GREMLIN Database
Q9HNX8 - Circadian regulator
UniProt: Q9HNX8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (192)
Sequences: 4352 (2468)
Seq/√Len: 178.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_V105_L3.7061.00
98_E137_A3.5931.00
38_E103_S3.5841.00
11_L131_T3.4761.00
39_R103_S3.3191.00
30_L40_A3.1911.00
33_A104_R3.0271.00
26_G144_T2.9981.00
30_L106_V2.9941.00
12_L166_A2.8421.00
27_L56_A2.6771.00
32_E35_S2.6381.00
205_T210_S2.5941.00
73_A100_F2.5111.00
134_L141_T2.4141.00
96_L99_E2.3491.00
32_E36_N2.3421.00
6_V142_M2.2321.00
38_E104_R2.1941.00
89_I116_M2.1511.00
105_L141_T2.1501.00
34_L72_L2.0521.00
26_G106_V1.9861.00
33_A38_E1.9211.00
95_R99_E1.8661.00
207_E210_S1.7991.00
49_R53_I1.7241.00
31_H61_W1.7101.00
39_R101_G1.6901.00
169_V188_Q1.6831.00
133_A139_V1.6631.00
44_T52_V1.6471.00
105_L139_V1.6261.00
133_A137_A1.6201.00
104_R142_M1.6161.00
8_E38_E1.5921.00
53_I57_D1.5871.00
29_F104_R1.5801.00
132_T136_E1.5751.00
55_S192_D1.5661.00
39_R100_F1.5661.00
184_A199_T1.5661.00
87_T92_E1.5501.00
94_P133_A1.5491.00
31_H35_S1.5441.00
203_E210_S1.5241.00
96_L100_F1.5231.00
8_E103_S1.5091.00
1_M200_K1.5041.00
75_V96_L1.4911.00
27_L52_V1.4761.00
41_V102_A1.4671.00
104_R140_T1.4671.00
24_T204_I1.4351.00
17_E20_T1.4241.00
62_A65_E1.3831.00
94_P129_D1.3801.00
26_G142_M1.3681.00
57_D64_S1.3611.00
146_E162_Y1.3251.00
97_V133_A1.3251.00
94_P98_E1.2881.00
11_L141_T1.2771.00
95_R98_E1.2621.00
11_L127_I1.2381.00
101_G137_A1.2381.00
24_T59_K1.2371.00
30_L104_R1.2361.00
16_G22_K1.2271.00
166_A190_I1.2191.00
45_L112_L1.2151.00
39_R65_E1.2021.00
31_H62_A1.1991.00
92_E95_R1.1811.00
110_V126_E1.1381.00
146_E149_E1.1271.00
175_P180_E1.1211.00
49_R74_V1.1101.00
171_R186_E1.0991.00
182_R201_P1.0961.00
107_L113_L1.0791.00
7_P190_I1.0721.00
94_P97_V1.0631.00
48_S51_R1.0561.00
190_I193_A1.0521.00
43_I93_L1.0511.00
13_V164_T1.0491.00
57_D62_A1.0471.00
39_R73_A1.0441.00
15_V169_V1.0180.99
90_R113_L1.0160.99
130_F141_T1.0110.99
127_I143_L1.0050.99
25_F209_I0.9950.99
90_R126_E0.9950.99
30_L42_F0.9880.99
52_V74_V0.9830.99
91_N115_M0.9740.99
28_Q32_E0.9660.99
29_F187_I0.9340.99
105_L134_L0.9340.99
54_Q57_D0.9320.99
47_E191_R0.9320.99
109_S144_T0.9310.99
60_G207_E0.9230.99
6_V12_L0.9230.99
75_V92_E0.9220.99
173_I184_A0.9200.99
90_R94_P0.9180.99
170_L209_I0.9150.99
63_F72_L0.9130.99
17_E169_V0.8930.99
34_L40_A0.8900.98
1_M187_I0.8820.98
164_T167_V0.8740.98
27_L44_T0.8680.98
174_R180_E0.8650.98
16_G21_G0.8600.98
42_F106_V0.8570.98
18_A156_R0.8490.98
29_F33_A0.8440.98
48_S145_S0.8370.98
185_V211_V0.8340.98
93_L113_L0.8340.98
14_A142_M0.8320.98
49_R76_D0.8320.98
12_L140_T0.8280.98
3_Q194_N0.8270.98
37_G213_R0.8270.98
170_L187_I0.8250.98
20_T170_L0.8110.97
129_D132_T0.8060.97
33_A40_A0.8030.97
161_E167_V0.7990.97
131_T163_L0.7930.97
107_L130_F0.7900.97
14_A168_V0.7900.97
181_T186_E0.7860.97
51_R135_K0.7680.96
6_V140_T0.7660.96
127_I160_I0.7650.96
60_G64_S0.7620.96
23_T52_V0.7480.96
27_L42_F0.7460.96
128_Y132_T0.7450.96
39_R99_E0.7430.95
196_S200_K0.7360.95
35_S98_E0.7320.95
89_I92_E0.7310.95
203_E206_H0.7260.95
22_K108_D0.7250.95
19_G189_K0.7130.94
44_T145_S0.7050.94
92_E96_L0.7040.94
106_V144_T0.7040.94
93_L101_G0.7030.94
46_E135_K0.7020.94
1_M185_V0.6890.93
46_E146_E0.6870.93
169_V195_H0.6860.93
98_E133_A0.6830.93
73_A96_L0.6710.92
115_M129_D0.6690.92
98_E136_E0.6660.92
94_P137_A0.6660.92
20_T150_D0.6660.92
148_S151_N0.6640.92
117_Y129_D0.6620.92
29_F170_L0.6590.92
32_E213_R0.6550.91
175_P206_H0.6540.91
103_S140_T0.6530.91
18_A164_T0.6470.91
6_V29_F0.6470.91
37_G103_S0.6450.91
175_P181_T0.6420.91
158_G161_E0.6420.91
207_E213_R0.6410.90
9_R138_G0.6370.90
187_I200_K0.6350.90
157_Y161_E0.6340.90
36_N210_S0.6330.90
24_T28_Q0.6320.90
170_L185_V0.6310.90
46_E124_R0.6290.90
97_V102_A0.6270.89
55_S165_D0.6270.89
131_T143_L0.6270.89
29_F32_E0.6260.89
166_A187_I0.6240.89
60_G213_R0.6240.89
10_S165_D0.6230.89
19_G108_D0.6230.89
34_L37_G0.6220.89
109_S162_Y0.6210.89
2_V12_L0.6160.89
94_P113_L0.6120.88
90_R129_D0.6110.88
42_F145_S0.6100.88
8_E138_G0.6090.88
40_A106_V0.6040.88
37_G140_T0.6030.88
24_T111_S0.6030.88
87_T102_A0.6020.88
112_L190_I0.6000.87
21_G204_I0.5990.87
169_V186_E0.5990.87
29_F38_E0.5970.87
7_P193_A0.5970.87
42_F112_L0.5950.87
46_E51_R0.5950.87
15_V145_S0.5900.86
23_T146_E0.5890.86
17_E147_A0.5870.86
18_A161_E0.5850.86
97_V134_L0.5840.86
90_R133_A0.5840.86
13_V143_L0.5820.86
32_E38_E0.5810.86
51_R55_S0.5800.86
202_Y209_I0.5790.85
17_E158_G0.5770.85
7_P26_G0.5740.85
109_S163_L0.5740.85
43_I105_L0.5730.85
55_S193_A0.5730.85
2_V6_V0.5730.85
51_R165_D0.5730.85
44_T76_D0.5710.85
50_G138_G0.5690.84
101_G213_R0.5670.84
16_G23_T0.5630.84
91_N116_M0.5630.84
25_F170_L0.5630.84
210_S213_R0.5620.84
182_R214_Q0.5610.84
157_Y160_I0.5590.83
186_E198_E0.5580.83
104_R206_H0.5570.83
38_E101_G0.5570.83
111_S164_T0.5560.83
39_R138_G0.5520.83
108_D189_K0.5480.82
194_N206_H0.5480.82
31_H63_F0.5470.82
35_S62_A0.5460.82
34_L65_E0.5450.82
16_G19_G0.5440.82
3_Q193_A0.5430.82
118_D122_T0.5430.82
108_D191_R0.5400.81
18_A109_S0.5400.81
30_L34_L0.5380.81
43_I75_V0.5370.81
42_F144_T0.5360.81
201_P212_Y0.5360.81
146_E190_I0.5360.81
16_G108_D0.5350.81
147_A158_G0.5310.80
50_G64_S0.5310.80
51_R192_D0.5300.80
14_A209_I0.5290.80
118_D135_K0.5280.80
75_V100_F0.5280.80
26_G29_F0.5240.79
65_E207_E0.5210.79
17_E188_Q0.5200.79
111_S162_Y0.5200.79
111_S145_S0.5200.79
125_T128_Y0.5200.79
129_D196_S0.5180.79
168_V187_I0.5170.78
22_K191_R0.5130.78
2_V168_V0.5120.78
204_I209_I0.5120.78
183_L208_G0.5110.78
8_E65_E0.5110.78
11_L164_T0.5080.77
63_F101_G0.5070.77
63_F207_E0.5060.77
174_R181_T0.5060.77
167_V186_E0.5060.77
19_G47_E0.5060.77
29_F211_V0.5050.77
110_V145_S0.5050.77
13_V167_V0.5040.77
48_S135_K0.5010.76
49_R181_T0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bs4A 1 0.9266 100 0.32 Contact Map
2dr3A 3 0.9771 100 0.364 Contact Map
1tf7A 3 0.9771 100 0.384 Contact Map
4bwyA 3 0.7844 100 0.419 Contact Map
4a8jA 1 0.8807 100 0.429 Contact Map
2w0mA 1 0.9037 100 0.44 Contact Map
2cvhA 1 0.9128 100 0.469 Contact Map
4tl6A 3 0.9817 100 0.476 Contact Map
2ztsA 3 0.945 100 0.48 Contact Map
1n0wA 1 0.8349 100 0.485 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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