Q9HP02 - HALSA - GREMLIN Contacts

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Q9HP02 - Spermidine/putrescine ABC transporter permease

UniProt:	Q9HP02	Sequences: MASPSTRSRLLGHALSAWTVAVLAVLWLPLVVIIVLSVAENAATILPFTGVTLAHYQATLQDGALLGSVANSATIATLASVLATAVGVPASVALVRYDVPLSNAFRVAVVLPMVVPGVVLGIGVLISIRTLPGITPGFVPTVLTHAVYGLPFVVLLVSARLAAVDDTLADAARDLGASPLVAFRDVTLPAIAPAVASGFLFAWVRSFEEFVRAYFVSGTTDVLTTEMYALLAYGTAPKLNVIATLVLFVLAVVLAVAMTAGDVVSAVTAGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	271 (251)
Sequences:	69136 (44678)
Seq/√Len:	2820.1

ECOLI - YCJO POTH UGPA YCJP YDCV POTB PSTC MALG YDCU UGPE POTI POTC PSTA CYST THIP CYSW YNJC MALF MODB TAUC SSUC YEHY PHNE YEHW METI PROW YECS GLNP
BACSU - AMYD GANQ GANP YESP MDXG ARAP ARAQ YESQ YURM YTEP YURN AMYC YQGI LPLB MDXF LPLC YTCP YQGH YVGM YTLD SSUC OPUAB METP TCYB YXEN TCYL OPUCB OPUBB OPUBD OPUCD ARTQ
HALSA - Q9HP02 Q9HML6 Q9HP01 Q9HMT4 Q9HHQ7 Q9HPK3 Q9HS11 Q9HHQ6 Q9HR05 Q9HNI9 Q9HS12 Q9HML7
SULSO - Q97YY2 Q97UF3 Q97ZC1 Q97YY3 Q97UZ0 Q97UY9 Q97ZT7 Q97UF4 Q97ZT6 Q97ZC2 Q97VC0 Q97Z98

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
181_V	185_D	3.966	1.00
70_A	74_T	3.181	1.00
173_R	182_A	3.066	1.00
158_S	162_A	2.971	1.00
67_G	70_A	2.616	1.00
68_S	226_E	2.590	1.00
37_S	56_Y	2.546	1.00
96_R	169_A	2.534	1.00
178_S	181_V	2.502	1.00
172_A	182_A	2.487	1.00
160_R	194_A	2.484	1.00
82_L	146_A	2.472	1.00
78_L	142_V	2.458	1.00
169_A	187_T	2.410	1.00
221_D	229_A	2.393	1.00
57_Q	61_Q	2.389	1.00
66_L	70_A	2.354	1.00
54_A	57_Q	2.311	1.00
179_P	182_A	2.299	1.00
80_S	199_F	2.275	1.00
180_L	184_R	2.214	1.00
235_T	238_K	2.203	1.00
157_V	195_V	2.195	1.00
54_A	58_A	2.191	1.00
177_A	181_V	2.024	1.00
181_V	184_R	2.008	1.00
88_V	183_F	1.951	1.00
74_T	138_F	1.909	1.00
35_V	39_A	1.905	1.00
95_V	162_A	1.898	1.00
153_V	198_G	1.892	1.00
161_L	191_I	1.885	1.00
168_L	190_A	1.871	1.00
172_A	177_A	1.867	1.00
88_V	191_I	1.792	1.00
106_R	158_S	1.788	1.00
99_V	102_S	1.787	1.00
84_T	199_F	1.749	1.00
31_V	35_V	1.742	1.00
67_G	71_N	1.731	1.00
173_R	179_P	1.729	1.00
169_A	182_A	1.697	1.00
58_A	238_K	1.684	1.00
76_A	203_W	1.679	1.00
255_A	259_T	1.672	1.00
87_G	153_V	1.644	1.00
74_T	78_L	1.630	1.00
79_A	206_S	1.620	1.00
226_E	230_L	1.606	1.00
90_A	154_V	1.599	1.00
169_A	173_R	1.590	1.00
88_V	157_V	1.587	1.00
138_F	220_T	1.538	1.00
34_I	244_T	1.514	1.00
94_L	154_V	1.508	1.00
166_D	169_A	1.470	1.00
58_A	61_Q	1.456	1.00
16_S	20_V	1.448	1.00
101_L	104_A	1.433	1.00
153_V	202_A	1.426	1.00
28_L	32_V	1.425	1.00
64_A	67_G	1.386	1.00
210_F	214_Y	1.384	1.00
75_I	222_V	1.372	1.00
85_A	89_P	1.365	1.00
32_V	36_L	1.365	1.00
188_L	195_V	1.363	1.00
95_V	158_S	1.358	1.00
98_D	102_S	1.349	1.00
52_T	55_H	1.348	1.00
53_L	57_Q	1.342	1.00
91_S	157_V	1.339	1.00
197_S	201_F	1.335	1.00
161_L	187_T	1.334	1.00
83_A	202_A	1.329	1.00
217_S	220_T	1.327	1.00
221_D	226_E	1.312	1.00
166_D	170_D	1.284	1.00
157_V	198_G	1.275	1.00
96_R	166_D	1.256	1.00
172_A	186_V	1.256	1.00
210_F	228_Y	1.239	1.00
230_L	233_Y	1.233	1.00
167_T	170_D	1.231	1.00
144_T	216_V	1.231	1.00
88_V	195_V	1.227	1.00
104_A	107_V	1.199	1.00
92_V	161_L	1.196	1.00
128_I	140_P	1.193	1.00
20_V	24_A	1.179	1.00
81_V	85_A	1.170	1.00
212_R	216_V	1.170	1.00
178_S	182_A	1.162	1.00
137_G	220_T	1.160	1.00
43_A	50_G	1.158	1.00
84_T	195_V	1.157	1.00
71_N	74_T	1.152	1.00
78_L	81_V	1.150	1.00
164_V	190_A	1.145	1.00
230_L	235_T	1.135	1.00
11_L	15_L	1.128	1.00
33_I	244_T	1.121	1.00
192_A	196_A	1.117	1.00
72_S	223_L	1.104	1.00
150_L	154_V	1.091	1.00
104_A	108_A	1.088	1.00
13_H	17_A	1.078	1.00
157_V	194_A	1.057	1.00
141_T	213_A	1.057	1.00
142_V	146_A	1.053	1.00
40_E	43_A	1.044	1.00
259_T	262_D	1.041	1.00
222_V	225_T	1.040	1.00
82_L	142_V	1.038	1.00
60_L	66_L	1.031	1.00
13_H	16_S	1.028	1.00
169_A	179_P	1.027	1.00
32_V	35_V	1.025	1.00
95_V	161_L	1.023	1.00
256_V	260_A	1.021	1.00
78_L	82_L	1.019	1.00
92_V	183_F	1.011	1.00
139_V	143_L	1.006	1.00
156_L	198_G	1.006	1.00
126_I	130_T	1.002	1.00
190_A	193_P	0.999	1.00
79_A	83_A	0.998	1.00
213_A	222_V	0.997	1.00
79_A	145_H	0.994	1.00
73_A	77_T	0.985	1.00
92_V	179_P	0.983	1.00
89_P	93_A	0.981	1.00
138_F	142_V	0.980	1.00
221_D	225_T	0.974	1.00
209_E	212_R	0.973	1.00
177_A	182_A	0.971	1.00
102_S	162_A	0.959	1.00
182_A	185_D	0.956	1.00
226_E	242_I	0.953	1.00
55_H	237_P	0.949	1.00
56_Y	244_T	0.948	1.00
81_V	199_F	0.938	1.00
69_V	223_L	0.937	1.00
58_A	62_D	0.937	1.00
74_T	139_V	0.926	1.00
226_E	229_A	0.925	1.00
79_A	142_V	0.922	1.00
209_E	213_A	0.920	1.00
12_G	16_S	0.919	1.00
71_N	138_F	0.919	1.00
74_T	77_T	0.915	1.00
134_I	139_V	0.907	1.00
124_V	216_V	0.906	1.00
77_T	81_V	0.903	1.00
23_L	27_W	0.901	1.00
36_L	240_N	0.898	1.00
65_L	242_I	0.897	1.00
91_S	95_V	0.895	1.00
231_L	239_L	0.895	1.00
191_I	194_A	0.888	1.00
100_P	103_N	0.887	1.00
214_Y	225_T	0.885	1.00
59_T	245_L	0.885	1.00
15_L	19_T	0.883	1.00
87_G	154_V	0.874	1.00
69_V	73_A	0.873	1.00
139_V	142_V	0.871	1.00
144_T	212_R	0.870	1.00
256_V	259_T	0.867	1.00
39_A	43_A	0.864	1.00
192_A	195_V	0.864	1.00
183_F	188_L	0.858	1.00
153_V	157_V	0.857	1.00
117_G	148_Y	0.855	1.00
75_I	138_F	0.850	1.00
133_G	136_P	0.848	1.00
184_R	188_L	0.848	1.00
110_V	155_L	0.847	1.00
160_R	191_I	0.845	1.00
145_H	206_S	0.845	1.00
182_A	187_T	0.843	1.00
83_A	87_G	0.843	1.00
157_V	191_I	0.839	1.00
230_L	242_I	0.835	1.00
94_L	106_R	0.822	1.00
202_A	206_S	0.822	1.00
177_A	185_D	0.822	1.00
103_N	106_R	0.820	1.00
93_A	99_V	0.818	1.00
91_S	154_V	0.817	1.00
125_L	129_R	0.816	1.00
230_L	238_K	0.815	1.00
257_A	260_A	0.814	1.00
70_A	73_A	0.812	1.00
124_V	144_T	0.808	1.00
229_A	232_A	0.805	1.00
82_L	85_A	0.804	1.00
78_L	146_A	0.801	1.00
252_V	256_V	0.799	1.00
91_S	161_L	0.778	1.00
36_L	39_A	0.775	1.00
62_D	66_L	0.767	1.00
75_I	145_H	0.767	1.00
28_L	31_V	0.763	1.00
83_A	149_G	0.762	1.00
33_I	243_A	0.762	1.00
37_S	41_N	0.758	1.00
33_I	240_N	0.756	1.00
179_P	183_F	0.753	1.00
83_A	153_V	0.750	1.00
137_G	140_P	0.749	1.00
121_G	211_V	0.745	1.00
168_L	186_V	0.745	1.00
58_A	235_T	0.743	1.00
121_G	215_F	0.742	1.00
40_E	50_G	0.741	1.00
183_F	187_T	0.740	1.00
80_S	203_W	0.739	1.00
84_T	157_V	0.739	1.00
40_E	49_T	0.738	1.00
94_L	158_S	0.729	1.00
238_K	242_I	0.725	1.00
44_T	47_P	0.721	1.00
55_H	58_A	0.721	1.00
217_S	221_D	0.720	1.00
68_S	71_N	0.709	1.00
149_G	202_A	0.707	1.00
94_L	105_F	0.704	1.00
39_A	48_F	0.704	1.00
14_A	18_W	0.704	1.00
63_G	67_G	0.701	1.00
17_A	20_V	0.700	1.00
42_A	45_I	0.699	1.00
227_M	242_I	0.699	1.00
76_A	80_S	0.699	1.00
87_G	157_V	0.698	1.00
110_V	113_M	0.696	1.00
42_A	46_L	0.695	1.00
43_A	49_T	0.694	1.00
19_T	23_L	0.694	1.00
57_Q	60_L	0.690	1.00
117_G	211_V	0.690	1.00
83_A	206_S	0.690	1.00
141_T	217_S	0.688	1.00
171_A	175_L	0.687	1.00
166_D	173_R	0.687	1.00
157_V	161_L	0.686	1.00
38_V	52_T	0.685	1.00
192_A	260_A	0.685	1.00
250_L	254_L	0.683	1.00
14_A	17_A	0.682	1.00
120_L	147_V	0.680	1.00
223_L	246_V	0.680	1.00
209_E	222_V	0.680	1.00
171_A	174_D	0.679	1.00
22_V	26_L	0.678	1.00
56_Y	241_V	0.675	1.00
195_V	198_G	0.674	1.00
66_L	69_V	0.672	1.00
187_T	190_A	0.668	1.00
225_T	229_A	0.667	1.00
38_V	51_V	0.667	1.00
149_G	205_R	0.666	1.00
164_V	191_I	0.665	1.00
80_S	84_T	0.664	1.00
90_A	150_L	0.663	1.00
140_P	144_T	0.661	1.00
99_V	105_F	0.660	1.00
129_R	135_T	0.660	1.00
126_I	129_R	0.658	1.00
51_V	54_A	0.657	1.00
75_I	141_T	0.656	1.00
93_A	97_Y	0.655	1.00
240_N	244_T	0.653	1.00
90_A	109_V	0.652	1.00
25_V	29_P	0.651	1.00
23_L	26_L	0.650	1.00
41_N	45_I	0.648	1.00
37_S	241_V	0.646	1.00
251_A	255_A	0.646	1.00
72_S	224_T	0.646	1.00
75_I	142_V	0.638	1.00
36_L	40_E	0.635	1.00
136_P	219_T	0.631	1.00
59_T	242_I	0.630	1.00
194_A	198_G	0.629	1.00
195_V	199_F	0.627	1.00
232_A	235_T	0.624	1.00
106_R	155_L	0.621	1.00
86_V	146_A	0.620	1.00
50_G	53_L	0.620	1.00
72_S	207_F	0.619	1.00
141_T	145_H	0.611	1.00
68_S	223_L	0.611	1.00
71_N	220_T	0.609	1.00
224_T	246_V	0.608	1.00
100_P	104_A	0.607	1.00
236_A	240_N	0.606	1.00
53_L	56_Y	0.600	1.00
91_S	158_S	0.598	1.00
83_A	146_A	0.597	1.00
109_V	151_P	0.597	1.00
156_L	194_A	0.595	1.00
211_V	215_F	0.592	1.00
140_P	216_V	0.591	1.00
43_A	46_L	0.590	1.00
118_V	215_F	0.590	1.00
63_G	66_L	0.588	1.00
101_L	105_F	0.585	1.00
246_V	250_L	0.583	1.00
79_A	146_A	0.582	1.00
39_A	50_G	0.580	1.00
18_W	22_V	0.579	1.00
103_N	107_V	0.579	1.00
213_A	225_T	0.576	1.00
196_A	199_F	0.575	1.00
27_W	31_V	0.575	1.00
86_V	150_L	0.574	1.00
205_R	208_E	0.573	1.00
204_V	208_E	0.572	1.00
107_V	111_L	0.571	1.00
37_S	244_T	0.571	1.00
64_A	226_E	0.569	1.00
131_L	135_T	0.569	1.00
12_G	15_L	0.568	1.00
113_M	152_F	0.566	1.00
92_V	187_T	0.566	1.00
64_A	221_D	0.565	1.00
59_T	238_K	0.564	1.00
75_I	79_A	0.564	1.00
184_R	187_T	0.563	1.00
113_M	151_P	0.561	1.00
237_P	240_N	0.560	1.00
117_G	121_G	0.558	1.00
199_F	202_A	0.554	1.00
124_V	127_S	0.553	1.00
131_L	134_I	0.553	1.00
98_D	103_N	0.551	1.00
213_A	217_S	0.551	1.00
39_A	49_T	0.551	1.00
182_A	186_V	0.549	1.00
41_N	48_F	0.549	1.00
76_A	206_S	0.548	1.00
84_T	88_V	0.547	1.00
112_P	151_P	0.546	1.00
76_A	207_F	0.545	1.00
97_Y	179_P	0.544	1.00
16_S	19_T	0.544	1.00
24_A	28_L	0.541	1.00
50_G	54_A	0.540	1.00
211_V	214_Y	0.540	1.00
206_S	209_E	0.540	1.00
257_A	261_G	0.540	1.00
98_D	166_D	0.533	1.00
145_H	209_E	0.532	1.00
240_N	243_A	0.528	1.00
90_A	93_A	0.528	1.00
178_S	184_R	0.527	1.00
254_L	258_M	0.523	1.00
249_V	252_V	0.522	1.00
164_V	169_A	0.520	1.00
187_T	191_I	0.519	1.00
62_D	238_K	0.518	1.00
145_H	213_A	0.518	1.00
121_G	125_L	0.516	1.00
34_I	38_V	0.515	1.00
108_A	112_P	0.513	1.00
105_F	109_V	0.513	1.00
35_V	38_V	0.507	1.00
87_G	150_L	0.507	1.00
170_D	173_R	0.506	1.00
128_I	135_T	0.506	1.00
106_R	162_A	0.504	1.00
198_G	202_A	0.504	1.00
71_N	222_V	0.502	1.00
80_S	206_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.893	100	0.246	Contact Map
3d31C	2	0.8745	100	0.267	Contact Map
4tquM	1	0.9373	100	0.284	Contact Map
3rlfG	1	0.9594	100	0.313	Contact Map
4tquN	1	0.952	100	0.324	Contact Map
3rlfF	1	0.9262	100	0.352	Contact Map
4ymuD	2	0.786	100	0.457	Contact Map
3tuiA	2	0.7675	99.9	0.497	Contact Map
2a65A	2	0.8598	27.3	0.935	Contact Map
2l2tA	2	0.155	14.2	0.943	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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