GREMLIN Database
Q9HNY6 - Uncharacterized protein
UniProt: Q9HNY6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 84 (68)
Sequences: 11956 (10019)
Seq/√Len: 1215.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_P68_G3.7151.00
54_V81_A3.1981.00
50_D69_E2.5731.00
76_N79_R2.4491.00
66_V73_E2.4151.00
77_D81_A2.3521.00
46_S66_V2.1761.00
55_A82_D2.0261.00
79_R82_D2.0131.00
19_E22_D1.9311.00
36_P57_Q1.6611.00
66_V71_G1.6301.00
52_G71_G1.6231.00
19_E26_P1.4931.00
54_V57_Q1.4671.00
17_G20_L1.3931.00
16_S19_E1.3851.00
29_W33_D1.3771.00
78_E82_D1.3591.00
68_G73_E1.3421.00
75_D79_R1.3301.00
26_P32_V1.2611.00
28_A31_H1.2281.00
22_D26_P1.1691.00
45_Y48_C1.1491.00
50_D57_Q1.1371.00
46_S52_G1.1051.00
29_W77_D1.0861.00
33_D81_A1.0821.00
76_N80_P1.0311.00
21_Y69_E1.0151.00
49_P57_Q1.0121.00
53_V80_P1.0091.00
22_D28_A0.9961.00
21_Y36_P0.9961.00
19_E35_D0.9951.00
15_D19_E0.9741.00
78_E81_A0.9661.00
67_C83_D0.9541.00
31_H34_V0.9231.00
26_P30_I0.9061.00
23_E26_P0.8881.00
56_P60_A0.8751.00
55_A58_R0.8661.00
25_N38_A0.8511.00
24_T72_A0.8471.00
51_C56_P0.8451.00
18_V21_Y0.8431.00
67_C70_C0.8391.00
30_I34_V0.8291.00
53_V56_P0.8061.00
55_A59_T0.8001.00
66_V69_E0.7931.00
48_C53_V0.7821.00
17_G22_D0.7821.00
20_L68_G0.7531.00
51_C60_A0.7351.00
18_V25_N0.7331.00
33_D36_P0.7311.00
48_C56_P0.7291.00
62_T75_D0.7281.00
45_Y51_C0.6891.00
16_S25_N0.6861.00
46_S49_P0.6841.00
20_L49_P0.6761.00
22_D25_N0.6721.00
35_D39_P0.6671.00
23_E29_W0.6601.00
77_D80_P0.6571.00
76_N82_D0.6191.00
24_T74_F0.6191.00
53_V60_A0.6171.00
33_D54_V0.6121.00
48_C51_C0.6111.00
77_D82_D0.6101.00
48_C60_A0.6091.00
23_E32_V0.6091.00
17_G21_Y0.6041.00
59_T64_H0.5931.00
15_D18_V0.5881.00
18_V27_D0.5881.00
64_H75_D0.5871.00
70_C74_F0.5801.00
67_C74_F0.5741.00
65_M73_E0.5741.00
24_T34_V0.5741.00
45_Y56_P0.5701.00
33_D37_G0.5641.00
27_D75_D0.5521.00
70_C83_D0.5521.00
29_W32_V0.5431.00
30_I33_D0.5401.00
49_P52_G0.5391.00
69_E80_P0.5271.00
66_V80_P0.5241.00
30_I35_D0.5201.00
55_A76_N0.5171.00
25_N31_H0.5161.00
38_A42_E0.5121.00
59_T63_D0.5111.00
19_E24_T0.5021.00
30_I38_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w5kB 1 0.9048 98.9 0.359 Contact Map
2i13A 1 0.9524 98.9 0.366 Contact Map
2rsjA 1 0.9048 98.9 0.372 Contact Map
2kmkA 1 0.8095 98.8 0.389 Contact Map
4x9jA 1 0.8333 98.8 0.394 Contact Map
2dmdA 1 0.8929 98.8 0.394 Contact Map
2m9aA 1 0.8452 98.8 0.396 Contact Map
2lt7A 1 0.9643 98.8 0.396 Contact Map
2ee8A 1 0.9881 98.8 0.401 Contact Map
2n25A 1 0.3452 98.7 0.406 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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