GREMLIN Database
Q9HNX1 - Uncharacterized protein
UniProt: Q9HNX1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (150)
Sequences: 1020 (788)
Seq/√Len: 64.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_W35_V3.6181.00
83_A101_I3.5051.00
17_V93_V3.2041.00
103_I106_T3.0971.00
76_D111_R3.0131.00
25_V92_L2.7741.00
21_F93_V2.4661.00
134_V138_G2.3791.00
41_T98_G2.3561.00
147_G150_P2.1751.00
41_T88_L2.0411.00
20_V31_W2.0351.00
85_A89_T2.0261.00
146_A149_D1.9581.00
14_V94_T1.9431.00
25_V37_L1.9211.00
61_Q65_A1.8901.00
135_Y138_G1.8301.00
136_T139_F1.7791.00
40_L44_L1.7110.99
146_A150_P1.7090.99
136_T142_G1.6530.99
145_G148_G1.6240.99
62_A66_R1.6230.99
36_A40_L1.6070.99
135_Y139_F1.5880.99
59_R73_E1.5810.99
138_G141_G1.5800.99
63_S68_D1.5350.99
148_G151_R1.5300.99
23_V26_A1.5250.99
142_G145_G1.4860.98
58_S61_Q1.4710.98
32_Q36_A1.4490.98
67_G70_P1.4370.98
49_V84_G1.4200.98
149_D153_G1.3980.98
22_L92_L1.3910.98
77_G98_G1.3740.97
22_L31_W1.3630.97
29_L33_L1.3180.97
139_F142_G1.2900.96
38_V41_T1.2800.96
149_D152_S1.2760.96
101_I106_T1.2750.96
63_S73_E1.2670.96
8_F11_L1.2580.96
128_G131_S1.2570.95
127_G130_V1.2410.95
46_T88_L1.2320.95
152_S155_G1.2190.95
109_A113_G1.2180.95
97_L100_L1.2090.94
41_T94_T1.2000.94
139_F143_D1.1940.94
60_L75_V1.1310.92
126_T131_S1.1290.92
130_V133_N1.1240.92
8_F12_L1.1010.91
22_L38_V1.0980.91
12_L15_P1.0960.91
134_V139_F1.0560.89
150_P153_G1.0560.89
26_A107_R1.0550.89
150_P154_F1.0480.89
53_G95_D1.0430.89
74_L81_I1.0420.89
84_G95_D1.0350.88
6_S10_A1.0350.88
26_A31_W1.0340.88
16_L20_V1.0290.88
85_A99_F1.0170.87
146_A151_R1.0150.87
56_T59_R1.0130.87
134_V137_F1.0110.87
144_G147_G1.0090.87
15_P26_A1.0080.87
137_F141_G1.0040.87
14_V88_L0.9920.86
96_A100_L0.9900.86
38_V98_G0.9870.86
117_Y120_P0.9820.86
106_T109_A0.9770.85
135_Y142_G0.9490.83
151_R155_G0.9450.83
89_T99_F0.9440.83
136_T140_P0.9430.83
56_T80_L0.9300.82
47_L51_A0.9300.82
148_G152_S0.9250.82
146_A152_S0.9230.82
139_F147_G0.9230.82
83_A102_V0.9210.82
151_R154_F0.9130.81
48_F52_E0.9090.81
15_P46_T0.9010.80
92_L96_A0.8940.80
103_I109_A0.8930.80
30_G34_T0.8890.79
143_D147_G0.8840.79
105_V109_A0.8750.78
101_I110_F0.8640.77
19_A22_L0.8540.76
50_R54_R0.8510.76
39_V43_L0.8510.76
46_T80_L0.8460.76
22_L34_T0.8410.75
19_A23_V0.8410.75
6_S118_V0.8380.75
138_G142_G0.8380.75
144_G151_R0.8350.75
63_S80_L0.8290.74
143_D146_A0.8250.74
84_G87_L0.8220.74
27_G32_Q0.8180.73
78_G93_V0.8140.73
83_A98_G0.8110.73
26_A30_G0.8090.73
55_A83_A0.8090.73
141_G146_A0.8050.72
67_G73_E0.8030.72
41_T87_L0.8000.72
141_G147_G0.8000.72
83_A106_T0.7960.71
129_F133_N0.7890.71
140_P143_D0.7870.70
37_L41_T0.7710.69
44_L99_F0.7690.69
21_F24_F0.7660.68
20_V83_A0.7610.68
108_V111_R0.7610.68
80_L107_R0.7600.68
148_G155_G0.7600.68
76_D80_L0.7580.68
53_G77_G0.7570.67
87_L98_G0.7460.66
30_G33_L0.7460.66
133_N138_G0.7370.65
148_G153_G0.7340.65
7_V11_L0.7310.65
147_G151_R0.7300.65
19_A78_G0.7260.64
79_L110_F0.7250.64
21_F94_T0.7180.63
28_E32_Q0.7170.63
19_A115_K0.7150.63
70_P77_G0.7110.63
75_V79_L0.7090.62
76_D107_R0.7060.62
14_V89_T0.7010.61
64_V132_G0.7010.61
106_T111_R0.6950.61
35_V76_D0.6920.60
8_F33_L0.6880.60
49_V59_R0.6880.60
12_L81_I0.6860.60
62_A127_G0.6820.59
63_S83_A0.6810.59
57_L80_L0.6800.59
82_A101_I0.6790.59
35_V94_T0.6790.59
117_Y122_L0.6720.58
141_G144_G0.6690.58
79_L111_R0.6600.57
58_S62_A0.6580.57
136_T141_G0.6550.56
72_N76_D0.6510.56
133_N142_G0.6450.55
113_G117_Y0.6410.55
17_V20_V0.6390.54
150_P155_G0.6370.54
33_L36_A0.6340.54
19_A69_P0.6340.54
7_V46_T0.6330.54
56_T73_E0.6280.53
60_L81_I0.6270.53
147_G152_S0.6270.53
14_V21_F0.6260.53
72_N112_W0.6180.52
62_A65_A0.6150.52
60_L83_A0.6080.51
72_N115_K0.6060.51
55_A64_V0.6000.50
142_G146_A0.5960.49
146_A153_G0.5870.48
19_A24_F0.5840.48
144_G149_D0.5830.48
73_E98_G0.5750.47
143_D148_G0.5750.47
51_A116_R0.5690.46
29_L37_L0.5690.46
135_Y140_P0.5590.45
103_I108_V0.5580.45
10_A116_R0.5570.45
148_G154_F0.5560.45
70_P73_E0.5550.45
138_G147_G0.5550.45
13_V89_T0.5510.44
94_T98_G0.5490.44
147_G153_G0.5470.44
25_V146_A0.5450.44
137_F143_D0.5450.44
35_V38_V0.5410.43
145_G149_D0.5400.43
15_P19_A0.5400.43
42_A77_G0.5380.43
29_L74_L0.5370.43
126_T129_F0.5350.42
82_A86_F0.5350.42
43_L46_T0.5340.42
23_V83_A0.5330.42
55_A60_L0.5330.42
138_G144_G0.5320.42
74_L78_G0.5300.42
39_V102_V0.5240.41
50_R53_G0.5220.41
143_D150_P0.5190.41
149_D155_G0.5150.40
105_V108_V0.5130.40
122_L125_K0.5100.40
79_L107_R0.5080.39
103_I119_T0.5070.39
49_V78_G0.5060.39
49_V83_A0.5010.39
144_G148_G0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k0jA 3 0.5514 54.8 0.924 Contact Map
4mt1A 3 0.6 50.9 0.926 Contact Map
4dx5A 3 0.6486 48.7 0.927 Contact Map
3w9iA 3 0.6 36.8 0.932 Contact Map
4u7aA 1 0 31.9 0.934 Contact Map
3wdoA 1 0.8973 23.6 0.938 Contact Map
3ne5A 3 0.5892 21.1 0.94 Contact Map
4pypA 1 0.5568 13.2 0.945 Contact Map
1ej6B 7 0.2811 10.5 0.947 Contact Map
4uerc 1 0 8.8 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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