GREMLIN Database
Q9HNZ7 - Isocitrate dehydrogenase, NADP
UniProt: Q9HNZ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (338)
Sequences: 7005 (3021)
Seq/√Len: 164.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_I253_D4.2611.00
209_R250_E3.9781.00
208_V243_G3.1111.00
47_I411_A3.0781.00
209_R213_D2.9281.00
31_I64_E2.8091.00
50_D412_E2.7431.00
286_A290_W2.7001.00
388_S417_R2.6851.00
367_E379_R2.6181.00
53_S65_W2.4711.00
84_E88_E2.4511.00
384_D417_R2.4211.00
413_A416_D2.3321.00
45_G358_L2.3281.00
59_T377_L2.2761.00
201_E205_K2.2501.00
47_I50_D2.2021.00
34_I49_Q2.1981.00
224_T280_E2.1821.00
367_E376_T2.1491.00
80_E84_E2.1051.00
68_V89_A2.0841.00
385_T417_R2.0451.00
243_G279_V2.0401.00
222_T280_E2.0401.00
148_V214_Y2.0281.00
33_P89_A1.9951.00
49_Q67_E1.9691.00
91_R120_L1.9651.00
360_L382_V1.9631.00
69_Y77_M1.9611.00
208_V302_A1.9291.00
356_T414_V1.9271.00
371_W374_A1.9251.00
205_K242_W1.9191.00
205_K245_E1.9151.00
222_T278_M1.8951.00
351_D406_S1.8601.00
213_D251_Y1.8591.00
359_I414_V1.8441.00
294_R297_E1.8381.00
74_A83_P1.8221.00
40_I353_A1.8211.00
351_D408_T1.8211.00
88_E92_E1.7781.00
376_T380_D1.7731.00
42_K46_P1.7681.00
363_R379_R1.7541.00
411_A415_I1.7521.00
201_E245_E1.7511.00
244_M281_E1.7191.00
390_T413_A1.7171.00
209_R251_Y1.6871.00
226_V287_M1.6631.00
130_Y383_E1.6581.00
242_W245_E1.6541.00
91_R119_T1.6421.00
205_K209_R1.6371.00
412_E416_D1.6371.00
372_D376_T1.6061.00
164_E241_D1.5931.00
29_T64_E1.5821.00
197_K304_P1.5631.00
126_V148_V1.5531.00
133_D387_E1.5501.00
191_D201_E1.5321.00
190_G202_K1.5291.00
123_Y332_A1.5241.00
55_A378_V1.5231.00
66_M92_E1.5181.00
33_P93_H1.5171.00
87_V119_T1.5141.00
29_T62_D1.5081.00
73_S77_M1.4991.00
88_E91_R1.4891.00
406_S409_T1.4831.00
30_P371_W1.4711.00
48_A362_G1.4711.00
246_V250_E1.4611.00
61_H371_W1.4561.00
212_I247_A1.4531.00
292_Q314_A1.4471.00
65_W362_G1.4421.00
35_I70_A1.4401.00
367_E375_S1.4341.00
225_L243_G1.4341.00
115_A119_T1.4321.00
50_D415_I1.4111.00
150_F210_E1.4091.00
209_R246_V1.3991.00
61_H374_A1.3951.00
351_D407_S1.3931.00
33_P68_V1.3901.00
52_L63_I1.3831.00
149_T312_S1.3821.00
220_R299_D1.3811.00
54_A415_I1.3751.00
49_Q53_S1.3611.00
134_G387_E1.3531.00
66_M93_H1.3471.00
213_D217_E1.3411.00
48_A97_I1.3381.00
36_H67_E1.3331.00
69_Y78_Y1.3161.00
356_T410_Y1.3121.00
82_L87_V1.3091.00
415_I418_I1.2971.00
352_K393_Y1.2701.00
238_Q242_W1.2681.00
150_F214_Y1.2651.00
288_L311_L1.2631.00
225_L281_E1.2531.00
213_D216_I1.2501.00
385_T413_A1.2461.00
367_E372_D1.2401.00
282_R290_W1.2321.00
69_Y74_A1.2281.00
58_A377_L1.2271.00
195_G234_F1.2241.00
30_P369_I1.2151.00
365_L369_I1.2131.00
66_M89_A1.2131.00
410_Y414_V1.2121.00
48_A358_L1.2121.00
221_D299_D1.2111.00
49_Q65_W1.2001.00
380_D384_D1.1931.00
208_V246_V1.1891.00
31_I66_M1.1761.00
245_E248_E1.1491.00
366_F374_A1.1481.00
282_R286_A1.1431.00
244_M248_E1.1411.00
51_V378_V1.1381.00
197_K234_F1.1361.00
149_T315_A1.1311.00
282_R298_F1.1291.00
409_T412_E1.1251.00
147_M291_M1.1171.00
34_I67_E1.1161.00
291_M301_L1.1121.00
74_A78_Y1.1111.00
201_E242_W1.1031.00
216_I221_D1.1011.00
126_V150_F1.0981.00
33_P90_I1.0971.00
241_D245_E1.0971.00
282_R287_M1.0951.00
205_K246_V1.0911.00
90_I96_A1.0851.00
351_D409_T1.0811.00
52_L362_G1.0801.00
97_I362_G1.0781.00
288_L314_A1.0730.99
130_Y146_D1.0690.99
413_A417_R1.0630.99
121_D206_R1.0620.99
347_R353_A1.0600.99
377_L418_I1.0600.99
212_I251_Y1.0530.99
54_A58_A1.0520.99
284_A310_Y1.0490.99
229_G240_G1.0470.99
144_E296_D1.0450.99
223_V279_V1.0450.99
55_A374_A1.0430.99
212_I254_D1.0430.99
50_D408_T1.0410.99
78_Y85_E1.0400.99
204_S208_V1.0330.99
124_A207_L1.0180.99
162_E196_L1.0160.99
384_D388_S1.0140.99
218_N299_D1.0100.99
157_V304_P1.0080.99
290_W297_E1.0040.99
157_V197_K1.0020.99
98_K113_N1.0010.99
214_Y218_N0.9980.99
396_A399_R0.9920.99
46_P50_D0.9900.99
47_I408_T0.9890.99
193_G238_Q0.9860.99
202_K205_K0.9840.99
50_D411_A0.9810.99
192_I198_P0.9800.99
76_E105_V0.9770.99
48_A359_I0.9760.99
85_E88_E0.9750.99
54_A57_E0.9720.99
356_T386_I0.9710.99
153_N329_N0.9670.99
226_V284_A0.9650.99
51_V415_I0.9640.99
199_I304_P0.9570.99
74_A86_T0.9540.99
243_G302_A0.9480.99
34_I45_G0.9480.99
211_A223_V0.9470.99
130_Y379_R0.9470.99
70_A116_L0.9450.99
133_D143_E0.9420.99
385_T390_T0.9340.99
293_L317_A0.9330.99
223_V246_V0.9310.99
83_P86_T0.9290.99
44_V358_L0.9270.98
76_E103_T0.9260.98
223_V300_V0.9230.98
356_T382_V0.9230.98
227_H240_G0.9230.98
156_D197_K0.9210.98
280_E297_E0.9200.98
55_A362_G0.9180.98
43_D349_G0.9180.98
199_I204_S0.9160.98
360_L379_R0.9030.98
36_H46_P0.9020.98
134_G383_E0.8980.98
31_I92_E0.8980.98
216_I251_Y0.8960.98
147_M315_A0.8940.98
51_V418_I0.8930.98
44_V99_G0.8930.98
376_T379_R0.8920.98
68_V86_T0.8860.98
339_P358_L0.8810.98
47_I351_D0.8800.98
236_E307_N0.8800.98
70_A112_L0.8800.98
347_R352_K0.8790.98
80_E115_A0.8720.98
223_V254_D0.8710.98
156_D304_P0.8670.98
392_T410_Y0.8670.98
132_L383_E0.8670.98
89_A93_H0.8660.98
47_I412_E0.8650.98
68_V93_H0.8590.98
223_V302_A0.8590.98
212_I223_V0.8540.97
225_L279_V0.8530.97
247_A279_V0.8500.97
192_I200_S0.8500.97
374_A377_L0.8490.97
51_V359_I0.8490.97
85_E89_A0.8480.97
363_R367_E0.8470.97
142_P296_D0.8460.97
34_I65_W0.8460.97
386_I391_V0.8450.97
347_R393_Y0.8450.97
359_I382_V0.8400.97
70_A98_K0.8400.97
290_W294_R0.8390.97
129_T315_A0.8320.97
384_D387_E0.8210.97
133_D383_E0.8160.97
350_Q393_Y0.8160.97
126_V210_E0.8130.97
75_R81_N0.8090.96
224_T282_R0.8070.96
121_D154_T0.8060.96
346_K393_Y0.8060.96
362_G365_L0.8060.96
45_G99_G0.8060.96
100_P341_H0.8040.96
95_V369_I0.8030.96
163_W194_I0.8010.96
55_A61_H0.7990.96
53_S57_E0.7950.96
124_A210_E0.7950.96
157_V306_L0.7940.96
229_G283_L0.7910.96
399_R409_T0.7900.96
52_L366_F0.7890.96
284_A304_P0.7880.96
227_H281_E0.7880.96
208_V279_V0.7830.96
381_A385_T0.7810.96
129_T319_I0.7810.96
149_T311_L0.7750.95
211_A302_A0.7730.95
242_W246_V0.7720.95
226_V301_L0.7700.95
331_G334_R0.7680.95
380_D383_E0.7680.95
125_N340_V0.7670.95
223_V247_A0.7660.95
72_E103_T0.7650.95
385_T414_V0.7650.95
244_M279_V0.7650.95
35_I90_I0.7650.95
291_M315_A0.7650.95
69_Y73_S0.7620.95
30_P61_H0.7610.95
197_K306_L0.7570.95
48_A52_L0.7530.95
328_A337_A0.7520.95
59_T374_A0.7510.95
47_I415_I0.7500.95
166_G192_I0.7400.94
216_I254_D0.7400.94
217_E370_G0.7400.94
97_I358_L0.7380.94
226_V311_L0.7370.94
210_E214_Y0.7370.94
393_Y406_S0.7360.94
89_A92_E0.7350.94
287_M298_F0.7340.94
72_E76_E0.7320.94
46_P408_T0.7320.94
247_A252_P0.7320.94
212_I279_V0.7300.94
122_L336_L0.7300.94
164_E193_G0.7290.94
141_A144_E0.7210.93
129_T147_M0.7190.93
87_V91_R0.7140.93
241_D248_E0.7140.93
284_A288_L0.7120.93
63_I362_G0.7110.93
408_T412_E0.7110.93
136_P391_V0.7100.93
346_K353_A0.7060.93
287_M301_L0.7050.93
146_D299_D0.7040.93
46_P67_E0.7000.92
107_A111_S0.6980.92
100_P358_L0.6970.92
326_P364_L0.6930.92
344_A347_R0.6920.92
82_L116_L0.6910.92
102_T343_S0.6900.92
150_F207_L0.6890.92
201_E238_Q0.6890.92
155_E203_G0.6880.92
326_P360_L0.6880.92
286_A322_L0.6880.92
80_E85_E0.6870.92
197_K307_N0.6870.92
162_E194_I0.6850.91
248_E252_P0.6800.91
362_G366_F0.6800.91
408_T411_A0.6780.91
52_L65_W0.6780.91
58_A418_I0.6680.90
136_P140_K0.6680.90
244_M247_A0.6660.90
385_T410_Y0.6660.90
47_I359_I0.6650.90
213_D250_E0.6650.90
246_V251_Y0.6620.90
240_G244_M0.6560.90
131_Y145_M0.6540.90
136_P395_L0.6500.89
290_W293_L0.6490.89
189_D202_K0.6480.89
328_A364_L0.6470.89
412_E415_I0.6470.89
195_G237_G0.6460.89
321_G357_A0.6460.89
148_V218_N0.6460.89
68_V85_E0.6460.89
72_E102_T0.6450.89
147_M318_Q0.6440.89
207_L302_A0.6420.89
390_T417_R0.6420.89
227_H283_L0.6420.89
191_D241_D0.6410.89
383_E387_E0.6370.88
96_A336_L0.6370.88
292_Q318_Q0.6370.88
375_S379_R0.6350.88
197_K236_E0.6280.88
164_E167_T0.6270.87
69_Y85_E0.6260.87
45_G48_A0.6260.87
84_E115_A0.6250.87
161_I198_P0.6250.87
359_I378_V0.6240.87
326_P357_A0.6230.87
167_T189_D0.6200.87
390_T399_R0.6190.87
99_G358_L0.6180.87
204_S242_W0.6180.87
112_L115_A0.6160.87
324_I395_L0.6150.86
340_V357_A0.6140.86
73_S76_E0.6130.86
373_D376_T0.6120.86
32_I365_L0.6090.86
392_T395_L0.6080.86
148_V300_V0.6080.86
162_E165_A0.6070.86
377_L381_A0.6060.86
110_R115_A0.6040.85
369_I372_D0.6030.85
226_V303_M0.6020.85
55_A60_G0.6000.85
50_D53_S0.6000.85
52_L378_V0.5990.85
330_F368_Y0.5960.85
121_D155_E0.5960.85
366_F378_V0.5960.85
353_A393_Y0.5950.85
148_V220_R0.5920.84
32_I63_I0.5900.84
132_L360_L0.5850.84
164_E233_K0.5850.84
391_V395_L0.5840.84
103_T111_S0.5840.84
70_A82_L0.5840.84
221_D253_D0.5830.83
149_T301_L0.5790.83
337_A368_Y0.5760.83
225_L239_F0.5750.83
204_S304_P0.5750.83
121_D331_G0.5740.82
82_L115_A0.5730.82
190_G200_S0.5720.82
80_E107_A0.5710.82
210_E332_A0.5710.82
45_G49_Q0.5710.82
123_Y207_L0.5700.82
35_I68_V0.5680.82
121_D202_K0.5680.82
145_M296_D0.5670.82
216_I247_A0.5650.82
158_Y338_E0.5650.82
359_I411_A0.5640.81
191_D202_K0.5630.81
102_T109_F0.5600.81
86_T112_L0.5590.81
232_M235_T0.5580.81
165_A241_D0.5580.81
286_A297_E0.5570.81
210_E213_D0.5520.80
161_I196_L0.5520.80
74_A82_L0.5500.80
335_C368_Y0.5500.80
32_I65_W0.5500.80
167_T188_H0.5490.80
70_A86_T0.5480.80
342_G345_P0.5480.80
203_G206_R0.5450.79
63_I374_A0.5440.79
228_K285_D0.5440.79
330_F335_C0.5440.79
189_D205_K0.5440.79
45_G97_I0.5420.79
90_I93_H0.5400.79
108_G111_S0.5390.78
393_Y398_Q0.5380.78
155_E200_S0.5360.78
321_G324_I0.5350.78
366_F375_S0.5350.78
395_L399_R0.5340.78
90_I116_L0.5340.78
46_P49_Q0.5340.78
67_E73_S0.5340.78
247_A251_Y0.5320.78
63_I371_W0.5320.78
48_A51_V0.5310.77
123_Y210_E0.5310.77
195_G232_M0.5300.77
111_S115_A0.5300.77
55_A377_L0.5300.77
101_L343_S0.5290.77
235_T304_P0.5290.77
146_D220_R0.5260.77
98_K116_L0.5250.77
192_I201_E0.5230.76
82_L86_T0.5200.76
194_I198_P0.5200.76
351_D412_E0.5200.76
42_K73_S0.5190.76
213_D246_V0.5190.76
143_E296_D0.5190.76
309_D313_D0.5180.76
55_A359_I0.5170.76
331_G335_C0.5160.75
304_P307_N0.5150.75
39_G353_A0.5150.75
208_V242_W0.5140.75
81_N109_F0.5130.75
90_I120_L0.5110.75
108_G283_L0.5100.75
189_D201_E0.5100.75
75_R107_A0.5090.74
68_V83_P0.5080.74
376_T383_E0.5060.74
74_A77_M0.5060.74
33_P66_M0.5050.74
407_S411_A0.5050.74
210_E330_F0.5040.74
391_V410_Y0.5030.74
216_I252_P0.5030.74
225_L302_A0.5020.73
390_T416_D0.5010.73
127_R309_D0.5010.73
98_K103_T0.5010.73
162_E197_K0.5000.73
36_H99_G0.5000.73
120_L336_L0.5000.73
150_F211_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dmsA 2 0.9668 100 0.09 Contact Map
2iv0A 2 0.9763 100 0.092 Contact Map
2d4vA 2 0.9787 100 0.1 Contact Map
1tyoA 2 0.9763 100 0.1 Contact Map
2e0cA 2 0.9431 100 0.109 Contact Map
1hqsA 2 0.9692 100 0.116 Contact Map
3flkA 3 0.8152 100 0.157 Contact Map
2d1cA 2 0.8436 100 0.161 Contact Map
2y3zA 2 0.8009 100 0.163 Contact Map
1x0lA 4 0.7844 100 0.165 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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