GREMLIN Database
Q9HNZ5 - 3-hydroxy-3-methylglutaryl coenzyme A reductase
UniProt: Q9HNZ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 405 (351)
Sequences: 1425 (821)
Seq/√Len: 43.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_S374_E6.1401.00
85_S123_A4.5701.00
166_T169_G4.4391.00
330_V377_A4.3721.00
337_V376_I4.0331.00
159_A171_L3.7761.00
83_A92_E3.7411.00
155_T173_D3.6961.00
296_A306_A3.5251.00
115_I121_A3.5121.00
154_N157_A3.3981.00
233_A331_N3.2151.00
118_A252_P3.1001.00
158_L207_A3.0491.00
87_G371_A3.0211.00
65_V105_V3.0111.00
95_L379_G2.8371.00
76_L352_A2.8141.00
300_L306_A2.6891.00
250_T325_A2.6681.00
147_V183_V2.6281.00
159_A163_E2.6071.00
335_L377_A2.5971.00
372_L376_I2.5861.00
123_A374_E2.5561.00
299_F376_I2.4691.00
84_L375_I2.3951.00
158_L210_L2.3801.00
155_T159_A2.2331.00
296_A309_V2.1771.00
298_V376_I2.1341.00
291_A315_A2.0110.99
79_A82_V2.0090.99
148_A152_D1.9970.99
187_F207_A1.9730.99
92_E116_T1.9340.99
76_L98_A1.9130.99
37_A41_R1.9020.99
118_A255_V1.9010.99
299_F309_V1.8690.99
93_Y371_A1.8510.99
177_Y186_R1.8460.99
132_R204_T1.8340.99
97_M108_V1.8300.99
74_L98_A1.8280.99
252_P255_V1.8190.98
72_A76_L1.8130.98
97_M298_V1.8120.98
163_E171_L1.8110.98
123_A377_A1.8110.98
97_M297_A1.7960.98
78_V355_V1.7950.98
121_A382_A1.7940.98
161_A210_L1.7810.98
79_A109_N1.7630.98
138_V147_V1.7580.98
99_T306_A1.7510.98
157_A160_A1.7500.98
332_L377_A1.7460.98
200_A204_T1.7260.98
228_T282_A1.6970.98
115_I249_V1.6810.97
95_L298_V1.6800.97
263_T266_A1.6710.97
143_E146_E1.6680.97
253_Q264_P1.6360.97
371_A375_I1.6360.97
299_F304_Q1.6260.97
292_A313_A1.6160.97
210_L213_D1.5880.96
122_N248_D1.5710.96
72_A98_A1.5480.96
31_A34_A1.5460.96
189_Y203_A1.5450.96
231_K331_N1.5400.96
84_L95_L1.5350.96
302_T356_L1.5270.95
295_V332_L1.5270.95
298_V379_G1.5260.95
172_T190_D1.5260.95
354_D359_R1.4880.95
264_P268_E1.4820.95
32_A36_R1.4770.95
270_A385_I1.4760.94
164_S167_S1.4700.94
275_N279_S1.4510.94
309_V313_A1.4280.93
83_A116_T1.4180.93
171_L203_A1.4140.93
265_A321_A1.4040.93
193_D353_L1.3990.93
156_D160_A1.3970.93
226_L285_L1.3860.92
274_K278_G1.3770.92
39_L78_V1.3760.92
111_G386_N1.3550.91
115_I118_A1.3430.91
77_G105_V1.3240.91
115_I251_I1.3190.90
77_G98_A1.3080.90
350_R354_D1.3050.90
339_T353_L1.2960.90
201_T397_S1.2910.89
46_D354_D1.2880.89
123_A234_A1.2870.89
129_G188_R1.2790.89
99_T296_A1.2780.89
253_Q324_D1.2610.88
130_M227_C1.2550.88
79_A95_L1.2500.88
302_T339_T1.2470.88
93_Y375_I1.2430.87
371_A374_E1.2300.87
129_G229_D1.2070.86
163_E170_E1.2050.86
266_A393_S1.1970.85
308_Q336_E1.1970.85
360_G371_A1.1920.85
209_E213_D1.1670.84
103_A201_T1.1640.84
212_E215_T1.1630.84
350_R359_R1.1630.84
394_R398_A1.1570.83
93_Y356_L1.1500.83
191_T230_K1.1490.83
102_G404_G1.1480.83
270_A388_L1.1440.83
298_V302_T1.1440.83
164_S199_M1.1400.82
180_G275_N1.1300.82
176_P179_V1.1200.81
253_Q325_A1.1040.80
111_G385_I1.0950.80
65_V77_G1.0930.80
253_Q267_I1.0920.80
220_V273_R1.0910.80
264_P324_D1.0800.79
150_W154_N1.0790.79
123_A378_V1.0650.78
251_I385_I1.0600.78
64_A346_L1.0460.77
171_L187_F1.0440.77
82_V112_C1.0420.76
79_A379_G1.0390.76
232_P284_S1.0380.76
133_A177_Y1.0290.75
34_A37_A1.0250.75
151_A211_V1.0230.75
248_D329_S1.0170.75
110_R114_A1.0060.74
131_T188_R1.0040.74
64_A130_M1.0030.74
82_V95_L0.9970.73
84_L378_V0.9940.73
179_V279_S0.9820.72
358_V375_I0.9780.72
312_G315_A0.9780.72
264_P321_A0.9760.72
95_L375_I0.9730.71
387_L396_L0.9730.71
161_A206_A0.9700.71
33_A37_A0.9610.70
222_V397_S0.9490.69
383_G387_L0.9450.69
137_R220_V0.9420.69
110_R389_A0.9400.69
43_T46_D0.9380.68
103_A403_L0.9340.68
345_T349_Q0.9310.68
205_E290_H0.9280.68
79_A108_V0.9270.68
151_A323_D0.9250.67
137_R140_D0.9250.67
248_D327_Y0.9230.67
86_G157_A0.9230.67
271_N274_K0.9210.67
128_T191_T0.9170.67
211_V218_E0.9160.67
68_L105_V0.9150.67
103_A397_S0.9110.66
79_A382_A0.9100.66
128_T230_K0.9100.66
339_T357_G0.9090.66
276_L279_S0.9060.66
40_E47_T0.9060.66
285_L315_A0.9050.66
356_L375_I0.9030.65
39_L42_E0.9020.65
202_I401_A0.9010.65
271_N275_N0.8910.64
315_A380_A0.8870.64
125_V374_E0.8860.64
144_G147_V0.8840.64
285_L336_E0.8820.64
70_G76_L0.8750.63
221_A391_L0.8740.63
115_I385_I0.8720.63
106_A195_M0.8710.63
130_M312_G0.8710.63
162_A203_A0.8700.63
257_E262_T0.8690.62
137_R218_E0.8690.62
197_M308_Q0.8670.62
170_E222_V0.8660.62
227_C312_G0.8660.62
128_T375_I0.8630.62
82_V379_G0.8620.62
290_H383_G0.8620.62
257_E263_T0.8610.62
74_L146_E0.8600.62
147_V150_W0.8560.61
233_A329_S0.8450.60
129_G172_T0.8380.60
106_A342_G0.8360.59
210_L214_E0.8350.59
82_V369_A0.8340.59
156_D159_A0.8310.59
189_Y200_A0.8280.59
212_E218_E0.8270.59
253_Q265_A0.8270.59
84_L356_L0.8260.59
128_T338_G0.8250.58
85_S371_A0.8250.58
33_A42_E0.8240.58
189_Y204_T0.8240.58
74_L87_G0.8230.58
197_M223_S0.8210.58
230_K373_A0.8180.58
209_E212_E0.8150.57
157_A210_L0.8140.57
229_D313_A0.8090.57
306_A310_V0.8050.57
291_A380_A0.8010.56
147_V151_A0.7950.56
110_R343_G0.7930.55
202_I397_S0.7930.55
114_A389_A0.7910.55
113_S259_R0.7880.55
312_G347_P0.7870.55
74_L93_Y0.7850.55
79_A84_L0.7850.55
195_M288_N0.7820.54
369_A372_L0.7800.54
124_R248_D0.7800.54
290_H384_E0.7780.54
223_S227_C0.7760.54
186_R312_G0.7750.54
30_T38_V0.7740.54
123_A392_A0.7740.54
77_G106_A0.7740.54
351_E355_V0.7720.53
128_T192_K0.7700.53
139_A218_E0.7670.53
84_L93_Y0.7660.53
104_L386_N0.7650.53
298_V356_L0.7640.53
162_A189_Y0.7640.53
375_I379_G0.7610.52
103_A286_G0.7600.52
296_A310_V0.7580.52
223_S396_L0.7560.52
120_G382_A0.7540.52
141_V174_V0.7530.52
258_E263_T0.7530.52
205_E397_S0.7530.52
158_L162_A0.7530.52
253_Q323_D0.7510.51
229_D282_A0.7510.51
134_P207_A0.7510.51
41_R156_D0.7500.51
295_V309_V0.7500.51
191_T386_N0.7480.51
131_T224_G0.7380.50
74_L105_V0.7360.50
289_A387_L0.7350.50
138_V211_V0.7350.50
125_V331_N0.7340.50
233_A280_A0.7330.50
167_S199_M0.7330.50
294_V379_G0.7320.50
290_H387_L0.7300.49
87_G93_Y0.7280.49
358_V371_A0.7230.49
103_A399_A0.7230.49
182_N273_R0.7220.49
278_G320_E0.7210.49
300_L355_V0.7150.48
147_V211_V0.7150.48
131_T227_C0.7130.48
310_V317_T0.7130.48
199_M343_G0.7110.48
27_D30_T0.7110.48
83_A350_R0.7110.48
152_D176_P0.7070.47
82_V109_N0.7060.47
299_F335_L0.7020.47
149_Q152_D0.7000.47
397_S401_A0.6980.46
28_A110_R0.6970.46
157_A161_A0.6940.46
34_A160_A0.6930.46
230_K338_G0.6920.46
72_A352_A0.6910.46
130_M191_T0.6910.46
302_T352_A0.6880.45
74_L92_E0.6870.45
142_T146_E0.6860.45
268_E271_N0.6850.45
343_G349_Q0.6850.45
181_D320_E0.6840.45
160_A213_D0.6830.45
156_D355_V0.6830.45
335_L376_I0.6820.45
197_M396_L0.6810.45
193_D336_E0.6810.45
140_D143_E0.6790.45
114_A251_I0.6790.45
114_A385_I0.6790.45
170_E190_D0.6760.44
191_T199_M0.6760.44
113_S117_A0.6750.44
64_A348_T0.6730.44
113_S379_G0.6720.44
76_L105_V0.6720.44
49_A54_A0.6720.44
160_A258_E0.6720.44
339_T356_L0.6710.44
127_K172_T0.6660.43
98_A187_F0.6650.43
73_Q348_T0.6600.43
30_T34_A0.6600.43
61_A68_L0.6600.43
41_R86_G0.6580.43
352_A386_N0.6570.42
99_T300_L0.6570.42
134_P187_F0.6570.42
39_L69_T0.6560.42
280_A287_F0.6520.42
130_M336_E0.6510.42
184_Y316_I0.6480.42
50_L76_L0.6480.42
398_A402_D0.6480.42
144_G148_A0.6440.41
133_A226_L0.6440.41
286_G395_R0.6440.41
73_Q200_A0.6430.41
287_F391_L0.6420.41
72_A348_T0.6410.41
261_D395_R0.6410.41
174_V185_L0.6400.41
65_V76_L0.6390.41
252_P325_A0.6390.41
146_E150_W0.6380.41
26_T29_D0.6380.41
50_L58_D0.6380.41
356_L385_I0.6370.41
313_A332_L0.6370.41
107_S189_Y0.6360.40
220_V269_E0.6350.40
193_D344_T0.6350.40
133_A186_R0.6340.40
115_I119_G0.6340.40
251_I377_A0.6330.40
321_A324_D0.6300.40
117_A258_E0.6300.40
208_S221_A0.6300.40
154_N214_E0.6280.40
142_T151_A0.6280.40
46_D350_R0.6260.40
195_M308_Q0.6240.39
191_T346_L0.6230.39
281_K285_L0.6230.39
84_L357_G0.6230.39
68_L71_G0.6210.39
47_T51_G0.6200.39
74_L306_A0.6200.39
122_N309_V0.6190.39
38_V42_E0.6190.39
158_L161_A0.6180.39
124_R232_P0.6150.39
308_Q396_L0.6130.38
179_V281_K0.6120.38
319_V388_L0.6110.38
199_M353_L0.6100.38
103_A401_A0.6090.38
359_R375_I0.6090.38
159_A174_V0.6080.38
53_F99_T0.6060.38
45_A50_L0.6040.38
74_L99_T0.6030.37
181_D248_D0.6030.37
80_G346_L0.6030.37
130_M199_M0.6020.37
277_I395_R0.6020.37
46_D84_L0.6010.37
230_K304_Q0.6000.37
300_L375_I0.6000.37
49_A53_F0.5970.37
95_L185_L0.5960.37
98_A311_E0.5960.37
83_A370_D0.5950.37
223_S289_A0.5950.37
296_A300_L0.5930.37
332_L335_L0.5890.36
161_A354_D0.5880.36
339_T360_G0.5870.36
195_M205_E0.5870.36
162_A171_L0.5860.36
209_E265_A0.5850.36
294_V380_A0.5830.36
26_T34_A0.5820.36
219_L226_L0.5800.35
179_V398_A0.5790.35
289_A396_L0.5790.35
106_A109_N0.5780.35
355_V393_S0.5770.35
33_A40_E0.5770.35
122_N327_Y0.5770.35
214_E300_L0.5770.35
41_R48_D0.5750.35
227_C231_K0.5740.35
100_T103_A0.5720.35
74_L310_V0.5700.35
303_G372_L0.5700.35
343_G353_L0.5690.34
146_E156_D0.5680.34
149_Q174_V0.5670.34
286_G384_E0.5670.34
195_M280_A0.5650.34
33_A39_L0.5630.34
395_R399_A0.5600.34
370_D374_E0.5600.34
144_G156_D0.5600.34
40_E48_D0.5590.34
144_G150_W0.5590.34
77_G342_G0.5590.34
151_A269_E0.5580.34
37_A211_V0.5580.34
113_S138_V0.5570.33
143_E216_P0.5570.33
40_E44_D0.5560.33
97_M201_T0.5560.33
294_V298_V0.5560.33
49_A56_D0.5530.33
344_T353_L0.5520.33
330_V380_A0.5520.33
349_Q353_L0.5520.33
374_E378_V0.5500.33
199_M229_D0.5500.33
175_T179_V0.5500.33
275_N278_G0.5500.33
137_R182_N0.5480.33
291_A317_T0.5470.33
384_E387_L0.5460.33
168_H222_V0.5460.33
30_T353_L0.5460.33
81_P208_S0.5460.33
223_S387_L0.5460.33
166_T376_I0.5450.32
289_A388_L0.5440.32
228_T295_V0.5430.32
254_D257_E0.5430.32
165_T169_G0.5430.32
44_D48_D0.5420.32
45_A157_A0.5410.32
107_S110_R0.5390.32
67_N195_M0.5380.32
226_L369_A0.5370.32
37_A154_N0.5360.32
126_T129_G0.5360.32
352_A355_V0.5360.32
267_I271_N0.5360.32
77_G349_Q0.5350.32
380_A401_A0.5350.32
204_T207_A0.5340.32
33_A216_P0.5340.32
80_G94_Y0.5330.31
273_R356_L0.5320.31
99_T297_A0.5310.31
48_D153_D0.5300.31
164_S206_A0.5300.31
107_S397_S0.5290.31
151_A174_V0.5290.31
289_A317_T0.5280.31
223_S284_S0.5280.31
205_E401_A0.5280.31
171_L353_L0.5270.31
153_D157_A0.5270.31
151_A185_L0.5260.31
185_L210_L0.5260.31
343_G347_P0.5250.31
114_A255_V0.5250.31
147_V185_L0.5220.31
132_R230_K0.5220.31
289_A308_Q0.5200.30
171_L346_L0.5200.30
287_F397_S0.5190.30
140_D147_V0.5180.30
128_T370_D0.5180.30
114_A261_D0.5170.30
114_A259_R0.5170.30
74_L113_S0.5150.30
319_V328_A0.5140.30
151_A158_L0.5140.30
267_I389_A0.5140.30
29_D385_I0.5130.30
223_S380_A0.5130.30
108_V294_V0.5110.30
98_A353_L0.5110.30
69_T78_V0.5090.29
194_A326_L0.5080.29
250_T327_Y0.5080.29
45_A354_D0.5070.29
201_T396_L0.5070.29
353_L373_A0.5060.29
202_I299_F0.5050.29
64_A70_G0.5050.29
205_E395_R0.5050.29
118_A326_L0.5040.29
99_T171_L0.5040.29
223_S391_L0.5040.29
224_G289_A0.5030.29
131_T229_D0.5010.29
52_A57_A0.5000.29
99_T110_R0.5000.29
170_E290_H0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r4fA 4 0.963 100 0.138 Contact Map
3qaeA 2 0.8444 100 0.184 Contact Map
4i6yA 2 0.8642 100 0.191 Contact Map
3r84A 2 0.1778 16.3 0.98 Contact Map
3fxhA 2 0.2543 13.7 0.98 Contact Map
3bypA 2 0.1975 8.6 0.982 Contact Map
2lw4A 1 0.1062 8.4 0.982 Contact Map
4by7X 1 0.1284 7.7 0.983 Contact Map
4nguA 1 0.1506 5 0.984 Contact Map
1qw2A 3 0.2519 4.9 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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