Q9HNW8 - HALSA - GREMLIN Contacts

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Q9HNW8 - Heme biosynthesis protein

UniProt:	Q9HNW8	Sequences: MVSGDWRDHIDDTDARLIDDYQSGFPVRERPFEALADDLDTTPSDVLDRVRSLRDDGVFRRFGAVLNPPVIGSSTLAAVAAPDDRFDEVADVINGYQQVNHNYERAHRYNQWFVVTAGDRETRDSILADIADRTGCAVLNLPMLTDYYIDLEFPVVNSDRFARESLAHTAVDATRISETATGDLATLDAELLLAIQDGFPLSATPYRDIAADIDADVSAVLDAVERLLADGCIKRVGCIVNHVVTGFDANCMVVWDVPDDELDERGVAVGELPYVTLCYHRPRRPDQDWQYNLFTMIHGRESSAVDEKIDELAATELPFEHERLYSKRTLKQTGARYDDLVDAAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	345 (318)
Sequences:	292 (209)
Seq/√Len:	11.7

HALSA - Q9HNW8 Q9HP70
SULSO - Q980P3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_D	49_R	7.150	1.00
147_Y	263_D	5.777	1.00
104_E	330_L	3.346	0.98
30_R	204_T	3.339	0.98
79_V	93_I	3.319	0.97
86_F	111_Q	3.268	0.97
194_A	212_D	3.262	0.97
75_T	140_N	3.165	0.97
104_E	328_R	3.082	0.96
11_D	49_R	3.081	0.96
277_L	332_Q	2.951	0.95
85_R	88_E	2.666	0.91
282_P	294_F	2.575	0.90
202_S	208_D	2.421	0.87
11_D	14_D	2.418	0.86
52_S	56_D	2.367	0.85
251_C	323_R	2.344	0.85
100_N	335_A	2.244	0.82
75_T	127_L	2.221	0.81
259_D	283_R	2.212	0.81
332_Q	335_A	2.197	0.81
29_E	217_V	2.118	0.78
151_L	277_L	2.087	0.77
299_G	305_V	2.054	0.76
64_A	236_V	2.052	0.76
188_D	223_A	2.035	0.75
96_Y	133_R	2.005	0.74
150_D	332_Q	1.978	0.73
242_H	279_Y	1.977	0.73
243_V	329_T	1.965	0.72
111_Q	330_L	1.951	0.72
153_F	276_T	1.942	0.71
17_L	46_V	1.934	0.71
30_R	43_P	1.926	0.71
256_D	283_R	1.917	0.70
271_E	290_Q	1.893	0.69
87_D	330_L	1.883	0.69
114_V	198_G	1.862	0.68
143_M	277_L	1.856	0.68
277_L	335_A	1.774	0.64
329_T	332_Q	1.774	0.64
100_N	277_L	1.770	0.64
283_R	292_N	1.730	0.62
86_F	330_L	1.680	0.60
61_R	334_G	1.667	0.59
33_E	43_P	1.654	0.58
235_R	279_Y	1.645	0.58
100_N	334_G	1.606	0.56
81_A	89_V	1.593	0.55
104_E	299_G	1.585	0.55
150_D	277_L	1.577	0.55
56_D	314_A	1.576	0.55
131_A	138_V	1.575	0.55
114_V	146_D	1.575	0.55
83_D	213_I	1.566	0.54
64_A	195_I	1.551	0.53
102_N	234_K	1.548	0.53
116_T	335_A	1.522	0.52
36_A	52_S	1.510	0.51
74_S	149_I	1.503	0.51
117_A	123_R	1.494	0.51
194_A	209_I	1.491	0.50
142_P	282_P	1.460	0.49
81_A	93_I	1.455	0.49
235_R	242_H	1.428	0.47
222_D	260_D	1.415	0.47
36_A	42_T	1.400	0.46
101_H	250_N	1.397	0.46
100_N	332_Q	1.395	0.46
207_R	217_V	1.390	0.45
204_T	217_V	1.389	0.45
143_M	332_Q	1.378	0.45
95_G	211_A	1.377	0.45
55_D	271_E	1.368	0.44
86_F	104_E	1.363	0.44
71_I	192_L	1.362	0.44
196_Q	294_F	1.361	0.44
151_L	332_Q	1.353	0.44
225_E	303_S	1.352	0.44
84_D	218_S	1.351	0.44
68_P	116_T	1.331	0.43
107_H	322_E	1.331	0.43
65_V	100_N	1.331	0.43
37_D	83_D	1.330	0.43
65_V	237_G	1.314	0.42
242_H	278_C	1.305	0.41
25_F	233_I	1.302	0.41
108_R	147_Y	1.301	0.41
48_D	89_V	1.300	0.41
100_N	116_T	1.295	0.41
94_N	102_N	1.293	0.41
102_N	113_F	1.289	0.41
255_W	278_C	1.287	0.40
239_I	314_A	1.286	0.40
36_A	180_A	1.283	0.40
301_E	305_V	1.274	0.40
29_E	207_R	1.270	0.40
195_I	224_V	1.265	0.39
51_R	55_D	1.264	0.39
100_N	150_D	1.262	0.39
190_E	222_D	1.260	0.39
106_A	325_Y	1.259	0.39
96_Y	338_D	1.255	0.39
153_F	237_G	1.250	0.39
260_D	264_E	1.245	0.38
131_A	240_V	1.241	0.38
25_F	237_G	1.241	0.38
275_V	278_C	1.231	0.38
235_R	278_C	1.221	0.37
28_R	84_D	1.215	0.37
277_L	329_T	1.192	0.36
107_H	294_F	1.187	0.36
239_I	330_L	1.184	0.36
256_D	259_D	1.178	0.35
44_S	229_A	1.170	0.35
114_V	334_G	1.169	0.35
69_P	154_P	1.168	0.35
261_E	264_E	1.166	0.35
120_R	124_D	1.164	0.35
87_D	328_R	1.157	0.34
29_E	221_L	1.153	0.34
151_L	321_H	1.153	0.34
90_A	111_Q	1.152	0.34
235_R	266_G	1.146	0.34
59_F	333_T	1.138	0.34
59_F	265_R	1.134	0.33
266_G	279_Y	1.132	0.33
83_D	210_A	1.129	0.33
28_R	34_A	1.116	0.33
198_G	334_G	1.112	0.32
26_P	205_P	1.111	0.32
192_L	317_L	1.110	0.32
114_V	151_L	1.108	0.32
130_I	136_C	1.107	0.32
68_P	77_A	1.100	0.32
47_L	201_L	1.090	0.31
61_R	130_I	1.090	0.31
116_T	334_G	1.085	0.31
81_A	147_Y	1.077	0.31
149_I	294_F	1.073	0.31
125_S	285_P	1.070	0.31
100_N	240_V	1.065	0.30
116_T	332_Q	1.065	0.30
60_R	329_T	1.063	0.30
196_Q	331_K	1.061	0.30
152_E	332_Q	1.055	0.30
43_P	203_A	1.050	0.30
22_Q	27_V	1.049	0.30
152_E	277_L	1.046	0.30
37_D	260_D	1.045	0.30
145_T	263_D	1.030	0.29
109_Y	141_L	1.030	0.29
274_Y	330_L	1.023	0.29
42_T	224_V	1.023	0.29
41_T	215_A	1.010	0.28
59_F	240_V	1.009	0.28
65_V	143_M	1.006	0.28
13_T	41_T	1.005	0.28
119_D	334_G	1.001	0.28
66_L	192_L	1.000	0.28
109_Y	310_D	0.994	0.28
186_T	203_A	0.993	0.27
103_Y	246_G	0.989	0.27
151_L	198_G	0.985	0.27
67_N	330_L	0.981	0.27
60_R	148_Y	0.978	0.27
257_V	294_F	0.971	0.27
114_V	237_G	0.968	0.26
116_T	150_D	0.965	0.26
255_W	279_Y	0.963	0.26
246_G	289_W	0.962	0.26
246_G	296_M	0.956	0.26
44_S	212_D	0.956	0.26
114_V	329_T	0.945	0.26
50_V	67_N	0.942	0.26
18_I	44_S	0.940	0.25
34_A	37_D	0.937	0.25
65_V	149_I	0.936	0.25
34_A	201_L	0.934	0.25
68_P	74_S	0.933	0.25
85_R	248_D	0.932	0.25
194_A	225_E	0.928	0.25
18_I	58_V	0.922	0.25
49_R	300_R	0.917	0.25
206_Y	236_V	0.916	0.25
225_E	260_D	0.913	0.24
68_P	277_L	0.912	0.24
69_P	123_R	0.911	0.24
86_F	251_C	0.904	0.24
127_L	140_N	0.904	0.24
254_V	326_S	0.902	0.24
44_S	52_S	0.901	0.24
43_P	74_S	0.901	0.24
130_I	138_V	0.899	0.24
77_A	151_L	0.899	0.24
242_H	266_G	0.892	0.24
35_L	311_E	0.892	0.24
100_N	149_I	0.892	0.24
27_V	155_V	0.891	0.24
61_R	335_A	0.890	0.24
99_V	220_V	0.887	0.23
227_L	230_D	0.885	0.23
90_A	254_V	0.885	0.23
265_R	317_L	0.883	0.23
151_L	154_P	0.883	0.23
147_Y	280_H	0.881	0.23
227_L	253_V	0.877	0.23
35_L	54_R	0.874	0.23
207_R	211_A	0.873	0.23
127_L	130_I	0.870	0.23
266_G	275_V	0.867	0.23
47_L	269_V	0.867	0.23
235_R	255_W	0.864	0.23
47_L	107_H	0.863	0.23
25_F	191_L	0.863	0.23
269_V	272_L	0.855	0.22
68_P	143_M	0.855	0.22
196_Q	278_C	0.854	0.22
142_P	196_Q	0.854	0.22
79_V	89_V	0.853	0.22
55_D	97_Q	0.852	0.22
68_P	335_A	0.849	0.22
61_R	119_D	0.848	0.22
148_Y	329_T	0.846	0.22
143_M	151_L	0.842	0.22
18_I	222_D	0.839	0.22
250_N	296_M	0.834	0.22
101_H	296_M	0.834	0.22
61_R	100_N	0.828	0.21
89_V	93_I	0.827	0.21
142_P	235_R	0.826	0.21
98_Q	234_K	0.825	0.21
32_F	47_L	0.823	0.21
94_N	320_E	0.823	0.21
142_P	293_L	0.822	0.21
40_D	44_S	0.820	0.21
192_L	196_Q	0.819	0.21
21_Y	100_N	0.818	0.21
59_F	88_E	0.818	0.21
253_V	295_T	0.812	0.21
146_D	234_K	0.812	0.21
128_A	203_A	0.811	0.21
197_D	336_R	0.808	0.21
250_N	298_H	0.808	0.21
101_H	298_H	0.808	0.21
48_D	260_D	0.805	0.21
24_G	304_A	0.805	0.21
222_D	285_P	0.804	0.21
273_P	301_E	0.803	0.21
100_N	151_L	0.795	0.20
149_I	337_Y	0.794	0.20
239_I	317_L	0.793	0.20
84_D	167_A	0.788	0.20
37_D	212_D	0.785	0.20
36_A	46_V	0.782	0.20
34_A	222_D	0.782	0.20
257_V	262_L	0.782	0.20
141_L	297_I	0.780	0.20
24_G	333_T	0.778	0.20
20_D	38_D	0.778	0.20
142_P	266_G	0.777	0.20
46_V	239_I	0.775	0.20
145_T	280_H	0.774	0.20
238_C	276_T	0.770	0.20
302_S	306_D	0.766	0.19
60_R	114_V	0.766	0.19
116_T	277_L	0.755	0.19
266_G	278_C	0.754	0.19
65_V	68_P	0.752	0.19
63_G	237_G	0.752	0.19
243_V	330_L	0.751	0.19
66_L	337_Y	0.749	0.19
17_L	307_E	0.749	0.19
48_D	51_R	0.747	0.19
189_A	211_A	0.743	0.19
116_T	143_M	0.739	0.19
102_N	289_W	0.735	0.19
74_S	255_W	0.727	0.18
145_T	234_K	0.725	0.18
35_L	325_Y	0.725	0.18
25_F	206_Y	0.723	0.18
183_D	203_A	0.722	0.18
233_I	236_V	0.720	0.18
114_V	277_L	0.716	0.18
290_Q	333_T	0.716	0.18
17_L	214_D	0.714	0.18
72_G	107_H	0.714	0.18
79_V	131_A	0.714	0.18
109_Y	317_L	0.712	0.18
146_D	294_F	0.712	0.18
114_V	276_T	0.711	0.18
251_C	277_L	0.711	0.18
147_Y	196_Q	0.709	0.18
34_A	38_D	0.708	0.18
153_F	251_C	0.703	0.18
278_C	294_F	0.700	0.17
251_C	330_L	0.700	0.17
188_D	227_L	0.697	0.17
71_I	114_V	0.695	0.17
148_Y	238_C	0.694	0.17
80_A	132_D	0.693	0.17
48_D	314_A	0.689	0.17
114_V	332_Q	0.688	0.17
97_Q	216_D	0.688	0.17
217_V	312_L	0.686	0.17
56_D	222_D	0.685	0.17
40_D	202_S	0.685	0.17
242_H	255_W	0.682	0.17
244_V	329_T	0.680	0.17
152_E	251_C	0.678	0.17
225_E	229_A	0.678	0.17
18_I	195_I	0.672	0.17
12_D	144_L	0.672	0.17
154_P	204_T	0.672	0.17
38_D	47_L	0.671	0.17
264_E	267_V	0.669	0.17
152_E	335_A	0.669	0.17
242_H	275_V	0.669	0.17
22_Q	149_I	0.666	0.17
69_P	139_L	0.663	0.16
14_D	53_L	0.662	0.16
63_G	334_G	0.660	0.16
71_I	255_W	0.659	0.16
100_N	329_T	0.659	0.16
23_S	151_L	0.658	0.16
57_G	191_L	0.656	0.16
35_L	301_E	0.655	0.16
59_F	74_S	0.654	0.16
60_R	279_Y	0.653	0.16
211_A	311_E	0.653	0.16
117_A	335_A	0.653	0.16
148_Y	247_F	0.650	0.16
229_A	260_D	0.650	0.16
179_T	195_I	0.649	0.16
212_D	220_V	0.649	0.16
178_E	218_S	0.649	0.16
28_R	44_S	0.648	0.16
32_F	192_L	0.648	0.16
219_A	222_D	0.647	0.16
45_D	218_S	0.647	0.16
125_S	261_E	0.646	0.16
72_G	283_R	0.645	0.16
260_D	311_E	0.645	0.16
216_D	219_A	0.644	0.16
155_V	241_N	0.644	0.16
35_L	206_Y	0.638	0.16
71_I	312_L	0.636	0.16
80_A	108_R	0.635	0.16
207_R	218_S	0.635	0.16
80_A	227_L	0.635	0.16
150_D	335_A	0.632	0.16
37_D	320_E	0.631	0.16
143_M	146_D	0.631	0.16
49_R	227_L	0.629	0.16
81_A	276_T	0.628	0.16
66_L	290_Q	0.627	0.15
100_N	143_M	0.626	0.15
218_S	310_D	0.626	0.15
262_L	280_H	0.626	0.15
133_R	219_A	0.625	0.15
188_D	230_D	0.625	0.15
259_D	336_R	0.624	0.15
190_E	219_A	0.623	0.15
149_I	236_V	0.622	0.15
74_S	253_V	0.622	0.15
77_A	116_T	0.619	0.15
12_D	229_A	0.619	0.15
40_D	48_D	0.618	0.15
77_A	115_V	0.617	0.15
221_L	309_I	0.617	0.15
203_A	226_R	0.615	0.15
44_S	56_D	0.615	0.15
72_G	280_H	0.614	0.15
210_A	221_L	0.612	0.15
50_V	239_I	0.606	0.15
276_T	332_Q	0.606	0.15
42_T	48_D	0.603	0.15
114_V	272_L	0.601	0.15
26_P	289_W	0.601	0.15
266_G	293_L	0.599	0.15
68_P	332_Q	0.596	0.15
77_A	117_A	0.596	0.15
35_L	299_G	0.595	0.15
77_A	277_L	0.593	0.15
211_A	313_A	0.592	0.15
73_S	117_A	0.592	0.15
186_T	189_A	0.592	0.15
142_P	278_C	0.588	0.14
44_S	48_D	0.588	0.14
102_N	246_G	0.588	0.14
147_Y	255_W	0.588	0.14
45_D	202_S	0.582	0.14
205_P	246_G	0.582	0.14
36_A	40_D	0.581	0.14
44_S	51_R	0.581	0.14
62_F	241_N	0.580	0.14
198_G	245_T	0.579	0.14
128_A	132_D	0.579	0.14
299_G	304_A	0.574	0.14
32_F	87_D	0.573	0.14
74_S	141_L	0.571	0.14
35_L	306_D	0.571	0.14
151_L	335_A	0.569	0.14
110_N	296_M	0.568	0.14
90_A	296_M	0.567	0.14
43_P	47_L	0.567	0.14
23_S	332_Q	0.563	0.14
50_V	57_G	0.562	0.14
35_L	50_V	0.561	0.14
275_V	279_Y	0.560	0.14
105_R	112_W	0.558	0.14
105_R	281_R	0.558	0.14
112_W	281_R	0.558	0.14
150_D	153_F	0.557	0.14
36_A	163_R	0.557	0.14
93_I	280_H	0.557	0.14
94_N	282_P	0.556	0.14
130_I	334_G	0.556	0.14
39_L	128_A	0.556	0.14
128_A	328_R	0.555	0.14
143_M	335_A	0.553	0.14
40_D	135_G	0.552	0.14
77_A	334_G	0.551	0.14
92_V	229_A	0.551	0.14
259_D	262_L	0.551	0.14
98_Q	245_T	0.550	0.14
36_A	41_T	0.549	0.14
137_A	225_E	0.545	0.13
162_A	310_D	0.545	0.13
45_D	156_V	0.544	0.13
12_D	36_A	0.544	0.13
114_V	143_M	0.544	0.13
61_R	65_V	0.544	0.13
61_R	198_G	0.543	0.13
106_A	315_T	0.543	0.13
42_T	218_S	0.542	0.13
235_R	293_L	0.540	0.13
27_V	204_T	0.540	0.13
85_R	314_A	0.540	0.13
203_A	248_D	0.539	0.13
36_A	181_T	0.538	0.13
143_M	243_V	0.537	0.13
270_G	312_L	0.537	0.13
214_D	304_A	0.537	0.13
55_D	106_A	0.537	0.13
128_A	207_R	0.537	0.13
15_A	145_T	0.536	0.13
121_E	230_D	0.533	0.13
123_R	127_L	0.533	0.13
57_G	323_R	0.532	0.13
275_V	282_P	0.532	0.13
121_E	186_T	0.531	0.13
113_F	130_I	0.530	0.13
189_A	313_A	0.529	0.13
266_G	270_G	0.527	0.13
25_F	265_R	0.526	0.13
38_D	81_A	0.520	0.13
25_F	331_K	0.519	0.13
191_L	214_D	0.515	0.13
113_F	291_Y	0.515	0.13
251_C	332_Q	0.514	0.13
88_E	131_A	0.513	0.13
126_I	147_Y	0.513	0.13
299_G	326_S	0.511	0.13
20_D	35_L	0.511	0.13
34_A	121_E	0.510	0.13
255_W	266_G	0.509	0.13
102_N	247_F	0.509	0.13
64_A	77_A	0.506	0.13
79_V	333_T	0.505	0.13
74_S	252_M	0.503	0.13
279_Y	292_N	0.503	0.13
23_S	277_L	0.501	0.12
306_D	310_D	0.501	0.12
74_S	312_L	0.501	0.12
93_I	113_F	0.500	0.12
36_A	177_S	0.500	0.12

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ch7A	1	0.858	100	0.518	Contact Map
4un1B	1	0.458	100	0.766	Contact Map
4un1A	1	0.4174	99.9	0.802	Contact Map
2e1cA	1	0.4232	99.9	0.828	Contact Map
4pcqA	2	0.4261	99.9	0.83	Contact Map
2ia0A	2	0.429	99.9	0.83	Contact Map
2cg4A	6	0.4261	99.9	0.837	Contact Map
2p5vA	5	0.4493	99.8	0.839	Contact Map
2pn6A	5	0.4232	99.8	0.843	Contact Map
2dbbA	4	0.4203	99.8	0.844	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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