GREMLIN Database
Q9HNZ9 - Spermidine/putrescine ABC transporter
UniProt: Q9HNZ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (308)
Sequences: 16373 (12277)
Seq/√Len: 699.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
238_G242_A4.1261.00
80_T87_P3.9601.00
51_E225_R3.9011.00
29_G42_D3.8611.00
54_T223_S3.7991.00
26_R46_T3.6331.00
28_D80_T3.5161.00
141_D146_T3.4951.00
38_T41_A3.3031.00
317_A333_L2.9471.00
239_T242_A2.7591.00
27_L30_V2.7271.00
53_F227_G2.6581.00
133_A137_E2.6241.00
41_A233_E2.6131.00
128_G131_E2.6011.00
114_A118_G2.5211.00
26_R82_R2.5151.00
48_R51_E2.5071.00
31_R78_E2.4881.00
33_T38_T2.4781.00
28_D82_R2.3861.00
31_R38_T2.3621.00
235_V249_S2.3481.00
32_K69_L2.3391.00
320_R334_A2.2781.00
30_V76_P2.2781.00
31_R42_D2.2451.00
148_S151_R2.1941.00
144_N193_Q2.1881.00
29_G44_T2.1861.00
114_A133_A2.1491.00
135_R173_E2.1291.00
220_M241_A2.1071.00
114_A150_E2.0911.00
97_D175_A2.0231.00
84_N175_A1.9561.00
40_V69_L1.9471.00
250_P295_T1.9401.00
32_K77_T1.9301.00
82_R87_P1.9171.00
67_L212_V1.8751.00
114_A137_E1.8571.00
111_M119_Y1.8481.00
69_L76_P1.8361.00
70_I210_C1.7841.00
227_G234_L1.7821.00
134_R138_S1.7751.00
131_E134_R1.7621.00
230_R235_V1.7471.00
227_G237_V1.7111.00
25_V176_V1.6851.00
135_R138_S1.6831.00
33_T77_T1.6801.00
27_L45_L1.6791.00
47_L53_F1.6381.00
68_R74_E1.6051.00
32_K74_E1.5981.00
87_P90_G1.5961.00
179_L209_F1.5791.00
88_A91_V1.5361.00
139_A171_V1.5351.00
140_L149_G1.5341.00
275_T278_V1.4881.00
130_D134_R1.4871.00
67_L178_L1.4781.00
69_L81_I1.4701.00
112_S115_E1.4551.00
110_H154_G1.4521.00
131_E135_R1.4391.00
281_W284_V1.4341.00
118_G136_V1.4281.00
43_L66_T1.4161.00
127_V131_E1.4041.00
241_A245_R1.4001.00
83_I88_A1.3841.00
31_R41_A1.3771.00
114_A136_V1.3731.00
45_L227_G1.3551.00
28_D44_T1.3431.00
137_E141_D1.3421.00
115_E118_G1.3341.00
289_D292_G1.3191.00
250_P254_S1.3151.00
86_E175_A1.3021.00
86_E91_V1.2871.00
273_A276_L1.2691.00
138_S141_D1.2681.00
288_T291_T1.2631.00
53_F237_V1.2571.00
318_V334_A1.2541.00
137_E149_G1.2311.00
71_S178_L1.2301.00
27_L66_T1.2241.00
250_P263_D1.2231.00
108_F111_M1.2211.00
27_L70_I1.2211.00
127_V132_V1.2171.00
53_F225_R1.2151.00
112_S152_S1.2131.00
40_V43_L1.2091.00
40_V66_T1.1991.00
76_P81_I1.1971.00
278_V281_W1.1891.00
118_G132_V1.1831.00
91_V95_R1.1801.00
225_R237_V1.1771.00
33_T78_E1.1691.00
280_D283_T1.1671.00
143_V167_A1.1611.00
254_S263_D1.1501.00
274_P277_T1.1411.00
48_R225_R1.1321.00
202_S209_F1.1271.00
54_T219_A1.1231.00
113_V156_L1.1211.00
274_P278_V1.1151.00
30_V69_L1.1141.00
150_E153_P1.1091.00
288_T292_G1.1081.00
80_T89_T1.1071.00
24_L46_T1.1041.00
132_V136_V1.1021.00
202_S207_G1.0851.00
259_T297_S1.0811.00
24_L49_R1.0781.00
228_V243_V1.0661.00
99_N169_A1.0661.00
76_P89_T1.0641.00
138_S142_L1.0571.00
144_N147_E1.0571.00
66_T229_M1.0401.00
99_N174_P1.0391.00
51_E224_D1.0281.00
138_S173_E1.0271.00
111_M115_E1.0271.00
199_R222_V1.0241.00
322_R331_Y1.0181.00
114_A149_G1.0171.00
29_G78_E1.0071.00
279_G282_V1.0061.00
116_N168_R1.0031.00
311_A314_A1.0011.00
56_V228_V1.0001.00
34_Y39_A0.9991.00
27_L81_I0.9961.00
125_P172_N0.9911.00
115_E122_E0.9881.00
213_T219_A0.9831.00
234_L237_V0.9761.00
283_T287_A0.9721.00
322_R325_Q0.9681.00
33_T36_D0.9651.00
129_A133_A0.9621.00
281_W285_P0.9611.00
122_E129_A0.9601.00
49_R84_N0.9551.00
61_C229_M0.9531.00
118_G122_E0.9531.00
33_T39_A0.9521.00
129_A132_V0.9471.00
199_R221_A0.9331.00
117_V140_L0.9331.00
199_R203_D0.9321.00
92_P95_R0.9311.00
50_N206_E0.9221.00
120_G172_N0.9201.00
68_R73_F0.9181.00
151_R155_A0.9181.00
47_L208_S0.9181.00
82_R85_G0.9121.00
282_V285_P0.9121.00
30_V81_I0.9121.00
81_I88_A0.9101.00
242_A246_N0.9041.00
119_Y123_K0.9041.00
280_D284_V0.9031.00
152_S155_A0.8981.00
173_E207_G0.8981.00
198_L209_F0.8981.00
291_T295_T0.8931.00
55_L227_G0.8911.00
26_R85_G0.8891.00
312_D318_V0.8881.00
298_I302_M0.8871.00
140_L145_L0.8851.00
314_A317_A0.8851.00
49_R175_A0.8831.00
191_R215_D0.8811.00
58_P61_C0.8771.00
321_E324_F0.8731.00
273_A277_T0.8721.00
137_E146_T0.8701.00
300_P304_A0.8661.00
276_L280_D0.8641.00
107_L116_N0.8641.00
317_A320_R0.8631.00
211_Y223_S0.8611.00
117_V171_V0.8591.00
296_A301_E0.8541.00
116_N153_P0.8511.00
325_Q330_R0.8501.00
24_L84_N0.8451.00
318_V321_E0.8451.00
265_T293_T0.8431.00
284_V287_A0.8401.00
263_D295_T0.8331.00
230_R251_F0.8291.00
52_L222_V0.8271.00
299_R303_V0.8251.00
120_G168_R0.8241.00
319_V322_R0.8241.00
117_V167_A0.8221.00
52_L209_F0.8181.00
139_A143_V0.8171.00
327_E330_R0.8141.00
225_R236_Q0.8081.00
324_F329_V0.8081.00
301_E305_R0.8061.00
139_A170_L0.8061.00
245_R324_F0.8051.00
139_A142_L0.8031.00
153_P164_V0.8021.00
50_N208_S0.7941.00
175_A207_G0.7911.00
295_T299_R0.7901.00
279_G284_V0.7881.00
329_V332_R0.7871.00
111_M116_N0.7791.00
188_R192_K0.7751.00
64_T68_R0.7731.00
298_I301_E0.7671.00
35_G38_T0.7671.00
217_E221_A0.7631.00
252_V255_F0.7621.00
108_F120_G0.7611.00
192_K196_A0.7601.00
53_F210_C0.7581.00
291_T298_I0.7551.00
45_L237_V0.7541.00
24_L48_R0.7531.00
117_V120_G0.7511.00
183_L198_L0.7511.00
272_G277_T0.7501.00
297_S301_E0.7491.00
228_V252_V0.7411.00
201_L207_G0.7401.00
69_L77_T0.7341.00
140_L143_V0.7321.00
316_E319_V0.7321.00
277_T284_V0.7311.00
306_T309_A0.7311.00
282_V286_V0.7301.00
304_A308_D0.7281.00
32_K65_T0.7281.00
71_S100_L0.7231.00
296_A300_P0.7221.00
230_R233_E0.7211.00
177_L207_G0.7191.00
228_V247_P0.7181.00
272_G276_L0.7171.00
25_V83_I0.7171.00
314_A318_V0.7161.00
324_F327_E0.7161.00
329_V333_L0.7131.00
325_Q328_A0.7131.00
52_L202_S0.7121.00
219_A223_S0.7121.00
197_E200_R0.7111.00
166_L179_L0.7101.00
112_S150_E0.7051.00
296_A299_R0.7031.00
287_A291_T0.7021.00
196_A200_R0.7021.00
319_V325_Q0.7001.00
28_D46_T0.6951.00
318_V322_R0.6951.00
272_G275_T0.6951.00
285_P288_T0.6941.00
328_A332_R0.6931.00
298_I303_V0.6901.00
291_T294_V0.6901.00
69_L74_E0.6891.00
319_V324_F0.6861.00
183_L211_Y0.6821.00
107_L153_P0.6801.00
322_R326_G0.6801.00
279_G283_T0.6791.00
101_V162_Q0.6771.00
42_D78_E0.6691.00
275_T279_G0.6691.00
229_M234_L0.6691.00
313_H316_E0.6681.00
240_P244_Y0.6661.00
108_F116_N0.6651.00
119_Y122_E0.6631.00
244_Y247_P0.6611.00
285_P289_D0.6611.00
292_G295_T0.6601.00
246_N249_S0.6591.00
251_F254_S0.6571.00
132_V135_R0.6571.00
32_K40_V0.6571.00
257_G260_T0.6561.00
305_R309_A0.6561.00
178_L210_C0.6541.00
247_P252_V0.6521.00
286_V289_D0.6511.00
305_R308_D0.6481.00
315_F318_V0.6471.00
127_V135_R0.6461.00
139_A167_A0.6441.00
99_N209_F0.6421.00
128_G132_V0.6401.00
323_T326_G0.6401.00
284_V288_T0.6401.00
312_D316_E0.6391.00
113_V164_V0.6371.00
55_L229_M0.6351.00
136_V139_A0.6341.00
277_T281_W0.6331.00
278_V283_T0.6331.00
34_Y74_E0.6311.00
193_Q197_E0.6301.00
101_V169_A0.6291.00
294_V297_S0.6291.00
278_V282_V0.6281.00
312_D319_V0.6261.00
295_T298_I0.6241.00
252_V256_I0.6241.00
251_F255_F0.6221.00
184_S188_R0.6211.00
52_L198_L0.6201.00
33_T41_A0.6191.00
281_W286_V0.6161.00
261_L297_S0.6161.00
300_P303_V0.6161.00
296_A303_V0.6151.00
276_L281_W0.6141.00
133_A136_V0.6101.00
211_Y219_A0.6101.00
43_L234_L0.6091.00
104_Q161_Q0.6091.00
135_R139_A0.6071.00
241_A324_F0.6051.00
120_G123_K0.6051.00
127_V130_D0.6041.00
99_N172_N0.6031.00
121_L171_V0.6021.00
276_L284_V0.6021.00
319_V333_L0.6011.00
254_S258_D0.6001.00
289_D293_T0.5991.00
98_T176_V0.5991.00
226_I240_P0.5991.00
47_L210_C0.5981.00
145_L148_S0.5971.00
253_A257_G0.5971.00
312_D315_F0.5971.00
325_Q329_V0.5951.00
319_V331_Y0.5941.00
31_R40_V0.5941.00
269_A272_G0.5941.00
321_E325_Q0.5931.00
181_E214_H0.5921.00
61_C66_T0.5901.00
291_T296_A0.5891.00
326_G329_V0.5871.00
286_V290_A0.5871.00
308_D312_D0.5861.00
283_T286_V0.5861.00
293_T297_S0.5811.00
105_H185_S0.5811.00
179_L211_Y0.5791.00
177_L209_F0.5791.00
196_A321_E0.5791.00
304_A307_D0.5771.00
273_A278_V0.5741.00
293_T296_A0.5731.00
185_S195_Q0.5721.00
110_H152_S0.5711.00
188_R195_Q0.5711.00
146_T149_G0.5701.00
271_G274_P0.5701.00
327_E334_A0.5681.00
130_D133_A0.5681.00
51_E237_V0.5671.00
276_L279_G0.5671.00
151_R154_G0.5671.00
143_V194_M0.5651.00
114_A117_V0.5641.00
278_V284_V0.5631.00
277_T280_D0.5631.00
312_D322_R0.5611.00
274_P279_G0.5601.00
310_A314_A0.5601.00
112_S116_N0.5601.00
83_I98_T0.5601.00
97_D125_P0.5591.00
313_H318_V0.5591.00
280_D285_P0.5591.00
250_P261_L0.5591.00
310_A313_H0.5591.00
198_L222_V0.5581.00
195_Q221_A0.5571.00
311_A315_F0.5561.00
268_P271_G0.5551.00
302_M305_R0.5551.00
200_R321_E0.5541.00
319_V326_G0.5531.00
283_T291_T0.5531.00
211_Y222_V0.5511.00
109_S154_G0.5501.00
302_M308_D0.5501.00
47_L176_V0.5491.00
317_A321_E0.5491.00
233_E237_V0.5461.00
116_N121_L0.5461.00
311_A319_V0.5461.00
25_V47_L0.5451.00
287_A295_T0.5451.00
55_L66_T0.5441.00
73_F102_F0.5441.00
291_T299_R0.5441.00
101_V166_L0.5431.00
238_G243_V0.5411.00
292_G296_A0.5411.00
34_Y65_T0.5401.00
24_L208_S0.5401.00
212_V215_D0.5391.00
301_E309_A0.5371.00
329_V334_A0.5361.00
158_G163_R0.5331.00
70_I178_L0.5321.00
259_T262_V0.5311.00
287_A290_A0.5281.00
27_L43_L0.5281.00
290_A294_V0.5251.00
194_M197_E0.5241.00
88_A98_T0.5221.00
174_P177_L0.5221.00
140_L146_T0.5211.00
316_E320_R0.5181.00
41_A231_D0.5181.00
114_A132_V0.5171.00
290_A293_T0.5171.00
42_D233_E0.5161.00
318_V326_G0.5140.99
191_R218_L0.5110.99
55_L210_C0.5090.99
52_L211_Y0.5080.99
279_G286_V0.5070.99
41_A44_T0.5070.99
269_A273_A0.5060.99
233_E236_Q0.5060.99
240_P252_V0.5050.99
219_A226_I0.5050.99
263_D266_V0.5040.99
284_V291_T0.5030.99
122_E132_V0.5030.99
73_F106_A0.5010.99
196_A332_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yyzA 1 0.9225 100 0.247 Contact Map
1v43A 2 0.9064 100 0.247 Contact Map
1oxxK 1 0.9091 100 0.249 Contact Map
2it1A 1 0.9198 100 0.249 Contact Map
1g291 4 0.9278 100 0.249 Contact Map
3fvqA 2 0.9198 100 0.249 Contact Map
3rlfA 2 0.9251 100 0.251 Contact Map
1z47A 2 0.9198 100 0.252 Contact Map
3d31A 2 0.9198 100 0.253 Contact Map
3tuiC 2 0.8797 100 0.277 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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