GREMLIN Database
Q9HNY9 - Nicotinate-nucleotide pyrophosphorylase [carboxylating]
UniProt: Q9HNY9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (259)
Sequences: 3895 (2440)
Seq/√Len: 151.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_R110_A3.9721.00
211_T214_E3.2131.00
240_P244_A3.0511.00
39_G262_L3.0351.00
128_T135_E3.0041.00
188_V194_A2.7711.00
9_E53_Y2.7051.00
105_T144_G2.5981.00
195_P221_L2.5661.00
234_I242_Y2.4351.00
57_E78_S2.2801.00
61_P76_R2.2781.00
63_A66_D2.2671.00
62_A72_D2.2221.00
30_T78_S2.1711.00
222_L228_A2.1701.00
189_E193_D2.1431.00
168_E196_R2.1381.00
84_V266_F2.1111.00
41_A62_A2.1041.00
42_A141_A1.9931.00
38_A69_D1.9591.00
51_F91_A1.9411.00
74_V264_L1.9221.00
59_D76_R1.9221.00
55_G83_S1.9151.00
195_P199_D1.8861.00
139_V144_G1.8811.00
215_T230_A1.8291.00
54_L87_A1.8241.00
122_A249_V1.8091.00
214_E217_R1.8061.00
6_A10_R1.7971.00
110_A113_R1.7521.00
137_R141_A1.7471.00
17_G152_S1.7461.00
168_E172_E1.7421.00
112_A121_I1.7351.00
41_A68_I1.7161.00
217_R220_D1.6991.00
169_G172_E1.6911.00
97_H128_T1.6631.00
30_T76_R1.6561.00
171_I186_V1.6521.00
108_A236_V1.6391.00
38_A70_A1.6141.00
113_R116_S1.5681.00
227_L249_V1.5571.00
241_A244_A1.5501.00
41_A44_L1.5391.00
111_A236_V1.5371.00
11_W94_V1.5351.00
22_T157_V1.5301.00
49_R53_Y1.5301.00
194_A222_L1.5301.00
112_A119_V1.5261.00
7_D10_R1.5201.00
121_I239_V1.5101.00
107_R236_V1.4961.00
16_L86_R1.4851.00
215_T242_Y1.4841.00
104_K259_A1.4821.00
96_G261_T1.4541.00
108_A239_V1.4521.00
33_L264_L1.4521.00
49_R52_E1.4451.00
169_G173_R1.4411.00
120_A145_D1.4401.00
108_A252_M1.4331.00
67_R110_A1.4261.00
97_H135_E1.4251.00
116_S244_A1.4241.00
45_D64_A1.4151.00
155_V178_K1.3871.00
21_V182_T1.3821.00
67_R106_R1.3811.00
69_D72_D1.3761.00
62_A66_D1.3721.00
116_S240_P1.3651.00
80_A83_S1.3601.00
18_H152_S1.3561.00
168_E199_D1.3371.00
48_V52_E1.3231.00
104_K236_V1.3081.00
37_Q260_P1.2891.00
56_C79_G1.2771.00
59_D78_S1.2771.00
183_K203_D1.2711.00
41_A74_V1.2641.00
194_A198_A1.2631.00
192_E195_P1.2481.00
47_A75_L1.2481.00
212_P242_Y1.2441.00
36_K265_S1.2281.00
111_A240_P1.2191.00
42_A102_A1.2161.00
6_A13_R1.2091.00
230_A242_Y1.2061.00
204_I227_L1.1991.00
33_L47_A1.1791.00
185_D206_L1.1731.00
191_P218_A1.1711.00
6_A9_E1.1631.00
73_T76_R1.1591.00
7_D134_V1.1591.00
42_A137_R1.1591.00
32_R73_T1.1531.00
101_V135_E1.1351.00
185_D204_I1.1331.00
41_A95_A1.1321.00
194_A205_V1.1100.99
117_D240_P1.1030.99
54_L83_S1.1000.99
50_V87_A1.0940.99
31_G266_F1.0840.99
239_V250_I1.0830.99
8_V53_Y1.0830.99
238_D241_A1.0800.99
56_C77_V1.0770.99
163_A189_E1.0710.99
117_D244_A1.0700.99
112_A116_S1.0690.99
119_V250_I1.0680.99
212_P241_A1.0670.99
111_A239_V1.0660.99
230_A245_T1.0640.99
181_A204_I1.0630.99
183_K204_I1.0610.99
40_V106_R1.0580.99
38_A67_R1.0560.99
171_I200_A1.0540.99
17_G150_D1.0530.99
32_R76_R1.0360.99
12_L54_L1.0330.99
64_A141_A1.0270.99
34_V265_S1.0270.99
48_V60_A1.0240.99
46_A137_R1.0240.99
194_A218_A1.0230.99
105_T109_V1.0220.99
40_V67_R1.0170.99
234_I238_D1.0120.99
100_G259_A1.0030.99
155_V174_F0.9940.99
238_D242_Y0.9930.99
44_L60_A0.9890.99
8_V94_V0.9790.99
172_E176_A0.9780.99
104_K107_R0.9770.99
104_K108_A0.9730.99
45_D137_R0.9690.99
58_A75_L0.9650.98
28_E80_A0.9630.98
213_A216_E0.9610.98
45_D48_V0.9590.98
56_C83_S0.9570.98
223_D226_A0.9540.98
34_V267_R0.9490.98
150_D153_H0.9430.98
162_V166_G0.9370.98
112_A243_A0.9270.98
33_L75_L0.9210.98
68_I74_V0.9170.98
107_R110_A0.9150.98
9_E13_R0.9140.98
7_D11_W0.9140.98
98_A138_A0.9080.98
219_V245_T0.9050.98
212_P245_T0.9010.98
175_R203_D0.9000.98
22_T156_M0.9000.98
212_P238_D0.8970.98
252_M255_L0.8960.98
195_P198_A0.8830.97
47_A91_A0.8710.97
235_T238_D0.8670.97
56_C80_A0.8660.97
190_T193_D0.8630.97
123_G146_T0.8610.97
253_G256_T0.8600.97
216_E244_A0.8590.97
109_V144_G0.8570.97
135_E259_A0.8550.97
154_M181_A0.8550.97
60_A66_D0.8540.97
98_A135_E0.8510.97
233_G252_M0.8500.97
81_A164_E0.8450.96
21_V155_V0.8440.96
222_L226_A0.8400.96
195_P217_R0.8400.96
8_V49_R0.8340.96
44_L48_V0.8250.96
217_R221_L0.8180.96
35_A74_V0.8180.96
207_L218_A0.8180.96
253_G257_H0.8170.96
47_A58_A0.8160.96
24_D82_Q0.8130.96
157_V174_F0.8130.96
33_L266_F0.8080.95
191_P221_L0.8070.95
189_E265_S0.8070.95
61_P73_T0.8060.95
147_H185_D0.8040.95
239_V252_M0.8030.95
216_E220_D0.8020.95
8_V50_V0.7970.95
219_V223_D0.7920.95
189_E267_R0.7910.95
236_V254_A0.7900.95
46_A134_V0.7900.95
94_V131_L0.7890.95
112_A117_D0.7860.95
210_M214_E0.7840.95
50_V91_A0.7830.95
197_A200_A0.7830.95
7_D94_V0.7810.95
230_A247_V0.7800.95
198_A226_A0.7790.94
159_D267_R0.7760.94
98_A134_V0.7710.94
210_M218_A0.7710.94
123_G139_V0.7660.94
14_E132_R0.7620.94
197_A202_A0.7590.94
109_V121_I0.7590.94
87_A91_A0.7590.94
27_G82_Q0.7570.94
8_V11_W0.7540.93
215_T245_T0.7500.93
149_L152_S0.7490.93
168_E200_A0.7470.93
194_A221_L0.7430.93
33_L92_V0.7420.93
205_V226_A0.7390.93
183_K227_L0.7330.92
191_P217_R0.7270.92
258_S261_T0.7260.92
33_L95_A0.7250.92
193_D196_R0.7210.92
165_L173_R0.7190.92
218_A222_L0.7190.92
175_R184_L0.7050.91
24_D86_R0.7030.91
197_A226_A0.7030.91
171_I197_A0.7020.91
206_L215_T0.6940.90
173_R176_A0.6920.90
28_E82_Q0.6920.90
198_A222_L0.6920.90
51_F56_C0.6880.90
191_P195_P0.6830.90
171_I202_A0.6750.89
41_A99_S0.6750.89
215_T219_V0.6740.89
204_I249_V0.6740.89
44_L64_A0.6700.89
162_V165_L0.6700.89
35_A68_I0.6700.89
35_A39_G0.6690.89
113_R117_D0.6670.88
213_A241_A0.6660.88
25_V81_A0.6650.88
37_Q262_L0.6650.88
122_A181_A0.6640.88
175_R201_G0.6640.88
112_A239_V0.6610.88
121_I250_I0.6530.87
113_R240_P0.6510.87
163_A193_D0.6500.87
179_S182_T0.6500.87
121_I252_M0.6480.87
205_V222_L0.6470.87
36_K267_R0.6460.87
118_D248_D0.6410.86
109_V113_R0.6400.86
50_V94_V0.6400.86
33_L77_V0.6380.86
178_K181_A0.6380.86
46_A98_A0.6370.86
227_L248_D0.6360.86
116_S119_V0.6350.86
253_G258_S0.6350.86
104_K111_A0.6320.86
104_K254_A0.6310.86
50_V90_V0.6260.85
94_V134_V0.6260.85
156_M159_D0.6250.85
51_F87_A0.6220.85
185_D203_D0.6160.84
159_D209_N0.6130.84
95_A264_L0.6110.84
192_E196_R0.6060.83
47_A50_V0.6060.83
230_A246_G0.6040.83
213_A217_R0.6030.83
77_V87_A0.6030.83
12_L50_V0.6010.83
68_I262_L0.6000.83
122_A251_S0.5990.83
172_E200_A0.5970.82
19_H150_D0.5960.82
234_I250_I0.5950.82
62_A74_V0.5920.82
202_A226_A0.5910.82
55_G79_G0.5910.82
106_R113_R0.5900.82
62_A68_I0.5870.81
33_L91_A0.5850.81
230_A234_I0.5830.81
235_T252_M0.5830.81
122_A204_I0.5820.81
39_G68_I0.5810.81
10_R13_R0.5810.81
108_A234_I0.5810.81
109_V142_G0.5800.81
212_P216_E0.5780.80
96_G123_G0.5780.80
112_A244_A0.5780.80
240_P243_A0.5740.80
29_T81_A0.5740.80
10_R131_L0.5740.80
122_A227_L0.5730.80
207_L222_L0.5720.80
31_G77_V0.5720.80
112_A144_G0.5710.79
44_L75_L0.5700.79
43_G99_S0.5650.79
58_A77_V0.5560.78
79_G84_V0.5540.77
173_R177_A0.5510.77
256_T261_T0.5500.77
119_V242_Y0.5450.76
194_A228_A0.5440.76
7_D133_G0.5430.76
34_V73_T0.5430.76
223_D228_A0.5430.76
55_G80_A0.5420.76
207_L215_T0.5420.76
190_T214_E0.5390.75
186_V202_A0.5390.75
174_F184_L0.5390.75
207_L210_M0.5380.75
160_N208_D0.5370.75
113_R118_D0.5370.75
23_N86_R0.5340.75
163_A267_R0.5330.75
104_K260_P0.5320.75
256_T259_A0.5290.74
194_A202_A0.5280.74
174_F178_K0.5260.74
122_A154_M0.5240.73
219_V246_G0.5240.73
210_M215_T0.5240.73
178_K182_T0.5220.73
236_V240_P0.5220.73
159_D189_E0.5210.73
193_D265_S0.5200.73
38_A68_I0.5200.73
111_A237_D0.5190.73
54_L86_R0.5190.73
257_H261_T0.5180.73
219_V222_L0.5140.72
24_D177_A0.5130.72
233_G258_S0.5130.72
191_P194_A0.5120.72
128_T261_T0.5110.72
252_M256_T0.5100.71
162_V167_L0.5100.71
60_A63_A0.5080.71
37_Q70_A0.5080.71
51_F77_V0.5050.71
87_A90_V0.5050.71
219_V247_V0.5050.71
36_K71_G0.5040.71
167_L196_R0.5030.70
97_H101_V0.5020.70
39_G99_S0.5020.70
19_H24_D0.5020.70
31_G84_V0.5020.70
188_V206_L0.5020.70
158_K209_N0.5010.70
128_T259_A0.5010.70
79_G83_S0.5010.70
243_A246_G0.5000.70
98_A137_R0.5000.70
39_G103_T0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l0gA 3 0.9888 100 0.196 Contact Map
3pajA 2 0.9888 100 0.212 Contact Map
2b7nA 6 0.9888 100 0.219 Contact Map
1qapA 2 0.9888 100 0.219 Contact Map
3gnnA 2 0.8993 100 0.228 Contact Map
1o4uA 2 0.9552 100 0.233 Contact Map
1qpoA 2 0.9888 100 0.234 Contact Map
3tqvA 2 0.9888 100 0.235 Contact Map
3c2eA 5 0.9216 100 0.237 Contact Map
2jbmA 5 1 100 0.246 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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