Q9HNZ8 - HALSA - GREMLIN Contacts

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Q9HNZ8 - Uncharacterized protein

UniProt:	Q9HNZ8	Sequences: MRVLVHGGAGAPPDAPAPRQDTLETAADTGASHATPVDAVTAAVRVLERDPAFNAGTGATPQSDGVIRTDAGMMTSDRAAGAAASMPGVEAAVAVARAVMADTPHVLLSGVHAVDFAADTGIPVESDLWTADTRARWDDLDSHPDGSPTDHRDWVRERFGRTDPGGRESPPGDHDTVGAVASDGDRFATATSTGGRWLALAGRVGDVPQIGAGFYAAPAGAASATGAGEAIAKTTLSRRAVRHLEAGLGAQAAADRAIEEFSELTGASAGVIVVDRDGGCGTAHNAAAMQTARH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	294 (274)
Sequences:	2029 (1243)
Seq/√Len:	75.1

ECOLI - IAAA
HALSA - Q9HNZ8
SULSO - Q97W87

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
29_T	34_A	4.887	1.00
41_T	94_A	4.669	1.00
275_D	279_G	4.403	1.00
44_V	190_A	4.225	1.00
186_R	218_P	4.136	1.00
134_R	138_D	4.094	1.00
187_F	221_A	3.712	1.00
45_R	94_A	3.514	1.00
93_V	190_A	3.388	1.00
49_R	91_A	3.243	1.00
86_M	95_V	3.232	1.00
59_A	69_T	3.061	1.00
240_A	271_V	3.002	1.00
251_Q	255_D	2.825	1.00
84_A	109_S	2.823	1.00
38_D	97_R	2.796	1.00
97_R	101_A	2.787	1.00
249_G	252_A	2.679	1.00
109_S	204_V	2.664	1.00
243_H	248_L	2.522	1.00
18_P	50_D	2.431	1.00
235_T	238_R	2.367	1.00
61_P	67_I	2.215	1.00
66_V	87_P	2.167	1.00
82_A	107_L	2.163	1.00
23_L	292_A	2.139	1.00
73_M	93_V	2.115	1.00
108_L	116_F	2.094	1.00
62_Q	68_R	2.064	1.00
62_Q	66_V	2.026	1.00
41_T	97_R	2.020	1.00
248_L	256_R	1.980	1.00
40_V	181_A	1.836	1.00
98_A	102_D	1.829	1.00
255_D	259_E	1.813	1.00
61_P	132_D	1.765	1.00
19_R	30_G	1.764	1.00
41_T	73_M	1.700	1.00
222_A	273_V	1.659	1.00
182_S	274_V	1.659	1.00
243_H	256_R	1.654	1.00
217_A	245_E	1.622	1.00
88_G	124_V	1.614	1.00
95_V	122_I	1.605	0.99
64_D	115_D	1.601	0.99
80_A	106_V	1.593	0.99
239_R	242_R	1.592	0.99
34_A	39_A	1.580	0.99
111_V	115_D	1.575	0.99
80_A	210_I	1.567	0.99
72_G	214_F	1.549	0.99
26_A	30_G	1.543	0.99
137_W	141_D	1.528	0.99
236_L	257_A	1.524	0.99
116_F	120_T	1.516	0.99
254_A	273_V	1.503	0.99
191_T	223_S	1.482	0.99
118_A	124_V	1.477	0.99
107_L	209_Q	1.445	0.99
43_A	179_A	1.445	0.99
187_F	216_A	1.418	0.99
258_I	285_N	1.413	0.99
25_T	28_D	1.410	0.99
84_A	204_V	1.385	0.98
196_R	227_A	1.383	0.98
44_V	177_V	1.377	0.98
231_I	269_A	1.365	0.98
75_T	79_A	1.363	0.98
68_R	87_P	1.363	0.98
78_R	215_Y	1.361	0.98
250_A	273_V	1.339	0.98
231_I	236_L	1.332	0.98
98_A	120_T	1.324	0.98
130_T	133_T	1.319	0.98
182_S	187_F	1.318	0.98
39_A	43_A	1.305	0.98
40_V	190_A	1.304	0.98
209_Q	212_A	1.301	0.98
132_D	137_W	1.285	0.98
268_S	286_A	1.275	0.97
88_G	127_D	1.270	0.97
85_S	109_S	1.269	0.97
41_T	45_R	1.262	0.97
88_G	114_V	1.258	0.97
238_R	242_R	1.245	0.97
89_V	95_V	1.239	0.97
29_T	39_A	1.237	0.97
25_T	46_V	1.235	0.97
49_R	90_E	1.222	0.97
240_A	273_V	1.212	0.96
222_A	237_S	1.192	0.96
34_A	38_D	1.178	0.96
103_T	200_L	1.176	0.96
94_A	97_R	1.155	0.95
189_T	214_F	1.150	0.95
44_V	93_V	1.148	0.95
45_R	91_A	1.137	0.95
243_H	246_A	1.133	0.95
19_R	26_A	1.133	0.95
219_A	241_V	1.117	0.94
84_A	107_L	1.107	0.94
223_S	272_I	1.107	0.94
75_T	186_R	1.105	0.94
61_P	137_W	1.095	0.94
42_A	45_R	1.094	0.94
209_Q	232_A	1.091	0.94
67_I	132_D	1.081	0.93
13_P	16_P	1.080	0.93
103_T	116_F	1.070	0.93
36_P	188_A	1.067	0.93
242_R	245_E	1.064	0.93
99_V	103_T	1.063	0.93
89_V	114_V	1.062	0.93
98_A	122_I	1.050	0.92
141_D	144_P	1.049	0.92
36_P	181_A	1.047	0.92
28_D	32_S	1.043	0.92
89_V	117_A	1.039	0.92
180_V	221_A	1.037	0.92
220_G	241_V	1.025	0.91
113_A	117_A	1.016	0.91
224_A	271_V	1.014	0.91
178_G	223_S	1.008	0.91
102_D	120_T	1.006	0.91
89_V	124_V	1.000	0.90
27_A	31_A	0.998	0.90
81_G	99_V	0.996	0.90
30_G	39_A	0.996	0.90
136_R	139_D	0.993	0.90
91_A	94_A	0.989	0.90
20_Q	24_E	0.986	0.90
220_G	244_L	0.981	0.90
21_D	50_D	0.980	0.90
72_G	235_T	0.979	0.89
187_F	275_D	0.974	0.89
76_S	216_A	0.970	0.89
134_R	137_W	0.965	0.89
248_L	252_A	0.962	0.89
69_T	125_E	0.950	0.88
69_T	86_M	0.949	0.88
19_R	27_A	0.944	0.88
90_E	129_W	0.942	0.88
49_R	129_W	0.940	0.87
239_R	243_H	0.926	0.87
180_V	223_S	0.922	0.86
193_T	207_V	0.920	0.86
41_T	101_A	0.916	0.86
65_G	137_W	0.915	0.86
236_L	261_F	0.902	0.85
37_V	73_M	0.900	0.85
224_A	237_S	0.898	0.85
140_L	144_P	0.898	0.85
25_T	43_A	0.896	0.85
36_P	183_D	0.896	0.85
193_T	206_D	0.891	0.84
110_G	117_A	0.890	0.84
18_P	22_T	0.890	0.84
54_N	60_T	0.884	0.84
10_G	54_N	0.877	0.84
22_T	46_V	0.876	0.83
4_L	221_A	0.875	0.83
42_A	46_V	0.873	0.83
47_L	55_A	0.872	0.83
37_V	188_A	0.867	0.83
59_A	67_I	0.864	0.83
25_T	42_A	0.860	0.82
37_V	101_A	0.860	0.82
284_H	291_T	0.856	0.82
244_L	273_V	0.855	0.82
5_V	292_A	0.852	0.82
57_T	91_A	0.851	0.82
217_A	276_R	0.850	0.82
133_T	140_L	0.848	0.81
99_V	116_F	0.845	0.81
135_A	139_D	0.845	0.81
252_A	255_D	0.844	0.81
205_G	208_P	0.840	0.81
179_A	190_A	0.837	0.81
30_G	33_H	0.836	0.81
114_V	118_A	0.833	0.80
67_I	127_D	0.833	0.80
29_T	42_A	0.828	0.80
183_D	186_R	0.822	0.79
225_T	289_M	0.814	0.79
63_S	201_A	0.813	0.79
45_R	49_R	0.809	0.78
50_D	57_T	0.806	0.78
83_A	99_V	0.804	0.78
52_A	231_I	0.802	0.78
31_A	77_D	0.800	0.78
46_V	50_D	0.799	0.77
246_A	256_R	0.797	0.77
128_L	134_R	0.792	0.77
64_D	201_A	0.783	0.76
106_V	229_E	0.782	0.76
40_V	188_A	0.778	0.76
44_V	179_A	0.777	0.75
88_G	125_E	0.775	0.75
11_A	290_Q	0.773	0.75
191_T	214_F	0.771	0.75
37_V	41_T	0.767	0.75
70_D	207_V	0.767	0.75
187_F	212_A	0.765	0.74
7_G	53_F	0.762	0.74
242_R	260_E	0.761	0.74
27_A	30_G	0.758	0.74
128_L	133_T	0.757	0.74
99_V	105_H	0.749	0.73
80_A	107_L	0.746	0.72
259_E	262_S	0.744	0.72
22_T	26_A	0.742	0.72
250_A	281_G	0.741	0.72
100_M	103_T	0.740	0.72
54_N	194_G	0.740	0.72
258_I	261_F	0.739	0.72
255_D	283_A	0.739	0.72
106_V	210_I	0.738	0.72
72_G	210_I	0.737	0.72
60_T	199_A	0.736	0.71
87_P	111_V	0.734	0.71
35_T	38_D	0.733	0.71
212_A	235_T	0.731	0.71
129_W	133_T	0.728	0.71
238_R	243_H	0.721	0.70
244_L	275_D	0.719	0.70
72_G	189_T	0.716	0.69
39_A	42_A	0.715	0.69
99_V	107_L	0.715	0.69
251_Q	281_G	0.710	0.69
70_D	112_H	0.708	0.68
4_L	280_C	0.706	0.68
37_V	97_R	0.705	0.68
98_A	101_A	0.703	0.68
112_H	116_F	0.703	0.68
26_A	43_A	0.701	0.68
55_A	177_V	0.699	0.67
59_A	194_G	0.695	0.67
19_R	23_L	0.694	0.67
189_T	216_A	0.693	0.67
70_D	204_V	0.691	0.67
106_V	232_A	0.689	0.66
167_R	170_P	0.687	0.66
18_P	21_D	0.684	0.66
269_A	289_M	0.682	0.66
29_T	32_S	0.679	0.65
191_T	272_I	0.677	0.65
107_L	204_V	0.675	0.65
222_A	241_V	0.674	0.65
180_V	191_T	0.674	0.65
69_T	114_V	0.671	0.64
5_V	22_T	0.671	0.64
91_A	123_P	0.670	0.64
11_A	288_A	0.670	0.64
210_I	214_F	0.670	0.64
63_S	144_P	0.669	0.64
284_H	289_M	0.668	0.64
95_V	221_A	0.666	0.64
251_Q	283_A	0.666	0.64
68_R	199_A	0.665	0.64
19_R	22_T	0.662	0.63
5_V	43_A	0.661	0.63
234_T	238_R	0.659	0.63
138_D	142_S	0.659	0.63
114_V	124_V	0.658	0.63
234_T	265_T	0.655	0.62
258_I	262_S	0.653	0.62
136_R	197_W	0.652	0.62
177_V	192_S	0.652	0.62
22_T	42_A	0.651	0.62
36_P	185_D	0.645	0.61
254_A	271_V	0.645	0.61
171_P	174_H	0.645	0.61
12_P	288_A	0.640	0.61
137_W	144_P	0.640	0.61
28_D	31_A	0.637	0.60
13_P	287_A	0.634	0.60
37_V	100_M	0.633	0.60
252_A	256_R	0.633	0.60
61_P	196_R	0.627	0.59
57_T	129_W	0.626	0.59
51_P	130_T	0.625	0.59
219_A	245_E	0.624	0.59
47_L	194_G	0.624	0.59
141_D	145_D	0.624	0.59
130_T	134_R	0.624	0.59
271_V	283_A	0.621	0.58
182_S	185_D	0.619	0.58
288_A	291_T	0.618	0.58
230_A	234_T	0.616	0.58
138_D	141_D	0.612	0.57
102_D	145_D	0.610	0.57
140_L	143_H	0.609	0.57
74_M	80_A	0.609	0.57
70_D	85_S	0.607	0.57
78_R	217_A	0.603	0.56
135_A	138_D	0.602	0.56
208_P	224_A	0.600	0.56
100_M	210_I	0.599	0.56
114_V	125_E	0.598	0.56
254_A	281_G	0.598	0.56
164_P	169_S	0.598	0.56
73_M	94_A	0.596	0.55
28_D	42_A	0.596	0.55
220_G	240_A	0.596	0.55
244_L	247_G	0.595	0.55
236_L	271_V	0.595	0.55
203_R	228_G	0.594	0.55
224_A	240_A	0.589	0.54
216_A	221_A	0.589	0.54
10_G	288_A	0.589	0.54
81_G	96_A	0.588	0.54
127_D	130_T	0.587	0.54
20_Q	32_S	0.586	0.54
126_S	130_T	0.586	0.54
57_T	130_T	0.585	0.54
17_A	21_D	0.583	0.54
24_E	28_D	0.582	0.54
57_T	128_L	0.582	0.54
60_T	194_G	0.581	0.53
27_A	69_T	0.581	0.53
169_S	172_G	0.580	0.53
95_V	98_A	0.579	0.53
97_R	100_M	0.578	0.53
70_D	107_L	0.577	0.53
169_S	292_A	0.577	0.53
51_P	57_T	0.574	0.53
286_A	289_M	0.574	0.53
53_F	191_T	0.573	0.52
64_D	143_H	0.573	0.52
33_H	183_D	0.570	0.52
55_A	194_G	0.569	0.52
149_T	164_P	0.568	0.52
270_G	284_H	0.568	0.52
112_H	229_E	0.568	0.52
54_N	61_P	0.564	0.51
7_G	206_D	0.563	0.51
39_A	181_A	0.560	0.51
67_I	197_W	0.560	0.51
86_M	92_A	0.559	0.51
18_P	30_G	0.559	0.51
176_T	228_G	0.559	0.51
4_L	88_G	0.558	0.51
57_T	133_T	0.557	0.50
238_R	245_E	0.557	0.50
115_D	119_D	0.556	0.50
191_T	225_T	0.555	0.50
7_G	193_T	0.554	0.50
125_E	128_L	0.554	0.50
12_P	15_A	0.551	0.50
175_D	223_S	0.546	0.49
76_S	188_A	0.545	0.49
31_A	167_R	0.544	0.49
132_D	141_D	0.544	0.49
49_R	57_T	0.544	0.49
53_F	60_T	0.544	0.49
258_I	269_A	0.544	0.49
270_G	289_M	0.541	0.48
219_A	244_L	0.541	0.48
83_A	95_V	0.539	0.48
256_R	260_E	0.538	0.48
11_A	14_D	0.536	0.48
244_L	249_G	0.535	0.48
67_I	137_W	0.535	0.48
11_A	207_V	0.533	0.47
85_S	112_H	0.533	0.47
13_P	244_L	0.532	0.47
43_A	181_A	0.531	0.47
282_T	285_N	0.531	0.47
282_T	291_T	0.530	0.47
130_T	137_W	0.528	0.47
10_G	13_P	0.528	0.47
142_S	145_D	0.528	0.47
224_A	231_I	0.527	0.47
193_T	208_P	0.526	0.47
72_G	80_A	0.526	0.47
38_D	41_T	0.526	0.47
5_V	18_P	0.525	0.46
191_T	206_D	0.525	0.46
143_H	198_L	0.522	0.46
217_A	241_V	0.521	0.46
125_E	129_W	0.521	0.46
206_D	215_Y	0.520	0.46
18_P	46_V	0.520	0.46
95_V	116_F	0.519	0.46
250_A	254_A	0.519	0.46
113_A	116_F	0.519	0.46
175_D	214_F	0.518	0.46
80_A	232_A	0.518	0.46
168_E	171_P	0.517	0.45
87_P	287_A	0.517	0.45
47_L	54_N	0.517	0.45
65_G	144_P	0.517	0.45
34_A	181_A	0.517	0.45
191_T	267_A	0.517	0.45
133_T	144_P	0.517	0.45
35_T	186_R	0.514	0.45
285_N	291_T	0.514	0.45
103_T	120_T	0.513	0.45
72_G	92_A	0.513	0.45
80_A	214_F	0.511	0.45
95_V	99_V	0.508	0.44
21_D	28_D	0.507	0.44
72_G	175_D	0.507	0.44
227_A	230_A	0.507	0.44
232_A	235_T	0.507	0.44
178_G	270_G	0.505	0.44
105_H	208_P	0.505	0.44
35_T	188_A	0.501	0.43
18_P	26_A	0.501	0.43
147_S	198_L	0.500	0.43
14_D	288_A	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3c17A	2	0.9422	100	0.096	Contact Map
4o0cA	2	0.8946	100	0.113	Contact Map
2a8jA	2	0.8231	100	0.139	Contact Map
1p4kA	2	0.9116	100	0.179	Contact Map
4pv2A	1	0.483	100	0.435	Contact Map
2gezA	2	0.5068	100	0.526	Contact Map
1k2xA	1	0.4864	100	0.528	Contact Map
1apyA	2	0.5408	100	0.56	Contact Map
1k2xB	2	0.4048	100	0.607	Contact Map
2gezB	2	0.398	100	0.614	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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