GREMLIN Database
Q9HP00 - Uncharacterized protein
UniProt: Q9HP00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 392 (331)
Sequences: 34554 (27700)
Seq/√Len: 1522.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_T85_N3.7261.00
174_S291_E3.4151.00
60_N85_N3.3091.00
127_A315_P3.2361.00
58_T83_T2.9021.00
188_F244_D2.9011.00
128_P157_T2.8821.00
175_R289_W2.7801.00
82_A317_L2.5301.00
243_I247_Q2.5121.00
183_S186_V2.4801.00
77_E83_T2.4001.00
75_A324_E2.3691.00
327_A330_T2.3621.00
80_V320_E2.3261.00
191_I194_V2.2591.00
75_A78_D2.2251.00
240_D244_D2.2161.00
320_E323_N2.1821.00
233_S237_A2.1731.00
75_A333_T2.1331.00
172_Y291_E2.0761.00
60_N87_T2.0711.00
174_S178_P2.0621.00
75_A79_A2.0531.00
130_P157_T2.0341.00
193_G197_S2.0331.00
94_K98_G2.0301.00
108_D314_H2.0201.00
237_A240_D2.0071.00
332_A336_R1.9971.00
71_D74_A1.9751.00
176_A270_H1.9391.00
57_P317_L1.9221.00
192_D196_L1.9141.00
160_G305_A1.8981.00
74_A78_D1.8981.00
314_H317_L1.8921.00
126_A307_V1.8831.00
70_D74_A1.8501.00
76_V80_V1.8501.00
139_A346_E1.8501.00
236_G240_D1.8301.00
241_A244_D1.8131.00
177_V271_V1.7931.00
76_V320_E1.7651.00
77_E80_V1.7591.00
153_A158_P1.7491.00
56_T83_T1.7281.00
186_V189_D1.7221.00
316_D320_E1.7031.00
73_A321_V1.6941.00
73_A77_E1.6891.00
127_A310_T1.6831.00
191_I195_D1.6621.00
330_T333_T1.6451.00
110_A309_S1.6351.00
142_D146_N1.6351.00
353_E357_E1.6241.00
263_G268_D1.6161.00
179_D182_P1.6101.00
185_S188_F1.6041.00
328_P332_A1.5981.00
189_D192_D1.5961.00
315_P319_W1.5911.00
79_A327_A1.5841.00
317_L320_E1.5811.00
333_T337_E1.5671.00
71_D75_A1.5541.00
62_L98_G1.5491.00
244_D248_S1.5371.00
74_A77_E1.5141.00
194_V197_S1.5101.00
188_F245_Q1.5001.00
188_F241_A1.4981.00
42_S45_T1.4931.00
333_T336_R1.4921.00
256_G259_S1.4861.00
41_A44_T1.4841.00
201_A204_D1.4711.00
353_E356_T1.4621.00
182_P186_V1.4621.00
57_P314_H1.4591.00
173_D176_A1.4511.00
234_Q237_A1.4511.00
188_F248_S1.4491.00
63_T86_V1.4331.00
49_C52_G1.4301.00
172_Y293_A1.4261.00
240_D243_I1.4251.00
220_R224_D1.4111.00
109_I318_A1.4101.00
262_K266_K1.4011.00
312_T315_P1.3981.00
241_A245_Q1.3751.00
308_V322_V1.3721.00
76_V321_V1.3721.00
170_Y293_A1.3711.00
223_F227_R1.3641.00
185_S189_D1.3531.00
181_D186_V1.3471.00
233_S236_G1.3201.00
146_N153_A1.3151.00
73_A86_V1.3131.00
121_A159_Y1.3051.00
142_D145_K1.3001.00
169_G292_M1.2751.00
76_V324_E1.2721.00
263_G269_F1.2671.00
192_D197_S1.2651.00
182_P296_T1.2641.00
364_P368_A1.2631.00
328_P346_E1.2501.00
205_N208_K1.2451.00
346_E349_A1.2441.00
112_P307_V1.2431.00
76_V82_A1.2341.00
132_S319_W1.2141.00
319_W323_N1.2101.00
152_L305_A1.2071.00
109_I321_V1.2041.00
193_G196_L1.2021.00
39_A43_A1.2011.00
264_I290_I1.2011.00
259_S262_K1.1991.00
136_S323_N1.1981.00
316_D319_W1.1961.00
174_S289_W1.1801.00
312_T318_A1.1781.00
177_V190_G1.1771.00
94_K97_A1.1701.00
134_L137_Y1.1621.00
308_V318_A1.1601.00
82_A320_E1.1501.00
332_A350_H1.1401.00
99_W106_Q1.1381.00
128_P158_P1.1371.00
171_G274_T1.1341.00
244_D247_Q1.1251.00
46_L49_C1.1201.00
61_V306_A1.1091.00
141_Y345_P1.1091.00
71_D333_T1.1051.00
76_V317_L1.1001.00
139_A344_N1.0991.00
135_D138_P1.0961.00
190_G271_V1.0931.00
56_T81_D1.0931.00
329_E333_T1.0911.00
329_E332_A1.0891.00
237_A241_A1.0781.00
321_V325_Y1.0771.00
59_I321_V1.0761.00
108_D312_T1.0741.00
49_C53_T1.0671.00
124_G310_T1.0661.00
200_V204_D1.0631.00
32_S35_A1.0631.00
170_Y271_V1.0611.00
133_D136_S1.0581.00
281_N284_A1.0521.00
73_A84_V1.0451.00
189_D193_G1.0401.00
223_F226_D1.0371.00
110_A307_V1.0311.00
365_A368_A1.0311.00
354_R357_E1.0301.00
344_N347_T1.0281.00
79_A324_E1.0271.00
45_T48_G1.0201.00
120_F126_A1.0171.00
96_F100_Q1.0171.00
75_A329_E1.0161.00
324_E330_T1.0131.00
308_V319_W1.0131.00
106_Q309_S1.0061.00
163_I306_A1.0021.00
102_G311_Q1.0021.00
219_F223_F0.9981.00
71_D337_E0.9851.00
59_I317_L0.9781.00
72_V75_A0.9751.00
72_V330_T0.9741.00
310_T315_P0.9711.00
121_A154_V0.9611.00
274_T278_N0.9581.00
187_L271_V0.9531.00
309_S312_T0.9531.00
43_A46_L0.9491.00
38_G42_S0.9481.00
176_A199_A0.9481.00
192_D195_D0.9471.00
118_P122_A0.9431.00
191_I248_S0.9411.00
217_L237_A0.9311.00
179_D186_V0.9291.00
308_V312_T0.9261.00
332_A347_T0.9231.00
97_A101_A0.9231.00
57_P81_D0.9211.00
127_A319_W0.9201.00
354_R359_Y0.9201.00
109_I322_V0.9191.00
352_S355_R0.9151.00
99_W125_L0.9131.00
93_E97_A0.9111.00
173_D289_W0.9061.00
75_A330_T0.8971.00
84_V321_V0.8971.00
160_G307_V0.8941.00
354_R358_L0.8941.00
79_A329_E0.8941.00
357_E360_G0.8921.00
232_E236_G0.8921.00
220_R223_F0.8911.00
262_K265_T0.8901.00
363_D366_R0.8881.00
280_T284_A0.8851.00
42_S46_L0.8831.00
362_I366_R0.8811.00
229_T232_E0.8811.00
133_D319_W0.8781.00
81_D320_E0.8711.00
77_E84_V0.8681.00
212_A215_L0.8661.00
41_A45_T0.8641.00
140_I326_I0.8601.00
323_N327_A0.8591.00
203_Y269_F0.8561.00
153_A156_G0.8541.00
189_D195_D0.8541.00
48_G51_G0.8531.00
352_S356_T0.8531.00
306_A322_V0.8531.00
321_V324_E0.8481.00
62_L107_F0.8471.00
47_A50_L0.8441.00
318_A322_V0.8431.00
96_F119_K0.8391.00
199_A270_H0.8341.00
65_E69_R0.8341.00
328_P344_N0.8341.00
40_A43_A0.8331.00
243_I246_K0.8321.00
119_K123_A0.8321.00
38_G41_A0.8261.00
152_L158_P0.8241.00
40_A44_T0.8231.00
132_S135_D0.8161.00
103_K106_Q0.8161.00
178_P289_W0.8151.00
134_L323_N0.8141.00
191_I197_S0.8091.00
172_Y180_H0.8081.00
65_E68_A0.8081.00
126_A159_Y0.8061.00
200_V203_Y0.8031.00
230_L235_L0.7951.00
232_E235_L0.7951.00
258_A261_V0.7931.00
213_A217_L0.7921.00
260_F272_G0.7911.00
131_V135_D0.7891.00
184_W188_F0.7871.00
201_A269_F0.7871.00
194_V199_A0.7861.00
143_F146_N0.7821.00
128_P159_Y0.7811.00
217_L241_A0.7781.00
242_L246_K0.7771.00
175_R178_P0.7771.00
356_T360_G0.7741.00
37_T40_A0.7721.00
145_K158_P0.7701.00
141_Y144_F0.7681.00
62_L89_S0.7661.00
127_A308_V0.7651.00
38_G44_T0.7621.00
89_S94_K0.7601.00
140_I145_K0.7591.00
93_E96_F0.7591.00
59_I314_H0.7571.00
175_R288_D0.7521.00
142_D345_P0.7491.00
193_G198_S0.7481.00
251_S254_I0.7471.00
362_I365_A0.7461.00
279_V283_R0.7461.00
265_T285_D0.7451.00
194_V270_H0.7431.00
258_A262_K0.7431.00
129_V322_V0.7421.00
37_T41_A0.7421.00
34_L37_T0.7401.00
98_G103_K0.7381.00
121_A126_A0.7381.00
251_S255_A0.7361.00
361_A365_A0.7331.00
127_A309_S0.7321.00
345_P349_A0.7251.00
54_T57_P0.7221.00
187_L202_L0.7211.00
39_A42_S0.7171.00
45_T49_C0.7151.00
110_A126_A0.7151.00
34_L38_G0.7141.00
180_H190_G0.7131.00
306_A325_Y0.7111.00
166_G302_W0.7111.00
57_P82_A0.7101.00
215_L218_G0.7101.00
355_R359_Y0.7081.00
214_A235_L0.7081.00
111_I306_A0.7071.00
127_A312_T0.7041.00
55_G58_T0.7031.00
356_T359_Y0.7021.00
361_A364_P0.7021.00
180_H293_A0.7011.00
219_F222_A0.7011.00
60_N108_D0.7001.00
130_P158_P0.6991.00
215_L220_R0.6971.00
139_A328_P0.6971.00
261_V265_T0.6971.00
44_T47_A0.6961.00
133_D137_Y0.6951.00
188_F191_I0.6951.00
184_W241_A0.6891.00
175_R267_G0.6891.00
47_A51_G0.6881.00
186_V190_G0.6871.00
285_D288_D0.6861.00
196_L199_A0.6821.00
171_G292_M0.6811.00
95_M110_A0.6811.00
138_P145_K0.6791.00
173_D267_G0.6781.00
116_Y119_K0.6771.00
239_T243_I0.6731.00
188_F250_L0.6721.00
281_N285_D0.6701.00
171_G279_V0.6691.00
131_V134_L0.6681.00
211_S215_L0.6681.00
181_D190_G0.6661.00
97_A100_Q0.6661.00
214_A219_F0.6651.00
48_G52_G0.6641.00
245_Q250_L0.6641.00
364_P367_L0.6621.00
80_V317_L0.6611.00
61_V86_V0.6601.00
43_A47_A0.6591.00
61_V109_I0.6561.00
66_H69_R0.6541.00
192_D248_S0.6531.00
130_P319_W0.6521.00
305_A309_S0.6491.00
77_E81_D0.6451.00
259_S263_G0.6431.00
210_M214_A0.6421.00
328_P331_G0.6421.00
363_D368_A0.6411.00
221_D224_D0.6401.00
117_V160_G0.6391.00
195_D198_S0.6381.00
255_A259_S0.6361.00
191_I250_L0.6361.00
133_D316_D0.6361.00
108_D318_A0.6351.00
139_A345_P0.6351.00
87_T107_F0.6301.00
77_E82_A0.6281.00
37_T44_T0.6271.00
112_P120_F0.6241.00
127_A311_Q0.6241.00
234_Q238_V0.6241.00
57_P60_N0.6231.00
231_S235_L0.6171.00
72_V324_E0.6121.00
350_H354_R0.6091.00
171_G290_I0.6091.00
238_V242_L0.6071.00
59_I318_A0.6031.00
141_Y348_T0.6011.00
214_A217_L0.6011.00
320_E324_E0.6011.00
177_V270_H0.5991.00
231_S234_Q0.5981.00
355_R358_L0.5981.00
99_W309_S0.5981.00
136_S139_A0.5971.00
170_Y273_H0.5971.00
161_V322_V0.5961.00
98_G101_A0.5961.00
153_A157_T0.5951.00
72_V333_T0.5941.00
32_S44_T0.5941.00
140_I144_F0.5941.00
172_Y177_V0.5931.00
226_D229_T0.5911.00
87_T98_G0.5891.00
113_N116_Y0.5891.00
60_N63_T0.5871.00
36_A40_A0.5871.00
350_H353_E0.5861.00
117_V121_A0.5851.00
141_Y145_K0.5851.00
280_T283_R0.5841.00
108_D313_D0.5821.00
213_A218_G0.5821.00
263_G266_K0.5821.00
278_N281_N0.5811.00
223_F229_T0.5791.00
164_R304_E0.5761.00
253_Y257_D0.5751.00
278_N282_M0.5741.00
121_A124_G0.5741.00
180_H186_V0.5731.00
261_V274_T0.5721.00
172_Y271_V0.5711.00
315_P318_A0.5691.00
212_A216_H0.5691.00
38_G45_T0.5681.00
228_I231_S0.5671.00
224_D227_R0.5661.00
363_D367_L0.5661.00
109_I306_A0.5651.00
34_L45_T0.5621.00
37_T43_A0.5611.00
61_V111_I0.5601.00
359_Y363_D0.5601.00
308_V315_P0.5591.00
34_L41_A0.5571.00
62_L87_T0.5561.00
191_I196_L0.5551.00
231_S236_G0.5541.00
83_T86_V0.5541.00
39_A44_T0.5531.00
219_F234_Q0.5521.00
319_W322_V0.5521.00
129_V319_W0.5521.00
190_G193_G0.5511.00
119_K122_A0.5511.00
347_T350_H0.5491.00
39_A45_T0.5491.00
46_L50_L0.5471.00
72_V325_Y0.5461.00
57_P320_E0.5431.00
120_F125_L0.5391.00
80_V324_E0.5391.00
345_P348_T0.5371.00
210_M215_L0.5361.00
195_D199_A0.5341.00
188_F192_D0.5321.00
152_L160_G0.5321.00
35_A38_G0.5311.00
55_G320_E0.5311.00
144_F165_F0.5301.00
301_S304_E0.5281.00
252_G255_A0.5261.00
331_G343_V0.5241.00
70_D73_A0.5231.00
87_T94_K0.5211.00
331_G335_A0.5211.00
324_E327_A0.5211.00
34_L44_T0.5211.00
129_V308_V0.5201.00
35_A39_A0.5181.00
133_D323_N0.5171.00
60_N107_F0.5161.00
352_S358_L0.5161.00
130_P153_A0.5151.00
179_D190_G0.5151.00
96_F123_A0.5151.00
311_Q315_P0.5141.00
205_N209_A0.5131.00
132_S136_S0.5131.00
138_P141_Y0.5111.00
261_V278_N0.5101.00
360_G363_D0.5101.00
270_H273_H0.5101.00
36_A39_A0.5091.00
80_V321_V0.5091.00
167_Y276_R0.5071.00
54_T81_D0.5061.00
125_L128_P0.5061.00
212_A217_L0.5051.00
305_A308_V0.5031.00
33_F36_A0.5021.00
236_G239_T0.5011.00
118_P154_V0.5011.00
82_A86_V0.5011.00
57_P63_T0.5001.00
111_I163_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uorA 1 0.8316 100 0.295 Contact Map
4r2fA 1 0.8291 100 0.31 Contact Map
4r9fA 1 0.8342 100 0.323 Contact Map
4mfiA 1 0.8316 100 0.334 Contact Map
3woaA 1 0.9439 100 0.342 Contact Map
3vxbA 1 0.8342 100 0.343 Contact Map
2xd3A 1 0.8163 100 0.359 Contact Map
4ovjA 1 0.8342 100 0.366 Contact Map
3osrA 1 0.8367 100 0.366 Contact Map
2zyoA 1 0.8316 100 0.369 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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