GREMLIN Database
MPTA - GTP cyclohydrolase MptA
UniProt: Q9HNX6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (285)
Sequences: 575 (369)
Seq/√Len: 21.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_L98_K5.3471.00
203_L222_A4.8711.00
70_D116_R4.4461.00
48_E108_E4.3481.00
52_D103_T4.2221.00
179_G182_A4.2011.00
169_A190_V4.0871.00
157_V194_G3.9631.00
205_V218_L3.9181.00
47_F109_M3.6201.00
94_R97_E3.3281.00
111_A132_I3.0641.00
199_G283_N2.8510.99
117_E223_R2.8330.99
145_R206_E2.7140.99
168_T244_Y2.6020.98
54_P253_V2.5650.98
153_V230_I2.4550.98
282_S291_N2.4290.98
139_Q143_P2.3750.97
180_E184_R2.3470.97
151_R200_H2.3430.97
60_I65_N2.2930.97
25_T291_N2.2570.96
225_S263_G2.2420.96
49_V91_V2.2270.96
92_A95_L2.1440.95
108_E135_S2.0820.94
267_E273_E2.0120.93
87_M107_V1.9900.92
152_V222_A1.9620.92
132_I215_L1.9570.92
222_A260_M1.9480.92
174_A184_R1.9340.91
57_R61_D1.9230.91
27_V70_D1.9030.91
202_T282_S1.8920.90
20_S297_V1.8380.89
264_V279_M1.8130.88
157_V193_A1.7640.87
251_K259_S1.7400.86
124_L291_N1.7300.86
256_C283_N1.7070.85
241_H244_Y1.6610.83
156_T199_G1.6320.82
208_G275_A1.6240.82
55_R93_E1.5870.80
58_K253_V1.5860.80
164_M240_D1.5240.78
151_R202_T1.5020.77
161_S243_T1.4940.76
160_C196_S1.4540.74
179_G188_R1.4410.73
164_M283_N1.4280.73
19_L296_R1.3960.71
155_M246_S1.3930.71
243_T247_H1.3810.70
177_G181_D1.3730.70
161_S194_G1.3710.70
181_D185_E1.3440.68
33_I84_V1.3370.68
54_P103_T1.3250.67
150_A215_L1.3240.67
164_M199_G1.3180.66
33_I85_E1.3120.66
148_I207_A1.3030.66
120_P283_N1.2970.65
155_M283_N1.2920.65
24_V27_V1.2880.65
110_N266_E1.2690.63
88_C94_R1.2680.63
225_S259_S1.2680.63
194_G243_T1.2530.62
242_M246_S1.2460.62
228_A242_M1.2110.60
25_T280_K1.1970.59
228_A231_Y1.1900.58
229_R245_E1.1880.58
94_R98_K1.1870.58
242_M283_N1.1850.58
31_V181_D1.1840.58
230_I276_V1.1800.58
166_S223_R1.1730.57
283_N287_I1.1710.57
174_A177_G1.1600.56
174_A182_A1.1560.56
120_P242_M1.1480.56
107_V140_E1.1440.55
162_Q193_A1.1410.55
62_M292_A1.1150.53
234_A287_I1.1130.53
91_V190_V1.1080.53
28_E289_Q1.1060.53
234_A242_M1.1010.52
33_I278_T1.0990.52
194_G240_D1.0940.52
235_K252_F1.0890.52
83_R260_M1.0880.52
240_D243_T1.0830.51
106_T135_S1.0800.51
180_E183_V1.0790.51
88_C95_L1.0780.51
180_E185_E1.0780.51
110_N133_I1.0750.51
25_T295_E1.0710.50
246_S287_I1.0660.50
148_I215_L1.0620.50
278_T297_V1.0600.50
53_L134_A1.0540.49
73_L116_R1.0520.49
153_V219_V1.0500.49
115_L130_I1.0400.48
105_A132_I1.0390.48
85_E209_G1.0320.48
21_E60_I1.0310.48
229_R244_Y1.0270.47
60_I164_M1.0040.46
174_A181_D1.0020.46
116_R125_P0.9990.46
254_E258_R0.9960.45
9_Q244_Y0.9950.45
26_G46_E0.9930.45
276_V298_A0.9910.45
55_R145_R0.9900.45
55_R149_G0.9890.45
140_E143_P0.9880.45
27_V66_M0.9830.44
278_T295_E0.9820.44
88_C91_V0.9770.44
54_P58_K0.9760.44
265_V298_A0.9680.43
176_L179_G0.9680.43
154_G256_C0.9620.43
157_V247_H0.9580.43
7_D22_V0.9580.43
200_H284_D0.9560.43
45_A230_I0.9530.42
261_A277_V0.9520.42
86_E179_G0.9520.42
130_I223_R0.9480.42
84_V291_N0.9420.42
137_T181_D0.9400.42
136_A146_E0.9360.41
243_T283_N0.9340.41
284_D291_N0.9340.41
120_P231_Y0.9330.41
163_Q196_S0.9280.41
199_G256_C0.9260.41
186_F229_R0.9240.41
61_D163_Q0.9210.40
181_D188_R0.9180.40
4_Q8_V0.9170.40
111_A153_V0.9130.40
157_V243_T0.9100.40
61_D167_E0.9100.40
119_T233_T0.9070.39
134_A146_E0.9070.39
199_G281_Q0.9070.39
223_R292_A0.8960.39
214_N217_D0.8950.39
58_K113_L0.8910.38
161_S292_A0.8860.38
286_S292_A0.8860.38
164_M194_G0.8800.38
143_P218_L0.8780.38
280_K295_E0.8780.38
208_G222_A0.8760.37
147_E206_E0.8760.37
71_E90_E0.8710.37
122_S277_V0.8690.37
128_G161_S0.8680.37
67_R280_K0.8650.37
136_A297_V0.8620.37
175_E179_G0.8620.37
104_T139_Q0.8620.37
231_Y287_I0.8620.37
234_A243_T0.8610.37
170_R190_V0.8600.36
114_M129_T0.8600.36
178_V182_A0.8560.36
120_P287_I0.8550.36
62_M231_Y0.8520.36
25_T48_E0.8510.36
85_E144_T0.8500.36
164_M193_A0.8470.36
161_S240_D0.8460.36
203_L260_M0.8460.36
84_V191_P0.8450.36
194_G234_A0.8420.35
181_D217_D0.8420.35
261_A296_R0.8410.35
243_T287_I0.8410.35
234_A283_N0.8380.35
202_T280_K0.8370.35
98_K127_Q0.8340.35
179_G217_D0.8280.34
154_G287_I0.8270.34
176_L181_D0.8220.34
171_R182_A0.8180.34
178_V186_F0.8160.34
62_M161_S0.8160.34
29_K256_C0.8120.33
106_T136_A0.8070.33
90_E139_Q0.8060.33
18_G31_V0.8060.33
59_G63_S0.8040.33
59_G158_C0.8040.33
63_S158_C0.8040.33
91_V94_R0.8030.33
19_L22_V0.8010.33
80_P143_P0.8000.33
164_M242_M0.8000.33
162_Q247_H0.7990.33
117_E220_S0.7970.33
120_P243_T0.7950.32
170_R244_Y0.7950.32
156_T256_C0.7950.32
228_A245_E0.7940.32
35_R50_Y0.7880.32
234_A240_D0.7870.32
286_S290_H0.7830.32
149_G204_T0.7830.32
66_M259_S0.7790.32
199_G240_D0.7740.31
165_M190_V0.7730.31
96_L210_D0.7720.31
184_R188_R0.7720.31
33_I96_L0.7710.31
33_I131_D0.7680.31
31_V45_A0.7670.31
171_R248_A0.7670.31
35_R39_R0.7650.31
174_A179_G0.7630.31
190_V253_V0.7550.30
126_T232_N0.7550.30
152_V219_V0.7490.30
67_R253_V0.7480.30
59_G195_H0.7450.30
63_S195_H0.7450.30
158_C195_H0.7450.30
226_M283_N0.7420.29
20_S146_E0.7400.29
228_A243_T0.7400.29
31_V140_E0.7350.29
280_K291_N0.7340.29
119_T232_N0.7340.29
26_G291_N0.7330.29
138_A144_T0.7320.29
6_P256_C0.7310.29
237_P276_V0.7310.29
157_V242_M0.7300.29
5_L201_A0.7290.29
231_Y242_M0.7280.29
43_L112_E0.7280.29
231_Y283_N0.7270.29
25_T149_G0.7270.29
143_P219_V0.7260.29
246_S283_N0.7240.28
8_V72_T0.7230.28
122_S238_D0.7200.28
43_L148_I0.7200.28
161_S165_M0.7190.28
234_A246_S0.7180.28
265_V277_V0.7180.28
130_I199_G0.7160.28
67_R233_T0.7070.27
61_D66_M0.7020.27
13_P272_P0.7020.27
20_S56_G0.6990.27
156_T234_A0.6960.27
241_H245_E0.6950.27
175_E184_R0.6910.27
34_A216_M0.6880.26
231_Y240_D0.6840.26
58_K70_D0.6830.26
154_G243_T0.6830.26
113_L143_P0.6770.26
194_G256_C0.6730.26
115_L122_S0.6730.26
13_P55_R0.6710.26
83_R87_M0.6700.26
154_G246_S0.6690.25
157_V192_Q0.6690.25
7_D23_G0.6660.25
244_Y248_A0.6650.25
90_E107_V0.6650.25
154_G194_G0.6650.25
242_M287_I0.6630.25
154_G228_A0.6600.25
127_Q247_H0.6590.25
120_P246_S0.6560.25
132_I203_L0.6560.25
87_M176_L0.6550.25
123_D181_D0.6530.25
92_A172_K0.6530.25
158_C254_E0.6520.25
63_S254_E0.6520.25
59_G254_E0.6520.25
123_D284_D0.6520.25
155_M228_A0.6510.25
34_A147_E0.6490.24
178_V213_V0.6470.24
177_G180_E0.6470.24
140_E215_L0.6460.24
165_M172_K0.6460.24
174_A180_E0.6440.24
192_Q234_A0.6420.24
285_E288_H0.6420.24
240_D283_N0.6410.24
175_E188_R0.6400.24
188_R248_A0.6370.24
247_H287_I0.6360.24
34_A204_T0.6360.24
176_L182_A0.6350.24
130_I228_A0.6340.24
24_V134_A0.6300.24
139_Q142_A0.6290.23
267_E279_M0.6280.23
29_K47_F0.6260.23
50_Y124_L0.6240.23
71_E135_S0.6230.23
155_M256_C0.6180.23
252_F258_R0.6170.23
234_A293_H0.6160.23
156_T283_N0.6150.23
169_A191_P0.6150.23
196_S283_N0.6150.23
96_L140_E0.6140.23
158_C258_R0.6090.23
63_S258_R0.6090.23
98_K253_V0.6090.23
59_G258_R0.6090.23
117_E291_N0.6090.23
122_S237_P0.6090.23
32_E81_I0.6090.23
93_E210_D0.6090.23
119_T259_S0.6050.22
8_V104_T0.6040.22
74_E87_M0.6030.22
34_A209_G0.6020.22
61_D199_G0.6000.22
32_E73_L0.5990.22
195_H254_E0.5920.22
154_G283_N0.5920.22
154_G201_A0.5920.22
32_E40_P0.5910.22
18_G279_M0.5880.22
91_V170_R0.5880.22
149_G200_H0.5880.22
20_S294_A0.5870.21
11_T56_G0.5860.21
151_R295_E0.5830.21
9_Q233_T0.5820.21
137_T297_V0.5810.21
199_G238_D0.5760.21
123_D275_A0.5730.21
124_L237_P0.5720.21
115_L252_F0.5700.21
56_G210_D0.5700.21
110_N218_L0.5660.21
56_G140_E0.5650.20
171_R175_E0.5640.20
231_Y246_S0.5600.20
243_T246_S0.5590.20
171_R185_E0.5580.20
231_Y243_T0.5580.20
6_P48_E0.5580.20
56_G109_M0.5570.20
203_L215_L0.5570.20
245_E276_V0.5550.20
50_Y123_D0.5550.20
232_N242_M0.5540.20
235_K248_A0.5530.20
34_A77_V0.5510.20
154_G234_A0.5490.20
40_P118_E0.5490.20
126_T192_Q0.5480.20
105_A116_R0.5460.20
260_M281_Q0.5450.20
195_H258_R0.5450.20
61_D126_T0.5440.20
67_R124_L0.5430.20
162_Q283_N0.5390.19
155_M287_I0.5390.19
242_M256_C0.5360.19
87_M260_M0.5360.19
183_V189_D0.5340.19
204_T278_T0.5340.19
105_A237_P0.5330.19
157_V251_K0.5320.19
30_L193_A0.5320.19
86_E93_E0.5310.19
162_Q250_A0.5310.19
45_A84_V0.5300.19
162_Q199_G0.5300.19
231_Y234_A0.5290.19
32_E42_V0.5290.19
103_T116_R0.5290.19
120_P234_A0.5290.19
155_M240_D0.5290.19
14_D74_E0.5260.19
92_A229_R0.5260.19
185_E266_E0.5250.19
87_M262_R0.5250.19
4_Q224_D0.5220.19
26_G295_E0.5220.19
208_G262_R0.5210.19
196_S234_A0.5210.19
135_S205_V0.5210.19
247_H283_N0.5200.19
60_I233_T0.5190.19
49_V190_V0.5190.19
175_E262_R0.5180.18
104_T171_R0.5150.18
154_G164_M0.5130.18
31_V208_G0.5130.18
154_G231_Y0.5130.18
60_I291_N0.5130.18
14_D31_V0.5100.18
28_E148_I0.5100.18
127_Q234_A0.5090.18
9_Q292_A0.5050.18
201_A260_M0.5050.18
180_E280_K0.5040.18
33_I221_V0.5020.18
257_V281_Q0.5000.18
66_M166_S0.5000.18
137_T175_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r5rA 4 0.791 100 0.208 Contact Map
3d2oA 4 0.7846 100 0.211 Contact Map
2cg8A 4 0.7492 55.2 0.965 Contact Map
1sqlA 5 0.3633 53.1 0.965 Contact Map
3v9oA 3 0.3666 44.8 0.967 Contact Map
2o90A 4 0.3408 40.4 0.968 Contact Map
3o1kA 4 0.3505 35.6 0.969 Contact Map
1b9lA 4 0.3537 33.2 0.969 Contact Map
3r2eA 4 0.3473 30.5 0.97 Contact Map
4aeyA 3 0.3344 27.9 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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