Q9HNX1 - HALSA - GREMLIN Contacts

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Q9HNX1 - Uncharacterized protein

UniProt:	Q9HNX1	Sequences: MPRFRSVFLALLVVPLVDAVFLVFVAGELGWQLTVALVVLTALLGTLFVRAEGRATLSRLQASVARGDPPTNELVDGGLLIAAGAFLLTPGLVTDALGFLIVIPVTRVAFRWGVKRYVTPKLDAKTGGFVSGNVYTFGFPGGDGGAGGDPRSGFGGGAGDGDDDTINLGDDAYDVSFEDDADGDQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	185 (150)
Sequences:	1020 (788)
Seq/√Len:	64.4

ECOLI - FXSA
BACSU - YTZA
HALSA - Q9HNX1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_W	35_V	3.618	1.00
83_A	101_I	3.505	1.00
17_V	93_V	3.204	1.00
103_I	106_T	3.097	1.00
76_D	111_R	3.013	1.00
25_V	92_L	2.774	1.00
21_F	93_V	2.466	1.00
134_V	138_G	2.379	1.00
41_T	98_G	2.356	1.00
147_G	150_P	2.175	1.00
41_T	88_L	2.041	1.00
20_V	31_W	2.035	1.00
85_A	89_T	2.026	1.00
146_A	149_D	1.958	1.00
14_V	94_T	1.943	1.00
25_V	37_L	1.921	1.00
61_Q	65_A	1.890	1.00
135_Y	138_G	1.830	1.00
136_T	139_F	1.779	1.00
40_L	44_L	1.711	0.99
146_A	150_P	1.709	0.99
136_T	142_G	1.653	0.99
145_G	148_G	1.624	0.99
62_A	66_R	1.623	0.99
36_A	40_L	1.607	0.99
135_Y	139_F	1.588	0.99
59_R	73_E	1.581	0.99
138_G	141_G	1.580	0.99
63_S	68_D	1.535	0.99
148_G	151_R	1.530	0.99
23_V	26_A	1.525	0.99
142_G	145_G	1.486	0.98
58_S	61_Q	1.471	0.98
32_Q	36_A	1.449	0.98
67_G	70_P	1.437	0.98
49_V	84_G	1.420	0.98
149_D	153_G	1.398	0.98
22_L	92_L	1.391	0.98
77_G	98_G	1.374	0.97
22_L	31_W	1.363	0.97
29_L	33_L	1.318	0.97
139_F	142_G	1.290	0.96
38_V	41_T	1.280	0.96
149_D	152_S	1.276	0.96
101_I	106_T	1.275	0.96
63_S	73_E	1.267	0.96
8_F	11_L	1.258	0.96
128_G	131_S	1.257	0.95
127_G	130_V	1.241	0.95
46_T	88_L	1.232	0.95
152_S	155_G	1.219	0.95
109_A	113_G	1.218	0.95
97_L	100_L	1.209	0.94
41_T	94_T	1.200	0.94
139_F	143_D	1.194	0.94
60_L	75_V	1.131	0.92
126_T	131_S	1.129	0.92
130_V	133_N	1.124	0.92
8_F	12_L	1.101	0.91
22_L	38_V	1.098	0.91
12_L	15_P	1.096	0.91
134_V	139_F	1.056	0.89
150_P	153_G	1.056	0.89
26_A	107_R	1.055	0.89
150_P	154_F	1.048	0.89
53_G	95_D	1.043	0.89
74_L	81_I	1.042	0.89
84_G	95_D	1.035	0.88
6_S	10_A	1.035	0.88
26_A	31_W	1.034	0.88
16_L	20_V	1.029	0.88
85_A	99_F	1.017	0.87
146_A	151_R	1.015	0.87
56_T	59_R	1.013	0.87
134_V	137_F	1.011	0.87
144_G	147_G	1.009	0.87
15_P	26_A	1.008	0.87
137_F	141_G	1.004	0.87
14_V	88_L	0.992	0.86
96_A	100_L	0.990	0.86
38_V	98_G	0.987	0.86
117_Y	120_P	0.982	0.86
106_T	109_A	0.977	0.85
135_Y	142_G	0.949	0.83
151_R	155_G	0.945	0.83
89_T	99_F	0.944	0.83
136_T	140_P	0.943	0.83
56_T	80_L	0.930	0.82
47_L	51_A	0.930	0.82
148_G	152_S	0.925	0.82
146_A	152_S	0.923	0.82
139_F	147_G	0.923	0.82
83_A	102_V	0.921	0.82
151_R	154_F	0.913	0.81
48_F	52_E	0.909	0.81
15_P	46_T	0.901	0.80
92_L	96_A	0.894	0.80
103_I	109_A	0.893	0.80
30_G	34_T	0.889	0.79
143_D	147_G	0.884	0.79
105_V	109_A	0.875	0.78
101_I	110_F	0.864	0.77
19_A	22_L	0.854	0.76
50_R	54_R	0.851	0.76
39_V	43_L	0.851	0.76
46_T	80_L	0.846	0.76
22_L	34_T	0.841	0.75
19_A	23_V	0.841	0.75
6_S	118_V	0.838	0.75
138_G	142_G	0.838	0.75
144_G	151_R	0.835	0.75
63_S	80_L	0.829	0.74
143_D	146_A	0.825	0.74
84_G	87_L	0.822	0.74
27_G	32_Q	0.818	0.73
78_G	93_V	0.814	0.73
83_A	98_G	0.811	0.73
26_A	30_G	0.809	0.73
55_A	83_A	0.809	0.73
141_G	146_A	0.805	0.72
67_G	73_E	0.803	0.72
41_T	87_L	0.800	0.72
141_G	147_G	0.800	0.72
83_A	106_T	0.796	0.71
129_F	133_N	0.789	0.71
140_P	143_D	0.787	0.70
37_L	41_T	0.771	0.69
44_L	99_F	0.769	0.69
21_F	24_F	0.766	0.68
20_V	83_A	0.761	0.68
108_V	111_R	0.761	0.68
80_L	107_R	0.760	0.68
148_G	155_G	0.760	0.68
76_D	80_L	0.758	0.68
53_G	77_G	0.757	0.67
87_L	98_G	0.746	0.66
30_G	33_L	0.746	0.66
133_N	138_G	0.737	0.65
148_G	153_G	0.734	0.65
7_V	11_L	0.731	0.65
147_G	151_R	0.730	0.65
19_A	78_G	0.726	0.64
79_L	110_F	0.725	0.64
21_F	94_T	0.718	0.63
28_E	32_Q	0.717	0.63
19_A	115_K	0.715	0.63
70_P	77_G	0.711	0.63
75_V	79_L	0.709	0.62
76_D	107_R	0.706	0.62
14_V	89_T	0.701	0.61
64_V	132_G	0.701	0.61
106_T	111_R	0.695	0.61
35_V	76_D	0.692	0.60
8_F	33_L	0.688	0.60
49_V	59_R	0.688	0.60
12_L	81_I	0.686	0.60
62_A	127_G	0.682	0.59
63_S	83_A	0.681	0.59
57_L	80_L	0.680	0.59
82_A	101_I	0.679	0.59
35_V	94_T	0.679	0.59
117_Y	122_L	0.672	0.58
141_G	144_G	0.669	0.58
79_L	111_R	0.660	0.57
58_S	62_A	0.658	0.57
136_T	141_G	0.655	0.56
72_N	76_D	0.651	0.56
133_N	142_G	0.645	0.55
113_G	117_Y	0.641	0.55
17_V	20_V	0.639	0.54
150_P	155_G	0.637	0.54
33_L	36_A	0.634	0.54
19_A	69_P	0.634	0.54
7_V	46_T	0.633	0.54
56_T	73_E	0.628	0.53
60_L	81_I	0.627	0.53
147_G	152_S	0.627	0.53
14_V	21_F	0.626	0.53
72_N	112_W	0.618	0.52
62_A	65_A	0.615	0.52
60_L	83_A	0.608	0.51
72_N	115_K	0.606	0.51
55_A	64_V	0.600	0.50
142_G	146_A	0.596	0.49
146_A	153_G	0.587	0.48
19_A	24_F	0.584	0.48
144_G	149_D	0.583	0.48
73_E	98_G	0.575	0.47
143_D	148_G	0.575	0.47
51_A	116_R	0.569	0.46
29_L	37_L	0.569	0.46
135_Y	140_P	0.559	0.45
103_I	108_V	0.558	0.45
10_A	116_R	0.557	0.45
148_G	154_F	0.556	0.45
70_P	73_E	0.555	0.45
138_G	147_G	0.555	0.45
13_V	89_T	0.551	0.44
94_T	98_G	0.549	0.44
147_G	153_G	0.547	0.44
25_V	146_A	0.545	0.44
137_F	143_D	0.545	0.44
35_V	38_V	0.541	0.43
145_G	149_D	0.540	0.43
15_P	19_A	0.540	0.43
42_A	77_G	0.538	0.43
29_L	74_L	0.537	0.43
126_T	129_F	0.535	0.42
82_A	86_F	0.535	0.42
43_L	46_T	0.534	0.42
23_V	83_A	0.533	0.42
55_A	60_L	0.533	0.42
138_G	144_G	0.532	0.42
74_L	78_G	0.530	0.42
39_V	102_V	0.524	0.41
50_R	53_G	0.522	0.41
143_D	150_P	0.519	0.41
149_D	155_G	0.515	0.40
105_V	108_V	0.513	0.40
122_L	125_K	0.510	0.40
79_L	107_R	0.508	0.39
103_I	119_T	0.507	0.39
49_V	78_G	0.506	0.39
49_V	83_A	0.501	0.39
144_G	148_G	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k0jA	3	0.5514	54.8	0.924	Contact Map
4mt1A	3	0.6	50.9	0.926	Contact Map
4dx5A	3	0.6486	48.7	0.927	Contact Map
3w9iA	3	0.6	36.8	0.932	Contact Map
4u7aA	1	0	31.9	0.934	Contact Map
3wdoA	1	0.8973	23.6	0.938	Contact Map
3ne5A	3	0.5892	21.1	0.94	Contact Map
4pypA	1	0.5568	13.2	0.945	Contact Map
1ej6B	7	0.2811	10.5	0.947	Contact Map
4uerc	1	0	8.8	0.949	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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