GREMLIN Database
Q9HNY8 - Uncharacterized protein
UniProt: Q9HNY8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 263 (240)
Sequences: 2219 (1798)
Seq/√Len: 116.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_T167_T4.3341.00
13_E48_G3.5711.00
134_A212_V3.5381.00
20_L55_V3.2241.00
139_R214_D3.1261.00
13_E52_R3.0131.00
137_E214_D2.9141.00
172_R250_E2.8461.00
141_A252_A2.7051.00
12_Y38_P2.7021.00
10_S48_G2.6241.00
17_Y21_L2.6151.00
41_R44_D2.5921.00
170_S198_S2.5631.00
134_A138_V2.4791.00
12_Y41_R2.4491.00
132_E163_E2.3551.00
119_G122_T2.3211.00
130_V216_R2.3151.00
23_R26_S2.2871.00
10_S13_E2.2841.00
54_L73_A2.2771.00
214_D246_Q2.1681.00
46_L55_V2.1281.00
27_T30_A2.1201.00
38_P41_R2.1131.00
46_L65_Y2.1041.00
129_Q133_D2.0211.00
123_A233_A1.9541.00
29_R33_D1.8981.00
12_Y37_V1.8521.00
202_T256_A1.8031.00
130_V218_Y1.7951.00
16_C42_V1.7881.00
211_I246_Q1.7201.00
14_E18_R1.7091.00
84_E88_Q1.7001.00
115_T126_L1.6941.00
12_Y35_S1.6821.00
139_R246_Q1.6741.00
38_P42_V1.6671.00
157_E161_F1.6631.00
163_E166_P1.6371.00
140_S210_D1.6101.00
16_C45_V1.5951.00
126_L235_E1.5921.00
56_E66_C1.5831.00
131_F212_V1.5821.00
99_L103_L1.5771.00
174_L252_A1.5581.00
162_D166_P1.5291.00
141_A174_L1.5141.00
16_C37_V1.5001.00
138_V212_V1.4841.00
117_P235_E1.4781.00
39_M43_Y1.4751.00
141_A206_A1.4621.00
131_F138_V1.4511.00
85_L89_T1.4511.00
127_T210_D1.4481.00
19_A34_A1.4421.00
242_L246_Q1.4281.00
246_Q250_E1.4041.00
54_L77_L1.4031.00
164_T169_Q1.3831.00
9_L54_L1.3591.00
11_G15_Q1.3431.00
26_S34_A1.3321.00
162_D195_E1.3291.00
134_A164_T1.3251.00
180_L201_V1.3121.00
23_R34_A1.3021.00
38_P45_V1.2570.99
58_R66_C1.2550.99
239_D243_A1.2480.99
37_V42_V1.2400.99
16_C31_V1.2380.99
22_A34_A1.2340.99
172_R253_W1.2340.99
25_P64_R1.2260.99
141_A205_L1.2230.99
138_V171_V1.2160.99
177_A201_V1.2040.99
123_A232_G1.2020.99
158_I162_D1.1980.99
40_G44_D1.1930.99
19_A35_S1.1830.99
128_R163_E1.1800.99
91_R94_R1.1800.99
12_Y44_D1.1690.99
202_T252_A1.1490.99
31_V42_V1.1450.99
87_E91_R1.1330.99
126_L129_Q1.1310.99
144_R176_A1.1040.98
145_P185_A1.1030.98
35_S42_V1.0870.98
88_Q91_R1.0800.98
175_V199_L1.0720.98
131_F171_V1.0600.98
139_R211_I1.0580.98
19_A31_V1.0550.98
28_A43_Y1.0520.98
238_D243_A1.0400.98
53_D119_G1.0380.98
67_A99_L1.0320.98
140_S173_V1.0290.98
74_A77_L1.0290.98
18_R21_L1.0210.97
161_F165_L1.0190.97
244_R248_R1.0170.97
145_P208_T1.0090.97
126_L130_V1.0060.97
88_Q92_Y0.9940.97
141_A238_D0.9910.97
202_T255_R0.9870.97
28_A39_M0.9860.97
70_P74_A0.9790.97
236_L245_L0.9770.97
37_V43_Y0.9760.97
47_N51_A0.9730.97
135_S215_D0.9620.96
103_L106_V0.9590.96
207_A244_R0.9540.96
114_W117_P0.9530.96
216_R235_E0.9500.96
17_Y70_P0.9480.96
158_I161_F0.9450.96
175_V196_A0.9420.96
211_I242_L0.9390.96
141_A209_F0.9390.96
48_G51_A0.9350.96
12_Y45_V0.9320.96
21_L70_P0.9250.95
96_A106_V0.9240.95
78_L89_T0.9220.95
115_T237_R0.9220.95
139_R250_E0.9220.95
30_A33_D0.9210.95
86_A89_T0.9140.95
138_V164_T0.9110.95
234_V241_L0.9080.95
176_A208_T0.9050.95
120_S230_R0.9050.95
30_A34_A0.9000.95
44_D47_N0.8980.95
57_T62_P0.8930.94
31_V35_S0.8920.94
137_E250_E0.8920.94
215_D237_R0.8900.94
29_R40_G0.8800.94
200_R253_W0.8720.94
119_G123_A0.8680.94
183_V187_V0.8620.93
161_F188_R0.8600.93
164_T212_V0.8600.93
96_A105_A0.8580.93
178_P201_V0.8560.93
13_E45_V0.8550.93
169_Q213_D0.8520.93
91_R121_E0.8500.93
29_R36_G0.8470.93
12_Y16_C0.8460.93
50_A57_T0.8450.93
139_R249_F0.8430.93
127_T208_T0.8390.92
182_T185_A0.8380.92
27_T65_Y0.8380.92
236_L241_L0.8310.92
19_A26_S0.8240.92
185_A188_R0.8230.92
125_S129_Q0.8230.92
131_F164_T0.8200.92
70_P172_R0.8170.91
35_S45_V0.8150.91
12_Y28_A0.8140.91
239_D242_L0.8120.91
132_E160_A0.8100.91
73_A78_L0.8060.91
103_L107_P0.8040.91
247_D251_R0.8020.91
86_A128_R0.7980.90
92_Y96_A0.7920.90
127_T131_F0.7920.90
90_D234_V0.7840.90
67_A89_T0.7820.89
161_F197_V0.7800.89
124_V156_A0.7740.89
53_D236_L0.7740.89
188_R192_L0.7730.89
86_A121_E0.7680.89
38_P44_D0.7630.88
138_V194_R0.7630.88
94_R159_A0.7590.88
29_R32_S0.7500.87
42_V248_R0.7480.87
142_M208_T0.7470.87
126_L237_R0.7430.87
120_S124_V0.7400.87
136_D214_D0.7390.87
172_R200_R0.7330.86
20_L65_Y0.7320.86
158_I191_Y0.7300.86
123_A183_V0.7290.86
137_E170_S0.7290.86
20_L46_L0.7230.85
35_S38_P0.7220.85
199_L202_T0.7220.85
68_V73_A0.7150.85
169_Q214_D0.7100.84
139_R172_R0.7080.84
221_V238_D0.7080.84
177_A180_L0.7080.84
134_A213_D0.7060.84
148_G154_Y0.7060.84
99_L102_E0.7050.84
146_Y185_A0.7010.84
63_T207_A0.6940.83
96_A102_E0.6940.83
7_L218_Y0.6930.83
96_A100_G0.6900.83
114_W241_L0.6870.82
28_A42_V0.6860.82
217_V245_L0.6860.82
70_P103_L0.6860.82
252_A255_R0.6840.82
126_L216_R0.6790.82
123_A234_V0.6780.82
159_A163_E0.6770.82
209_F248_R0.6760.81
249_F253_W0.6750.81
119_G232_G0.6740.81
93_E97_A0.6730.81
146_Y182_T0.6720.81
216_R237_R0.6680.81
23_R30_A0.6680.81
78_L138_V0.6680.81
33_D39_M0.6620.80
218_Y233_A0.6620.80
137_E213_D0.6610.80
205_L209_F0.6600.80
168_E213_D0.6600.80
23_R79_A0.6570.80
175_V208_T0.6570.80
52_R130_V0.6520.79
42_V55_V0.6520.79
136_D170_S0.6510.79
186_A190_A0.6500.79
221_V232_G0.6430.78
89_T158_I0.6430.78
178_P181_D0.6410.78
99_L120_S0.6410.78
110_E186_A0.6400.78
28_A73_A0.6330.77
211_I217_V0.6320.77
189_D196_A0.6290.77
38_P46_L0.6270.76
144_R147_V0.6260.76
127_T215_D0.6250.76
141_A244_R0.6250.76
35_S43_Y0.6210.76
33_D37_V0.6200.76
181_D201_V0.6190.75
64_R218_Y0.6180.75
110_E136_D0.6180.75
62_P166_P0.6140.75
126_L218_Y0.6130.75
128_R160_A0.6110.75
187_V190_A0.6090.74
108_P163_E0.6090.74
127_T212_V0.6060.74
206_A244_R0.6050.74
55_V65_Y0.6020.73
43_Y47_N0.6020.73
141_A248_R0.6010.73
163_E167_T0.5960.73
18_R22_A0.5950.73
124_V157_E0.5930.72
178_P215_D0.5910.72
176_A180_L0.5890.72
140_S171_V0.5870.72
26_S33_D0.5860.71
27_T64_R0.5850.71
27_T39_M0.5840.71
182_T186_A0.5830.71
47_N50_A0.5770.70
102_E106_V0.5770.70
186_A189_D0.5770.70
50_A55_V0.5760.70
173_V180_L0.5740.70
206_A209_F0.5710.69
76_R221_V0.5710.69
48_G67_A0.5710.69
54_L68_V0.5710.69
42_V155_D0.5700.69
147_V159_A0.5690.69
218_Y235_E0.5680.69
56_E68_V0.5680.69
115_T235_E0.5660.69
96_A103_L0.5650.69
95_L99_L0.5650.69
89_T93_E0.5650.69
132_E167_T0.5620.68
113_F116_A0.5610.68
87_E98_A0.5610.68
57_T102_E0.5610.68
12_Y43_Y0.5600.68
193_D199_L0.5590.68
102_E105_A0.5590.68
97_A100_G0.5580.68
37_V41_R0.5560.67
45_V60_G0.5550.67
109_T135_S0.5550.67
143_S176_A0.5510.67
113_F237_R0.5490.66
75_D89_T0.5470.66
79_A159_A0.5430.66
41_R45_V0.5420.65
133_D215_D0.5410.65
32_S55_V0.5410.65
125_S128_R0.5410.65
163_E182_T0.5400.65
46_L109_T0.5390.65
40_G109_T0.5380.65
126_L233_A0.5380.65
94_R97_A0.5370.65
167_T213_D0.5360.65
144_R208_T0.5350.65
175_V242_L0.5340.64
109_T112_R0.5340.64
32_S42_V0.5340.64
205_L208_T0.5320.64
251_R255_R0.5300.64
157_E164_T0.5290.64
139_R238_D0.5270.63
28_A46_L0.5260.63
173_V188_R0.5260.63
221_V236_L0.5250.63
7_L228_G0.5240.63
88_Q96_A0.5200.62
84_E122_T0.5190.62
117_P122_T0.5190.62
20_L26_S0.5160.62
166_P215_D0.5150.62
39_M232_G0.5150.62
176_A188_R0.5130.61
165_L196_A0.5130.61
75_D119_G0.5120.61
93_E223_H0.5120.61
126_L212_V0.5120.61
162_D167_T0.5100.61
236_L253_W0.5080.61
25_P132_E0.5060.60
209_F245_L0.5050.60
143_S206_A0.5050.60
160_A240_A0.5030.60
32_S40_G0.5010.60
236_L242_L0.5000.59
138_V210_D0.5000.59
206_A248_R0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.8973 100 0.372 Contact Map
1byrA 2 0.5475 99.3 0.734 Contact Map
4ggjA 2 0.6008 99.3 0.741 Contact Map
2f5tX 2 0.4943 99.1 0.758 Contact Map
4gelA 2 0.6578 98.7 0.791 Contact Map
4urjA 1 0.5627 98.7 0.792 Contact Map
1v0wA 1 0.7224 98.4 0.815 Contact Map
1ku9A 2 0.5019 98.3 0.818 Contact Map
1qgpA 1 0.27 98.3 0.82 Contact Map
1sfxA 3 0.365 98.2 0.822 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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