Q9HNW7 - HALSA - GREMLIN Contacts

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Q9HNW7 - Phosphoribosyl transferase

UniProt:	Q9HNW7	Sequences: MADEYGEWPLKRLNTEVVASGPKSAGDMDREQAREAFQRILDLKPDQTTLGAFWLANRWKKNNPEELGAYVDVMYEESRHTAAPDADPVDCGANYDGKARSAVLGVAAGIVAAAAGTPIVVHSGDHVPSQKEVAYKHVLDALGVRTELTPEASARMVDEHGFGFYYQPAFNPTVDALWDRRDKMGVRTFVNTVETLANPADAAVHLGSFYHLAFAEKMVETVRESEHAGFERVLMFQGLEGYDDVRPGSTTVAEWDAGSDLADFTIETPEYGMDFETEDLHVEDVAADSATITKDVLSGERTDQFHDAVLVNAALRLYARTDVDTLDEGIEAAERVISDGTAEALLADLRAF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	352 (326)
Sequences:	4275 (2797)
Seq/√Len:	154.9

ECOLI - TRPGD YBIB
BACSU - TRPD
HALSA - Q9HNW7 TRPD
SULSO - TRPD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
295_D	300_E	3.910	1.00
30_R	72_D	3.348	1.00
114_A	336_V	3.248	1.00
21_G	32_Q	3.205	1.00
345_L	348_D	3.103	1.00
245_V	250_T	3.078	1.00
306_H	338_S	3.008	1.00
27_D	60_K	2.876	1.00
298_S	343_E	2.829	1.00
269_P	275_F	2.563	1.00
216_E	263_D	2.559	1.00
34_R	72_D	2.554	1.00
291_T	295_D	2.541	1.00
245_V	315_L	2.504	1.00
285_V	288_D	2.469	1.00
107_A	293_T	2.370	1.00
46_D	183_K	2.366	1.00
215_A	253_A	2.355	1.00
155_R	159_E	2.344	1.00
34_R	76_E	2.323	1.00
310_L	334_E	2.287	1.00
157_V	163_G	2.281	1.00
38_Q	77_E	2.244	1.00
52_A	55_L	2.221	1.00
277_T	280_L	2.143	1.00
68_G	227_H	2.141	1.00
115_A	336_V	2.110	1.00
335_R	339_D	2.080	1.00
325_T	328_E	1.996	1.00
29_D	32_Q	1.992	1.00
36_A	53_F	1.983	1.00
153_S	163_G	1.941	1.00
254_E	264_F	1.916	1.00
212_L	251_T	1.902	1.00
239_L	251_T	1.897	1.00
234_L	319_A	1.883	1.00
46_D	49_T	1.881	1.00
111_V	309_V	1.842	1.00
115_A	317_L	1.836	1.00
223_R	255_W	1.832	1.00
91_C	205_H	1.822	1.00
141_A	287_A	1.816	1.00
33_A	70_Y	1.813	1.00
38_Q	76_E	1.813	1.00
283_E	289_S	1.807	1.00
117_T	317_L	1.787	1.00
216_E	220_E	1.777	1.00
267_E	270_E	1.775	1.00
42_D	77_E	1.773	1.00
21_G	26_G	1.771	1.00
331_E	334_E	1.755	1.00
234_L	315_L	1.742	1.00
149_T	152_A	1.740	1.00
253_A	261_L	1.737	1.00
267_E	275_F	1.732	1.00
112_A	117_T	1.715	1.00
252_V	264_F	1.694	1.00
69_A	73_V	1.681	1.00
40_I	50_L	1.648	1.00
160_H	345_L	1.641	1.00
39_R	44_K	1.624	1.00
104_L	308_A	1.609	1.00
344_A	347_A	1.603	1.00
144_V	349_L	1.592	1.00
154_A	158_D	1.573	1.00
38_Q	73_V	1.560	1.00
74_M	197_A	1.553	1.00
114_A	345_L	1.550	1.00
30_R	69_A	1.534	1.00
249_S	265_T	1.532	1.00
343_E	347_A	1.514	1.00
112_A	316_R	1.511	1.00
232_R	256_D	1.500	1.00
148_L	152_A	1.495	1.00
233_V	255_W	1.493	1.00
203_A	231_E	1.479	1.00
55_L	186_V	1.478	1.00
284_D	289_S	1.474	1.00
192_T	214_F	1.470	1.00
294_K	350_R	1.462	1.00
70_Y	189_F	1.460	1.00
314_A	329_G	1.453	1.00
341_T	344_A	1.446	1.00
108_A	313_A	1.431	1.00
323_V	329_G	1.419	1.00
52_A	184_M	1.418	1.00
82_A	154_A	1.411	1.00
279_D	282_V	1.399	1.00
299_G	338_S	1.395	1.00
23_K	186_V	1.389	1.00
80_H	201_D	1.368	1.00
37_F	70_Y	1.356	1.00
138_V	293_T	1.355	1.00
276_E	304_Q	1.354	1.00
99_A	242_Y	1.351	1.00
58_R	62_N	1.345	1.00
251_T	263_D	1.345	1.00
240_E	248_G	1.345	1.00
162_F	349_L	1.345	1.00
294_K	298_S	1.341	1.00
314_A	318_Y	1.332	1.00
239_L	248_G	1.323	1.00
89_V	316_R	1.313	1.00
222_V	233_V	1.313	1.00
334_E	338_S	1.312	1.00
249_S	267_E	1.311	1.00
47_Q	183_K	1.311	1.00
142_L	290_A	1.307	1.00
23_K	55_L	1.303	1.00
113_A	345_L	1.295	1.00
230_F	233_V	1.294	1.00
306_H	334_E	1.292	1.00
322_D	332_A	1.291	1.00
30_R	227_H	1.291	1.00
148_L	156_M	1.283	1.00
138_V	290_A	1.274	1.00
152_A	155_R	1.271	1.00
55_L	59_W	1.262	1.00
347_A	350_R	1.262	1.00
36_A	45_P	1.252	1.00
344_A	348_D	1.246	1.00
97_G	100_R	1.242	1.00
310_L	330_I	1.239	1.00
324_D	328_E	1.232	1.00
64_P	68_G	1.213	1.00
64_P	221_T	1.207	1.00
48_T	183_K	1.203	1.00
50_L	180_R	1.203	1.00
253_A	263_D	1.202	1.00
294_K	347_A	1.169	1.00
18_V	36_A	1.163	1.00
125_D	137_H	1.160	1.00
91_C	135_Y	1.153	1.00
297_L	342_A	1.152	1.00
45_P	50_L	1.143	1.00
303_D	307_D	1.142	1.00
144_V	350_R	1.139	1.00
223_R	261_L	1.129	1.00
48_T	51_G	1.128	1.00
238_G	248_G	1.121	1.00
174_V	177_L	1.120	1.00
314_A	330_I	1.109	0.99
329_G	333_A	1.107	0.99
65_E	227_H	1.101	0.99
88_P	202_A	1.098	0.99
257_A	260_D	1.096	0.99
220_E	223_R	1.095	0.99
34_R	73_V	1.094	0.99
232_R	254_E	1.084	0.99
73_V	77_E	1.070	0.99
108_A	112_A	1.067	0.99
177_L	180_R	1.066	0.99
266_I	271_Y	1.063	0.99
125_D	140_D	1.058	0.99
117_T	320_R	1.058	0.99
33_A	69_A	1.057	0.99
251_T	265_T	1.052	0.99
296_V	305_F	1.045	0.99
53_F	70_Y	1.038	0.99
245_V	311_V	1.035	0.99
91_C	108_A	1.033	0.99
136_K	166_Y	1.028	0.99
38_Q	42_D	1.025	0.99
223_R	227_H	1.019	0.99
245_V	266_I	1.017	0.99
284_D	288_D	1.014	0.99
271_Y	330_I	1.010	0.99
250_T	268_T	1.005	0.99
74_M	174_V	1.000	0.99
327_D	331_E	0.998	0.99
205_H	230_F	0.998	0.99
49_T	183_K	0.997	0.99
273_M	311_V	0.994	0.99
239_L	249_S	0.987	0.99
153_S	170_F	0.972	0.99
87_D	203_A	0.972	0.99
41_L	74_M	0.964	0.99
48_T	180_R	0.963	0.99
267_E	271_Y	0.962	0.99
102_A	292_I	0.957	0.99
255_W	261_L	0.957	0.99
254_E	318_Y	0.955	0.98
144_V	162_F	0.954	0.98
291_T	294_K	0.952	0.98
31_E	34_R	0.946	0.98
296_V	309_V	0.945	0.98
20_S	24_S	0.931	0.98
335_R	341_T	0.928	0.98
332_A	335_R	0.926	0.98
117_T	322_D	0.926	0.98
127_V	168_P	0.923	0.98
294_K	343_E	0.917	0.98
307_D	334_E	0.917	0.98
239_L	265_T	0.915	0.98
323_V	332_A	0.911	0.98
112_A	119_I	0.909	0.98
130_Q	285_V	0.906	0.98
153_S	157_V	0.905	0.98
331_E	335_R	0.903	0.98
204_V	231_E	0.903	0.98
276_E	307_D	0.900	0.98
179_D	183_K	0.893	0.98
62_N	67_L	0.893	0.98
88_P	120_V	0.893	0.98
206_L	236_F	0.891	0.98
65_E	69_A	0.886	0.98
60_K	66_E	0.883	0.97
332_A	336_V	0.883	0.97
204_V	319_A	0.882	0.97
204_V	232_R	0.881	0.97
27_D	65_E	0.875	0.97
276_E	281_H	0.874	0.97
64_P	220_E	0.873	0.97
45_P	49_T	0.873	0.97
68_G	221_T	0.870	0.97
62_N	187_R	0.870	0.97
50_L	177_L	0.866	0.97
287_A	291_T	0.861	0.97
33_A	189_F	0.858	0.97
290_A	294_K	0.858	0.97
234_L	318_Y	0.847	0.97
280_L	304_Q	0.844	0.97
68_G	72_D	0.841	0.97
274_D	307_D	0.840	0.97
159_E	348_D	0.840	0.97
286_A	290_A	0.839	0.97
112_A	118_P	0.838	0.97
87_D	204_V	0.835	0.96
39_R	45_P	0.834	0.96
23_K	58_R	0.833	0.96
71_V	228_A	0.829	0.96
28_M	66_E	0.829	0.96
75_Y	201_D	0.829	0.96
321_T	329_G	0.827	0.96
238_G	246_R	0.826	0.96
118_P	158_D	0.824	0.96
156_M	163_G	0.824	0.96
40_I	177_L	0.821	0.96
84_P	158_D	0.821	0.96
303_D	338_S	0.819	0.96
47_Q	180_R	0.817	0.96
310_L	338_S	0.816	0.96
295_D	301_R	0.815	0.96
273_M	330_I	0.814	0.96
74_M	193_V	0.813	0.96
156_M	160_H	0.812	0.96
111_V	337_I	0.811	0.96
52_A	186_V	0.810	0.96
209_F	218_M	0.808	0.96
67_L	221_T	0.805	0.96
237_Q	241_G	0.805	0.96
47_Q	179_D	0.804	0.96
22_P	56_A	0.802	0.96
160_H	349_L	0.802	0.96
218_M	235_M	0.801	0.96
318_Y	323_V	0.798	0.95
79_R	172_P	0.797	0.95
41_L	197_A	0.793	0.95
35_E	39_R	0.793	0.95
147_E	169_A	0.790	0.95
142_L	346_L	0.789	0.95
314_A	326_L	0.788	0.95
27_D	63_N	0.787	0.95
34_R	69_A	0.778	0.95
99_A	278_E	0.778	0.95
96_D	101_S	0.777	0.95
297_L	343_E	0.777	0.95
106_V	139_L	0.776	0.95
56_A	60_K	0.774	0.95
270_E	327_D	0.773	0.95
30_R	68_G	0.769	0.94
240_E	246_R	0.769	0.94
43_L	176_A	0.763	0.94
107_A	297_L	0.758	0.94
214_F	217_K	0.757	0.94
64_P	227_H	0.756	0.94
247_P	277_T	0.755	0.94
318_Y	325_T	0.754	0.94
150_P	154_A	0.752	0.94
315_L	326_L	0.751	0.94
111_V	313_A	0.749	0.94
102_A	305_F	0.743	0.93
153_S	165_Y	0.742	0.93
112_A	115_A	0.740	0.93
245_V	271_Y	0.737	0.93
89_V	119_I	0.737	0.93
141_A	286_A	0.732	0.93
110_I	345_L	0.731	0.93
131_K	286_A	0.729	0.93
231_E	257_A	0.726	0.93
155_R	158_D	0.724	0.92
101_S	242_Y	0.718	0.92
234_L	264_F	0.715	0.92
51_G	180_R	0.714	0.92
210_Y	214_F	0.711	0.92
144_V	346_L	0.709	0.92
216_E	253_A	0.708	0.92
36_A	40_I	0.707	0.92
317_L	323_V	0.706	0.91
234_L	252_V	0.705	0.91
207_G	218_M	0.699	0.91
81_T	153_S	0.696	0.91
304_Q	307_D	0.689	0.90
83_A	157_V	0.688	0.90
16_E	185_G	0.687	0.90
110_I	349_L	0.685	0.90
78_S	197_A	0.684	0.90
321_T	332_A	0.682	0.90
64_P	217_K	0.681	0.90
174_V	197_A	0.678	0.90
47_Q	176_A	0.676	0.90
31_E	35_E	0.672	0.89
110_I	162_F	0.672	0.89
34_R	38_Q	0.672	0.89
25_A	59_W	0.669	0.89
242_Y	278_E	0.668	0.89
345_L	349_L	0.667	0.89
306_H	310_L	0.666	0.89
206_L	319_A	0.665	0.89
318_Y	326_L	0.659	0.88
336_V	342_A	0.656	0.88
152_A	156_M	0.656	0.88
100_R	282_V	0.655	0.88
57_N	62_N	0.654	0.88
41_L	176_A	0.651	0.88
240_E	247_P	0.650	0.88
212_L	263_D	0.650	0.88
37_F	189_F	0.647	0.88
23_K	59_W	0.645	0.87
288_D	291_T	0.645	0.87
149_T	169_A	0.644	0.87
138_V	142_L	0.644	0.87
67_L	192_T	0.644	0.87
54_W	174_V	0.643	0.87
79_R	150_P	0.642	0.87
204_V	320_R	0.641	0.87
136_K	140_D	0.641	0.87
100_R	130_Q	0.640	0.87
30_R	65_E	0.639	0.87
114_A	342_A	0.638	0.87
75_Y	228_A	0.637	0.87
21_G	25_A	0.637	0.87
346_L	350_R	0.632	0.86
240_E	250_T	0.631	0.86
254_E	262_A	0.629	0.86
153_S	156_M	0.625	0.86
326_L	329_G	0.625	0.86
306_H	309_V	0.623	0.86
317_L	333_A	0.621	0.85
220_E	261_L	0.621	0.85
317_L	322_D	0.618	0.85
222_V	230_F	0.618	0.85
66_E	69_A	0.616	0.85
70_Y	193_V	0.616	0.85
112_A	313_A	0.615	0.85
276_E	280_L	0.615	0.85
188_T	191_N	0.614	0.85
109_G	162_F	0.614	0.85
120_V	165_Y	0.612	0.84
168_P	182_D	0.612	0.84
256_D	262_A	0.611	0.84
141_A	290_A	0.611	0.84
318_Y	329_G	0.611	0.84
292_I	296_V	0.609	0.84
318_Y	322_D	0.608	0.84
16_E	20_S	0.607	0.84
107_A	296_V	0.607	0.84
83_A	154_A	0.607	0.84
271_Y	326_L	0.606	0.84
72_D	76_E	0.605	0.84
283_E	292_I	0.604	0.84
96_D	100_R	0.604	0.84
71_V	193_V	0.602	0.84
55_L	184_M	0.600	0.83
330_I	334_E	0.600	0.83
247_P	278_E	0.598	0.83
112_A	317_L	0.598	0.83
63_N	66_E	0.597	0.83
223_R	260_D	0.592	0.83
264_F	318_Y	0.592	0.83
145_R	152_A	0.591	0.82
71_V	74_M	0.590	0.82
89_V	202_A	0.588	0.82
52_A	59_W	0.587	0.82
269_P	274_D	0.585	0.82
303_D	306_H	0.585	0.82
220_E	227_H	0.585	0.82
215_A	263_D	0.584	0.82
51_G	55_L	0.582	0.81
110_I	346_L	0.582	0.81
255_W	258_G	0.581	0.81
234_L	326_L	0.579	0.81
291_T	300_E	0.579	0.81
56_A	59_W	0.579	0.81
310_L	337_I	0.578	0.81
240_E	278_E	0.577	0.81
247_P	280_L	0.575	0.81
110_I	144_V	0.574	0.81
73_V	76_E	0.574	0.81
135_Y	138_V	0.573	0.80
281_H	308_A	0.572	0.80
336_V	345_L	0.567	0.80
36_A	39_R	0.567	0.80
89_V	319_A	0.566	0.80
99_A	282_V	0.566	0.80
207_G	222_V	0.564	0.79
215_A	251_T	0.564	0.79
212_L	239_L	0.564	0.79
249_S	275_F	0.562	0.79
91_C	192_T	0.561	0.79
314_A	325_T	0.559	0.79
107_A	131_K	0.558	0.79
71_V	75_Y	0.557	0.79
310_L	314_A	0.556	0.78
138_V	346_L	0.555	0.78
52_A	56_A	0.555	0.78
120_V	157_V	0.555	0.78
342_A	346_L	0.555	0.78
110_I	114_A	0.552	0.78
207_G	235_M	0.552	0.78
161_G	345_L	0.551	0.78
328_E	331_E	0.551	0.78
101_S	104_L	0.550	0.78
219_V	255_W	0.550	0.78
293_T	297_L	0.549	0.78
94_N	194_E	0.548	0.77
142_L	294_K	0.547	0.77
22_P	53_F	0.546	0.77
151_E	154_A	0.546	0.77
296_V	301_R	0.545	0.77
317_L	329_G	0.545	0.77
58_R	185_G	0.545	0.77
18_V	39_R	0.543	0.77
97_G	128_P	0.542	0.77
89_V	108_A	0.541	0.77
340_G	343_E	0.540	0.76
108_A	309_V	0.539	0.76
83_A	86_A	0.538	0.76
232_R	321_T	0.538	0.76
107_A	309_V	0.538	0.76
32_Q	69_A	0.538	0.76
96_D	129_S	0.538	0.76
239_L	246_R	0.537	0.76
81_T	165_Y	0.537	0.76
271_Y	311_V	0.534	0.76
54_W	177_L	0.533	0.76
257_A	262_A	0.533	0.76
232_R	318_Y	0.531	0.75
110_I	293_T	0.531	0.75
52_A	180_R	0.531	0.75
292_I	305_F	0.529	0.75
313_A	316_R	0.529	0.75
91_C	109_G	0.527	0.75
78_S	171_N	0.526	0.75
159_E	344_A	0.525	0.74
339_D	342_A	0.523	0.74
17_V	20_S	0.523	0.74
127_V	210_Y	0.522	0.74
301_R	304_Q	0.522	0.74
71_V	196_L	0.520	0.74
156_M	162_F	0.519	0.74
21_G	29_D	0.519	0.74
95_Y	195_T	0.518	0.73
236_F	245_V	0.517	0.73
341_T	345_L	0.516	0.73
314_A	333_A	0.515	0.73
145_R	148_L	0.515	0.73
96_D	99_A	0.515	0.73
83_A	88_P	0.515	0.73
299_G	306_H	0.514	0.73
268_T	275_F	0.512	0.73
86_A	158_D	0.512	0.73
48_T	55_L	0.511	0.72
46_D	180_R	0.510	0.72
328_E	332_A	0.510	0.72
317_L	332_A	0.509	0.72
205_H	233_V	0.507	0.72
103_V	121_V	0.506	0.72
125_D	166_Y	0.505	0.72
301_R	305_F	0.505	0.72
40_I	53_F	0.505	0.72
17_V	21_G	0.504	0.71
94_N	121_V	0.502	0.71
236_F	252_V	0.501	0.71
217_K	220_E	0.501	0.71
118_P	161_G	0.501	0.71
33_A	37_F	0.500	0.71
46_D	50_L	0.500	0.71
92_G	243_D	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4gtnA	2	0.9233	100	0.094	Contact Map
1khdA	2	0.9318	100	0.101	Contact Map
1vquA	2	0.9318	100	0.103	Contact Map
4giuA	2	0.9375	100	0.113	Contact Map
4hkmA	2	0.9176	100	0.122	Contact Map
2elcA	4	0.9233	100	0.122	Contact Map
1o17A	2	0.929	100	0.132	Contact Map
4muoA	2	0.8636	100	0.18	Contact Map
3h5qA	2	0.8438	100	0.324	Contact Map
1brwA	2	0.8352	100	0.334	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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