GREMLIN Database
Q9HNZ3 - Thiamin-binding periplasmic protein homolog
UniProt: Q9HNZ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (314)
Sequences: 35807 (28265)
Seq/√Len: 1595.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_R95_D3.6781.00
181_E284_Q3.6531.00
63_R95_D3.5231.00
142_A308_P3.2121.00
61_R93_D3.0221.00
194_T235_R2.9261.00
143_A164_T2.7831.00
182_T282_R2.6831.00
234_R238_D2.5181.00
87_Q93_D2.4871.00
92_V310_L2.4441.00
85_A317_F2.4121.00
235_R239_N2.4051.00
320_S323_T2.4001.00
90_Y313_T2.3721.00
189_T192_A2.3461.00
63_R97_V2.2111.00
104_T107_M2.1591.00
85_A88_S2.1481.00
80_N84_D2.1321.00
313_T316_S2.1311.00
183_V260_P2.0941.00
85_A89_E2.0881.00
179_Y284_Q2.0771.00
181_E185_D2.0551.00
85_A326_I2.0341.00
119_D307_N2.0301.00
325_R329_E2.0291.00
307_N310_L1.9881.00
60_P310_L1.9611.00
141_F300_T1.9461.00
232_Y235_R1.9361.00
81_W84_D1.9341.00
231_E235_R1.9071.00
145_D164_T1.8891.00
184_V261_M1.8301.00
76_T80_N1.7961.00
167_M298_G1.7921.00
86_V90_Y1.7831.00
147_D312_D1.7831.00
142_A303_E1.7701.00
321_G325_R1.7601.00
86_V313_T1.7471.00
84_D88_S1.7361.00
308_P312_D1.7351.00
83_K314_F1.7321.00
83_K87_Q1.7231.00
310_L313_T1.7201.00
192_A195_T1.7181.00
326_I330_K1.7031.00
253_A258_E1.6951.00
108_R112_Q1.6941.00
231_E234_R1.6741.00
323_T326_I1.6671.00
59_P93_D1.6521.00
309_A313_T1.6441.00
100_E104_T1.6421.00
121_Y302_F1.6111.00
232_Y236_L1.6091.00
65_G112_Q1.6071.00
180_D183_V1.6051.00
188_E192_A1.6051.00
344_A348_E1.5951.00
66_A96_W1.5891.00
326_I329_E1.5811.00
89_E320_S1.5751.00
240_G243_T1.5691.00
252_S256_G1.5551.00
156_H159_F1.5401.00
87_Q90_Y1.5231.00
191_A194_T1.4911.00
179_Y286_A1.4851.00
246_S249_A1.4831.00
196_D200_D1.4721.00
17_A20_G1.4721.00
86_V314_F1.4681.00
81_W85_A1.4641.00
194_T239_N1.4591.00
196_D239_N1.4511.00
155_V159_F1.4481.00
181_E282_R1.4471.00
120_G311_V1.4331.00
241_L244_A1.4211.00
16_A19_L1.4201.00
194_T232_Y1.4171.00
60_P307_N1.4021.00
253_A259_A1.3921.00
305_A308_P1.3901.00
197_E201_G1.3821.00
194_T236_L1.3731.00
187_P192_A1.3721.00
84_D87_Q1.3681.00
348_E351_H1.3621.00
86_V317_F1.3581.00
154_N339_N1.3441.00
136_L166_R1.3391.00
196_D199_S1.3391.00
301_K315_A1.3151.00
309_A312_D1.3101.00
149_V152_T1.3041.00
240_G244_A1.3041.00
305_A311_V1.2721.00
344_A347_R1.2651.00
86_V92_V1.2641.00
143_A146_T1.2491.00
235_R238_D1.2431.00
153_D156_H1.2401.00
301_K311_V1.2381.00
321_G339_N1.2361.00
177_I286_A1.2351.00
120_G314_F1.2341.00
191_A195_T1.2331.00
160_W165_D1.2281.00
143_A165_D1.2161.00
83_K96_W1.2071.00
322_D325_R1.2041.00
77_S80_N1.2011.00
249_A252_S1.1991.00
312_D316_S1.1951.00
254_Y283_H1.1821.00
178_I264_S1.1811.00
176_T285_V1.1521.00
99_A108_R1.1511.00
180_D282_R1.1481.00
83_K94_F1.1431.00
278_V281_A1.1351.00
14_A18_S1.1141.00
348_E352_V1.1131.00
349_Y352_V1.1071.00
85_A322_D1.1051.00
270_V274_Q1.0991.00
150_D153_D1.0981.00
198_Y201_G1.0921.00
180_D281_A1.0921.00
92_V313_T1.0901.00
64_M299_T1.0901.00
77_S81_W1.0891.00
81_W326_I1.0871.00
188_E289_G1.0851.00
62_L314_F1.0801.00
219_W222_D1.0781.00
106_F128_D1.0721.00
177_I261_M1.0701.00
302_F305_A1.0701.00
322_D326_I1.0671.00
89_E317_F1.0661.00
271_Y274_Q1.0641.00
110_A138_A1.0641.00
301_K312_D1.0641.00
87_Q91_T1.0631.00
89_E322_D1.0631.00
108_R111_Q1.0601.00
119_D305_A1.0571.00
221_V224_F1.0541.00
142_A312_D1.0511.00
317_F323_T1.0461.00
347_R351_H1.0431.00
24_C27_D1.0431.00
13_S17_A1.0421.00
120_G315_A1.0411.00
264_S268_D1.0371.00
81_W330_K1.0361.00
299_T315_A1.0341.00
279_D283_H1.0241.00
201_G260_P1.0231.00
220_T223_A1.0151.00
107_M111_Q1.0051.00
221_V226_E1.0051.00
86_V310_L1.0041.00
314_F318_M0.9991.00
321_G337_V0.9981.00
153_D157_D0.9971.00
248_N251_Y0.9941.00
62_L310_L0.9871.00
82_V323_T0.9851.00
78_A81_W0.9851.00
351_H354_E0.9821.00
182_T281_A0.9811.00
121_Y300_T0.9811.00
130_A137_S0.9801.00
117_G302_F0.9741.00
139_P303_E0.9721.00
170_T299_T0.9701.00
193_L261_M0.9661.00
325_R340_A0.9661.00
82_V85_A0.9651.00
85_A323_T0.9611.00
343_P347_R0.9551.00
124_V300_T0.9541.00
303_E308_P0.9531.00
131_R138_A0.9531.00
198_Y202_I0.9521.00
234_R237_A0.9501.00
94_F314_F0.9461.00
24_C28_R0.9461.00
112_Q116_L0.9451.00
337_V340_A0.9391.00
301_K305_A0.9381.00
211_A214_L0.9281.00
109_R121_Y0.9251.00
252_S255_S0.9141.00
350_V354_E0.9121.00
136_L161_I0.9101.00
179_Y186_A0.9061.00
197_E200_D0.9041.00
154_N337_V0.8971.00
132_A141_F0.8941.00
230_L234_R0.8881.00
65_G118_A0.8841.00
167_M300_T0.8781.00
65_G99_A0.8761.00
16_A20_G0.8761.00
18_S21_L0.8741.00
17_A21_L0.8711.00
202_I205_P0.8691.00
345_E348_E0.8661.00
203_L259_A0.8641.00
233_W237_A0.8641.00
218_L222_D0.8581.00
24_C29_E0.8561.00
107_M110_A0.8551.00
222_D225_G0.8541.00
190_L194_T0.8541.00
183_V198_Y0.8491.00
106_F110_A0.8451.00
152_T155_V0.8411.00
220_T224_F0.8381.00
55_Q58_T0.8291.00
128_D131_R0.8211.00
104_T108_R0.8201.00
154_N157_D0.8201.00
125_T128_D0.8201.00
255_S275_D0.8141.00
97_V108_R0.8111.00
206_N209_N0.8111.00
13_S16_A0.8061.00
219_W223_A0.8051.00
145_D165_D0.8041.00
144_F315_A0.8011.00
143_A166_R0.8011.00
222_D226_E0.7971.00
141_F166_R0.7971.00
217_V221_V0.7951.00
182_T185_D0.7891.00
15_T19_L0.7881.00
12_G16_A0.7881.00
271_Y275_D0.7871.00
24_C30_T0.7851.00
57_G60_P0.7821.00
142_A302_F0.7811.00
311_V315_A0.7791.00
196_D201_G0.7791.00
154_N158_R0.7781.00
142_A305_A0.7731.00
316_S320_S0.7731.00
314_F317_F0.7721.00
299_T318_M0.7711.00
136_L141_F0.7661.00
173_S295_Y0.7651.00
178_I269_Q0.7641.00
204_V207_P0.7631.00
247_W250_T0.7631.00
186_A286_A0.7611.00
13_S19_L0.7601.00
223_A226_E0.7581.00
14_A20_G0.7571.00
60_P92_V0.7521.00
79_G82_V0.7501.00
121_Y141_F0.7491.00
15_T18_S0.7491.00
19_L22_A0.7481.00
87_Q94_F0.7471.00
198_Y260_P0.7471.00
349_Y353_P0.7451.00
270_V273_S0.7391.00
62_L307_N0.7381.00
341_S344_A0.7371.00
115_D304_S0.7361.00
186_A192_A0.7351.00
122_V299_T0.7331.00
142_A146_T0.7321.00
251_Y255_S0.7311.00
341_S345_E0.7291.00
14_A17_A0.7271.00
18_S22_A0.7231.00
248_N252_S0.7201.00
350_V353_P0.7161.00
269_Q273_S0.7121.00
206_N212_T0.7111.00
106_F131_R0.7111.00
219_W224_F0.7111.00
110_A131_R0.7101.00
182_T257_G0.7081.00
65_G97_V0.7081.00
142_A301_K0.7061.00
21_L24_C0.7051.00
217_V222_D0.7021.00
245_G249_A0.7011.00
229_F233_W0.6991.00
119_D311_V0.6961.00
268_D271_Y0.6911.00
230_L233_W0.6911.00
63_R119_D0.6891.00
279_D282_R0.6881.00
93_D96_W0.6861.00
250_T262_V0.6861.00
178_I283_H0.6841.00
346_L349_Y0.6831.00
239_N242_Q0.6831.00
189_T290_D0.6801.00
180_D257_G0.6781.00
211_A215_A0.6771.00
185_D282_R0.6761.00
178_I285_V0.6731.00
346_L350_V0.6711.00
156_H338_T0.6711.00
284_Q287_F0.6701.00
349_Y354_E0.6691.00
20_G23_G0.6681.00
64_M122_V0.6671.00
199_S202_I0.6671.00
136_L139_P0.6651.00
341_S347_R0.6651.00
313_T317_F0.6621.00
245_G253_A0.6611.00
12_G19_L0.6601.00
147_D150_D0.6591.00
145_D312_D0.6591.00
179_Y184_V0.6581.00
142_A147_D0.6571.00
27_D30_T0.6541.00
343_P346_L0.6511.00
63_R66_A0.6501.00
208_Q212_T0.6491.00
151_N154_N0.6471.00
342_L347_R0.6441.00
60_P63_R0.6401.00
64_M120_G0.6401.00
253_A256_G0.6391.00
28_R31_T0.6381.00
209_N212_T0.6371.00
238_D241_L0.6361.00
160_W163_G0.6361.00
212_T215_A0.6341.00
179_Y261_M0.6281.00
308_P311_V0.6261.00
62_L311_V0.6211.00
9_A12_G0.6211.00
218_L224_F0.6191.00
161_I164_T0.6181.00
147_D309_A0.6181.00
206_N210_T0.6151.00
345_E349_Y0.6131.00
13_S20_G0.6131.00
215_A219_W0.6121.00
97_V112_Q0.6121.00
220_T225_G0.6121.00
207_P210_T0.6111.00
154_N159_F0.6111.00
218_L221_V0.6111.00
105_E109_R0.6101.00
190_L232_Y0.6091.00
218_L223_A0.6071.00
247_W251_Y0.6061.00
142_A304_S0.6061.00
321_G324_Q0.6051.00
184_V198_Y0.6021.00
22_A26_G0.6011.00
298_G302_F0.6011.00
12_G15_T0.6011.00
260_P263_M0.6011.00
22_A25_V0.6001.00
236_L239_N0.6001.00
301_K308_P0.5991.00
203_L206_N0.5951.00
97_V118_A0.5951.00
8_V11_V0.5941.00
210_T214_L0.5941.00
29_E32_T0.5931.00
129_L167_M0.5911.00
155_V158_R0.5901.00
229_F234_R0.5881.00
216_F220_T0.5861.00
82_V318_M0.5851.00
236_L241_L0.5821.00
347_R350_V0.5821.00
106_F132_A0.5791.00
58_T61_R0.5791.00
215_A218_L0.5761.00
229_F232_Y0.5761.00
62_L94_F0.5741.00
317_F320_S0.5721.00
87_Q92_V0.5711.00
144_F312_D0.5711.00
203_L208_Q0.5701.00
204_V210_T0.5701.00
82_V326_I0.5691.00
342_L346_L0.5681.00
324_Q336_T0.5671.00
59_P91_T0.5651.00
151_N316_S0.5651.00
208_Q213_G0.5641.00
204_V208_Q0.5631.00
154_N338_T0.5631.00
146_T164_T0.5611.00
304_S308_P0.5611.00
12_G18_S0.5611.00
60_P91_T0.5581.00
21_L25_V0.5571.00
206_N211_A0.5571.00
9_A13_S0.5561.00
210_T213_G0.5561.00
165_D168_L0.5561.00
64_M96_W0.5561.00
144_F147_D0.5551.00
207_P212_T0.5551.00
267_T270_V0.5541.00
15_T20_G0.5531.00
168_L319_L0.5531.00
249_A253_A0.5511.00
111_Q114_V0.5491.00
80_N83_K0.5491.00
177_I263_M0.5491.00
144_F301_K0.5471.00
173_S297_S0.5471.00
90_Y310_L0.5441.00
82_V317_F0.5441.00
26_G29_E0.5421.00
324_Q328_A0.5411.00
56_Q59_P0.5401.00
171_G297_S0.5391.00
217_V220_T0.5381.00
122_V170_T0.5361.00
345_E351_H0.5341.00
347_R353_P0.5341.00
23_G26_G0.5341.00
188_E193_L0.5321.00
342_L345_E0.5311.00
83_K93_D0.5311.00
64_M83_K0.5311.00
181_E281_A0.5301.00
208_Q211_A0.5291.00
155_V319_L0.5271.00
152_T316_S0.5261.00
345_E350_V0.5231.00
131_R137_S0.5231.00
217_V224_F0.5211.00
58_T313_T0.5211.00
105_E121_Y0.5201.00
24_C31_T0.5201.00
63_R118_A0.5181.00
143_A147_D0.5181.00
268_D272_A0.5171.00
22_A28_R0.5171.00
347_R354_E0.5171.00
214_L217_V0.5171.00
9_A20_G0.5131.00
333_G336_T0.5111.00
154_N321_G0.5111.00
174_Y266_S0.5111.00
20_G24_C0.5101.00
119_D306_T0.5091.00
68_E71_V0.5061.00
14_A19_L0.5051.00
251_Y264_S0.5041.00
119_D308_P0.5031.00
259_A263_M0.5031.00
120_G299_T0.5031.00
92_V96_W0.5021.00
140_L143_A0.5011.00
65_G105_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uorA 1 0.8115 100 0.308 Contact Map
4r9fA 1 0.8063 100 0.318 Contact Map
4r2fA 1 0.8141 100 0.324 Contact Map
4mfiA 1 0.8272 100 0.326 Contact Map
3vxbA 1 0.8168 100 0.329 Contact Map
4edpA 1 0.7958 100 0.339 Contact Map
3woaA 1 0.8874 100 0.352 Contact Map
2w7yA 1 0.8089 100 0.352 Contact Map
4r6kA 1 0.8115 100 0.355 Contact Map
4g68A 1 0.8246 100 0.356 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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