Q9HNX4 - HALSA - GREMLIN Contacts

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Q9HNX4 - Uncharacterized protein

UniProt:	Q9HNX4	Sequences: MGRIYDVLGSIESQHLVRSQAASRPKKYVAVEPETALNRLLEDRKRELQEKATQYENVVDTLARELDHPKAPEDGFWTAELGPAAALDLWLERIDAAQDTITLVSGTPASGFDLDDVSSQVFDRLAVAVERGVDVSVLLSSDLADCMPHDVNERYIDALADDPTYEVRIGDSIDGNVTIIDGAEVCLEVSNPVQPGEAFATIDLQDREFAADVRAAFEESWGDSTTLG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	228 (209)
Sequences:	1318 (1027)
Seq/√Len:	71.0

BACSU - YRHO
HALSA - Q9HNX4 Q9HNY8 TRMBR
SULSO - Q97ZZ5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
102_T	182_G	4.076	1.00
100_T	182_G	4.000	1.00
134_D	166_E	3.781	1.00
45_K	52_A	3.742	1.00
104_V	220_S	3.378	1.00
8_L	17_V	2.886	1.00
97_A	180_I	2.829	1.00
182_G	214_R	2.820	1.00
144_A	169_I	2.686	1.00
93_R	184_E	2.685	1.00
126_A	163_P	2.606	1.00
138_L	220_S	2.524	1.00
136_S	218_E	2.501	1.00
93_R	186_C	2.384	1.00
128_A	131_R	2.224	1.00
102_T	214_R	2.170	1.00
104_V	174_D	2.150	1.00
95_D	127_V	2.116	1.00
104_V	138_L	2.099	1.00
214_R	218_E	2.083	1.00
179_I	214_R	2.054	1.00
170_G	224_S	2.021	1.00
82_G	85_A	1.965	1.00
94_I	180_I	1.941	1.00
47_E	51_K	1.933	1.00
97_A	101_I	1.914	1.00
210_A	214_R	1.901	1.00
104_V	173_I	1.879	1.00
101_I	135_V	1.871	1.00
141_S	169_I	1.855	1.00
202_I	209_F	1.854	1.00
146_C	151_V	1.835	1.00
92_E	96_A	1.816	1.00
126_A	130_E	1.815	1.00
44_R	47_E	1.778	1.00
90_W	178_T	1.777	1.00
86_A	200_A	1.754	1.00
8_L	28_Y	1.749	1.00
207_R	211_A	1.704	1.00
80_E	203_D	1.668	1.00
179_I	210_A	1.643	0.99
212_D	216_A	1.599	0.99
50_E	54_Q	1.597	0.99
78_T	89_L	1.586	0.99
125_L	155_Y	1.576	0.99
147_M	151_V	1.567	0.99
46_R	50_E	1.558	0.99
170_G	220_S	1.534	0.99
104_V	177_V	1.514	0.99
99_D	183_A	1.498	0.99
89_L	205_Q	1.488	0.99
82_G	86_A	1.479	0.99
20_Q	23_S	1.463	0.99
62_L	66_L	1.453	0.99
86_A	201_T	1.448	0.99
89_L	203_D	1.443	0.99
146_C	152_N	1.441	0.99
174_D	216_A	1.435	0.99
109_A	152_N	1.435	0.99
9_G	13_S	1.414	0.98
137_V	217_F	1.409	0.98
101_I	128_A	1.389	0.98
108_P	176_N	1.389	0.98
105_S	176_N	1.383	0.98
62_L	65_E	1.371	0.98
89_L	93_R	1.359	0.98
44_R	51_K	1.347	0.98
141_S	144_A	1.343	0.98
78_T	203_D	1.335	0.98
154_R	157_D	1.318	0.97
48_L	52_A	1.310	0.97
129_V	164_T	1.301	0.97
170_G	223_D	1.275	0.97
173_I	220_S	1.257	0.97
90_W	176_N	1.256	0.97
206_D	211_A	1.236	0.96
107_T	140_S	1.188	0.95
115_D	119_S	1.179	0.95
31_V	36_A	1.178	0.95
140_S	172_S	1.136	0.94
104_V	206_D	1.134	0.94
29_V	171_D	1.119	0.94
17_V	28_Y	1.119	0.94
54_Q	57_N	1.106	0.93
146_C	156_I	1.095	0.93
90_W	180_I	1.095	0.93
125_L	129_V	1.086	0.93
104_V	216_A	1.085	0.93
103_L	178_T	1.080	0.92
207_R	210_A	1.055	0.91
78_T	205_Q	1.053	0.91
125_L	165_Y	1.052	0.91
165_Y	176_N	1.045	0.91
44_R	48_L	1.042	0.91
37_L	174_D	1.040	0.91
99_D	182_G	1.032	0.91
184_E	203_D	1.027	0.90
88_D	92_E	1.026	0.90
10_S	13_S	1.023	0.90
102_T	179_I	1.022	0.90
51_K	54_Q	1.002	0.89
98_Q	183_A	1.002	0.89
221_W	224_S	0.997	0.89
94_I	128_A	0.992	0.89
139_L	167_V	0.991	0.89
185_V	210_A	0.989	0.89
60_D	70_K	0.985	0.88
45_K	97_A	0.952	0.87
135_V	162_D	0.947	0.86
175_G	212_D	0.939	0.86
107_T	110_S	0.935	0.86
94_I	135_V	0.934	0.86
142_D	145_D	0.930	0.85
20_Q	29_V	0.924	0.85
151_V	154_R	0.920	0.85
41_L	51_K	0.910	0.84
189_V	204_L	0.909	0.84
96_A	183_A	0.908	0.84
12_E	17_V	0.907	0.84
39_R	189_V	0.904	0.84
59_V	65_E	0.893	0.83
125_L	167_V	0.881	0.82
93_R	203_D	0.881	0.82
43_D	141_S	0.880	0.82
14_Q	43_D	0.870	0.81
140_S	176_N	0.869	0.81
54_Q	84_A	0.862	0.81
26_K	204_L	0.857	0.80
90_W	222_G	0.854	0.80
106_G	208_E	0.849	0.80
101_I	180_I	0.840	0.79
125_L	176_N	0.833	0.78
79_A	187_L	0.825	0.78
117_V	120_Q	0.817	0.77
168_R	221_W	0.814	0.77
102_T	206_D	0.806	0.76
169_I	226_T	0.804	0.76
67_D	191_N	0.804	0.76
97_A	128_A	0.804	0.76
189_V	200_A	0.803	0.76
184_E	205_Q	0.803	0.76
67_D	138_L	0.803	0.76
15_H	82_G	0.793	0.75
49_Q	134_D	0.789	0.74
103_L	135_V	0.787	0.74
103_L	137_V	0.785	0.74
155_Y	159_L	0.777	0.73
16_L	36_A	0.777	0.73
129_V	165_Y	0.776	0.73
80_E	89_L	0.773	0.73
99_D	134_D	0.768	0.72
83_P	198_A	0.767	0.72
106_G	144_A	0.767	0.72
107_T	176_N	0.765	0.72
186_C	203_D	0.762	0.72
108_P	139_L	0.760	0.72
61_T	65_E	0.760	0.72
129_V	167_V	0.759	0.72
174_D	212_D	0.757	0.71
127_V	213_V	0.756	0.71
18_R	29_V	0.754	0.71
16_L	40_L	0.753	0.71
182_G	188_E	0.748	0.70
56_E	60_D	0.746	0.70
100_T	136_S	0.745	0.70
182_G	218_E	0.745	0.70
140_S	144_A	0.743	0.70
34_E	52_A	0.742	0.70
89_L	92_E	0.738	0.69
31_V	88_D	0.736	0.69
15_H	204_L	0.729	0.68
32_E	202_I	0.725	0.68
6_D	9_G	0.725	0.68
139_L	165_Y	0.713	0.67
127_V	146_C	0.712	0.67
199_F	208_E	0.711	0.67
153_E	157_D	0.706	0.66
21_A	81_L	0.702	0.66
86_A	92_E	0.702	0.66
18_R	159_L	0.696	0.65
164_T	174_D	0.693	0.65
128_A	133_V	0.687	0.64
64_R	134_D	0.685	0.64
101_I	153_E	0.682	0.63
197_E	206_D	0.682	0.63
104_V	217_F	0.678	0.63
108_P	152_N	0.671	0.62
48_L	175_G	0.671	0.62
7_V	23_S	0.667	0.62
30_A	62_L	0.665	0.61
86_A	202_I	0.664	0.61
146_C	164_T	0.663	0.61
91_L	153_E	0.663	0.61
155_Y	176_N	0.659	0.61
109_A	176_N	0.659	0.61
95_D	124_R	0.659	0.61
112_F	116_D	0.655	0.60
83_P	135_V	0.655	0.60
66_L	81_L	0.655	0.60
204_L	209_F	0.654	0.60
19_S	206_D	0.654	0.60
56_E	191_N	0.651	0.60
188_E	201_T	0.650	0.60
75_G	183_A	0.649	0.60
7_V	160_A	0.648	0.59
186_C	189_V	0.645	0.59
109_A	146_C	0.639	0.58
188_E	213_V	0.638	0.58
220_S	224_S	0.634	0.58
129_V	132_G	0.634	0.58
34_E	82_G	0.634	0.58
100_T	134_D	0.627	0.57
165_Y	179_I	0.624	0.57
97_A	189_V	0.623	0.56
89_L	141_S	0.617	0.56
15_H	147_M	0.617	0.56
139_L	176_N	0.617	0.56
78_T	189_V	0.615	0.55
61_T	130_E	0.612	0.55
185_V	188_E	0.612	0.55
38_N	179_I	0.612	0.55
57_N	60_D	0.610	0.55
37_L	202_I	0.609	0.55
184_E	209_F	0.608	0.55
26_K	175_G	0.605	0.54
38_N	215_A	0.604	0.54
175_G	215_A	0.603	0.54
34_E	139_L	0.601	0.54
97_A	141_S	0.596	0.53
7_V	30_A	0.596	0.53
38_N	52_A	0.593	0.53
101_I	178_T	0.590	0.52
32_E	66_L	0.589	0.52
177_V	225_T	0.587	0.52
100_T	181_D	0.586	0.52
141_S	212_D	0.585	0.52
138_L	219_E	0.585	0.52
138_L	206_D	0.584	0.52
110_S	115_D	0.583	0.52
106_G	176_N	0.582	0.51
86_A	184_E	0.581	0.51
139_L	164_T	0.580	0.51
96_A	224_S	0.580	0.51
51_K	55_Y	0.580	0.51
155_Y	158_A	0.580	0.51
104_V	202_I	0.580	0.51
187_L	212_D	0.578	0.51
53_T	215_A	0.576	0.51
51_K	59_V	0.573	0.50
105_S	109_A	0.573	0.50
137_V	220_S	0.569	0.50
177_V	213_V	0.569	0.50
120_Q	124_R	0.569	0.50
62_L	79_A	0.568	0.50
21_A	26_K	0.567	0.50
26_K	119_S	0.567	0.50
54_Q	163_P	0.565	0.49
43_D	46_R	0.563	0.49
55_Y	59_V	0.559	0.49
46_R	138_L	0.559	0.49
27_K	99_D	0.558	0.49
57_N	99_D	0.556	0.48
112_F	167_V	0.556	0.48
115_D	118_S	0.555	0.48
66_L	70_K	0.555	0.48
77_W	209_F	0.555	0.48
102_T	183_A	0.554	0.48
128_A	187_L	0.550	0.48
38_N	129_V	0.547	0.47
89_L	186_C	0.547	0.47
102_T	217_F	0.547	0.47
72_P	196_G	0.547	0.47
21_A	47_E	0.545	0.47
185_V	213_V	0.544	0.47
39_R	88_D	0.542	0.47
176_N	179_I	0.541	0.46
204_L	211_A	0.540	0.46
142_D	169_I	0.540	0.46
53_T	130_E	0.539	0.46
78_T	212_D	0.539	0.46
183_A	205_Q	0.538	0.46
111_G	152_N	0.535	0.46
178_T	188_E	0.535	0.46
117_V	121_V	0.535	0.46
177_V	216_A	0.531	0.45
17_V	155_Y	0.531	0.45
90_W	94_I	0.530	0.45
220_S	223_D	0.527	0.45
185_V	218_E	0.526	0.45
125_L	135_V	0.522	0.44
26_K	98_Q	0.520	0.44
59_V	103_L	0.518	0.44
127_V	138_L	0.516	0.43
140_S	155_Y	0.516	0.43
173_I	204_L	0.516	0.43
119_S	158_A	0.514	0.43
107_T	143_L	0.513	0.43
117_V	133_V	0.512	0.43
159_L	186_C	0.511	0.43
103_L	187_L	0.511	0.43
36_A	48_L	0.511	0.43
6_D	224_S	0.510	0.43
151_V	156_I	0.510	0.43
27_K	186_C	0.508	0.42
30_A	203_D	0.507	0.42
43_D	227_L	0.504	0.42
177_V	212_D	0.503	0.42
12_E	39_R	0.503	0.42
21_A	46_R	0.503	0.42
10_S	216_A	0.502	0.42
103_L	198_A	0.501	0.42
23_S	71_A	0.501	0.42
86_A	94_I	0.500	0.42
105_S	140_S	0.500	0.42

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qphA	2	0.8553	99.9	0.502	Contact Map
1byrA	2	0.6272	99.4	0.704	Contact Map
4ggjA	2	0.693	99.3	0.712	Contact Map
4urjA	1	0.6579	98.6	0.785	Contact Map
4gelA	2	0.75	98.4	0.797	Contact Map
1v0wA	1	0.8333	98.3	0.802	Contact Map
2f5tX	2	0.5702	98.2	0.807	Contact Map
2o8rA	2	0.8421	97.8	0.826	Contact Map
1xdpA	4	0.8377	97.6	0.834	Contact Map
3hsiA	2	0.7193	97.5	0.836	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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