GREMLIN Database
Q9HNX4 - Uncharacterized protein
UniProt: Q9HNX4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 228 (209)
Sequences: 1318 (1027)
Seq/√Len: 71.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_T182_G4.0761.00
100_T182_G4.0001.00
134_D166_E3.7811.00
45_K52_A3.7421.00
104_V220_S3.3781.00
8_L17_V2.8861.00
97_A180_I2.8291.00
182_G214_R2.8201.00
144_A169_I2.6861.00
93_R184_E2.6851.00
126_A163_P2.6061.00
138_L220_S2.5241.00
136_S218_E2.5011.00
93_R186_C2.3841.00
128_A131_R2.2241.00
102_T214_R2.1701.00
104_V174_D2.1501.00
95_D127_V2.1161.00
104_V138_L2.0991.00
214_R218_E2.0831.00
179_I214_R2.0541.00
170_G224_S2.0211.00
82_G85_A1.9651.00
94_I180_I1.9411.00
47_E51_K1.9331.00
97_A101_I1.9141.00
210_A214_R1.9011.00
104_V173_I1.8791.00
101_I135_V1.8711.00
141_S169_I1.8551.00
202_I209_F1.8541.00
146_C151_V1.8351.00
92_E96_A1.8161.00
126_A130_E1.8151.00
44_R47_E1.7781.00
90_W178_T1.7771.00
86_A200_A1.7541.00
8_L28_Y1.7491.00
207_R211_A1.7041.00
80_E203_D1.6681.00
179_I210_A1.6430.99
212_D216_A1.5990.99
50_E54_Q1.5970.99
78_T89_L1.5860.99
125_L155_Y1.5760.99
147_M151_V1.5670.99
46_R50_E1.5580.99
170_G220_S1.5340.99
104_V177_V1.5140.99
99_D183_A1.4980.99
89_L205_Q1.4880.99
82_G86_A1.4790.99
20_Q23_S1.4630.99
62_L66_L1.4530.99
86_A201_T1.4480.99
89_L203_D1.4430.99
146_C152_N1.4410.99
174_D216_A1.4350.99
109_A152_N1.4350.99
9_G13_S1.4140.98
137_V217_F1.4090.98
101_I128_A1.3890.98
108_P176_N1.3890.98
105_S176_N1.3830.98
62_L65_E1.3710.98
89_L93_R1.3590.98
44_R51_K1.3470.98
141_S144_A1.3430.98
78_T203_D1.3350.98
154_R157_D1.3180.97
48_L52_A1.3100.97
129_V164_T1.3010.97
170_G223_D1.2750.97
173_I220_S1.2570.97
90_W176_N1.2560.97
206_D211_A1.2360.96
107_T140_S1.1880.95
115_D119_S1.1790.95
31_V36_A1.1780.95
140_S172_S1.1360.94
104_V206_D1.1340.94
29_V171_D1.1190.94
17_V28_Y1.1190.94
54_Q57_N1.1060.93
146_C156_I1.0950.93
90_W180_I1.0950.93
125_L129_V1.0860.93
104_V216_A1.0850.93
103_L178_T1.0800.92
207_R210_A1.0550.91
78_T205_Q1.0530.91
125_L165_Y1.0520.91
165_Y176_N1.0450.91
44_R48_L1.0420.91
37_L174_D1.0400.91
99_D182_G1.0320.91
184_E203_D1.0270.90
88_D92_E1.0260.90
10_S13_S1.0230.90
102_T179_I1.0220.90
51_K54_Q1.0020.89
98_Q183_A1.0020.89
221_W224_S0.9970.89
94_I128_A0.9920.89
139_L167_V0.9910.89
185_V210_A0.9890.89
60_D70_K0.9850.88
45_K97_A0.9520.87
135_V162_D0.9470.86
175_G212_D0.9390.86
107_T110_S0.9350.86
94_I135_V0.9340.86
142_D145_D0.9300.85
20_Q29_V0.9240.85
151_V154_R0.9200.85
41_L51_K0.9100.84
189_V204_L0.9090.84
96_A183_A0.9080.84
12_E17_V0.9070.84
39_R189_V0.9040.84
59_V65_E0.8930.83
125_L167_V0.8810.82
93_R203_D0.8810.82
43_D141_S0.8800.82
14_Q43_D0.8700.81
140_S176_N0.8690.81
54_Q84_A0.8620.81
26_K204_L0.8570.80
90_W222_G0.8540.80
106_G208_E0.8490.80
101_I180_I0.8400.79
125_L176_N0.8330.78
79_A187_L0.8250.78
117_V120_Q0.8170.77
168_R221_W0.8140.77
102_T206_D0.8060.76
169_I226_T0.8040.76
67_D191_N0.8040.76
97_A128_A0.8040.76
189_V200_A0.8030.76
184_E205_Q0.8030.76
67_D138_L0.8030.76
15_H82_G0.7930.75
49_Q134_D0.7890.74
103_L135_V0.7870.74
103_L137_V0.7850.74
155_Y159_L0.7770.73
16_L36_A0.7770.73
129_V165_Y0.7760.73
80_E89_L0.7730.73
99_D134_D0.7680.72
83_P198_A0.7670.72
106_G144_A0.7670.72
107_T176_N0.7650.72
186_C203_D0.7620.72
108_P139_L0.7600.72
61_T65_E0.7600.72
129_V167_V0.7590.72
174_D212_D0.7570.71
127_V213_V0.7560.71
18_R29_V0.7540.71
16_L40_L0.7530.71
182_G188_E0.7480.70
56_E60_D0.7460.70
100_T136_S0.7450.70
182_G218_E0.7450.70
140_S144_A0.7430.70
34_E52_A0.7420.70
89_L92_E0.7380.69
31_V88_D0.7360.69
15_H204_L0.7290.68
32_E202_I0.7250.68
6_D9_G0.7250.68
139_L165_Y0.7130.67
127_V146_C0.7120.67
199_F208_E0.7110.67
153_E157_D0.7060.66
21_A81_L0.7020.66
86_A92_E0.7020.66
18_R159_L0.6960.65
164_T174_D0.6930.65
128_A133_V0.6870.64
64_R134_D0.6850.64
101_I153_E0.6820.63
197_E206_D0.6820.63
104_V217_F0.6780.63
108_P152_N0.6710.62
48_L175_G0.6710.62
7_V23_S0.6670.62
30_A62_L0.6650.61
86_A202_I0.6640.61
146_C164_T0.6630.61
91_L153_E0.6630.61
155_Y176_N0.6590.61
109_A176_N0.6590.61
95_D124_R0.6590.61
112_F116_D0.6550.60
83_P135_V0.6550.60
66_L81_L0.6550.60
204_L209_F0.6540.60
19_S206_D0.6540.60
56_E191_N0.6510.60
188_E201_T0.6500.60
75_G183_A0.6490.60
7_V160_A0.6480.59
186_C189_V0.6450.59
109_A146_C0.6390.58
188_E213_V0.6380.58
220_S224_S0.6340.58
129_V132_G0.6340.58
34_E82_G0.6340.58
100_T134_D0.6270.57
165_Y179_I0.6240.57
97_A189_V0.6230.56
89_L141_S0.6170.56
15_H147_M0.6170.56
139_L176_N0.6170.56
78_T189_V0.6150.55
61_T130_E0.6120.55
185_V188_E0.6120.55
38_N179_I0.6120.55
57_N60_D0.6100.55
37_L202_I0.6090.55
184_E209_F0.6080.55
26_K175_G0.6050.54
38_N215_A0.6040.54
175_G215_A0.6030.54
34_E139_L0.6010.54
97_A141_S0.5960.53
7_V30_A0.5960.53
38_N52_A0.5930.53
101_I178_T0.5900.52
32_E66_L0.5890.52
177_V225_T0.5870.52
100_T181_D0.5860.52
141_S212_D0.5850.52
138_L219_E0.5850.52
138_L206_D0.5840.52
110_S115_D0.5830.52
106_G176_N0.5820.51
86_A184_E0.5810.51
139_L164_T0.5800.51
96_A224_S0.5800.51
51_K55_Y0.5800.51
155_Y158_A0.5800.51
104_V202_I0.5800.51
187_L212_D0.5780.51
53_T215_A0.5760.51
51_K59_V0.5730.50
105_S109_A0.5730.50
137_V220_S0.5690.50
177_V213_V0.5690.50
120_Q124_R0.5690.50
62_L79_A0.5680.50
21_A26_K0.5670.50
26_K119_S0.5670.50
54_Q163_P0.5650.49
43_D46_R0.5630.49
55_Y59_V0.5590.49
46_R138_L0.5590.49
27_K99_D0.5580.49
57_N99_D0.5560.48
112_F167_V0.5560.48
115_D118_S0.5550.48
66_L70_K0.5550.48
77_W209_F0.5550.48
102_T183_A0.5540.48
128_A187_L0.5500.48
38_N129_V0.5470.47
89_L186_C0.5470.47
102_T217_F0.5470.47
72_P196_G0.5470.47
21_A47_E0.5450.47
185_V213_V0.5440.47
39_R88_D0.5420.47
176_N179_I0.5410.46
204_L211_A0.5400.46
142_D169_I0.5400.46
53_T130_E0.5390.46
78_T212_D0.5390.46
183_A205_Q0.5380.46
111_G152_N0.5350.46
178_T188_E0.5350.46
117_V121_V0.5350.46
177_V216_A0.5310.45
17_V155_Y0.5310.45
90_W94_I0.5300.45
220_S223_D0.5270.45
185_V218_E0.5260.45
125_L135_V0.5220.44
26_K98_Q0.5200.44
59_V103_L0.5180.44
127_V138_L0.5160.43
140_S155_Y0.5160.43
173_I204_L0.5160.43
119_S158_A0.5140.43
107_T143_L0.5130.43
117_V133_V0.5120.43
159_L186_C0.5110.43
103_L187_L0.5110.43
36_A48_L0.5110.43
6_D224_S0.5100.43
151_V156_I0.5100.43
27_K186_C0.5080.42
30_A203_D0.5070.42
43_D227_L0.5040.42
177_V212_D0.5030.42
12_E39_R0.5030.42
21_A46_R0.5030.42
10_S216_A0.5020.42
103_L198_A0.5010.42
23_S71_A0.5010.42
86_A94_I0.5000.42
105_S140_S0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qphA 2 0.8553 99.9 0.502 Contact Map
1byrA 2 0.6272 99.4 0.704 Contact Map
4ggjA 2 0.693 99.3 0.712 Contact Map
4urjA 1 0.6579 98.6 0.785 Contact Map
4gelA 2 0.75 98.4 0.797 Contact Map
1v0wA 1 0.8333 98.3 0.802 Contact Map
2f5tX 2 0.5702 98.2 0.807 Contact Map
2o8rA 2 0.8421 97.8 0.826 Contact Map
1xdpA 4 0.8377 97.6 0.834 Contact Map
3hsiA 2 0.7193 97.5 0.836 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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