GREMLIN Database
Q9HNZ8 - Uncharacterized protein
UniProt: Q9HNZ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (274)
Sequences: 2029 (1243)
Seq/√Len: 75.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_T34_A4.8871.00
41_T94_A4.6691.00
275_D279_G4.4031.00
44_V190_A4.2251.00
186_R218_P4.1361.00
134_R138_D4.0941.00
187_F221_A3.7121.00
45_R94_A3.5141.00
93_V190_A3.3881.00
49_R91_A3.2431.00
86_M95_V3.2321.00
59_A69_T3.0611.00
240_A271_V3.0021.00
251_Q255_D2.8251.00
84_A109_S2.8231.00
38_D97_R2.7961.00
97_R101_A2.7871.00
249_G252_A2.6791.00
109_S204_V2.6641.00
243_H248_L2.5221.00
18_P50_D2.4311.00
235_T238_R2.3671.00
61_P67_I2.2151.00
66_V87_P2.1671.00
82_A107_L2.1631.00
23_L292_A2.1391.00
73_M93_V2.1151.00
108_L116_F2.0941.00
62_Q68_R2.0641.00
62_Q66_V2.0261.00
41_T97_R2.0201.00
248_L256_R1.9801.00
40_V181_A1.8361.00
98_A102_D1.8291.00
255_D259_E1.8131.00
61_P132_D1.7651.00
19_R30_G1.7641.00
41_T73_M1.7001.00
222_A273_V1.6591.00
182_S274_V1.6591.00
243_H256_R1.6541.00
217_A245_E1.6221.00
88_G124_V1.6141.00
95_V122_I1.6050.99
64_D115_D1.6010.99
80_A106_V1.5930.99
239_R242_R1.5920.99
34_A39_A1.5800.99
111_V115_D1.5750.99
80_A210_I1.5670.99
72_G214_F1.5490.99
26_A30_G1.5430.99
137_W141_D1.5280.99
236_L257_A1.5240.99
116_F120_T1.5160.99
254_A273_V1.5030.99
191_T223_S1.4820.99
118_A124_V1.4770.99
107_L209_Q1.4450.99
43_A179_A1.4450.99
187_F216_A1.4180.99
258_I285_N1.4130.99
25_T28_D1.4100.99
84_A204_V1.3850.98
196_R227_A1.3830.98
44_V177_V1.3770.98
231_I269_A1.3650.98
75_T79_A1.3630.98
68_R87_P1.3630.98
78_R215_Y1.3610.98
250_A273_V1.3390.98
231_I236_L1.3320.98
98_A120_T1.3240.98
130_T133_T1.3190.98
182_S187_F1.3180.98
39_A43_A1.3050.98
40_V190_A1.3040.98
209_Q212_A1.3010.98
132_D137_W1.2850.98
268_S286_A1.2750.97
88_G127_D1.2700.97
85_S109_S1.2690.97
41_T45_R1.2620.97
88_G114_V1.2580.97
238_R242_R1.2450.97
89_V95_V1.2390.97
29_T39_A1.2370.97
25_T46_V1.2350.97
49_R90_E1.2220.97
240_A273_V1.2120.96
222_A237_S1.1920.96
34_A38_D1.1780.96
103_T200_L1.1760.96
94_A97_R1.1550.95
189_T214_F1.1500.95
44_V93_V1.1480.95
45_R91_A1.1370.95
243_H246_A1.1330.95
19_R26_A1.1330.95
219_A241_V1.1170.94
84_A107_L1.1070.94
223_S272_I1.1070.94
75_T186_R1.1050.94
61_P137_W1.0950.94
42_A45_R1.0940.94
209_Q232_A1.0910.94
67_I132_D1.0810.93
13_P16_P1.0800.93
103_T116_F1.0700.93
36_P188_A1.0670.93
242_R245_E1.0640.93
99_V103_T1.0630.93
89_V114_V1.0620.93
98_A122_I1.0500.92
141_D144_P1.0490.92
36_P181_A1.0470.92
28_D32_S1.0430.92
89_V117_A1.0390.92
180_V221_A1.0370.92
220_G241_V1.0250.91
113_A117_A1.0160.91
224_A271_V1.0140.91
178_G223_S1.0080.91
102_D120_T1.0060.91
89_V124_V1.0000.90
27_A31_A0.9980.90
81_G99_V0.9960.90
30_G39_A0.9960.90
136_R139_D0.9930.90
91_A94_A0.9890.90
20_Q24_E0.9860.90
220_G244_L0.9810.90
21_D50_D0.9800.90
72_G235_T0.9790.89
187_F275_D0.9740.89
76_S216_A0.9700.89
134_R137_W0.9650.89
248_L252_A0.9620.89
69_T125_E0.9500.88
69_T86_M0.9490.88
19_R27_A0.9440.88
90_E129_W0.9420.88
49_R129_W0.9400.87
239_R243_H0.9260.87
180_V223_S0.9220.86
193_T207_V0.9200.86
41_T101_A0.9160.86
65_G137_W0.9150.86
236_L261_F0.9020.85
37_V73_M0.9000.85
224_A237_S0.8980.85
140_L144_P0.8980.85
25_T43_A0.8960.85
36_P183_D0.8960.85
193_T206_D0.8910.84
110_G117_A0.8900.84
18_P22_T0.8900.84
54_N60_T0.8840.84
10_G54_N0.8770.84
22_T46_V0.8760.83
4_L221_A0.8750.83
42_A46_V0.8730.83
47_L55_A0.8720.83
37_V188_A0.8670.83
59_A67_I0.8640.83
25_T42_A0.8600.82
37_V101_A0.8600.82
284_H291_T0.8560.82
244_L273_V0.8550.82
5_V292_A0.8520.82
57_T91_A0.8510.82
217_A276_R0.8500.82
133_T140_L0.8480.81
99_V116_F0.8450.81
135_A139_D0.8450.81
252_A255_D0.8440.81
205_G208_P0.8400.81
179_A190_A0.8370.81
30_G33_H0.8360.81
114_V118_A0.8330.80
67_I127_D0.8330.80
29_T42_A0.8280.80
183_D186_R0.8220.79
225_T289_M0.8140.79
63_S201_A0.8130.79
45_R49_R0.8090.78
50_D57_T0.8060.78
83_A99_V0.8040.78
52_A231_I0.8020.78
31_A77_D0.8000.78
46_V50_D0.7990.77
246_A256_R0.7970.77
128_L134_R0.7920.77
64_D201_A0.7830.76
106_V229_E0.7820.76
40_V188_A0.7780.76
44_V179_A0.7770.75
88_G125_E0.7750.75
11_A290_Q0.7730.75
191_T214_F0.7710.75
37_V41_T0.7670.75
70_D207_V0.7670.75
187_F212_A0.7650.74
7_G53_F0.7620.74
242_R260_E0.7610.74
27_A30_G0.7580.74
128_L133_T0.7570.74
99_V105_H0.7490.73
80_A107_L0.7460.72
259_E262_S0.7440.72
22_T26_A0.7420.72
250_A281_G0.7410.72
100_M103_T0.7400.72
54_N194_G0.7400.72
258_I261_F0.7390.72
255_D283_A0.7390.72
106_V210_I0.7380.72
72_G210_I0.7370.72
60_T199_A0.7360.71
87_P111_V0.7340.71
35_T38_D0.7330.71
212_A235_T0.7310.71
129_W133_T0.7280.71
238_R243_H0.7210.70
244_L275_D0.7190.70
72_G189_T0.7160.69
39_A42_A0.7150.69
99_V107_L0.7150.69
251_Q281_G0.7100.69
70_D112_H0.7080.68
4_L280_C0.7060.68
37_V97_R0.7050.68
98_A101_A0.7030.68
112_H116_F0.7030.68
26_A43_A0.7010.68
55_A177_V0.6990.67
59_A194_G0.6950.67
19_R23_L0.6940.67
189_T216_A0.6930.67
70_D204_V0.6910.67
106_V232_A0.6890.66
167_R170_P0.6870.66
18_P21_D0.6840.66
269_A289_M0.6820.66
29_T32_S0.6790.65
191_T272_I0.6770.65
107_L204_V0.6750.65
222_A241_V0.6740.65
180_V191_T0.6740.65
69_T114_V0.6710.64
5_V22_T0.6710.64
91_A123_P0.6700.64
11_A288_A0.6700.64
210_I214_F0.6700.64
63_S144_P0.6690.64
284_H289_M0.6680.64
95_V221_A0.6660.64
251_Q283_A0.6660.64
68_R199_A0.6650.64
19_R22_T0.6620.63
5_V43_A0.6610.63
234_T238_R0.6590.63
138_D142_S0.6590.63
114_V124_V0.6580.63
234_T265_T0.6550.62
258_I262_S0.6530.62
136_R197_W0.6520.62
177_V192_S0.6520.62
22_T42_A0.6510.62
36_P185_D0.6450.61
254_A271_V0.6450.61
171_P174_H0.6450.61
12_P288_A0.6400.61
137_W144_P0.6400.61
28_D31_A0.6370.60
13_P287_A0.6340.60
37_V100_M0.6330.60
252_A256_R0.6330.60
61_P196_R0.6270.59
57_T129_W0.6260.59
51_P130_T0.6250.59
219_A245_E0.6240.59
47_L194_G0.6240.59
141_D145_D0.6240.59
130_T134_R0.6240.59
271_V283_A0.6210.58
182_S185_D0.6190.58
288_A291_T0.6180.58
230_A234_T0.6160.58
138_D141_D0.6120.57
102_D145_D0.6100.57
140_L143_H0.6090.57
74_M80_A0.6090.57
70_D85_S0.6070.57
78_R217_A0.6030.56
135_A138_D0.6020.56
208_P224_A0.6000.56
100_M210_I0.5990.56
114_V125_E0.5980.56
254_A281_G0.5980.56
164_P169_S0.5980.56
73_M94_A0.5960.55
28_D42_A0.5960.55
220_G240_A0.5960.55
244_L247_G0.5950.55
236_L271_V0.5950.55
203_R228_G0.5940.55
224_A240_A0.5890.54
216_A221_A0.5890.54
10_G288_A0.5890.54
81_G96_A0.5880.54
127_D130_T0.5870.54
20_Q32_S0.5860.54
126_S130_T0.5860.54
57_T130_T0.5850.54
17_A21_D0.5830.54
24_E28_D0.5820.54
57_T128_L0.5820.54
60_T194_G0.5810.53
27_A69_T0.5810.53
169_S172_G0.5800.53
95_V98_A0.5790.53
97_R100_M0.5780.53
70_D107_L0.5770.53
169_S292_A0.5770.53
51_P57_T0.5740.53
286_A289_M0.5740.53
53_F191_T0.5730.52
64_D143_H0.5730.52
33_H183_D0.5700.52
55_A194_G0.5690.52
149_T164_P0.5680.52
270_G284_H0.5680.52
112_H229_E0.5680.52
54_N61_P0.5640.51
7_G206_D0.5630.51
39_A181_A0.5600.51
67_I197_W0.5600.51
86_M92_A0.5590.51
18_P30_G0.5590.51
176_T228_G0.5590.51
4_L88_G0.5580.51
57_T133_T0.5570.50
238_R245_E0.5570.50
115_D119_D0.5560.50
191_T225_T0.5550.50
7_G193_T0.5540.50
125_E128_L0.5540.50
12_P15_A0.5510.50
175_D223_S0.5460.49
76_S188_A0.5450.49
31_A167_R0.5440.49
132_D141_D0.5440.49
49_R57_T0.5440.49
53_F60_T0.5440.49
258_I269_A0.5440.49
270_G289_M0.5410.48
219_A244_L0.5410.48
83_A95_V0.5390.48
256_R260_E0.5380.48
11_A14_D0.5360.48
244_L249_G0.5350.48
67_I137_W0.5350.48
11_A207_V0.5330.47
85_S112_H0.5330.47
13_P244_L0.5320.47
43_A181_A0.5310.47
282_T285_N0.5310.47
282_T291_T0.5300.47
130_T137_W0.5280.47
10_G13_P0.5280.47
142_S145_D0.5280.47
224_A231_I0.5270.47
193_T208_P0.5260.47
72_G80_A0.5260.47
38_D41_T0.5260.47
5_V18_P0.5250.46
191_T206_D0.5250.46
143_H198_L0.5220.46
217_A241_V0.5210.46
125_E129_W0.5210.46
206_D215_Y0.5200.46
18_P46_V0.5200.46
95_V116_F0.5190.46
250_A254_A0.5190.46
113_A116_F0.5190.46
175_D214_F0.5180.46
80_A232_A0.5180.46
168_E171_P0.5170.45
87_P287_A0.5170.45
47_L54_N0.5170.45
65_G144_P0.5170.45
34_A181_A0.5170.45
191_T267_A0.5170.45
133_T144_P0.5170.45
35_T186_R0.5140.45
285_N291_T0.5140.45
103_T120_T0.5130.45
72_G92_A0.5130.45
80_A214_F0.5110.45
95_V99_V0.5080.44
21_D28_D0.5070.44
72_G175_D0.5070.44
227_A230_A0.5070.44
232_A235_T0.5070.44
178_G270_G0.5050.44
105_H208_P0.5050.44
35_T188_A0.5010.43
18_P26_A0.5010.43
147_S198_L0.5000.43
14_D288_A0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c17A 2 0.9422 100 0.096 Contact Map
4o0cA 2 0.8946 100 0.113 Contact Map
2a8jA 2 0.8231 100 0.139 Contact Map
1p4kA 2 0.9116 100 0.179 Contact Map
4pv2A 1 0.483 100 0.435 Contact Map
2gezA 2 0.5068 100 0.526 Contact Map
1k2xA 1 0.4864 100 0.528 Contact Map
1apyA 2 0.5408 100 0.56 Contact Map
1k2xB 2 0.4048 100 0.607 Contact Map
2gezB 2 0.398 100 0.614 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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