GREMLIN Database
Q9HNW8 - Heme biosynthesis protein
UniProt: Q9HNW8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (318)
Sequences: 292 (209)
Seq/√Len: 11.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_D49_R7.1501.00
147_Y263_D5.7771.00
104_E330_L3.3460.98
30_R204_T3.3390.98
79_V93_I3.3190.97
86_F111_Q3.2680.97
194_A212_D3.2620.97
75_T140_N3.1650.97
104_E328_R3.0820.96
11_D49_R3.0810.96
277_L332_Q2.9510.95
85_R88_E2.6660.91
282_P294_F2.5750.90
202_S208_D2.4210.87
11_D14_D2.4180.86
52_S56_D2.3670.85
251_C323_R2.3440.85
100_N335_A2.2440.82
75_T127_L2.2210.81
259_D283_R2.2120.81
332_Q335_A2.1970.81
29_E217_V2.1180.78
151_L277_L2.0870.77
299_G305_V2.0540.76
64_A236_V2.0520.76
188_D223_A2.0350.75
96_Y133_R2.0050.74
150_D332_Q1.9780.73
242_H279_Y1.9770.73
243_V329_T1.9650.72
111_Q330_L1.9510.72
153_F276_T1.9420.71
17_L46_V1.9340.71
30_R43_P1.9260.71
256_D283_R1.9170.70
271_E290_Q1.8930.69
87_D330_L1.8830.69
114_V198_G1.8620.68
143_M277_L1.8560.68
277_L335_A1.7740.64
329_T332_Q1.7740.64
100_N277_L1.7700.64
283_R292_N1.7300.62
86_F330_L1.6800.60
61_R334_G1.6670.59
33_E43_P1.6540.58
235_R279_Y1.6450.58
100_N334_G1.6060.56
81_A89_V1.5930.55
104_E299_G1.5850.55
150_D277_L1.5770.55
56_D314_A1.5760.55
131_A138_V1.5750.55
114_V146_D1.5750.55
83_D213_I1.5660.54
64_A195_I1.5510.53
102_N234_K1.5480.53
116_T335_A1.5220.52
36_A52_S1.5100.51
74_S149_I1.5030.51
117_A123_R1.4940.51
194_A209_I1.4910.50
142_P282_P1.4600.49
81_A93_I1.4550.49
235_R242_H1.4280.47
222_D260_D1.4150.47
36_A42_T1.4000.46
101_H250_N1.3970.46
100_N332_Q1.3950.46
207_R217_V1.3900.45
204_T217_V1.3890.45
143_M332_Q1.3780.45
95_G211_A1.3770.45
55_D271_E1.3680.44
86_F104_E1.3630.44
71_I192_L1.3620.44
196_Q294_F1.3610.44
151_L332_Q1.3530.44
225_E303_S1.3520.44
84_D218_S1.3510.44
68_P116_T1.3310.43
107_H322_E1.3310.43
65_V100_N1.3310.43
37_D83_D1.3300.43
65_V237_G1.3140.42
242_H278_C1.3050.41
25_F233_I1.3020.41
108_R147_Y1.3010.41
48_D89_V1.3000.41
100_N116_T1.2950.41
94_N102_N1.2930.41
102_N113_F1.2890.41
255_W278_C1.2870.40
239_I314_A1.2860.40
36_A180_A1.2830.40
301_E305_V1.2740.40
29_E207_R1.2700.40
195_I224_V1.2650.39
51_R55_D1.2640.39
100_N150_D1.2620.39
190_E222_D1.2600.39
106_A325_Y1.2590.39
96_Y338_D1.2550.39
153_F237_G1.2500.39
260_D264_E1.2450.38
131_A240_V1.2410.38
25_F237_G1.2410.38
275_V278_C1.2310.38
235_R278_C1.2210.37
28_R84_D1.2150.37
277_L329_T1.1920.36
107_H294_F1.1870.36
239_I330_L1.1840.36
256_D259_D1.1780.35
44_S229_A1.1700.35
114_V334_G1.1690.35
69_P154_P1.1680.35
261_E264_E1.1660.35
120_R124_D1.1640.35
87_D328_R1.1570.34
29_E221_L1.1530.34
151_L321_H1.1530.34
90_A111_Q1.1520.34
235_R266_G1.1460.34
59_F333_T1.1380.34
59_F265_R1.1340.33
266_G279_Y1.1320.33
83_D210_A1.1290.33
28_R34_A1.1160.33
198_G334_G1.1120.32
26_P205_P1.1110.32
192_L317_L1.1100.32
114_V151_L1.1080.32
130_I136_C1.1070.32
68_P77_A1.1000.32
47_L201_L1.0900.31
61_R130_I1.0900.31
116_T334_G1.0850.31
81_A147_Y1.0770.31
149_I294_F1.0730.31
125_S285_P1.0700.31
100_N240_V1.0650.30
116_T332_Q1.0650.30
60_R329_T1.0630.30
196_Q331_K1.0610.30
152_E332_Q1.0550.30
43_P203_A1.0500.30
22_Q27_V1.0490.30
152_E277_L1.0460.30
37_D260_D1.0450.30
145_T263_D1.0300.29
109_Y141_L1.0300.29
274_Y330_L1.0230.29
42_T224_V1.0230.29
41_T215_A1.0100.28
59_F240_V1.0090.28
65_V143_M1.0060.28
13_T41_T1.0050.28
119_D334_G1.0010.28
66_L192_L1.0000.28
109_Y310_D0.9940.28
186_T203_A0.9930.27
103_Y246_G0.9890.27
151_L198_G0.9850.27
67_N330_L0.9810.27
60_R148_Y0.9780.27
257_V294_F0.9710.27
114_V237_G0.9680.26
116_T150_D0.9650.26
255_W279_Y0.9630.26
246_G289_W0.9620.26
246_G296_M0.9560.26
44_S212_D0.9560.26
114_V329_T0.9450.26
50_V67_N0.9420.26
18_I44_S0.9400.25
34_A37_D0.9370.25
65_V149_I0.9360.25
34_A201_L0.9340.25
68_P74_S0.9330.25
85_R248_D0.9320.25
194_A225_E0.9280.25
18_I58_V0.9220.25
49_R300_R0.9170.25
206_Y236_V0.9160.25
225_E260_D0.9130.24
68_P277_L0.9120.24
69_P123_R0.9110.24
86_F251_C0.9040.24
127_L140_N0.9040.24
254_V326_S0.9020.24
44_S52_S0.9010.24
43_P74_S0.9010.24
130_I138_V0.8990.24
77_A151_L0.8990.24
242_H266_G0.8920.24
35_L311_E0.8920.24
100_N149_I0.8920.24
27_V155_V0.8910.24
61_R335_A0.8900.24
99_V220_V0.8870.23
227_L230_D0.8850.23
90_A254_V0.8850.23
265_R317_L0.8830.23
151_L154_P0.8830.23
147_Y280_H0.8810.23
227_L253_V0.8770.23
35_L54_R0.8740.23
207_R211_A0.8730.23
127_L130_I0.8700.23
266_G275_V0.8670.23
47_L269_V0.8670.23
235_R255_W0.8640.23
47_L107_H0.8630.23
25_F191_L0.8630.23
269_V272_L0.8550.22
68_P143_M0.8550.22
196_Q278_C0.8540.22
142_P196_Q0.8540.22
79_V89_V0.8530.22
55_D97_Q0.8520.22
68_P335_A0.8490.22
61_R119_D0.8480.22
148_Y329_T0.8460.22
143_M151_L0.8420.22
18_I222_D0.8390.22
250_N296_M0.8340.22
101_H296_M0.8340.22
61_R100_N0.8280.21
89_V93_I0.8270.21
142_P235_R0.8260.21
98_Q234_K0.8250.21
32_F47_L0.8230.21
94_N320_E0.8230.21
142_P293_L0.8220.21
40_D44_S0.8200.21
192_L196_Q0.8190.21
21_Y100_N0.8180.21
59_F88_E0.8180.21
253_V295_T0.8120.21
146_D234_K0.8120.21
128_A203_A0.8110.21
197_D336_R0.8080.21
250_N298_H0.8080.21
101_H298_H0.8080.21
48_D260_D0.8050.21
24_G304_A0.8050.21
222_D285_P0.8040.21
273_P301_E0.8030.21
100_N151_L0.7950.20
149_I337_Y0.7940.20
239_I317_L0.7930.20
84_D167_A0.7880.20
37_D212_D0.7850.20
36_A46_V0.7820.20
34_A222_D0.7820.20
257_V262_L0.7820.20
141_L297_I0.7800.20
24_G333_T0.7780.20
20_D38_D0.7780.20
142_P266_G0.7770.20
46_V239_I0.7750.20
145_T280_H0.7740.20
238_C276_T0.7700.20
302_S306_D0.7660.19
60_R114_V0.7660.19
116_T277_L0.7550.19
266_G278_C0.7540.19
65_V68_P0.7520.19
63_G237_G0.7520.19
243_V330_L0.7510.19
66_L337_Y0.7490.19
17_L307_E0.7490.19
48_D51_R0.7470.19
189_A211_A0.7430.19
116_T143_M0.7390.19
102_N289_W0.7350.19
74_S255_W0.7270.18
145_T234_K0.7250.18
35_L325_Y0.7250.18
25_F206_Y0.7230.18
183_D203_A0.7220.18
233_I236_V0.7200.18
114_V277_L0.7160.18
290_Q333_T0.7160.18
17_L214_D0.7140.18
72_G107_H0.7140.18
79_V131_A0.7140.18
109_Y317_L0.7120.18
146_D294_F0.7120.18
114_V276_T0.7110.18
251_C277_L0.7110.18
147_Y196_Q0.7090.18
34_A38_D0.7080.18
153_F251_C0.7030.18
278_C294_F0.7000.17
251_C330_L0.7000.17
188_D227_L0.6970.17
71_I114_V0.6950.17
148_Y238_C0.6940.17
80_A132_D0.6930.17
48_D314_A0.6890.17
114_V332_Q0.6880.17
97_Q216_D0.6880.17
217_V312_L0.6860.17
56_D222_D0.6850.17
40_D202_S0.6850.17
242_H255_W0.6820.17
244_V329_T0.6800.17
152_E251_C0.6780.17
225_E229_A0.6780.17
18_I195_I0.6720.17
12_D144_L0.6720.17
154_P204_T0.6720.17
38_D47_L0.6710.17
264_E267_V0.6690.17
152_E335_A0.6690.17
242_H275_V0.6690.17
22_Q149_I0.6660.17
69_P139_L0.6630.16
14_D53_L0.6620.16
63_G334_G0.6600.16
71_I255_W0.6590.16
100_N329_T0.6590.16
23_S151_L0.6580.16
57_G191_L0.6560.16
35_L301_E0.6550.16
59_F74_S0.6540.16
60_R279_Y0.6530.16
211_A311_E0.6530.16
117_A335_A0.6530.16
148_Y247_F0.6500.16
229_A260_D0.6500.16
179_T195_I0.6490.16
212_D220_V0.6490.16
178_E218_S0.6490.16
28_R44_S0.6480.16
32_F192_L0.6480.16
219_A222_D0.6470.16
45_D218_S0.6470.16
125_S261_E0.6460.16
72_G283_R0.6450.16
260_D311_E0.6450.16
216_D219_A0.6440.16
155_V241_N0.6440.16
35_L206_Y0.6380.16
71_I312_L0.6360.16
80_A108_R0.6350.16
207_R218_S0.6350.16
80_A227_L0.6350.16
150_D335_A0.6320.16
37_D320_E0.6310.16
143_M146_D0.6310.16
49_R227_L0.6290.16
81_A276_T0.6280.16
66_L290_Q0.6270.15
100_N143_M0.6260.15
218_S310_D0.6260.15
262_L280_H0.6260.15
133_R219_A0.6250.15
188_D230_D0.6250.15
259_D336_R0.6240.15
190_E219_A0.6230.15
149_I236_V0.6220.15
74_S253_V0.6220.15
77_A116_T0.6190.15
12_D229_A0.6190.15
40_D48_D0.6180.15
77_A115_V0.6170.15
221_L309_I0.6170.15
203_A226_R0.6150.15
44_S56_D0.6150.15
72_G280_H0.6140.15
210_A221_L0.6120.15
50_V239_I0.6060.15
276_T332_Q0.6060.15
42_T48_D0.6030.15
114_V272_L0.6010.15
26_P289_W0.6010.15
266_G293_L0.5990.15
68_P332_Q0.5960.15
77_A117_A0.5960.15
35_L299_G0.5950.15
77_A277_L0.5930.15
211_A313_A0.5920.15
73_S117_A0.5920.15
186_T189_A0.5920.15
142_P278_C0.5880.14
44_S48_D0.5880.14
102_N246_G0.5880.14
147_Y255_W0.5880.14
45_D202_S0.5820.14
205_P246_G0.5820.14
36_A40_D0.5810.14
44_S51_R0.5810.14
62_F241_N0.5800.14
198_G245_T0.5790.14
128_A132_D0.5790.14
299_G304_A0.5740.14
32_F87_D0.5730.14
74_S141_L0.5710.14
35_L306_D0.5710.14
151_L335_A0.5690.14
110_N296_M0.5680.14
90_A296_M0.5670.14
43_P47_L0.5670.14
23_S332_Q0.5630.14
50_V57_G0.5620.14
35_L50_V0.5610.14
275_V279_Y0.5600.14
105_R112_W0.5580.14
105_R281_R0.5580.14
112_W281_R0.5580.14
150_D153_F0.5570.14
36_A163_R0.5570.14
93_I280_H0.5570.14
94_N282_P0.5560.14
130_I334_G0.5560.14
39_L128_A0.5560.14
128_A328_R0.5550.14
143_M335_A0.5530.14
40_D135_G0.5520.14
77_A334_G0.5510.14
92_V229_A0.5510.14
259_D262_L0.5510.14
98_Q245_T0.5500.14
36_A41_T0.5490.14
137_A225_E0.5450.13
162_A310_D0.5450.13
45_D156_V0.5440.13
12_D36_A0.5440.13
114_V143_M0.5440.13
61_R65_V0.5440.13
61_R198_G0.5430.13
106_A315_T0.5430.13
42_T218_S0.5420.13
235_R293_L0.5400.13
27_V204_T0.5400.13
85_R314_A0.5400.13
203_A248_D0.5390.13
36_A181_T0.5380.13
143_M243_V0.5370.13
270_G312_L0.5370.13
214_D304_A0.5370.13
55_D106_A0.5370.13
128_A207_R0.5370.13
15_A145_T0.5360.13
121_E230_D0.5330.13
123_R127_L0.5330.13
57_G323_R0.5320.13
275_V282_P0.5320.13
121_E186_T0.5310.13
113_F130_I0.5300.13
189_A313_A0.5290.13
266_G270_G0.5270.13
25_F265_R0.5260.13
38_D81_A0.5200.13
25_F331_K0.5190.13
191_L214_D0.5150.13
113_F291_Y0.5150.13
251_C332_Q0.5140.13
88_E131_A0.5130.13
126_I147_Y0.5130.13
299_G326_S0.5110.13
20_D35_L0.5110.13
34_A121_E0.5100.13
255_W266_G0.5090.13
102_N247_F0.5090.13
64_A77_A0.5060.13
79_V333_T0.5050.13
74_S252_M0.5030.13
279_Y292_N0.5030.13
23_S277_L0.5010.12
306_D310_D0.5010.12
74_S312_L0.5010.12
93_I113_F0.5000.12
36_A177_S0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.858 100 0.518 Contact Map
4un1B 1 0.458 100 0.766 Contact Map
4un1A 1 0.4174 99.9 0.802 Contact Map
2e1cA 1 0.4232 99.9 0.828 Contact Map
4pcqA 2 0.4261 99.9 0.83 Contact Map
2ia0A 2 0.429 99.9 0.83 Contact Map
2cg4A 6 0.4261 99.9 0.837 Contact Map
2p5vA 5 0.4493 99.8 0.839 Contact Map
2pn6A 5 0.4232 99.8 0.843 Contact Map
2dbbA 4 0.4203 99.8 0.844 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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