Q9HP00 - HALSA - GREMLIN Contacts

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Q9HP00 - Uncharacterized protein

UniProt:	Q9HP00	Sequences: MSPRQPDASDADAPADTTSDAGHPHSTVGRRSFLAATGAAASATTLAGCLGGTTGTPTINVLTWEHYARDDVAAAVEDAVDATVNVTKSISSEKMFAGWQAGKDQQFDIAIPNNNYVPKFAAAGLAAPVPVSDLDSYPAIYDFFKNAMDTQLAVDGTPYGVPIRFGYYGYGYDSRAVPDHDPSWSVLFDGIDGVDLSSAVALYDNHFKAMSAAALHLGFRDAFDGDRITLSESQLGAVTDALIDQKQSLLSGYIAGDASFVKGITKGDFHVGHTGRMNVTNMRADGTDWIEMATPTEGALSWFEAAVVSTQTDHPDLAWEVVNEYIAPETGATLAREGHAPSVNPETTAHLSERRTELYGAIDPARLADMIPSKAVANEDAWRAAWERVKTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	392 (331)
Sequences:	34554 (27700)
Seq/√Len:	1522.5

ECOLI - YDCS POTF POTD MALE YCJN YNJB UGPB THIB
BACSU - CYCB MDXE ARAN YURO YESO LIPO YTCQ MSME
HALSA - Q9HP00 Q9HR87 Q9HHQ8 Q9HMT5 Q9HNZ3 Q9HR04
SULSO - Q97YY1 Q97ZC3 Q97UZ1 Q97VC2 Q97UF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
58_T	85_N	3.726	1.00
174_S	291_E	3.415	1.00
60_N	85_N	3.309	1.00
127_A	315_P	3.236	1.00
58_T	83_T	2.902	1.00
188_F	244_D	2.901	1.00
128_P	157_T	2.882	1.00
175_R	289_W	2.780	1.00
82_A	317_L	2.530	1.00
243_I	247_Q	2.512	1.00
183_S	186_V	2.480	1.00
77_E	83_T	2.400	1.00
75_A	324_E	2.369	1.00
327_A	330_T	2.362	1.00
80_V	320_E	2.326	1.00
191_I	194_V	2.259	1.00
75_A	78_D	2.225	1.00
240_D	244_D	2.216	1.00
320_E	323_N	2.182	1.00
233_S	237_A	2.173	1.00
75_A	333_T	2.133	1.00
172_Y	291_E	2.076	1.00
60_N	87_T	2.071	1.00
174_S	178_P	2.062	1.00
75_A	79_A	2.053	1.00
130_P	157_T	2.034	1.00
193_G	197_S	2.033	1.00
94_K	98_G	2.030	1.00
108_D	314_H	2.020	1.00
237_A	240_D	2.007	1.00
332_A	336_R	1.997	1.00
71_D	74_A	1.975	1.00
176_A	270_H	1.939	1.00
57_P	317_L	1.922	1.00
192_D	196_L	1.914	1.00
160_G	305_A	1.898	1.00
74_A	78_D	1.898	1.00
314_H	317_L	1.892	1.00
126_A	307_V	1.883	1.00
70_D	74_A	1.850	1.00
76_V	80_V	1.850	1.00
139_A	346_E	1.850	1.00
236_G	240_D	1.830	1.00
241_A	244_D	1.813	1.00
177_V	271_V	1.793	1.00
76_V	320_E	1.765	1.00
77_E	80_V	1.759	1.00
153_A	158_P	1.749	1.00
56_T	83_T	1.728	1.00
186_V	189_D	1.722	1.00
316_D	320_E	1.703	1.00
73_A	321_V	1.694	1.00
73_A	77_E	1.689	1.00
127_A	310_T	1.683	1.00
191_I	195_D	1.662	1.00
330_T	333_T	1.645	1.00
110_A	309_S	1.635	1.00
142_D	146_N	1.635	1.00
353_E	357_E	1.624	1.00
263_G	268_D	1.616	1.00
179_D	182_P	1.610	1.00
185_S	188_F	1.604	1.00
328_P	332_A	1.598	1.00
189_D	192_D	1.596	1.00
315_P	319_W	1.591	1.00
79_A	327_A	1.584	1.00
317_L	320_E	1.581	1.00
333_T	337_E	1.567	1.00
71_D	75_A	1.554	1.00
62_L	98_G	1.549	1.00
244_D	248_S	1.537	1.00
74_A	77_E	1.514	1.00
194_V	197_S	1.510	1.00
188_F	245_Q	1.500	1.00
188_F	241_A	1.498	1.00
42_S	45_T	1.493	1.00
333_T	336_R	1.492	1.00
256_G	259_S	1.486	1.00
41_A	44_T	1.484	1.00
201_A	204_D	1.471	1.00
353_E	356_T	1.462	1.00
182_P	186_V	1.462	1.00
57_P	314_H	1.459	1.00
173_D	176_A	1.451	1.00
234_Q	237_A	1.451	1.00
188_F	248_S	1.449	1.00
63_T	86_V	1.433	1.00
49_C	52_G	1.430	1.00
172_Y	293_A	1.426	1.00
240_D	243_I	1.425	1.00
220_R	224_D	1.411	1.00
109_I	318_A	1.410	1.00
262_K	266_K	1.401	1.00
312_T	315_P	1.398	1.00
241_A	245_Q	1.375	1.00
308_V	322_V	1.372	1.00
76_V	321_V	1.372	1.00
170_Y	293_A	1.371	1.00
223_F	227_R	1.364	1.00
185_S	189_D	1.353	1.00
181_D	186_V	1.347	1.00
233_S	236_G	1.320	1.00
146_N	153_A	1.315	1.00
73_A	86_V	1.313	1.00
121_A	159_Y	1.305	1.00
142_D	145_K	1.300	1.00
169_G	292_M	1.275	1.00
76_V	324_E	1.272	1.00
263_G	269_F	1.267	1.00
192_D	197_S	1.265	1.00
182_P	296_T	1.264	1.00
364_P	368_A	1.263	1.00
328_P	346_E	1.250	1.00
205_N	208_K	1.245	1.00
346_E	349_A	1.244	1.00
112_P	307_V	1.243	1.00
76_V	82_A	1.234	1.00
132_S	319_W	1.214	1.00
319_W	323_N	1.210	1.00
152_L	305_A	1.207	1.00
109_I	321_V	1.204	1.00
193_G	196_L	1.202	1.00
39_A	43_A	1.201	1.00
264_I	290_I	1.201	1.00
259_S	262_K	1.199	1.00
136_S	323_N	1.198	1.00
316_D	319_W	1.196	1.00
174_S	289_W	1.180	1.00
312_T	318_A	1.178	1.00
177_V	190_G	1.177	1.00
94_K	97_A	1.170	1.00
134_L	137_Y	1.162	1.00
308_V	318_A	1.160	1.00
82_A	320_E	1.150	1.00
332_A	350_H	1.140	1.00
99_W	106_Q	1.138	1.00
128_P	158_P	1.137	1.00
171_G	274_T	1.134	1.00
244_D	247_Q	1.125	1.00
46_L	49_C	1.120	1.00
61_V	306_A	1.109	1.00
141_Y	345_P	1.109	1.00
71_D	333_T	1.105	1.00
76_V	317_L	1.100	1.00
139_A	344_N	1.099	1.00
135_D	138_P	1.096	1.00
190_G	271_V	1.093	1.00
56_T	81_D	1.093	1.00
329_E	333_T	1.091	1.00
329_E	332_A	1.089	1.00
237_A	241_A	1.078	1.00
321_V	325_Y	1.077	1.00
59_I	321_V	1.076	1.00
108_D	312_T	1.074	1.00
49_C	53_T	1.067	1.00
124_G	310_T	1.066	1.00
200_V	204_D	1.063	1.00
32_S	35_A	1.063	1.00
170_Y	271_V	1.061	1.00
133_D	136_S	1.058	1.00
281_N	284_A	1.052	1.00
73_A	84_V	1.045	1.00
189_D	193_G	1.040	1.00
223_F	226_D	1.037	1.00
110_A	307_V	1.031	1.00
365_A	368_A	1.031	1.00
354_R	357_E	1.030	1.00
344_N	347_T	1.028	1.00
79_A	324_E	1.027	1.00
45_T	48_G	1.020	1.00
120_F	126_A	1.017	1.00
96_F	100_Q	1.017	1.00
75_A	329_E	1.016	1.00
324_E	330_T	1.013	1.00
308_V	319_W	1.013	1.00
106_Q	309_S	1.006	1.00
163_I	306_A	1.002	1.00
102_G	311_Q	1.002	1.00
219_F	223_F	0.998	1.00
71_D	337_E	0.985	1.00
59_I	317_L	0.978	1.00
72_V	75_A	0.975	1.00
72_V	330_T	0.974	1.00
310_T	315_P	0.971	1.00
121_A	154_V	0.961	1.00
274_T	278_N	0.958	1.00
187_L	271_V	0.953	1.00
309_S	312_T	0.953	1.00
43_A	46_L	0.949	1.00
38_G	42_S	0.948	1.00
176_A	199_A	0.948	1.00
192_D	195_D	0.947	1.00
118_P	122_A	0.943	1.00
191_I	248_S	0.941	1.00
217_L	237_A	0.931	1.00
179_D	186_V	0.929	1.00
308_V	312_T	0.926	1.00
332_A	347_T	0.923	1.00
97_A	101_A	0.923	1.00
57_P	81_D	0.921	1.00
127_A	319_W	0.920	1.00
354_R	359_Y	0.920	1.00
109_I	322_V	0.919	1.00
352_S	355_R	0.915	1.00
99_W	125_L	0.913	1.00
93_E	97_A	0.911	1.00
173_D	289_W	0.906	1.00
75_A	330_T	0.897	1.00
84_V	321_V	0.897	1.00
160_G	307_V	0.894	1.00
354_R	358_L	0.894	1.00
79_A	329_E	0.894	1.00
357_E	360_G	0.892	1.00
232_E	236_G	0.892	1.00
220_R	223_F	0.891	1.00
262_K	265_T	0.890	1.00
363_D	366_R	0.888	1.00
280_T	284_A	0.885	1.00
42_S	46_L	0.883	1.00
362_I	366_R	0.881	1.00
229_T	232_E	0.881	1.00
133_D	319_W	0.878	1.00
81_D	320_E	0.871	1.00
77_E	84_V	0.868	1.00
212_A	215_L	0.866	1.00
41_A	45_T	0.864	1.00
140_I	326_I	0.860	1.00
323_N	327_A	0.859	1.00
203_Y	269_F	0.856	1.00
153_A	156_G	0.854	1.00
189_D	195_D	0.854	1.00
48_G	51_G	0.853	1.00
352_S	356_T	0.853	1.00
306_A	322_V	0.853	1.00
321_V	324_E	0.848	1.00
62_L	107_F	0.847	1.00
47_A	50_L	0.844	1.00
318_A	322_V	0.843	1.00
96_F	119_K	0.839	1.00
199_A	270_H	0.834	1.00
65_E	69_R	0.834	1.00
328_P	344_N	0.834	1.00
40_A	43_A	0.833	1.00
243_I	246_K	0.832	1.00
119_K	123_A	0.832	1.00
38_G	41_A	0.826	1.00
152_L	158_P	0.824	1.00
40_A	44_T	0.823	1.00
132_S	135_D	0.816	1.00
103_K	106_Q	0.816	1.00
178_P	289_W	0.815	1.00
134_L	323_N	0.814	1.00
191_I	197_S	0.809	1.00
172_Y	180_H	0.808	1.00
65_E	68_A	0.808	1.00
126_A	159_Y	0.806	1.00
200_V	203_Y	0.803	1.00
230_L	235_L	0.795	1.00
232_E	235_L	0.795	1.00
258_A	261_V	0.793	1.00
213_A	217_L	0.792	1.00
260_F	272_G	0.791	1.00
131_V	135_D	0.789	1.00
184_W	188_F	0.787	1.00
201_A	269_F	0.787	1.00
194_V	199_A	0.786	1.00
143_F	146_N	0.782	1.00
128_P	159_Y	0.781	1.00
217_L	241_A	0.778	1.00
242_L	246_K	0.777	1.00
175_R	178_P	0.777	1.00
356_T	360_G	0.774	1.00
37_T	40_A	0.772	1.00
145_K	158_P	0.770	1.00
141_Y	144_F	0.768	1.00
62_L	89_S	0.766	1.00
127_A	308_V	0.765	1.00
38_G	44_T	0.762	1.00
89_S	94_K	0.760	1.00
140_I	145_K	0.759	1.00
93_E	96_F	0.759	1.00
59_I	314_H	0.757	1.00
175_R	288_D	0.752	1.00
142_D	345_P	0.749	1.00
193_G	198_S	0.748	1.00
251_S	254_I	0.747	1.00
362_I	365_A	0.746	1.00
279_V	283_R	0.746	1.00
265_T	285_D	0.745	1.00
194_V	270_H	0.743	1.00
258_A	262_K	0.743	1.00
129_V	322_V	0.742	1.00
37_T	41_A	0.742	1.00
34_L	37_T	0.740	1.00
98_G	103_K	0.738	1.00
121_A	126_A	0.738	1.00
251_S	255_A	0.736	1.00
361_A	365_A	0.733	1.00
127_A	309_S	0.732	1.00
345_P	349_A	0.725	1.00
54_T	57_P	0.722	1.00
187_L	202_L	0.721	1.00
39_A	42_S	0.717	1.00
45_T	49_C	0.715	1.00
110_A	126_A	0.715	1.00
34_L	38_G	0.714	1.00
180_H	190_G	0.713	1.00
306_A	325_Y	0.711	1.00
166_G	302_W	0.711	1.00
57_P	82_A	0.710	1.00
215_L	218_G	0.710	1.00
355_R	359_Y	0.708	1.00
214_A	235_L	0.708	1.00
111_I	306_A	0.707	1.00
127_A	312_T	0.704	1.00
55_G	58_T	0.703	1.00
356_T	359_Y	0.702	1.00
361_A	364_P	0.702	1.00
180_H	293_A	0.701	1.00
219_F	222_A	0.701	1.00
60_N	108_D	0.700	1.00
130_P	158_P	0.699	1.00
215_L	220_R	0.697	1.00
139_A	328_P	0.697	1.00
261_V	265_T	0.697	1.00
44_T	47_A	0.696	1.00
133_D	137_Y	0.695	1.00
188_F	191_I	0.695	1.00
184_W	241_A	0.689	1.00
175_R	267_G	0.689	1.00
47_A	51_G	0.688	1.00
186_V	190_G	0.687	1.00
285_D	288_D	0.686	1.00
196_L	199_A	0.682	1.00
171_G	292_M	0.681	1.00
95_M	110_A	0.681	1.00
138_P	145_K	0.679	1.00
173_D	267_G	0.678	1.00
116_Y	119_K	0.677	1.00
239_T	243_I	0.673	1.00
188_F	250_L	0.672	1.00
281_N	285_D	0.670	1.00
171_G	279_V	0.669	1.00
131_V	134_L	0.668	1.00
211_S	215_L	0.668	1.00
181_D	190_G	0.666	1.00
97_A	100_Q	0.666	1.00
214_A	219_F	0.665	1.00
48_G	52_G	0.664	1.00
245_Q	250_L	0.664	1.00
364_P	367_L	0.662	1.00
80_V	317_L	0.661	1.00
61_V	86_V	0.660	1.00
43_A	47_A	0.659	1.00
61_V	109_I	0.656	1.00
66_H	69_R	0.654	1.00
192_D	248_S	0.653	1.00
130_P	319_W	0.652	1.00
305_A	309_S	0.649	1.00
77_E	81_D	0.645	1.00
259_S	263_G	0.643	1.00
210_M	214_A	0.642	1.00
328_P	331_G	0.642	1.00
363_D	368_A	0.641	1.00
221_D	224_D	0.640	1.00
117_V	160_G	0.639	1.00
195_D	198_S	0.638	1.00
255_A	259_S	0.636	1.00
191_I	250_L	0.636	1.00
133_D	316_D	0.636	1.00
108_D	318_A	0.635	1.00
139_A	345_P	0.635	1.00
87_T	107_F	0.630	1.00
77_E	82_A	0.628	1.00
37_T	44_T	0.627	1.00
112_P	120_F	0.624	1.00
127_A	311_Q	0.624	1.00
234_Q	238_V	0.624	1.00
57_P	60_N	0.623	1.00
231_S	235_L	0.617	1.00
72_V	324_E	0.612	1.00
350_H	354_R	0.609	1.00
171_G	290_I	0.609	1.00
238_V	242_L	0.607	1.00
59_I	318_A	0.603	1.00
141_Y	348_T	0.601	1.00
214_A	217_L	0.601	1.00
320_E	324_E	0.601	1.00
177_V	270_H	0.599	1.00
231_S	234_Q	0.598	1.00
355_R	358_L	0.598	1.00
99_W	309_S	0.598	1.00
136_S	139_A	0.597	1.00
170_Y	273_H	0.597	1.00
161_V	322_V	0.596	1.00
98_G	101_A	0.596	1.00
153_A	157_T	0.595	1.00
72_V	333_T	0.594	1.00
32_S	44_T	0.594	1.00
140_I	144_F	0.594	1.00
172_Y	177_V	0.593	1.00
226_D	229_T	0.591	1.00
87_T	98_G	0.589	1.00
113_N	116_Y	0.589	1.00
60_N	63_T	0.587	1.00
36_A	40_A	0.587	1.00
350_H	353_E	0.586	1.00
117_V	121_A	0.585	1.00
141_Y	145_K	0.585	1.00
280_T	283_R	0.584	1.00
108_D	313_D	0.582	1.00
213_A	218_G	0.582	1.00
263_G	266_K	0.582	1.00
278_N	281_N	0.581	1.00
223_F	229_T	0.579	1.00
164_R	304_E	0.576	1.00
253_Y	257_D	0.575	1.00
278_N	282_M	0.574	1.00
121_A	124_G	0.574	1.00
180_H	186_V	0.573	1.00
261_V	274_T	0.572	1.00
172_Y	271_V	0.571	1.00
315_P	318_A	0.569	1.00
212_A	216_H	0.569	1.00
38_G	45_T	0.568	1.00
228_I	231_S	0.567	1.00
224_D	227_R	0.566	1.00
363_D	367_L	0.566	1.00
109_I	306_A	0.565	1.00
34_L	45_T	0.562	1.00
37_T	43_A	0.561	1.00
61_V	111_I	0.560	1.00
359_Y	363_D	0.560	1.00
308_V	315_P	0.559	1.00
34_L	41_A	0.557	1.00
62_L	87_T	0.556	1.00
191_I	196_L	0.555	1.00
231_S	236_G	0.554	1.00
83_T	86_V	0.554	1.00
39_A	44_T	0.553	1.00
219_F	234_Q	0.552	1.00
319_W	322_V	0.552	1.00
129_V	319_W	0.552	1.00
190_G	193_G	0.551	1.00
119_K	122_A	0.551	1.00
347_T	350_H	0.549	1.00
39_A	45_T	0.549	1.00
46_L	50_L	0.547	1.00
72_V	325_Y	0.546	1.00
57_P	320_E	0.543	1.00
120_F	125_L	0.539	1.00
80_V	324_E	0.539	1.00
345_P	348_T	0.537	1.00
210_M	215_L	0.536	1.00
195_D	199_A	0.534	1.00
188_F	192_D	0.532	1.00
152_L	160_G	0.532	1.00
35_A	38_G	0.531	1.00
55_G	320_E	0.531	1.00
144_F	165_F	0.530	1.00
301_S	304_E	0.528	1.00
252_G	255_A	0.526	1.00
331_G	343_V	0.524	1.00
70_D	73_A	0.523	1.00
87_T	94_K	0.521	1.00
331_G	335_A	0.521	1.00
324_E	327_A	0.521	1.00
34_L	44_T	0.521	1.00
129_V	308_V	0.520	1.00
35_A	39_A	0.518	1.00
133_D	323_N	0.517	1.00
60_N	107_F	0.516	1.00
352_S	358_L	0.516	1.00
130_P	153_A	0.515	1.00
179_D	190_G	0.515	1.00
96_F	123_A	0.515	1.00
311_Q	315_P	0.514	1.00
205_N	209_A	0.513	1.00
132_S	136_S	0.513	1.00
138_P	141_Y	0.511	1.00
261_V	278_N	0.510	1.00
360_G	363_D	0.510	1.00
270_H	273_H	0.510	1.00
36_A	39_A	0.509	1.00
80_V	321_V	0.509	1.00
167_Y	276_R	0.507	1.00
54_T	81_D	0.506	1.00
125_L	128_P	0.506	1.00
212_A	217_L	0.505	1.00
305_A	308_V	0.503	1.00
33_F	36_A	0.502	1.00
236_G	239_T	0.501	1.00
118_P	154_V	0.501	1.00
82_A	86_V	0.501	1.00
57_P	63_T	0.500	1.00
111_I	163_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3uorA	1	0.8316	100	0.295	Contact Map
4r2fA	1	0.8291	100	0.31	Contact Map
4r9fA	1	0.8342	100	0.323	Contact Map
4mfiA	1	0.8316	100	0.334	Contact Map
3woaA	1	0.9439	100	0.342	Contact Map
3vxbA	1	0.8342	100	0.343	Contact Map
2xd3A	1	0.8163	100	0.359	Contact Map
4ovjA	1	0.8342	100	0.366	Contact Map
3osrA	1	0.8367	100	0.366	Contact Map
2zyoA	1	0.8316	100	0.369	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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