GREMLIN Database
Q9HNX9 - Uncharacterized protein
UniProt: Q9HNX9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 150 (135)
Sequences: 19367 (15703)
Seq/√Len: 1351.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_T94_A3.0591.00
12_R40_T2.7241.00
101_S137_N2.6341.00
14_L113_I2.6191.00
38_T92_E2.5541.00
12_R38_T2.4441.00
29_H147_T2.4271.00
94_A107_Y2.2061.00
115_K147_T2.2021.00
107_Y111_N2.1981.00
118_M138_V1.8931.00
81_Q93_T1.8891.00
98_G103_T1.8821.00
40_T92_E1.8621.00
116_I144_I1.8571.00
136_E140_R1.8561.00
96_E103_T1.8361.00
40_T111_N1.7991.00
108_A116_I1.7971.00
31_L35_D1.7951.00
40_T113_I1.7331.00
42_L107_Y1.7261.00
38_T90_T1.7161.00
40_T107_Y1.7041.00
16_P118_M1.6661.00
15_V30_A1.6241.00
44_V103_T1.6231.00
28_N83_A1.5971.00
12_R114_D1.5911.00
16_P104_I1.5141.00
103_T106_S1.4961.00
81_Q85_D1.4931.00
109_E143_P1.4431.00
116_I142_S1.3971.00
70_K74_E1.3841.00
105_V141_R1.3491.00
37_A114_D1.3471.00
43_N73_A1.3391.00
96_E107_Y1.3241.00
137_N141_R1.3071.00
108_A143_P1.2901.00
24_E83_A1.2891.00
15_V27_I1.2821.00
94_A111_N1.2681.00
74_E78_A1.2541.00
116_I138_V1.2391.00
32_T35_D1.2031.00
142_S146_V1.1731.00
10_M145_P1.1401.00
100_P134_V1.1331.00
78_A81_Q1.1281.00
76_L80_A1.1241.00
42_L96_E1.1081.00
126_V130_L1.0991.00
73_A77_F1.0771.00
66_F70_K1.0691.00
76_L79_D1.0681.00
10_M29_H1.0641.00
44_V100_P1.0631.00
120_S148_I1.0451.00
69_S72_A1.0431.00
108_A144_I1.0001.00
128_R136_E0.9981.00
139_V148_I0.9931.00
13_V115_K0.9891.00
80_A83_A0.9841.00
45_I97_V0.9821.00
17_I80_A0.9731.00
78_A82_E0.9661.00
72_A76_L0.9571.00
71_A75_E0.9571.00
105_V108_A0.9541.00
108_A113_I0.9351.00
20_S23_A0.9341.00
42_L104_I0.9341.00
118_M135_A0.9261.00
61_Y64_E0.9171.00
24_E79_D0.9161.00
12_R111_N0.9091.00
23_A26_A0.9091.00
67_E71_A0.9061.00
80_A84_A0.9061.00
41_V91_L0.9061.00
12_R113_I0.8941.00
19_G43_N0.8901.00
29_H149_V0.8851.00
73_A76_L0.8841.00
83_A86_E0.8771.00
72_A75_E0.8671.00
27_I41_V0.8661.00
45_I95_T0.8651.00
35_D114_D0.8611.00
33_E87_Y0.8611.00
78_A93_T0.8601.00
30_A117_V0.8591.00
123_R127_T0.8551.00
77_F93_T0.8551.00
107_Y113_I0.8541.00
69_S73_A0.8521.00
17_I41_V0.8511.00
27_I80_A0.8481.00
59_P62_S0.8461.00
125_G128_R0.8421.00
73_A95_T0.8381.00
135_A148_I0.8371.00
120_S135_A0.8291.00
105_V138_V0.8271.00
24_E28_N0.8231.00
84_A91_L0.8221.00
17_I27_I0.7981.00
74_E93_T0.7941.00
29_H145_P0.7931.00
14_L116_I0.7901.00
82_E86_E0.7881.00
16_P119_G0.7831.00
14_L42_L0.7821.00
104_I138_V0.7781.00
105_V142_S0.7771.00
82_E85_D0.7771.00
99_R102_R0.7771.00
79_D82_E0.7761.00
117_V147_T0.7731.00
15_V39_I0.7711.00
63_E67_E0.7601.00
17_I24_E0.7481.00
79_D83_A0.7481.00
10_M115_K0.7461.00
25_T28_N0.7341.00
41_V84_A0.7291.00
30_A39_I0.7281.00
32_T37_A0.7241.00
77_F81_Q0.7201.00
75_E79_D0.7181.00
71_A74_E0.7181.00
122_G131_L0.7141.00
17_I26_A0.7131.00
92_E111_N0.7111.00
14_L107_Y0.7011.00
11_P37_A0.6991.00
17_I23_A0.6981.00
20_S122_G0.6981.00
125_G129_I0.6981.00
126_V129_I0.6971.00
33_E88_D0.6961.00
12_R37_A0.6951.00
32_T39_I0.6921.00
10_M114_D0.6921.00
75_E78_A0.6891.00
11_P114_D0.6841.00
43_N76_L0.6821.00
41_V80_A0.6781.00
63_E66_F0.6741.00
118_M148_I0.6741.00
112_D144_I0.6731.00
42_L103_T0.6681.00
101_S138_V0.6631.00
67_E70_K0.6611.00
64_E68_Q0.6581.00
64_E67_E0.6551.00
94_A97_V0.6541.00
31_L34_F0.6501.00
68_Q72_A0.6461.00
131_L135_A0.6451.00
103_T107_Y0.6441.00
68_Q71_A0.6321.00
66_F97_V0.6221.00
30_A37_A0.6171.00
101_S134_V0.6171.00
62_S65_W0.6161.00
45_I73_A0.6151.00
22_Q25_T0.6081.00
101_S105_V0.6061.00
13_V117_V0.5961.00
120_S130_L0.5941.00
81_Q84_A0.5891.00
109_E144_I0.5861.00
21_P24_E0.5841.00
105_V137_N0.5811.00
98_G106_S0.5761.00
117_V149_V0.5761.00
81_Q91_L0.5721.00
10_M37_A0.5701.00
24_E80_A0.5651.00
101_S141_R0.5611.00
19_G76_L0.5591.00
70_K97_V0.5591.00
102_R106_S0.5531.00
24_E76_L0.5491.00
15_V26_A0.5461.00
49_E52_Y0.5351.00
77_F80_A0.5311.00
121_H135_A0.5291.00
18_D23_A0.5211.00
48_I51_G0.5211.00
16_P100_P0.5211.00
138_V146_V0.5201.00
13_V32_T0.5201.00
62_S66_F0.5191.00
139_V146_V0.5141.00
26_A117_V0.5131.00
119_G149_V0.5111.00
83_A87_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gm3A 2 0.8267 99.9 0.198 Contact Map
3hgmA 2 0.94 99.9 0.209 Contact Map
3s3tA 4 0.94 99.9 0.211 Contact Map
1mjhA 2 0.9133 99.9 0.216 Contact Map
4wnyA 2 0.8467 99.9 0.22 Contact Map
5ahwA 4 0.94 99.9 0.224 Contact Map
2dumA 2 0.9133 99.9 0.227 Contact Map
3fg9A 3 0.96 99.9 0.234 Contact Map
1tq8A 4 0.82 99.9 0.237 Contact Map
3fdxA 2 0.82 99.9 0.238 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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