GREMLIN Database
Q9HNZ4 - Uncharacterized protein
UniProt: Q9HNZ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 105 (92)
Sequences: 1005 (570)
Seq/√Len: 59.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_A59_T3.1081.00
40_H45_T2.8741.00
38_R87_E2.6461.00
84_L88_E2.5211.00
91_D95_D2.1691.00
58_V74_L2.1361.00
20_D96_R2.0951.00
56_A60_A1.9741.00
35_V46_I1.9311.00
5_A58_V1.8030.99
85_A88_E1.8010.99
33_F60_A1.7550.99
32_E60_A1.7390.99
29_A64_A1.6980.99
36_R87_E1.6710.99
10_A71_G1.6360.99
48_A54_L1.5930.99
87_E91_D1.5580.98
42_M77_D1.5310.98
25_S28_D1.5300.98
6_M75_K1.5300.98
21_A96_R1.4890.98
6_M43_E1.4650.98
5_A54_L1.4420.97
28_D32_E1.3860.97
93_V97_L1.3860.97
71_G75_K1.3770.97
41_P86_V1.3320.96
26_A65_V1.3110.96
25_S66_D1.3040.95
62_H72_T1.3020.95
90_V93_V1.2840.95
7_L58_V1.2790.95
7_L61_A1.2720.95
31_E37_Y1.2100.93
62_H78_H1.2010.93
41_P45_T1.1780.92
26_A61_A1.1690.92
92_R96_R1.1410.91
52_A76_I1.1310.91
82_E85_A1.1230.90
30_L57_A1.0920.89
72_T76_I1.0580.87
84_L87_E1.0520.87
13_D19_F0.9860.83
39_T93_V0.9860.83
51_M54_L0.9780.83
26_A64_A0.9690.82
34_D53_E0.9670.82
27_V39_T0.9570.81
10_A13_D0.9560.81
28_D97_L0.9530.81
33_F57_A0.9480.81
55_M58_V0.9430.80
9_V26_A0.9410.80
42_M89_K0.9330.80
53_E56_A0.9240.79
48_A61_A0.9190.79
29_A61_A0.9120.78
35_V54_L0.9120.78
7_L30_L0.9040.78
7_L46_I0.9030.77
59_T63_Q0.8800.76
5_A74_L0.8750.75
51_M55_M0.8740.75
30_L33_F0.8490.73
6_M45_T0.8490.73
4_T45_T0.8450.73
33_F53_E0.8410.72
54_L61_A0.8380.72
29_A48_A0.8330.72
27_V37_Y0.8330.72
94_E98_G0.8270.71
14_S66_D0.8260.71
92_R95_D0.8250.71
30_L72_T0.8150.70
20_D92_R0.8050.69
31_E94_E0.7930.68
46_I74_L0.7920.68
5_A46_I0.7900.67
14_S22_Q0.7860.67
20_D85_A0.7680.65
12_V71_G0.7570.64
8_S89_K0.7540.64
62_H76_I0.7310.61
23_I89_K0.7210.60
40_H77_D0.7180.60
14_S18_D0.7100.59
10_A73_T0.7090.59
25_S64_A0.7080.59
55_M76_I0.7030.58
12_V19_F0.7010.58
56_A59_T0.6990.58
91_D94_E0.6890.57
35_V48_A0.6750.55
38_R90_V0.6730.55
4_T86_V0.6720.55
13_D67_A0.6620.54
61_A65_V0.6500.53
39_T74_L0.6490.53
48_A55_M0.6440.52
81_E84_L0.6430.52
31_E97_L0.6420.52
39_T94_E0.6300.50
72_T78_H0.6270.50
75_K89_K0.6260.50
88_E92_R0.6240.50
35_V57_A0.6160.49
7_L75_K0.6140.49
55_M59_T0.6090.48
18_D70_V0.6050.48
42_M80_R0.6000.47
54_L62_H0.5970.47
38_R45_T0.5960.47
18_D82_E0.5950.46
10_A30_L0.5860.45
29_A57_A0.5840.45
31_E34_D0.5790.45
93_V96_R0.5750.44
36_R81_E0.5670.43
48_A51_M0.5540.42
51_M61_A0.5470.41
25_S65_V0.5460.41
43_E75_K0.5460.41
9_V86_V0.5420.41
9_V23_I0.5360.40
81_E85_A0.5310.39
13_D79_Y0.5260.39
36_R47_E0.5230.39
10_A72_T0.5230.39
70_V80_R0.5210.38
15_P67_A0.5150.38
60_A64_A0.5140.38
60_A63_Q0.5070.37
42_M45_T0.5060.37
63_Q95_D0.5050.37
57_A64_A0.5000.36
95_D98_G0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lxjA 4 0.9333 100 0.205 Contact Map
1lxnA 4 0.9143 100 0.225 Contact Map
1yqhA 3 0.9143 100 0.244 Contact Map
2epiA 4 0.8952 100 0.258 Contact Map
2iboA 4 0.8286 100 0.291 Contact Map
1vk8A 4 0.8667 100 0.299 Contact Map
1s99A 2 0.781 99.7 0.559 Contact Map
4f3qA 1 0.7619 28.2 0.921 Contact Map
1konA 1 0.7905 20.6 0.926 Contact Map
4m7tA 1 0.8857 18 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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