GREMLIN Database
Q9HP01 - Spermidine/putrescine ABC transporter permease
UniProt: Q9HP01 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (253)
Sequences: 70208 (45183)
Seq/√Len: 2840.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
208_A212_D3.8821.00
83_L87_G3.2061.00
200_R209_V3.1071.00
185_Y189_E2.9981.00
81_S254_L2.7031.00
80_T83_L2.6441.00
45_S64_Y2.6001.00
187_G221_N2.5311.00
205_S208_A2.5071.00
65_T69_D2.4791.00
109_R196_L2.4551.00
199_A209_V2.4541.00
91_A169_V2.4501.00
249_L257_G2.4451.00
95_V173_A2.4391.00
196_L214_L2.3981.00
79_V83_L2.3711.00
62_A65_T2.3351.00
206_R209_V2.3081.00
93_T226_S2.2751.00
263_N266_S2.2471.00
184_L222_V2.1821.00
207_R211_R2.1761.00
62_A66_A2.0951.00
204_A208_A2.0551.00
208_A211_R2.0281.00
43_A47_A1.9841.00
180_M225_G1.9651.00
101_Y210_F1.9551.00
195_V217_L1.9271.00
108_A189_E1.8981.00
188_I218_T1.8691.00
199_A204_A1.8631.00
39_S43_A1.8551.00
118_F185_Y1.8411.00
101_Y218_T1.8191.00
283_G287_R1.8021.00
80_T84_L1.7571.00
97_L226_S1.7331.00
200_R206_R1.7291.00
196_L209_V1.6911.00
92_T233_A1.6811.00
89_A230_F1.6641.00
66_A266_S1.6561.00
87_G91_A1.6441.00
100_A180_M1.6231.00
101_Y184_L1.6091.00
196_L200_R1.5941.00
103_V181_L1.5681.00
107_L181_L1.5221.00
193_F196_L1.5141.00
254_L258_R1.5131.00
24_A28_G1.4691.00
66_A69_D1.4511.00
77_P80_T1.4471.00
165_V248_V1.4471.00
111_D114_R1.4451.00
113_G116_V1.4451.00
36_A40_F1.4351.00
40_F44_V1.4251.00
42_V272_T1.4231.00
180_M229_V1.4171.00
61_A65_T1.4151.00
88_I250_L1.3971.00
237_F241_R1.3861.00
108_A185_Y1.3861.00
60_T63_N1.3701.00
87_G165_V1.3541.00
188_I214_L1.3411.00
215_L222_V1.3391.00
104_A184_L1.3331.00
244_S248_V1.3321.00
96_C229_V1.3271.00
258_R261_S1.3211.00
98_V102_P1.3201.00
224_A228_F1.3151.00
184_L225_G1.3031.00
193_F197_E1.2841.00
258_R263_N1.2731.00
105_Y188_I1.2711.00
237_F256_A1.2701.00
249_L254_L1.2561.00
66_A70_A1.2551.00
116_V119_F1.2541.00
17_A21_A1.2521.00
109_R193_F1.2441.00
194_D197_E1.2351.00
101_Y222_V1.2281.00
239_A243_L1.2271.00
18_R22_L1.2171.00
199_A213_V1.2011.00
97_L222_V1.1931.00
84_L87_G1.1921.00
19_L23_L1.1821.00
171_G243_L1.1771.00
94_V98_V1.1751.00
91_A94_V1.1711.00
140_F167_A1.1711.00
85_S251_V1.1701.00
28_G32_A1.1621.00
51_D58_H1.1541.00
40_F43_A1.1491.00
191_V217_L1.1441.00
219_L223_V1.1431.00
205_S209_V1.1281.00
138_L142_D1.1201.00
41_M272_T1.1121.00
116_V120_L1.1111.00
21_A25_P1.1081.00
48_R51_D1.0991.00
168_I240_P1.0801.00
184_L221_N1.0751.00
169_V173_A1.0601.00
177_F181_L1.0531.00
196_L206_R1.0521.00
18_R21_A1.0511.00
95_V169_V1.0421.00
236_S239_A1.0401.00
91_A95_V1.0351.00
249_L253_Q1.0321.00
254_L270_A1.0311.00
287_R290_D1.0271.00
108_A188_I1.0261.00
250_L253_Q1.0221.00
105_Y210_F1.0141.00
21_A24_A1.0131.00
240_P250_L1.0111.00
217_L220_P1.0061.00
102_P106_A1.0041.00
92_T96_C1.0021.00
105_Y206_R1.0011.00
183_T225_G0.9921.00
68_V79_V0.9911.00
284_V288_Y0.9881.00
204_A209_V0.9821.00
86_V90_A0.9821.00
64_Y272_T0.9781.00
254_L257_G0.9751.00
92_T172_L0.9661.00
82_L251_V0.9591.00
114_R189_E0.9561.00
94_V226_S0.9501.00
63_N265_A0.9431.00
209_V212_D0.9391.00
67_L273_V0.9341.00
70_A77_P0.9321.00
136_W243_L0.9271.00
241_R253_Q0.9241.00
50_S53_S0.9231.00
23_L27_G0.9211.00
87_G90_A0.9131.00
31_V35_F0.9121.00
20_A24_A0.9121.00
44_V268_S0.9081.00
78_F270_A0.9071.00
236_S240_P0.9071.00
96_C100_A0.8771.00
92_T169_V0.8751.00
90_A94_V0.8741.00
44_V47_A0.8711.00
219_L222_V0.8701.00
55_I58_H0.8701.00
115_R118_F0.8701.00
104_A108_A0.8681.00
257_G260_D0.8651.00
258_R266_S0.8651.00
172_L233_A0.8641.00
204_A212_D0.8621.00
209_V214_L0.8591.00
187_G218_T0.8571.00
82_L86_V0.8521.00
107_L118_F0.8511.00
218_T221_N0.8501.00
100_A181_L0.8481.00
139_L146_L0.8481.00
284_V287_R0.8461.00
47_A51_D0.8431.00
145_V166_P0.8421.00
180_M184_L0.8381.00
258_R270_A0.8381.00
112_R115_R0.8341.00
136_W171_G0.8341.00
129_Y175_A0.8331.00
211_R215_L0.8261.00
88_I172_L0.8241.00
122_L182_L0.8231.00
210_F215_L0.8221.00
95_V98_V0.8201.00
184_L218_T0.8191.00
88_I165_V0.8171.00
104_A181_L0.8151.00
229_V233_A0.8111.00
246_S249_L0.8081.00
83_L86_V0.8051.00
45_S49_V0.7971.00
48_R58_H0.7951.00
76_T80_T0.7931.00
206_R210_F0.7911.00
44_V48_R0.7911.00
133_V238_V0.7891.00
171_G239_A0.7891.00
137_Y141_G0.7841.00
163_F166_P0.7831.00
33_L37_P0.7761.00
280_A284_V0.7751.00
41_M268_S0.7741.00
41_M271_A0.7741.00
96_C180_M0.7741.00
104_A188_I0.7711.00
65_T68_V0.7631.00
236_S250_L0.7581.00
91_A173_A0.7571.00
195_V213_V0.7531.00
264_I267_A0.7501.00
244_S249_L0.7491.00
81_S84_L0.7451.00
255_I270_A0.7451.00
93_T230_F0.7401.00
66_A263_N0.7381.00
191_V218_T0.7341.00
63_N66_A0.7311.00
96_C176_Q0.7301.00
285_A288_Y0.7301.00
253_Q257_G0.7271.00
96_C233_A0.7251.00
100_A184_L0.7241.00
266_S270_A0.7241.00
49_V53_S0.7221.00
219_L288_Y0.7181.00
198_A201_D0.7171.00
122_L125_F0.7161.00
46_F59_P0.7151.00
36_A39_S0.7151.00
210_F214_L0.7141.00
168_I244_S0.7101.00
97_L184_L0.7101.00
107_L185_Y0.7101.00
198_A202_L0.7081.00
133_V242_F0.7071.00
89_A93_T0.7071.00
107_L117_V0.7051.00
81_S251_V0.7051.00
79_V82_L0.7031.00
129_Y238_V0.7021.00
222_V225_G0.6991.00
176_Q232_P0.6981.00
278_I282_F0.6941.00
110_R114_R0.6851.00
193_F200_R0.6841.00
138_L141_G0.6831.00
30_L34_L0.6821.00
251_V274_V0.6811.00
176_Q229_V0.6801.00
103_V121_V0.6791.00
167_A171_G0.6791.00
93_T97_L0.6761.00
31_V34_L0.6751.00
22_L25_P0.6721.00
25_P28_G0.6701.00
76_T79_V0.6691.00
22_L26_S0.6671.00
184_L188_I0.6661.00
85_S252_G0.6651.00
88_I168_I0.6641.00
103_V177_F0.6621.00
214_L217_L0.6621.00
113_G117_V0.6531.00
47_A56_I0.6501.00
221_N225_G0.6491.00
112_R116_V0.6481.00
106_A110_R0.6481.00
121_V178_P0.6461.00
222_V226_S0.6451.00
132_R174_H0.6451.00
58_H61_A0.6451.00
260_D263_N0.6441.00
252_G274_V0.6431.00
20_A23_L0.6421.00
279_A283_G0.6391.00
17_A20_A0.6381.00
136_W139_L0.6381.00
59_P62_A0.6351.00
84_L248_V0.6341.00
64_Y269_A0.6311.00
51_D57_W0.6301.00
70_A76_T0.6291.00
168_I172_L0.6271.00
45_S269_A0.6251.00
48_R57_W0.6211.00
55_I59_P0.6201.00
163_F246_S0.6201.00
67_L270_A0.6191.00
238_V242_F0.6181.00
99_A173_A0.6181.00
46_F60_T0.6171.00
130_L242_F0.6151.00
58_H62_A0.6141.00
85_S234_F0.6081.00
47_A58_H0.6071.00
67_L266_S0.6061.00
165_V169_V0.6051.00
27_G31_V0.6041.00
89_A233_A0.6021.00
209_V213_V0.6021.00
183_T221_N0.6011.00
264_I268_S0.6001.00
77_P254_L0.6001.00
211_R214_L0.5991.00
268_S272_T0.5981.00
56_I59_P0.5981.00
88_I169_V0.5971.00
88_I92_T0.5951.00
238_V241_R0.5951.00
240_P253_Q0.5941.00
89_A234_F0.5871.00
223_V226_S0.5841.00
26_S30_L0.5841.00
115_R119_F0.5841.00
96_C173_A0.5831.00
64_Y68_V0.5821.00
60_T64_Y0.5821.00
35_F39_S0.5761.00
105_Y214_L0.5741.00
37_P49_V0.5741.00
104_A185_Y0.5741.00
125_F179_Y0.5741.00
118_F182_L0.5721.00
97_L101_Y0.5721.00
164_G167_A0.5701.00
233_A236_S0.5681.00
45_S272_T0.5661.00
49_V56_I0.5651.00
119_F123_L0.5641.00
274_V278_I0.5641.00
226_S229_V0.5631.00
99_A177_F0.5621.00
231_V235_G0.5621.00
37_P41_M0.5581.00
133_V137_Y0.5571.00
129_Y133_V0.5561.00
77_P249_L0.5561.00
120_L124_P0.5551.00
61_A64_Y0.5531.00
32_A36_A0.5531.00
65_T70_A0.5521.00
47_A57_W0.5501.00
232_P235_G0.5501.00
100_A177_F0.5471.00
114_R118_F0.5461.00
92_T173_A0.5441.00
240_P244_S0.5431.00
124_P178_P0.5431.00
172_L236_S0.5421.00
167_A243_L0.5401.00
191_V196_L0.5391.00
80_T87_G0.5391.00
205_S211_R0.5391.00
125_F178_P0.5381.00
29_L33_L0.5371.00
253_Q256_A0.5371.00
282_F286_A0.5351.00
127_T131_V0.5311.00
197_E200_R0.5301.00
24_A27_G0.5231.00
42_V46_F0.5231.00
84_L250_L0.5211.00
103_V106_A0.5201.00
117_V121_V0.5201.00
48_R52_A0.5191.00
175_A239_A0.5181.00
78_F254_L0.5151.00
44_V49_V0.5151.00
43_A46_F0.5141.00
268_S271_A0.5111.00
77_P81_S0.5081.00
283_G286_A0.5061.00
257_G261_S0.5031.00
166_P169_V0.5031.00
256_A259_I0.5021.00
276_V280_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.8418 100 0.308 Contact Map
4tquM 1 0.9125 100 0.324 Contact Map
3d31C 2 0.8316 100 0.33 Contact Map
3rlfG 1 0.9057 100 0.393 Contact Map
4tquN 1 0.8754 100 0.4 Contact Map
3rlfF 1 0.9192 100 0.401 Contact Map
4ymuD 2 0.7205 100 0.515 Contact Map
3tuiA 2 0.697 99.9 0.546 Contact Map
2kogA 1 0.1481 20.3 0.945 Contact Map
3tx3A 2 0.2088 12.8 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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