Q9HNY8 - HALSA - GREMLIN Contacts

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Q9HNY8 - Uncharacterized protein

UniProt:	Q9HNY8	Sequences: MSRLAELGLSGYEEQCYRALLARGPSTARAVSDASGVPMGRVYDVLNGLAARDLVETRPGEPTRYCAVDPETAADRLLAERKRELAEQTDRYERLAAALGDELAAVPPTESRFWTAPLGSETAVSLTRQVFEDASDEVRSAMSRPYVGAPWDRYDAEIAAFDETLPTEQSVRVLVAAPVLDTVPAAVRDAYLDREAVSLRVTTALAATFDIVDDDRVYLHVPHPLDEGERLGAVELRDDALLARLQDRFERAWERAETLSALR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	263 (240)
Sequences:	2219 (1798)
Seq/√Len:	116.1

BACSU - YRHO
HALSA - Q9HNY8 TRMBR Q9HNX4
SULSO - Q97ZZ5 Q7LYK2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
164_T	167_T	4.334	1.00
13_E	48_G	3.571	1.00
134_A	212_V	3.538	1.00
20_L	55_V	3.224	1.00
139_R	214_D	3.126	1.00
13_E	52_R	3.013	1.00
137_E	214_D	2.914	1.00
172_R	250_E	2.846	1.00
141_A	252_A	2.705	1.00
12_Y	38_P	2.702	1.00
10_S	48_G	2.624	1.00
17_Y	21_L	2.615	1.00
41_R	44_D	2.592	1.00
170_S	198_S	2.563	1.00
134_A	138_V	2.479	1.00
12_Y	41_R	2.449	1.00
132_E	163_E	2.355	1.00
119_G	122_T	2.321	1.00
130_V	216_R	2.315	1.00
23_R	26_S	2.287	1.00
10_S	13_E	2.284	1.00
54_L	73_A	2.277	1.00
214_D	246_Q	2.168	1.00
46_L	55_V	2.128	1.00
27_T	30_A	2.120	1.00
38_P	41_R	2.113	1.00
46_L	65_Y	2.104	1.00
129_Q	133_D	2.021	1.00
123_A	233_A	1.954	1.00
29_R	33_D	1.898	1.00
12_Y	37_V	1.852	1.00
202_T	256_A	1.803	1.00
130_V	218_Y	1.795	1.00
16_C	42_V	1.788	1.00
211_I	246_Q	1.720	1.00
14_E	18_R	1.709	1.00
84_E	88_Q	1.700	1.00
115_T	126_L	1.694	1.00
12_Y	35_S	1.682	1.00
139_R	246_Q	1.674	1.00
38_P	42_V	1.667	1.00
157_E	161_F	1.663	1.00
163_E	166_P	1.637	1.00
140_S	210_D	1.610	1.00
16_C	45_V	1.595	1.00
126_L	235_E	1.592	1.00
56_E	66_C	1.583	1.00
131_F	212_V	1.582	1.00
99_L	103_L	1.577	1.00
174_L	252_A	1.558	1.00
162_D	166_P	1.529	1.00
141_A	174_L	1.514	1.00
16_C	37_V	1.500	1.00
138_V	212_V	1.484	1.00
117_P	235_E	1.478	1.00
39_M	43_Y	1.475	1.00
141_A	206_A	1.462	1.00
131_F	138_V	1.451	1.00
85_L	89_T	1.451	1.00
127_T	210_D	1.448	1.00
19_A	34_A	1.442	1.00
242_L	246_Q	1.428	1.00
246_Q	250_E	1.404	1.00
54_L	77_L	1.403	1.00
164_T	169_Q	1.383	1.00
9_L	54_L	1.359	1.00
11_G	15_Q	1.343	1.00
26_S	34_A	1.332	1.00
162_D	195_E	1.329	1.00
134_A	164_T	1.325	1.00
180_L	201_V	1.312	1.00
23_R	34_A	1.302	1.00
38_P	45_V	1.257	0.99
58_R	66_C	1.255	0.99
239_D	243_A	1.248	0.99
37_V	42_V	1.240	0.99
16_C	31_V	1.238	0.99
22_A	34_A	1.234	0.99
172_R	253_W	1.234	0.99
25_P	64_R	1.226	0.99
141_A	205_L	1.223	0.99
138_V	171_V	1.216	0.99
177_A	201_V	1.204	0.99
123_A	232_G	1.202	0.99
158_I	162_D	1.198	0.99
40_G	44_D	1.193	0.99
19_A	35_S	1.183	0.99
128_R	163_E	1.180	0.99
91_R	94_R	1.180	0.99
12_Y	44_D	1.169	0.99
202_T	252_A	1.149	0.99
31_V	42_V	1.145	0.99
87_E	91_R	1.133	0.99
126_L	129_Q	1.131	0.99
144_R	176_A	1.104	0.98
145_P	185_A	1.103	0.98
35_S	42_V	1.087	0.98
88_Q	91_R	1.080	0.98
175_V	199_L	1.072	0.98
131_F	171_V	1.060	0.98
139_R	211_I	1.058	0.98
19_A	31_V	1.055	0.98
28_A	43_Y	1.052	0.98
238_D	243_A	1.040	0.98
53_D	119_G	1.038	0.98
67_A	99_L	1.032	0.98
140_S	173_V	1.029	0.98
74_A	77_L	1.029	0.98
18_R	21_L	1.021	0.97
161_F	165_L	1.019	0.97
244_R	248_R	1.017	0.97
145_P	208_T	1.009	0.97
126_L	130_V	1.006	0.97
88_Q	92_Y	0.994	0.97
141_A	238_D	0.991	0.97
202_T	255_R	0.987	0.97
28_A	39_M	0.986	0.97
70_P	74_A	0.979	0.97
236_L	245_L	0.977	0.97
37_V	43_Y	0.976	0.97
47_N	51_A	0.973	0.97
135_S	215_D	0.962	0.96
103_L	106_V	0.959	0.96
207_A	244_R	0.954	0.96
114_W	117_P	0.953	0.96
216_R	235_E	0.950	0.96
17_Y	70_P	0.948	0.96
158_I	161_F	0.945	0.96
175_V	196_A	0.942	0.96
211_I	242_L	0.939	0.96
141_A	209_F	0.939	0.96
48_G	51_A	0.935	0.96
12_Y	45_V	0.932	0.96
21_L	70_P	0.925	0.95
96_A	106_V	0.924	0.95
78_L	89_T	0.922	0.95
115_T	237_R	0.922	0.95
139_R	250_E	0.922	0.95
30_A	33_D	0.921	0.95
86_A	89_T	0.914	0.95
138_V	164_T	0.911	0.95
234_V	241_L	0.908	0.95
176_A	208_T	0.905	0.95
120_S	230_R	0.905	0.95
30_A	34_A	0.900	0.95
44_D	47_N	0.898	0.95
57_T	62_P	0.893	0.94
31_V	35_S	0.892	0.94
137_E	250_E	0.892	0.94
215_D	237_R	0.890	0.94
29_R	40_G	0.880	0.94
200_R	253_W	0.872	0.94
119_G	123_A	0.868	0.94
183_V	187_V	0.862	0.93
161_F	188_R	0.860	0.93
164_T	212_V	0.860	0.93
96_A	105_A	0.858	0.93
178_P	201_V	0.856	0.93
13_E	45_V	0.855	0.93
169_Q	213_D	0.852	0.93
91_R	121_E	0.850	0.93
29_R	36_G	0.847	0.93
12_Y	16_C	0.846	0.93
50_A	57_T	0.845	0.93
139_R	249_F	0.843	0.93
127_T	208_T	0.839	0.92
182_T	185_A	0.838	0.92
27_T	65_Y	0.838	0.92
236_L	241_L	0.831	0.92
19_A	26_S	0.824	0.92
185_A	188_R	0.823	0.92
125_S	129_Q	0.823	0.92
131_F	164_T	0.820	0.92
70_P	172_R	0.817	0.91
35_S	45_V	0.815	0.91
12_Y	28_A	0.814	0.91
239_D	242_L	0.812	0.91
132_E	160_A	0.810	0.91
73_A	78_L	0.806	0.91
103_L	107_P	0.804	0.91
247_D	251_R	0.802	0.91
86_A	128_R	0.798	0.90
92_Y	96_A	0.792	0.90
127_T	131_F	0.792	0.90
90_D	234_V	0.784	0.90
67_A	89_T	0.782	0.89
161_F	197_V	0.780	0.89
124_V	156_A	0.774	0.89
53_D	236_L	0.774	0.89
188_R	192_L	0.773	0.89
86_A	121_E	0.768	0.89
38_P	44_D	0.763	0.88
138_V	194_R	0.763	0.88
94_R	159_A	0.759	0.88
29_R	32_S	0.750	0.87
42_V	248_R	0.748	0.87
142_M	208_T	0.747	0.87
126_L	237_R	0.743	0.87
120_S	124_V	0.740	0.87
136_D	214_D	0.739	0.87
172_R	200_R	0.733	0.86
20_L	65_Y	0.732	0.86
158_I	191_Y	0.730	0.86
123_A	183_V	0.729	0.86
137_E	170_S	0.729	0.86
20_L	46_L	0.723	0.85
35_S	38_P	0.722	0.85
199_L	202_T	0.722	0.85
68_V	73_A	0.715	0.85
169_Q	214_D	0.710	0.84
139_R	172_R	0.708	0.84
221_V	238_D	0.708	0.84
177_A	180_L	0.708	0.84
134_A	213_D	0.706	0.84
148_G	154_Y	0.706	0.84
99_L	102_E	0.705	0.84
146_Y	185_A	0.701	0.84
63_T	207_A	0.694	0.83
96_A	102_E	0.694	0.83
7_L	218_Y	0.693	0.83
96_A	100_G	0.690	0.83
114_W	241_L	0.687	0.82
28_A	42_V	0.686	0.82
217_V	245_L	0.686	0.82
70_P	103_L	0.686	0.82
252_A	255_R	0.684	0.82
126_L	216_R	0.679	0.82
123_A	234_V	0.678	0.82
159_A	163_E	0.677	0.82
209_F	248_R	0.676	0.81
249_F	253_W	0.675	0.81
119_G	232_G	0.674	0.81
93_E	97_A	0.673	0.81
146_Y	182_T	0.672	0.81
216_R	237_R	0.668	0.81
23_R	30_A	0.668	0.81
78_L	138_V	0.668	0.81
33_D	39_M	0.662	0.80
218_Y	233_A	0.662	0.80
137_E	213_D	0.661	0.80
205_L	209_F	0.660	0.80
168_E	213_D	0.660	0.80
23_R	79_A	0.657	0.80
175_V	208_T	0.657	0.80
52_R	130_V	0.652	0.79
42_V	55_V	0.652	0.79
136_D	170_S	0.651	0.79
186_A	190_A	0.650	0.79
221_V	232_G	0.643	0.78
89_T	158_I	0.643	0.78
178_P	181_D	0.641	0.78
99_L	120_S	0.641	0.78
110_E	186_A	0.640	0.78
28_A	73_A	0.633	0.77
211_I	217_V	0.632	0.77
189_D	196_A	0.629	0.77
38_P	46_L	0.627	0.76
144_R	147_V	0.626	0.76
127_T	215_D	0.625	0.76
141_A	244_R	0.625	0.76
35_S	43_Y	0.621	0.76
33_D	37_V	0.620	0.76
181_D	201_V	0.619	0.75
64_R	218_Y	0.618	0.75
110_E	136_D	0.618	0.75
62_P	166_P	0.614	0.75
126_L	218_Y	0.613	0.75
128_R	160_A	0.611	0.75
187_V	190_A	0.609	0.74
108_P	163_E	0.609	0.74
127_T	212_V	0.606	0.74
206_A	244_R	0.605	0.74
55_V	65_Y	0.602	0.73
43_Y	47_N	0.602	0.73
141_A	248_R	0.601	0.73
163_E	167_T	0.596	0.73
18_R	22_A	0.595	0.73
124_V	157_E	0.593	0.72
178_P	215_D	0.591	0.72
176_A	180_L	0.589	0.72
140_S	171_V	0.587	0.72
26_S	33_D	0.586	0.71
27_T	64_R	0.585	0.71
27_T	39_M	0.584	0.71
182_T	186_A	0.583	0.71
47_N	50_A	0.577	0.70
102_E	106_V	0.577	0.70
186_A	189_D	0.577	0.70
50_A	55_V	0.576	0.70
173_V	180_L	0.574	0.70
206_A	209_F	0.571	0.69
76_R	221_V	0.571	0.69
48_G	67_A	0.571	0.69
54_L	68_V	0.571	0.69
42_V	155_D	0.570	0.69
147_V	159_A	0.569	0.69
218_Y	235_E	0.568	0.69
56_E	68_V	0.568	0.69
115_T	235_E	0.566	0.69
96_A	103_L	0.565	0.69
95_L	99_L	0.565	0.69
89_T	93_E	0.565	0.69
132_E	167_T	0.562	0.68
113_F	116_A	0.561	0.68
87_E	98_A	0.561	0.68
57_T	102_E	0.561	0.68
12_Y	43_Y	0.560	0.68
193_D	199_L	0.559	0.68
102_E	105_A	0.559	0.68
97_A	100_G	0.558	0.68
37_V	41_R	0.556	0.67
45_V	60_G	0.555	0.67
109_T	135_S	0.555	0.67
143_S	176_A	0.551	0.67
113_F	237_R	0.549	0.66
75_D	89_T	0.547	0.66
79_A	159_A	0.543	0.66
41_R	45_V	0.542	0.65
133_D	215_D	0.541	0.65
32_S	55_V	0.541	0.65
125_S	128_R	0.541	0.65
163_E	182_T	0.540	0.65
46_L	109_T	0.539	0.65
40_G	109_T	0.538	0.65
126_L	233_A	0.538	0.65
94_R	97_A	0.537	0.65
167_T	213_D	0.536	0.65
144_R	208_T	0.535	0.65
175_V	242_L	0.534	0.64
109_T	112_R	0.534	0.64
32_S	42_V	0.534	0.64
205_L	208_T	0.532	0.64
251_R	255_R	0.530	0.64
157_E	164_T	0.529	0.64
139_R	238_D	0.527	0.63
28_A	46_L	0.526	0.63
173_V	188_R	0.526	0.63
221_V	236_L	0.525	0.63
7_L	228_G	0.524	0.63
88_Q	96_A	0.520	0.62
84_E	122_T	0.519	0.62
117_P	122_T	0.519	0.62
20_L	26_S	0.516	0.62
166_P	215_D	0.515	0.62
39_M	232_G	0.515	0.62
176_A	188_R	0.513	0.61
165_L	196_A	0.513	0.61
75_D	119_G	0.512	0.61
93_E	223_H	0.512	0.61
126_L	212_V	0.512	0.61
162_D	167_T	0.510	0.61
236_L	253_W	0.508	0.61
25_P	132_E	0.506	0.60
209_F	245_L	0.505	0.60
143_S	206_A	0.505	0.60
160_A	240_A	0.503	0.60
32_S	40_G	0.501	0.60
236_L	242_L	0.500	0.59
138_V	210_D	0.500	0.59
206_A	248_R	0.500	0.59

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qphA	2	0.8973	100	0.372	Contact Map
1byrA	2	0.5475	99.3	0.734	Contact Map
4ggjA	2	0.6008	99.3	0.741	Contact Map
2f5tX	2	0.4943	99.1	0.758	Contact Map
4gelA	2	0.6578	98.7	0.791	Contact Map
4urjA	1	0.5627	98.7	0.792	Contact Map
1v0wA	1	0.7224	98.4	0.815	Contact Map
1ku9A	2	0.5019	98.3	0.818	Contact Map
1qgpA	1	0.27	98.3	0.82	Contact Map
1sfxA	3	0.365	98.2	0.822	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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