_Y225_T0.8851.00
59_T245_L0.8851.00
15_L19_T0.8831.00
87_G154_V0.8741.00
69_V73_A0.8731.00
139_V142_V0.8711.00
144_T212_R0.8701.00
256_V259_T0.8671.00
39_A43_A0.8641.00
192_A195_V0.8641.00
183_F188_L0.8581.00
153_V157_V0.8571.00
117_G148_Y0.8551.00
75_I138_F0.8501.00
133_G136_P0.8481.00
184_R188_L0.8481.00
110_V155_L0.8471.00
160_R191_I0.8451.00
145_H206_S0.8451.00
182_A187_T0.8431.00
83_A87_G0.8431.00
157_V191_I0.8391.00
230_L242_I0.8351.00
94_L106_R0.8221.00
202_A206_S0.8221.00
177_A185_D0.8221.00
103_N106_R0.8201.00
93_A99_V0.8181.00
91_S154_V0.8171.00
125_L129_R0.8161.00
230_L238_K0.8151.00
257_A260_A0.8141.00
70_A73_A0.8121.00
124_V144_T0.8081.00
229_A232_A0.8051.00
82_L85_A0.8041.00
78_L146_A0.8011.00
252_V256_V0.7991.00
91_S161_L0.7781.00
36_L39_A0.7751.00
62_D66_L0.7671.00
75_I145_H0.7671.00
28_L31_V0.7631.00
83_A149_G0.7621.00
33_I243_A0.7621.00
37_S41_N0.7581.00
33_I240_N0.7561.00
179_P183_F0.7531.00
83_A153_V0.7501.00
137_G140_P0.7491.00
121_G211_V0.7451.00
168_L186_V0.7451.00
58_A235_T0.7431.00
121_G215_F0.7421.00
40_E50_G0.7411.00
183_F187_T0.7401.00
80_S203_W0.7391.00
84_T157_V0.7391.00
40_E49_T0.7381.00
94_L158_S0.7291.00
238_K242_I0.7251.00
44_T47_P0.7211.00
55_H58_A0.7211.00
217_S221_D0.7201.00
68_S71_N0.7091.00
149_G202_A0.7071.00
94_L105_F0.7041.00
39_A48_F0.7041.00
14_A18_W0.7041.00
63_G67_G0.7011.00
17_A20_V0.7001.00
42_A45_I0.6991.00
227_M242_I0.6991.00
76_A80_S0.6991.00
87_G157_V0.6981.00
110_V113_M0.6961.00
42_A46_L0.6951.00
43_A49_T0.6941.00
19_T23_L0.6941.00
57_Q60_L0.6901.00
117_G211_V0.6901.00
83_A206_S0.6901.00
141_T217_S0.6881.00
171_A175_L0.6871.00
166_D173_R0.6871.00
157_V161_L0.6861.00
38_V52_T0.6851.00
192_A260_A0.6851.00
250_L254_L0.6831.00
14_A17_A0.6821.00
120_L147_V0.6801.00
223_L246_V0.6801.00
209_E222_V0.6801.00
171_A174_D0.6791.00
22_V26_L0.6781.00
56_Y241_V0.6751.00
195_V198_G0.6741.00
66_L69_V0.6721.00
187_T190_A0.6681.00
225_T229_A0.6671.00
38_V51_V0.6671.00
149_G205_R0.6661.00
164_V191_I0.6651.00
80_S84_T0.6641.00
90_A150_L0.6631.00
140_P144_T0.6611.00
99_V105_F0.6601.00
129_R135_T0.6601.00
126_I129_R0.6581.00
51_V54_A0.6571.00
75_I141_T0.6561.00
93_A97_Y0.6551.00
240_N244_T0.6531.00
90_A109_V0.6521.00
25_V29_P0.6511.00
23_L26_L0.6501.00
41_N45_I0.6481.00
37_S241_V0.6461.00
251_A255_A0.6461.00
72_S224_T0.6461.00
75_I142_V0.6381.00
36_L40_E0.6351.00
136_P219_T0.6311.00
59_T242_I0.6301.00
194_A198_G0.6291.00
195_V199_F0.6271.00
232_A235_T0.6241.00
106_R155_L0.6211.00
86_V146_A0.6201.00
50_G53_L0.6201.00
72_S207_F0.6191.00
141_T145_H0.6111.00
68_S223_L0.6111.00
71_N220_T0.6091.00
224_T246_V0.6081.00
100_P104_A0.6071.00
236_A240_N0.6061.00
53_L56_Y0.6001.00
91_S158_S0.5981.00
83_A146_A0.5971.00
109_V151_P0.5971.00
156_L194_A0.5951.00
211_V215_F0.5921.00
140_P216_V0.5911.00
43_A46_L0.5901.00
118_V215_F0.5901.00
63_G66_L0.5881.00
101_L105_F0.5851.00
246_V250_L0.5831.00
79_A146_A0.5821.00
39_A50_G0.5801.00
18_W22_V0.5791.00
103_N107_V0.5791.00
213_A225_T0.5761.00
196_A199_F0.5751.00
27_W31_V0.5751.00
86_V150_L0.5741.00
205_R208_E0.5731.00
204_V208_E0.5721.00
107_V111_L0.5711.00
37_S244_T0.5711.00
64_A226_E0.5691.00
131_L135_T0.5691.00
12_G15_L0.5681.00
113_M152_F0.5661.00
92_V187_T0.5661.00
64_A221_D0.5651.00
59_T238_K0.5641.00
75_I79_A0.5641.00
184_R187_T0.5631.00
113_M151_P0.5611.00
237_P240_N0.5601.00
117_G121_G0.5581.00
199_F202_A0.5541.00
124_V127_S0.5531.00
131_L134_I0.5531.00
98_D103_N0.5511.00
213_A217_S0.5511.00
39_A49_T0.5511.00
182_A186_V0.5491.00
41_N48_F0.5491.00
76_A206_S0.5481.00
84_T88_V0.5471.00
112_P151_P0.5461.00
76_A207_F0.5451.00
97_Y179_P0.5441.00
16_S19_T0.5441.00
24_A28_L0.5411.00
50_G54_A0.5401.00
211_V214_Y0.5401.00
206_S209_E0.5401.00
257_A261_G0.5401.00
98_D166_D0.5331.00
145_H209_E0.5321.00
240_N243_A0.5281.00
90_A93_A0.5281.00
178_S184_R0.5271.00
254_L258_M0.5231.00
249_V252_V0.5221.00
164_V169_A0.5201.00
187_T191_I0.5191.00
62_D238_K0.5181.00
145_H213_A0.5181.00
121_G125_L0.5161.00
34_I38_V0.5151.00
108_A112_P0.5131.00
105_F109_V0.5131.00
35_V38_V0.5071.00
87_G150_L0.5071.00
170_D173_R0.5061.00
128_I135_T0.5061.00
106_R162_A0.5041.00
198_G202_A0.5041.00
71_N222_V0.5021.00
80_S206_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.893 100 0.246 Contact Map
3d31C 2 0.8745 100 0.267 Contact Map
4tquM 1 0.9373 100 0.284 Contact Map
3rlfG 1 0.9594 100 0.313 Contact Map
4tquN 1 0.952 100 0.324 Contact Map
3rlfF 1 0.9262 100 0.352 Contact Map
4ymuD 2 0.786 100 0.457 Contact Map
3tuiA 2 0.7675 99.9 0.497 Contact Map
2a65A 2 0.8598 27.3 0.935 Contact Map
2l2tA 2 0.155 14.2 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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