GREMLIN Database
NADA - Quinolinate synthase A
UniProt: Q9HNZ1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (303)
Sequences: 2293 (1196)
Seq/√Len: 68.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_D83_D5.0861.00
36_R343_E3.8081.00
369_D373_E3.1961.00
294_T315_N3.1271.00
275_V281_T2.9801.00
39_A45_G2.8351.00
358_S361_A2.8101.00
254_H294_T2.8071.00
256_D294_T2.7611.00
284_E288_D2.7441.00
261_V270_V2.6821.00
185_K228_D2.5821.00
356_V361_A2.5031.00
62_E305_N2.4941.00
361_A365_Q2.4651.00
358_S362_E2.4551.00
96_S368_L2.4431.00
261_V273_A2.3211.00
33_R339_A2.3171.00
111_S337_Y2.2971.00
36_R39_A2.2961.00
287_A310_W2.2871.00
195_G231_L2.2641.00
128_D162_Q2.2511.00
106_S353_V2.2241.00
365_Q369_D2.2011.00
76_E79_N2.1921.00
147_T151_S2.1421.00
248_A272_A2.0911.00
289_A295_W2.0451.00
173_H198_T2.0431.00
36_R339_A2.0321.00
84_Y108_I2.0091.00
72_Q76_E1.9471.00
258_N285_T1.9431.00
306_H310_W1.9251.00
115_S120_G1.9101.00
72_Q280_A1.8951.00
287_A311_H1.8851.00
38_E41_R1.8511.00
66_F72_Q1.8471.00
251_R274_D1.8451.00
258_N292_G1.8311.00
282_I307_L1.8291.00
147_T163_G1.7861.00
270_V276_V1.7711.00
244_P272_A1.7621.00
133_D136_A1.7311.00
78_A101_T1.6901.00
293_E313_E1.6710.99
339_A343_E1.6710.99
286_V316_V1.6490.99
341_V352_N1.6300.99
173_H177_E1.6240.99
248_A252_A1.6110.99
87_F97_A1.5970.99
258_N289_A1.5840.99
46_D84_Y1.5700.99
84_Y106_S1.5650.99
370_R373_E1.5530.99
98_D353_V1.5490.99
173_H201_R1.5390.99
286_V311_H1.5110.99
46_D106_S1.5050.99
165_L178_W1.4940.99
363_L366_V1.4830.99
142_T184_D1.4610.99
133_D137_A1.4600.99
118_M121_M1.4530.99
66_F76_E1.4310.98
293_E315_N1.4220.98
247_V259_V1.4190.98
47_D84_Y1.4070.98
267_R271_E1.3970.98
86_I108_I1.3930.98
88_G338_L1.3920.98
51_L77_A1.3810.98
176_F198_T1.3800.98
192_K233_D1.3480.98
260_V286_V1.3450.98
98_D355_E1.3420.97
52_G64_A1.3410.97
178_W374_L1.3390.97
138_A185_K1.3270.97
249_E253_D1.3260.97
99_I153_A1.3220.97
74_S87_F1.3140.97
142_T179_A1.3050.97
289_A314_V1.3040.97
329_A332_Q1.2980.97
117_P329_A1.2860.97
238_V329_A1.2770.97
99_I361_A1.2760.97
49_V82_A1.2730.97
74_S101_T1.2720.97
289_A292_G1.2710.97
34_T38_E1.2630.96
200_H267_R1.2490.96
284_E287_A1.2440.96
294_T317_V1.2410.96
60_I338_L1.2370.96
237_Q329_A1.2150.95
200_H271_E1.2070.95
174_R177_E1.2020.95
340_W344_E1.1930.95
254_H317_V1.1920.95
261_V298_G1.1860.95
260_V297_I1.1780.95
257_A296_A1.1780.95
142_T183_G1.1630.94
94_A109_L1.1590.94
141_E185_K1.1500.94
106_S345_L1.1430.94
128_D136_A1.1380.94
31_T35_E1.1370.94
47_D81_D1.1340.93
75_K372_L1.1310.93
46_D345_L1.1310.93
91_T115_S1.1290.93
73_L87_F1.1270.93
286_V307_L1.1230.93
196_E199_A1.1230.93
86_I338_L1.1150.93
280_A284_E1.1150.93
108_I341_V1.1000.92
170_S280_A1.1000.92
192_K240_E1.0990.92
251_R272_A1.0970.92
177_E202_L1.0950.92
175_A374_L1.0940.92
141_E230_V1.0820.92
84_Y345_L1.0810.92
303_L307_L1.0770.92
138_A230_V1.0700.91
47_D82_A1.0630.91
277_G282_I1.0590.91
33_R335_P1.0530.91
48_V86_I1.0510.91
121_M235_Y1.0480.90
155_L189_L1.0400.90
334_D337_Y1.0380.90
71_Y75_K1.0370.90
141_E228_D1.0360.90
242_F319_L1.0280.90
33_R336_N1.0270.90
147_T189_L1.0230.89
109_L354_I1.0220.89
301_I318_P1.0190.89
357_D360_E1.0070.89
198_T229_I1.0050.89
244_P248_A1.0030.88
123_E126_Q1.0020.88
362_E365_Q0.9950.88
295_W314_V0.9940.88
124_A155_L0.9900.88
122_A155_L0.9880.88
149_M166_V0.9790.87
260_V282_I0.9780.87
52_G61_V0.9770.87
296_A319_L0.9760.87
37_I339_A0.9740.87
124_A154_D0.9690.87
196_E200_H0.9690.87
56_Q60_I0.9670.87
197_N270_V0.9660.86
48_V84_Y0.9650.86
360_E363_L0.9640.86
151_S260_V0.9590.86
285_T295_W0.9590.86
117_P235_Y0.9560.86
112_M352_N0.9540.86
163_G367_G0.9520.86
140_D185_K0.9490.85
58_R62_E0.9490.85
245_E249_E0.9460.85
146_I175_A0.9440.85
72_Q75_K0.9370.85
111_S332_Q0.9330.85
98_D356_V0.9290.84
362_E366_V0.9290.84
196_E267_R0.9250.84
249_E252_A0.9250.84
126_Q133_D0.9210.84
238_V241_R0.9200.84
250_V317_V0.9160.83
127_V189_L0.9140.83
245_E248_A0.9100.83
135_T143_I0.9090.83
359_E363_L0.9030.83
75_K79_N0.8980.82
35_E39_A0.8970.82
197_N276_V0.8940.82
340_W343_E0.8920.82
51_L73_L0.8890.82
162_Q363_L0.8880.81
259_V298_G0.8840.81
54_N306_H0.8800.81
188_F195_G0.8740.80
305_N309_R0.8740.80
196_E270_V0.8740.80
181_E227_A0.8720.80
366_V370_R0.8690.80
157_A356_V0.8640.80
38_E42_A0.8640.80
54_N277_G0.8620.79
117_P324_C0.8610.79
49_V80_A0.8580.79
34_T62_E0.8560.79
146_I179_A0.8540.79
117_P237_Q0.8530.79
250_V296_A0.8510.79
58_R305_N0.8490.78
81_D84_Y0.8460.78
118_M329_A0.8440.78
49_V66_F0.8440.78
311_H316_V0.8370.77
151_S235_Y0.8340.77
61_V305_N0.8330.77
101_T163_G0.8310.77
298_G319_L0.8290.77
256_D293_E0.8280.77
200_H270_V0.8250.76
106_S355_E0.8220.76
117_P238_V0.8190.76
311_H314_V0.8170.76
56_Q94_A0.8140.75
134_I187_L0.8090.75
71_Y149_M0.8080.75
147_T367_G0.8050.75
111_S333_I0.8040.75
251_R259_V0.7990.74
356_V360_E0.7970.74
170_S282_I0.7970.74
283_T303_L0.7920.73
170_S284_E0.7880.73
244_P269_V0.7820.73
277_G281_T0.7770.72
306_H309_R0.7770.72
185_K230_V0.7750.72
78_A369_D0.7660.71
250_V253_D0.7660.71
182_R227_A0.7650.71
187_L230_V0.7640.71
184_D228_D0.7610.70
248_A251_R0.7610.70
122_A232_W0.7610.70
118_M237_Q0.7610.70
40_A45_G0.7600.70
172_A194_L0.7590.70
54_N303_L0.7570.70
307_L316_V0.7560.70
72_Q170_S0.7560.70
86_I110_P0.7520.70
46_D342_L0.7510.69
285_T289_A0.7500.69
241_R328_N0.7430.69
108_I345_L0.7410.68
138_A141_E0.7380.68
99_I364_A0.7380.68
199_A229_I0.7370.68
282_I303_L0.7370.68
237_Q242_F0.7360.68
308_Q315_N0.7360.68
235_Y240_E0.7350.68
258_N261_V0.7350.68
260_V295_W0.7340.68
121_M234_G0.7330.68
60_I333_I0.7310.67
122_A189_L0.7300.67
257_A294_T0.7280.67
183_G186_V0.7280.67
48_V342_L0.7280.67
35_E38_E0.7240.67
244_P268_E0.7230.67
124_A128_D0.7220.66
50_V88_G0.7220.66
318_P323_A0.7190.66
356_V365_Q0.7120.65
203_G227_A0.7120.65
142_T186_V0.7120.65
71_Y170_S0.7110.65
238_V242_F0.7110.65
165_L179_A0.7110.65
139_P185_K0.7100.65
62_E309_R0.7100.65
32_A35_E0.7090.65
118_M235_Y0.7070.65
54_N282_I0.7010.64
326_D331_R0.6940.63
134_I141_E0.6930.63
146_I165_L0.6920.63
85_V97_A0.6920.63
356_V367_G0.6910.63
136_A162_Q0.6800.62
42_A293_E0.6790.62
35_E252_A0.6790.62
51_L87_F0.6750.61
338_L341_V0.6740.61
359_E362_E0.6730.61
330_M333_I0.6710.61
269_V274_D0.6700.61
337_Y340_W0.6690.61
177_E181_E0.6670.60
203_G229_I0.6650.60
143_I187_L0.6610.60
113_E332_Q0.6610.60
199_A231_L0.6610.60
192_K235_Y0.6610.60
146_I167_C0.6550.59
41_R65_D0.6550.59
149_M175_A0.6520.59
344_E352_N0.6510.58
153_A356_V0.6470.58
101_T105_Q0.6470.58
304_A308_Q0.6460.58
75_K281_T0.6460.58
86_I341_V0.6450.58
197_N231_L0.6440.58
176_F186_V0.6420.57
56_Q64_A0.6420.57
139_P187_L0.6380.57
323_A333_I0.6380.57
360_E367_G0.6380.57
117_P121_M0.6330.56
41_R50_V0.6300.56
141_E187_L0.6290.56
175_A373_E0.6280.56
29_T32_A0.6270.56
155_L232_W0.6260.55
242_F323_A0.6260.55
312_P316_V0.6240.55
123_E127_V0.6240.55
61_V302_H0.6230.55
302_H331_R0.6220.55
48_V108_I0.6200.55
281_T286_V0.6190.55
117_P242_F0.6150.54
238_V328_N0.6140.54
151_S163_G0.6120.54
124_A157_A0.6110.54
344_E351_R0.6110.54
32_A36_R0.6100.54
64_A67_V0.6060.53
127_V135_T0.6060.53
345_L353_V0.6050.53
103_D106_S0.6050.53
247_V298_G0.6040.53
197_N201_R0.6030.53
147_T166_V0.6030.53
127_V134_I0.6020.53
250_V254_H0.6000.52
324_C329_A0.6000.52
340_W346_V0.5990.52
254_H315_N0.5980.52
167_C171_N0.5970.52
197_N200_H0.5970.52
109_L333_I0.5960.52
199_A228_D0.5950.52
157_A360_E0.5940.52
57_R331_R0.5940.52
91_T119_A0.5930.52
56_Q109_L0.5910.51
99_I365_Q0.5910.51
297_I307_L0.5910.51
177_E203_G0.5900.51
52_G60_I0.5890.51
91_T356_V0.5870.51
134_I138_A0.5850.51
115_S118_M0.5850.51
114_A333_I0.5840.50
125_L133_D0.5830.50
36_R340_W0.5810.50
52_G88_G0.5810.50
134_I229_I0.5800.50
99_I356_V0.5790.50
345_L351_R0.5790.50
80_A149_M0.5790.50
184_D227_A0.5780.50
135_T162_Q0.5770.50
290_D293_E0.5770.50
121_M329_A0.5760.49
235_Y329_A0.5720.49
187_L234_G0.5710.49
66_F283_T0.5710.49
122_A127_V0.5710.49
34_T59_E0.5700.49
286_V295_W0.5700.49
49_V84_Y0.5700.49
331_R335_P0.5680.49
282_I297_I0.5670.48
163_G189_L0.5670.48
99_I363_L0.5670.48
175_A198_T0.5660.48
366_V373_E0.5640.48
42_A45_G0.5600.48
228_D232_W0.5600.48
30_P59_E0.5580.47
109_L112_M0.5540.47
157_A364_A0.5520.47
127_V155_L0.5510.46
173_H176_F0.5500.46
303_L306_H0.5490.46
91_T120_G0.5480.46
167_C186_V0.5440.46
304_A318_P0.5420.45
61_V67_V0.5410.45
176_F179_A0.5380.45
135_T187_L0.5360.45
290_D314_V0.5360.45
192_K196_E0.5360.45
91_T109_L0.5350.45
136_A358_S0.5340.44
33_R36_R0.5330.44
138_A183_G0.5330.44
245_E359_E0.5330.44
240_E266_R0.5320.44
56_Q115_S0.5320.44
179_A199_A0.5310.44
30_P34_T0.5310.44
333_I337_Y0.5280.44
340_W351_R0.5280.44
335_P338_L0.5280.44
341_V345_L0.5250.43
79_N335_P0.5240.43
336_N340_W0.5230.43
258_N295_W0.5230.43
39_A252_A0.5230.43
126_Q232_W0.5220.43
295_W316_V0.5220.43
177_E201_R0.5170.42
54_N122_A0.5150.42
362_E369_D0.5130.42
110_P232_W0.5120.42
320_C333_I0.5120.42
54_N94_A0.5100.42
88_G333_I0.5090.42
108_I352_N0.5090.42
39_A346_V0.5080.41
151_S367_G0.5080.41
259_V269_V0.5080.41
128_D135_T0.5070.41
51_L94_A0.5060.41
54_N195_G0.5050.41
277_G306_H0.5050.41
329_A333_I0.5050.41
167_C260_V0.5040.41
103_D125_L0.5030.41
79_N288_D0.5020.41
258_N274_D0.5010.41
98_D107_V0.5010.41
243_T246_H0.5010.41
320_C323_A0.5010.41
251_R296_A0.5010.41
74_S77_A0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wzuA 1 0.7246 100 0.225 Contact Map
4p3xA 1 0.8048 100 0.235 Contact Map
2q5cA 2 0.4866 72.9 0.972 Contact Map
3pg7A 1 0.6417 64.6 0.973 Contact Map
3cg6A 3 0.3102 61.4 0.974 Contact Map
2ekcA 1 0.6257 41.8 0.977 Contact Map
3mw8A 1 0.5027 34.1 0.978 Contact Map
3fxaA 4 0.492 30 0.978 Contact Map
4ht3A 1 0.6497 27.5 0.979 Contact Map
3v7eA 1 0.2166 26.9 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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