Q9HNZ5 - HALSA - GREMLIN Contacts

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Q9HNZ5 - 3-hydroxy-3-methylglutaryl coenzyme A reductase

UniProt:	Q9HNZ5	Sequences: MPDDASDLADRVQAGDLRLYELDDETDADTAAAARRAVLERETDADTDALGAFAFDADQAADTAVENLTGGAQLPLGVAGPVALSGGAADGEYYLPMATTEGALVASVNRGCSAITAAGGANARVTKTGMTRAPVFRVADVTEGAEVAQWADDNTDALAAAAESTTSHGELTDVTPYVVGDNVYLRFRYDTKDAMGMNMATIATEAASELVEDETPAELVAVSGNLCTDKKPAAINAVEGRGRTVTADVTIPQDVVEERFDTTPAAIEEANTRKNLIGSAKAGSLGFNAHAANVVAAVFLATGQDAAQVVEGANAITTVEARDDALYASVNLASLEVGTVGGGTTLPTQREALDVLGVRGGGDPAGANADALAEIIAVGALAGEINLLAALASRRLSAAHADLGR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	405 (351)
Sequences:	1425 (821)
Seq/√Len:	43.8

HALSA - Q9HNZ5
SULSO - HMDH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
85_S	374_E	6.140	1.00
85_S	123_A	4.570	1.00
166_T	169_G	4.439	1.00
330_V	377_A	4.372	1.00
337_V	376_I	4.033	1.00
159_A	171_L	3.776	1.00
83_A	92_E	3.741	1.00
155_T	173_D	3.696	1.00
296_A	306_A	3.525	1.00
115_I	121_A	3.512	1.00
154_N	157_A	3.398	1.00
233_A	331_N	3.215	1.00
118_A	252_P	3.100	1.00
158_L	207_A	3.049	1.00
87_G	371_A	3.021	1.00
65_V	105_V	3.011	1.00
95_L	379_G	2.837	1.00
76_L	352_A	2.814	1.00
300_L	306_A	2.689	1.00
250_T	325_A	2.668	1.00
147_V	183_V	2.628	1.00
159_A	163_E	2.607	1.00
335_L	377_A	2.597	1.00
372_L	376_I	2.586	1.00
123_A	374_E	2.556	1.00
299_F	376_I	2.469	1.00
84_L	375_I	2.395	1.00
158_L	210_L	2.380	1.00
155_T	159_A	2.233	1.00
296_A	309_V	2.177	1.00
298_V	376_I	2.134	1.00
291_A	315_A	2.011	0.99
79_A	82_V	2.009	0.99
148_A	152_D	1.997	0.99
187_F	207_A	1.973	0.99
92_E	116_T	1.934	0.99
76_L	98_A	1.913	0.99
37_A	41_R	1.902	0.99
118_A	255_V	1.901	0.99
299_F	309_V	1.869	0.99
93_Y	371_A	1.851	0.99
177_Y	186_R	1.846	0.99
132_R	204_T	1.834	0.99
97_M	108_V	1.830	0.99
74_L	98_A	1.828	0.99
252_P	255_V	1.819	0.98
72_A	76_L	1.813	0.98
97_M	298_V	1.812	0.98
163_E	171_L	1.811	0.98
123_A	377_A	1.811	0.98
97_M	297_A	1.796	0.98
78_V	355_V	1.795	0.98
121_A	382_A	1.794	0.98
161_A	210_L	1.781	0.98
79_A	109_N	1.763	0.98
138_V	147_V	1.758	0.98
99_T	306_A	1.751	0.98
157_A	160_A	1.750	0.98
332_L	377_A	1.746	0.98
200_A	204_T	1.726	0.98
228_T	282_A	1.697	0.98
115_I	249_V	1.681	0.97
95_L	298_V	1.680	0.97
263_T	266_A	1.671	0.97
143_E	146_E	1.668	0.97
253_Q	264_P	1.636	0.97
371_A	375_I	1.636	0.97
299_F	304_Q	1.626	0.97
292_A	313_A	1.616	0.97
210_L	213_D	1.588	0.96
122_N	248_D	1.571	0.96
72_A	98_A	1.548	0.96
31_A	34_A	1.546	0.96
189_Y	203_A	1.545	0.96
231_K	331_N	1.540	0.96
84_L	95_L	1.535	0.96
302_T	356_L	1.527	0.95
295_V	332_L	1.527	0.95
298_V	379_G	1.526	0.95
172_T	190_D	1.526	0.95
354_D	359_R	1.488	0.95
264_P	268_E	1.482	0.95
32_A	36_R	1.477	0.95
270_A	385_I	1.476	0.94
164_S	167_S	1.470	0.94
275_N	279_S	1.451	0.94
309_V	313_A	1.428	0.93
83_A	116_T	1.418	0.93
171_L	203_A	1.414	0.93
265_A	321_A	1.404	0.93
193_D	353_L	1.399	0.93
156_D	160_A	1.397	0.93
226_L	285_L	1.386	0.92
274_K	278_G	1.377	0.92
39_L	78_V	1.376	0.92
111_G	386_N	1.355	0.91
115_I	118_A	1.343	0.91
77_G	105_V	1.324	0.91
115_I	251_I	1.319	0.90
77_G	98_A	1.308	0.90
350_R	354_D	1.305	0.90
339_T	353_L	1.296	0.90
201_T	397_S	1.291	0.89
46_D	354_D	1.288	0.89
123_A	234_A	1.287	0.89
129_G	188_R	1.279	0.89
99_T	296_A	1.278	0.89
253_Q	324_D	1.261	0.88
130_M	227_C	1.255	0.88
79_A	95_L	1.250	0.88
302_T	339_T	1.247	0.88
93_Y	375_I	1.243	0.87
371_A	374_E	1.230	0.87
129_G	229_D	1.207	0.86
163_E	170_E	1.205	0.86
266_A	393_S	1.197	0.85
308_Q	336_E	1.197	0.85
360_G	371_A	1.192	0.85
209_E	213_D	1.167	0.84
103_A	201_T	1.164	0.84
212_E	215_T	1.163	0.84
350_R	359_R	1.163	0.84
394_R	398_A	1.157	0.83
93_Y	356_L	1.150	0.83
191_T	230_K	1.149	0.83
102_G	404_G	1.148	0.83
270_A	388_L	1.144	0.83
298_V	302_T	1.144	0.83
164_S	199_M	1.140	0.82
180_G	275_N	1.130	0.82
176_P	179_V	1.120	0.81
253_Q	325_A	1.104	0.80
111_G	385_I	1.095	0.80
65_V	77_G	1.093	0.80
253_Q	267_I	1.092	0.80
220_V	273_R	1.091	0.80
264_P	324_D	1.080	0.79
150_W	154_N	1.079	0.79
123_A	378_V	1.065	0.78
251_I	385_I	1.060	0.78
64_A	346_L	1.046	0.77
171_L	187_F	1.044	0.77
82_V	112_C	1.042	0.76
79_A	379_G	1.039	0.76
232_P	284_S	1.038	0.76
133_A	177_Y	1.029	0.75
34_A	37_A	1.025	0.75
151_A	211_V	1.023	0.75
248_D	329_S	1.017	0.75
110_R	114_A	1.006	0.74
131_T	188_R	1.004	0.74
64_A	130_M	1.003	0.74
82_V	95_L	0.997	0.73
84_L	378_V	0.994	0.73
179_V	279_S	0.982	0.72
358_V	375_I	0.978	0.72
312_G	315_A	0.978	0.72
264_P	321_A	0.976	0.72
95_L	375_I	0.973	0.71
387_L	396_L	0.973	0.71
161_A	206_A	0.970	0.71
33_A	37_A	0.961	0.70
222_V	397_S	0.949	0.69
383_G	387_L	0.945	0.69
137_R	220_V	0.942	0.69
110_R	389_A	0.940	0.69
43_T	46_D	0.938	0.68
103_A	403_L	0.934	0.68
345_T	349_Q	0.931	0.68
205_E	290_H	0.928	0.68
79_A	108_V	0.927	0.68
151_A	323_D	0.925	0.67
137_R	140_D	0.925	0.67
248_D	327_Y	0.923	0.67
86_G	157_A	0.923	0.67
271_N	274_K	0.921	0.67
128_T	191_T	0.917	0.67
211_V	218_E	0.916	0.67
68_L	105_V	0.915	0.67
103_A	397_S	0.911	0.66
79_A	382_A	0.910	0.66
128_T	230_K	0.910	0.66
339_T	357_G	0.909	0.66
276_L	279_S	0.906	0.66
40_E	47_T	0.906	0.66
285_L	315_A	0.905	0.66
356_L	375_I	0.903	0.65
39_L	42_E	0.902	0.65
202_I	401_A	0.901	0.65
271_N	275_N	0.891	0.64
315_A	380_A	0.887	0.64
125_V	374_E	0.886	0.64
144_G	147_V	0.884	0.64
285_L	336_E	0.882	0.64
70_G	76_L	0.875	0.63
221_A	391_L	0.874	0.63
115_I	385_I	0.872	0.63
106_A	195_M	0.871	0.63
130_M	312_G	0.871	0.63
162_A	203_A	0.870	0.63
257_E	262_T	0.869	0.62
137_R	218_E	0.869	0.62
197_M	308_Q	0.867	0.62
170_E	222_V	0.866	0.62
227_C	312_G	0.866	0.62
128_T	375_I	0.863	0.62
82_V	379_G	0.862	0.62
290_H	383_G	0.862	0.62
257_E	263_T	0.861	0.62
74_L	146_E	0.860	0.62
147_V	150_W	0.856	0.61
233_A	329_S	0.845	0.60
129_G	172_T	0.838	0.60
106_A	342_G	0.836	0.59
210_L	214_E	0.835	0.59
82_V	369_A	0.834	0.59
156_D	159_A	0.831	0.59
189_Y	200_A	0.828	0.59
212_E	218_E	0.827	0.59
253_Q	265_A	0.827	0.59
84_L	356_L	0.826	0.59
128_T	338_G	0.825	0.58
85_S	371_A	0.825	0.58
33_A	42_E	0.824	0.58
189_Y	204_T	0.824	0.58
74_L	87_G	0.823	0.58
197_M	223_S	0.821	0.58
230_K	373_A	0.818	0.58
209_E	212_E	0.815	0.57
157_A	210_L	0.814	0.57
229_D	313_A	0.809	0.57
306_A	310_V	0.805	0.57
291_A	380_A	0.801	0.56
147_V	151_A	0.795	0.56
110_R	343_G	0.793	0.55
202_I	397_S	0.793	0.55
114_A	389_A	0.791	0.55
113_S	259_R	0.788	0.55
312_G	347_P	0.787	0.55
74_L	93_Y	0.785	0.55
79_A	84_L	0.785	0.55
195_M	288_N	0.782	0.54
369_A	372_L	0.780	0.54
124_R	248_D	0.780	0.54
290_H	384_E	0.778	0.54
223_S	227_C	0.776	0.54
186_R	312_G	0.775	0.54
30_T	38_V	0.774	0.54
123_A	392_A	0.774	0.54
77_G	106_A	0.774	0.54
351_E	355_V	0.772	0.53
128_T	192_K	0.770	0.53
139_A	218_E	0.767	0.53
84_L	93_Y	0.766	0.53
104_L	386_N	0.765	0.53
298_V	356_L	0.764	0.53
162_A	189_Y	0.764	0.53
375_I	379_G	0.761	0.52
103_A	286_G	0.760	0.52
296_A	310_V	0.758	0.52
223_S	396_L	0.756	0.52
120_G	382_A	0.754	0.52
141_V	174_V	0.753	0.52
258_E	263_T	0.753	0.52
205_E	397_S	0.753	0.52
158_L	162_A	0.753	0.52
253_Q	323_D	0.751	0.51
229_D	282_A	0.751	0.51
134_P	207_A	0.751	0.51
41_R	156_D	0.750	0.51
295_V	309_V	0.750	0.51
191_T	386_N	0.748	0.51
131_T	224_G	0.738	0.50
74_L	105_V	0.736	0.50
289_A	387_L	0.735	0.50
138_V	211_V	0.735	0.50
125_V	331_N	0.734	0.50
233_A	280_A	0.733	0.50
167_S	199_M	0.733	0.50
294_V	379_G	0.732	0.50
290_H	387_L	0.730	0.49
87_G	93_Y	0.728	0.49
358_V	371_A	0.723	0.49
103_A	399_A	0.723	0.49
182_N	273_R	0.722	0.49
278_G	320_E	0.721	0.49
300_L	355_V	0.715	0.48
147_V	211_V	0.715	0.48
131_T	227_C	0.713	0.48
310_V	317_T	0.713	0.48
199_M	343_G	0.711	0.48
27_D	30_T	0.711	0.48
83_A	350_R	0.711	0.48
152_D	176_P	0.707	0.47
82_V	109_N	0.706	0.47
299_F	335_L	0.702	0.47
149_Q	152_D	0.700	0.47
397_S	401_A	0.698	0.46
28_A	110_R	0.697	0.46
157_A	161_A	0.694	0.46
34_A	160_A	0.693	0.46
230_K	338_G	0.692	0.46
72_A	352_A	0.691	0.46
130_M	191_T	0.691	0.46
302_T	352_A	0.688	0.45
74_L	92_E	0.687	0.45
142_T	146_E	0.686	0.45
268_E	271_N	0.685	0.45
343_G	349_Q	0.685	0.45
181_D	320_E	0.684	0.45
160_A	213_D	0.683	0.45
156_D	355_V	0.683	0.45
335_L	376_I	0.682	0.45
197_M	396_L	0.681	0.45
193_D	336_E	0.681	0.45
140_D	143_E	0.679	0.45
114_A	251_I	0.679	0.45
114_A	385_I	0.679	0.45
170_E	190_D	0.676	0.44
191_T	199_M	0.676	0.44
113_S	117_A	0.675	0.44
64_A	348_T	0.673	0.44
113_S	379_G	0.672	0.44
76_L	105_V	0.672	0.44
49_A	54_A	0.672	0.44
160_A	258_E	0.672	0.44
339_T	356_L	0.671	0.44
127_K	172_T	0.666	0.43
98_A	187_F	0.665	0.43
73_Q	348_T	0.660	0.43
30_T	34_A	0.660	0.43
61_A	68_L	0.660	0.43
41_R	86_G	0.658	0.43
352_A	386_N	0.657	0.42
99_T	300_L	0.657	0.42
134_P	187_F	0.657	0.42
39_L	69_T	0.656	0.42
280_A	287_F	0.652	0.42
130_M	336_E	0.651	0.42
184_Y	316_I	0.648	0.42
50_L	76_L	0.648	0.42
398_A	402_D	0.648	0.42
144_G	148_A	0.644	0.41
133_A	226_L	0.644	0.41
286_G	395_R	0.644	0.41
73_Q	200_A	0.643	0.41
287_F	391_L	0.642	0.41
72_A	348_T	0.641	0.41
261_D	395_R	0.641	0.41
174_V	185_L	0.640	0.41
65_V	76_L	0.639	0.41
252_P	325_A	0.639	0.41
146_E	150_W	0.638	0.41
26_T	29_D	0.638	0.41
50_L	58_D	0.638	0.41
356_L	385_I	0.637	0.41
313_A	332_L	0.637	0.41
107_S	189_Y	0.636	0.40
220_V	269_E	0.635	0.40
193_D	344_T	0.635	0.40
133_A	186_R	0.634	0.40
115_I	119_G	0.634	0.40
251_I	377_A	0.633	0.40
321_A	324_D	0.630	0.40
117_A	258_E	0.630	0.40
208_S	221_A	0.630	0.40
154_N	214_E	0.628	0.40
142_T	151_A	0.628	0.40
46_D	350_R	0.626	0.40
195_M	308_Q	0.624	0.39
191_T	346_L	0.623	0.39
281_K	285_L	0.623	0.39
84_L	357_G	0.623	0.39
68_L	71_G	0.621	0.39
47_T	51_G	0.620	0.39
74_L	306_A	0.620	0.39
122_N	309_V	0.619	0.39
38_V	42_E	0.619	0.39
158_L	161_A	0.618	0.39
124_R	232_P	0.615	0.39
308_Q	396_L	0.613	0.38
179_V	281_K	0.612	0.38
319_V	388_L	0.611	0.38
199_M	353_L	0.610	0.38
103_A	401_A	0.609	0.38
359_R	375_I	0.609	0.38
159_A	174_V	0.608	0.38
53_F	99_T	0.606	0.38
45_A	50_L	0.604	0.38
74_L	99_T	0.603	0.37
181_D	248_D	0.603	0.37
80_G	346_L	0.603	0.37
130_M	199_M	0.602	0.37
277_I	395_R	0.602	0.37
46_D	84_L	0.601	0.37
230_K	304_Q	0.600	0.37
300_L	375_I	0.600	0.37
49_A	53_F	0.597	0.37
95_L	185_L	0.596	0.37
98_A	311_E	0.596	0.37
83_A	370_D	0.595	0.37
223_S	289_A	0.595	0.37
296_A	300_L	0.593	0.37
332_L	335_L	0.589	0.36
161_A	354_D	0.588	0.36
339_T	360_G	0.587	0.36
195_M	205_E	0.587	0.36
162_A	171_L	0.586	0.36
209_E	265_A	0.585	0.36
294_V	380_A	0.583	0.36
26_T	34_A	0.582	0.36
219_L	226_L	0.580	0.35
179_V	398_A	0.579	0.35
289_A	396_L	0.579	0.35
106_A	109_N	0.578	0.35
355_V	393_S	0.577	0.35
33_A	40_E	0.577	0.35
122_N	327_Y	0.577	0.35
214_E	300_L	0.577	0.35
41_R	48_D	0.575	0.35
227_C	231_K	0.574	0.35
100_T	103_A	0.572	0.35
74_L	310_V	0.570	0.35
303_G	372_L	0.570	0.35
343_G	353_L	0.569	0.34
146_E	156_D	0.568	0.34
149_Q	174_V	0.567	0.34
286_G	384_E	0.567	0.34
195_M	280_A	0.565	0.34
33_A	39_L	0.563	0.34
395_R	399_A	0.560	0.34
370_D	374_E	0.560	0.34
144_G	156_D	0.560	0.34
40_E	48_D	0.559	0.34
144_G	150_W	0.559	0.34
77_G	342_G	0.559	0.34
151_A	269_E	0.558	0.34
37_A	211_V	0.558	0.34
113_S	138_V	0.557	0.33
143_E	216_P	0.557	0.33
40_E	44_D	0.556	0.33
97_M	201_T	0.556	0.33
294_V	298_V	0.556	0.33
49_A	56_D	0.553	0.33
344_T	353_L	0.552	0.33
330_V	380_A	0.552	0.33
349_Q	353_L	0.552	0.33
374_E	378_V	0.550	0.33
199_M	229_D	0.550	0.33
175_T	179_V	0.550	0.33
275_N	278_G	0.550	0.33
137_R	182_N	0.548	0.33
291_A	317_T	0.547	0.33
384_E	387_L	0.546	0.33
168_H	222_V	0.546	0.33
30_T	353_L	0.546	0.33
81_P	208_S	0.546	0.33
223_S	387_L	0.546	0.33
166_T	376_I	0.545	0.32
289_A	388_L	0.544	0.32
228_T	295_V	0.543	0.32
254_D	257_E	0.543	0.32
165_T	169_G	0.543	0.32
44_D	48_D	0.542	0.32
45_A	157_A	0.541	0.32
107_S	110_R	0.539	0.32
67_N	195_M	0.538	0.32
226_L	369_A	0.537	0.32
37_A	154_N	0.536	0.32
126_T	129_G	0.536	0.32
352_A	355_V	0.536	0.32
267_I	271_N	0.536	0.32
77_G	349_Q	0.535	0.32
380_A	401_A	0.535	0.32
204_T	207_A	0.534	0.32
33_A	216_P	0.534	0.32
80_G	94_Y	0.533	0.31
273_R	356_L	0.532	0.31
99_T	297_A	0.531	0.31
48_D	153_D	0.530	0.31
164_S	206_A	0.530	0.31
107_S	397_S	0.529	0.31
151_A	174_V	0.529	0.31
289_A	317_T	0.528	0.31
223_S	284_S	0.528	0.31
205_E	401_A	0.528	0.31
171_L	353_L	0.527	0.31
153_D	157_A	0.527	0.31
151_A	185_L	0.526	0.31
185_L	210_L	0.526	0.31
343_G	347_P	0.525	0.31
114_A	255_V	0.525	0.31
147_V	185_L	0.522	0.31
132_R	230_K	0.522	0.31
289_A	308_Q	0.520	0.30
171_L	346_L	0.520	0.30
287_F	397_S	0.519	0.30
140_D	147_V	0.518	0.30
128_T	370_D	0.518	0.30
114_A	261_D	0.517	0.30
114_A	259_R	0.517	0.30
74_L	113_S	0.515	0.30
319_V	328_A	0.514	0.30
151_A	158_L	0.514	0.30
267_I	389_A	0.514	0.30
29_D	385_I	0.513	0.30
223_S	380_A	0.513	0.30
108_V	294_V	0.511	0.30
98_A	353_L	0.511	0.30
69_T	78_V	0.509	0.29
194_A	326_L	0.508	0.29
250_T	327_Y	0.508	0.29
45_A	354_D	0.507	0.29
201_T	396_L	0.507	0.29
353_L	373_A	0.506	0.29
202_I	299_F	0.505	0.29
64_A	70_G	0.505	0.29
205_E	395_R	0.505	0.29
118_A	326_L	0.504	0.29
99_T	171_L	0.504	0.29
223_S	391_L	0.504	0.29
224_G	289_A	0.503	0.29
131_T	229_D	0.501	0.29
52_A	57_A	0.500	0.29
99_T	110_R	0.500	0.29
170_E	290_H	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r4fA	4	0.963	100	0.138	Contact Map
3qaeA	2	0.8444	100	0.184	Contact Map
4i6yA	2	0.8642	100	0.191	Contact Map
3r84A	2	0.1778	16.3	0.98	Contact Map
3fxhA	2	0.2543	13.7	0.98	Contact Map
3bypA	2	0.1975	8.6	0.982	Contact Map
2lw4A	1	0.1062	8.4	0.982	Contact Map
4by7X	1	0.1284	7.7	0.983	Contact Map
4nguA	1	0.1506	5	0.984	Contact Map
1qw2A	3	0.2519	4.9	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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