GREMLIN Database
NADK - NAD kinase
UniProt: Q9HNX7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (262)
Sequences: 4083 (2830)
Seq/√Len: 174.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_V266_R4.1651.00
222_E259_T3.7141.00
224_R255_E3.6651.00
162_D221_S3.5991.00
107_E112_Y3.2201.00
186_N204_T3.1581.00
158_D226_R3.0721.00
123_V259_T3.0641.00
199_D219_L3.0471.00
224_R257_T3.0151.00
157_V225_I2.9561.00
128_A254_V2.9361.00
28_L106_R2.8931.00
123_V135_S2.8201.00
226_R255_E2.7551.00
70_F267_V2.6181.00
194_V202_V2.5311.00
125_R257_T2.5151.00
119_R180_T2.4571.00
20_E102_V2.4421.00
118_V264_P2.4311.00
222_E257_T2.2781.00
163_G224_R2.2401.00
160_R165_Q2.2061.00
100_D103_E2.1901.00
24_Q106_R2.1751.00
106_R110_N2.1631.00
203_V217_T2.1211.00
124_P142_V2.0731.00
159_V203_V2.0481.00
160_R226_R2.0481.00
164_S273_D1.9921.00
142_V240_V1.8641.00
125_R135_S1.8611.00
160_R224_R1.8591.00
144_I225_I1.8391.00
117_A269_G1.8281.00
125_R259_T1.8191.00
14_A18_A1.8101.00
61_V77_A1.8071.00
64_I87_L1.7921.00
163_G222_E1.7841.00
121_R265_A1.7351.00
137_P261_A1.7071.00
23_E27_A1.7031.00
70_F84_G1.6831.00
116_G266_R1.6701.00
24_Q28_L1.6541.00
158_D228_E1.6491.00
161_V223_I1.6351.00
189_E204_T1.6001.00
155_V238_V1.5851.00
75_R245_G1.5831.00
165_Q168_A1.5611.00
122_E201_L1.5471.00
159_V174_V1.5321.00
161_V221_S1.4841.00
123_V261_A1.4701.00
176_V225_I1.4481.00
127_V132_G1.4211.00
21_I105_V1.4191.00
183_T193_L1.4131.00
189_E207_C1.3931.00
121_R261_A1.3901.00
142_V258_V1.3891.00
21_I64_I1.3861.00
74_A82_I1.3811.00
95_A269_G1.3491.00
70_F94_N1.3311.00
127_V257_T1.3271.00
79_A263_E1.3261.00
129_A132_G1.3261.00
24_Q102_V1.3211.00
127_V255_E1.3171.00
142_V242_S1.2871.00
90_V209_A1.2861.00
158_D168_A1.2821.00
96_V104_A1.2781.00
217_T223_I1.2731.00
164_S276_E1.2691.00
60_L108_E1.2621.00
138_A242_S1.2471.00
195_Q218_G1.2461.00
194_V216_V1.2461.00
35_D38_T1.2351.00
192_P202_V1.2341.00
175_L189_E1.2081.00
19_G23_E1.2051.00
199_D264_P1.2011.00
177_A202_V1.2001.00
17_L20_E1.1911.00
192_P216_V1.1901.00
83_L108_E1.1851.00
124_P242_S1.1811.00
274_F278_L1.1751.00
33_W58_C1.1661.00
176_V258_V1.1591.00
121_R264_P1.1551.00
194_V200_A1.1251.00
38_T41_A1.1221.00
16_S20_E1.1171.00
172_D185_Y1.1161.00
195_Q275_F1.1091.00
123_V262_D1.1011.00
15_T18_A1.0941.00
79_A266_R1.0931.00
60_L268_A1.0901.00
141_E175_L1.0851.00
86_N91_G1.0841.00
22_R26_R1.0801.00
50_R53_T1.0771.00
85_V96_V1.0751.00
227_V238_V1.0731.00
12_E15_T1.0671.00
24_Q105_V1.0621.00
157_V171_A1.0591.00
103_E107_E1.0390.99
16_S19_G1.0390.99
162_D222_E1.0340.99
112_Y271_A1.0220.99
251_D254_V1.0210.99
92_F275_F1.0190.99
128_A131_D1.0150.99
176_V203_V1.0140.99
83_L96_V1.0130.99
201_L223_I0.9970.99
119_R196_P0.9910.99
276_E280_K0.9860.99
237_R251_D0.9790.99
187_L209_A0.9690.99
176_V201_L0.9680.99
83_L268_A0.9570.99
62_V105_V0.9470.99
180_T196_P0.9420.99
50_R54_A0.9370.99
120_C199_D0.9360.99
120_C260_A0.9290.99
120_C200_A0.9280.99
161_V217_T0.9260.99
160_R163_G0.9170.99
127_V254_V0.9150.99
136_T242_S0.9110.99
120_C179_P0.9010.99
219_L260_A0.8990.98
143_A175_L0.8990.98
217_T221_S0.8980.98
36_T40_E0.8940.98
195_Q221_S0.8850.98
129_A133_W0.8850.98
237_R249_R0.8840.98
260_A264_P0.8740.98
187_L192_P0.8730.98
53_T56_T0.8690.98
137_P263_E0.8690.98
15_T19_G0.8650.98
23_E26_R0.8640.98
18_A22_R0.8610.98
22_R34_V0.8600.98
107_E270_P0.8590.98
61_V82_I0.8580.98
39_A42_L0.8550.98
132_G135_S0.8520.98
199_D220_D0.8500.98
55_F77_A0.8440.98
272_A277_A0.8410.98
78_G261_A0.8390.98
108_E114_E0.8310.97
123_V137_P0.8250.97
166_Y275_F0.8230.97
199_D260_A0.8210.97
147_E237_R0.8100.97
128_A133_W0.8100.97
108_E111_R0.8100.97
21_I101_A0.8080.97
202_V216_V0.8080.97
195_Q274_F0.8070.97
22_R32_V0.8060.97
28_L110_N0.7980.97
166_Y217_T0.7970.97
111_R114_E0.7970.97
27_A102_V0.7960.97
104_A270_P0.7960.97
139_L180_T0.7960.97
21_I62_V0.7950.97
225_I258_V0.7940.97
30_V109_V0.7940.97
103_E106_R0.7930.97
156_A170_R0.7930.97
95_A184_A0.7910.97
153_H245_G0.7890.97
25_L32_V0.7800.96
74_A265_A0.7780.96
121_R139_L0.7770.96
141_E145_Q0.7760.96
74_A139_L0.7750.96
187_L213_P0.7740.96
159_V225_I0.7710.96
85_V101_A0.7700.96
200_A214_P0.7700.96
120_C219_L0.7690.96
39_A43_A0.7630.96
16_S27_A0.7630.96
169_T193_L0.7570.96
10_G18_A0.7560.96
239_V247_L0.7540.96
218_G221_S0.7520.96
204_T214_P0.7510.95
55_F58_C0.7510.95
54_A58_C0.7470.95
274_F277_A0.7450.95
26_R44_C0.7440.95
100_D104_A0.7430.95
62_V83_L0.7420.95
89_E170_R0.7410.95
108_E270_P0.7400.95
20_E23_E0.7380.95
114_E268_A0.7330.95
152_G241_A0.7320.95
159_V169_T0.7250.95
29_E32_V0.7250.95
14_A17_L0.7220.94
161_V166_Y0.7210.94
124_P256_M0.7200.94
128_A251_D0.7200.94
78_G121_R0.7150.94
197_S218_G0.7150.94
273_D277_A0.7060.94
31_T47_E0.7060.94
174_V203_V0.7030.94
210_D213_P0.7030.94
239_V249_R0.7020.94
156_A168_A0.7010.93
68_G88_G0.7000.93
139_L265_A0.6970.93
26_R31_T0.6970.93
63_S70_F0.6950.93
126_V240_V0.6920.93
186_N202_V0.6880.93
122_E138_A0.6870.93
126_V250_V0.6860.93
77_A80_T0.6850.93
120_C201_L0.6830.93
63_S73_A0.6820.93
26_R33_W0.6780.92
196_P274_F0.6740.92
24_Q101_A0.6730.92
36_T39_A0.6710.92
209_A213_P0.6710.92
23_E31_T0.6700.92
124_P240_V0.6690.92
60_L83_L0.6670.92
141_E167_E0.6670.92
188_S191_G0.6630.91
70_F82_I0.6620.91
95_A270_P0.6620.91
275_F278_L0.6610.91
172_D207_C0.6590.91
45_A49_G0.6570.91
36_T50_R0.6560.91
169_T205_E0.6550.91
26_R30_V0.6550.91
95_A277_A0.6530.91
102_V106_R0.6520.91
114_E270_P0.6500.91
273_D276_E0.6480.91
165_Q279_S0.6470.90
79_A121_R0.6460.90
153_H241_A0.6460.90
208_G213_P0.6450.90
48_C51_D0.6420.90
19_G26_R0.6420.90
78_G137_P0.6400.90
200_A216_V0.6390.90
119_R274_F0.6380.90
220_D260_A0.6360.90
45_A48_C0.6350.90
17_L21_I0.6350.90
17_L98_P0.6330.89
28_L109_V0.6330.89
82_I265_A0.6330.89
146_G153_H0.6320.89
13_R144_I0.6300.89
146_G152_G0.6270.89
72_F75_R0.6260.89
141_E245_G0.6260.89
126_V256_M0.6260.89
148_Q239_V0.6230.89
90_V210_D0.6220.89
153_H244_G0.6200.89
127_V133_W0.6190.88
71_L186_N0.6160.88
157_V174_V0.6150.88
176_V223_I0.6140.88
95_A117_A0.6140.88
69_T207_C0.6110.88
77_A82_I0.6050.87
95_A272_A0.6050.87
19_G27_A0.6040.87
141_E241_A0.6040.87
115_T269_G0.6020.87
117_A197_S0.6010.87
61_V80_T0.5970.87
16_S23_E0.5900.86
20_E36_T0.5860.86
97_A270_P0.5860.86
110_N132_G0.5840.85
158_D165_Q0.5840.85
133_W136_T0.5830.85
28_L102_V0.5830.85
157_V238_V0.5820.85
157_V168_A0.5800.85
72_F245_G0.5800.85
189_E206_M0.5770.85
12_E16_S0.5750.85
168_A228_E0.5750.85
141_E244_G0.5740.84
27_A33_W0.5730.84
188_S262_D0.5720.84
145_Q239_V0.5710.84
74_A210_D0.5710.84
127_V177_A0.5700.84
167_E209_A0.5690.84
37_A43_A0.5690.84
51_D76_G0.5680.84
64_I85_V0.5680.84
195_Q211_A0.5670.84
18_A37_A0.5650.83
13_R26_R0.5620.83
61_V83_L0.5610.83
23_E28_L0.5590.83
175_L205_E0.5590.83
98_P206_M0.5590.83
125_R133_W0.5570.83
166_Y169_T0.5570.83
34_V38_T0.5560.83
12_E18_A0.5560.83
91_G94_N0.5550.82
82_I193_L0.5540.82
75_R78_G0.5530.82
187_L193_L0.5520.82
26_R32_V0.5520.82
141_E264_P0.5510.82
43_A220_D0.5500.82
228_E235_E0.5500.82
144_I238_V0.5500.82
52_T106_R0.5500.82
115_T271_A0.5490.82
78_G263_E0.5480.82
173_G206_M0.5460.81
31_T39_A0.5450.81
26_R29_E0.5440.81
22_R42_L0.5420.81
81_P266_R0.5420.81
268_A277_A0.5400.81
127_V131_D0.5400.81
23_E44_C0.5390.81
125_R132_G0.5350.80
154_G209_A0.5320.80
210_D244_G0.5280.79
229_T234_G0.5280.79
121_R137_P0.5270.79
17_L64_I0.5250.79
93_L180_T0.5240.79
151_H247_L0.5230.79
250_V256_M0.5230.79
197_S220_D0.5220.78
39_A44_C0.5200.78
210_D258_V0.5190.78
80_T85_V0.5190.78
36_T52_T0.5160.78
31_T35_D0.5160.78
174_V225_I0.5150.78
185_Y206_M0.5150.78
58_C77_A0.5140.77
172_D179_P0.5140.77
177_A261_A0.5140.77
17_L37_A0.5120.77
143_A241_A0.5110.77
53_T57_D0.5110.77
14_A73_A0.5110.77
31_T57_D0.5110.77
167_E277_A0.5110.77
27_A43_A0.5100.77
83_L104_A0.5090.77
209_A270_P0.5090.77
198_V219_L0.5060.76
249_R252_P0.5050.76
84_G91_G0.5040.76
36_T43_A0.5020.76
118_V199_D0.5010.76
61_V278_L0.5010.76
58_C80_T0.5010.76
15_T20_E0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfnA 4 0.9787 100 0.121 Contact Map
3afoA 4 0.9894 100 0.168 Contact Map
2an1A 4 0.9504 100 0.326 Contact Map
1u0tA 4 0.9291 100 0.336 Contact Map
2i2cA 3 0.883 100 0.369 Contact Map
1yt5A 4 0.8688 100 0.377 Contact Map
1z0sA 4 0.8546 100 0.389 Contact Map
2qv7A 2 0.883 100 0.628 Contact Map
3s40A 3 0.8617 100 0.654 Contact Map
4werA 2 0.8582 99.9 0.675 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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