GREMLIN Database
Q9HNW7 - Phosphoribosyl transferase
UniProt: Q9HNW7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (326)
Sequences: 4275 (2797)
Seq/√Len: 154.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
295_D300_E3.9101.00
30_R72_D3.3481.00
114_A336_V3.2481.00
21_G32_Q3.2051.00
345_L348_D3.1031.00
245_V250_T3.0781.00
306_H338_S3.0081.00
27_D60_K2.8761.00
298_S343_E2.8291.00
269_P275_F2.5631.00
216_E263_D2.5591.00
34_R72_D2.5541.00
291_T295_D2.5411.00
245_V315_L2.5041.00
285_V288_D2.4691.00
107_A293_T2.3701.00
46_D183_K2.3661.00
215_A253_A2.3551.00
155_R159_E2.3441.00
34_R76_E2.3231.00
310_L334_E2.2871.00
157_V163_G2.2811.00
38_Q77_E2.2441.00
52_A55_L2.2211.00
277_T280_L2.1431.00
68_G227_H2.1411.00
115_A336_V2.1101.00
335_R339_D2.0801.00
325_T328_E1.9961.00
29_D32_Q1.9921.00
36_A53_F1.9831.00
153_S163_G1.9411.00
254_E264_F1.9161.00
212_L251_T1.9021.00
239_L251_T1.8971.00
234_L319_A1.8831.00
46_D49_T1.8811.00
111_V309_V1.8421.00
115_A317_L1.8361.00
223_R255_W1.8321.00
91_C205_H1.8221.00
141_A287_A1.8161.00
33_A70_Y1.8131.00
38_Q76_E1.8131.00
283_E289_S1.8071.00
117_T317_L1.7871.00
216_E220_E1.7771.00
267_E270_E1.7751.00
42_D77_E1.7731.00
21_G26_G1.7711.00
331_E334_E1.7551.00
234_L315_L1.7421.00
149_T152_A1.7401.00
253_A261_L1.7371.00
267_E275_F1.7321.00
112_A117_T1.7151.00
252_V264_F1.6941.00
69_A73_V1.6811.00
40_I50_L1.6481.00
160_H345_L1.6411.00
39_R44_K1.6241.00
104_L308_A1.6091.00
344_A347_A1.6031.00
144_V349_L1.5921.00
154_A158_D1.5731.00
38_Q73_V1.5601.00
74_M197_A1.5531.00
114_A345_L1.5501.00
30_R69_A1.5341.00
249_S265_T1.5321.00
343_E347_A1.5141.00
112_A316_R1.5111.00
232_R256_D1.5001.00
148_L152_A1.4951.00
233_V255_W1.4931.00
203_A231_E1.4791.00
55_L186_V1.4781.00
284_D289_S1.4741.00
192_T214_F1.4701.00
294_K350_R1.4621.00
70_Y189_F1.4601.00
314_A329_G1.4531.00
341_T344_A1.4461.00
108_A313_A1.4311.00
323_V329_G1.4191.00
52_A184_M1.4181.00
82_A154_A1.4111.00
279_D282_V1.3991.00
299_G338_S1.3951.00
23_K186_V1.3891.00
80_H201_D1.3681.00
37_F70_Y1.3561.00
138_V293_T1.3551.00
276_E304_Q1.3541.00
99_A242_Y1.3511.00
58_R62_N1.3451.00
251_T263_D1.3451.00
240_E248_G1.3451.00
162_F349_L1.3451.00
294_K298_S1.3411.00
314_A318_Y1.3321.00
239_L248_G1.3231.00
89_V316_R1.3131.00
222_V233_V1.3131.00
334_E338_S1.3121.00
249_S267_E1.3111.00
47_Q183_K1.3111.00
142_L290_A1.3071.00
23_K55_L1.3031.00
113_A345_L1.2951.00
230_F233_V1.2941.00
306_H334_E1.2921.00
322_D332_A1.2911.00
30_R227_H1.2911.00
148_L156_M1.2831.00
138_V290_A1.2741.00
152_A155_R1.2711.00
55_L59_W1.2621.00
347_A350_R1.2621.00
36_A45_P1.2521.00
344_A348_D1.2461.00
97_G100_R1.2421.00
310_L330_I1.2391.00
324_D328_E1.2321.00
64_P68_G1.2131.00
64_P221_T1.2071.00
48_T183_K1.2031.00
50_L180_R1.2031.00
253_A263_D1.2021.00
294_K347_A1.1691.00
18_V36_A1.1631.00
125_D137_H1.1601.00
91_C135_Y1.1531.00
297_L342_A1.1521.00
45_P50_L1.1431.00
303_D307_D1.1421.00
144_V350_R1.1391.00
223_R261_L1.1291.00
48_T51_G1.1281.00
238_G248_G1.1211.00
174_V177_L1.1201.00
314_A330_I1.1090.99
329_G333_A1.1070.99
65_E227_H1.1010.99
88_P202_A1.0980.99
257_A260_D1.0960.99
220_E223_R1.0950.99
34_R73_V1.0940.99
232_R254_E1.0840.99
73_V77_E1.0700.99
108_A112_A1.0670.99
177_L180_R1.0660.99
266_I271_Y1.0630.99
125_D140_D1.0580.99
117_T320_R1.0580.99
33_A69_A1.0570.99
251_T265_T1.0520.99
296_V305_F1.0450.99
53_F70_Y1.0380.99
245_V311_V1.0350.99
91_C108_A1.0330.99
136_K166_Y1.0280.99
38_Q42_D1.0250.99
223_R227_H1.0190.99
245_V266_I1.0170.99
284_D288_D1.0140.99
271_Y330_I1.0100.99
250_T268_T1.0050.99
74_M174_V1.0000.99
327_D331_E0.9980.99
205_H230_F0.9980.99
49_T183_K0.9970.99
273_M311_V0.9940.99
239_L249_S0.9870.99
153_S170_F0.9720.99
87_D203_A0.9720.99
41_L74_M0.9640.99
48_T180_R0.9630.99
267_E271_Y0.9620.99
102_A292_I0.9570.99
255_W261_L0.9570.99
254_E318_Y0.9550.98
144_V162_F0.9540.98
291_T294_K0.9520.98
31_E34_R0.9460.98
296_V309_V0.9450.98
20_S24_S0.9310.98
335_R341_T0.9280.98
332_A335_R0.9260.98
117_T322_D0.9260.98
127_V168_P0.9230.98
294_K343_E0.9170.98
307_D334_E0.9170.98
239_L265_T0.9150.98
323_V332_A0.9110.98
112_A119_I0.9090.98
130_Q285_V0.9060.98
153_S157_V0.9050.98
331_E335_R0.9030.98
204_V231_E0.9030.98
276_E307_D0.9000.98
179_D183_K0.8930.98
62_N67_L0.8930.98
88_P120_V0.8930.98
206_L236_F0.8910.98
65_E69_A0.8860.98
60_K66_E0.8830.97
332_A336_V0.8830.97
204_V319_A0.8820.97
204_V232_R0.8810.97
27_D65_E0.8750.97
276_E281_H0.8740.97
64_P220_E0.8730.97
45_P49_T0.8730.97
68_G221_T0.8700.97
62_N187_R0.8700.97
50_L177_L0.8660.97
287_A291_T0.8610.97
33_A189_F0.8580.97
290_A294_K0.8580.97
234_L318_Y0.8470.97
280_L304_Q0.8440.97
68_G72_D0.8410.97
274_D307_D0.8400.97
159_E348_D0.8400.97
286_A290_A0.8390.97
112_A118_P0.8380.97
87_D204_V0.8350.96
39_R45_P0.8340.96
23_K58_R0.8330.96
71_V228_A0.8290.96
28_M66_E0.8290.96
75_Y201_D0.8290.96
321_T329_G0.8270.96
238_G246_R0.8260.96
118_P158_D0.8240.96
156_M163_G0.8240.96
40_I177_L0.8210.96
84_P158_D0.8210.96
303_D338_S0.8190.96
47_Q180_R0.8170.96
310_L338_S0.8160.96
295_D301_R0.8150.96
273_M330_I0.8140.96
74_M193_V0.8130.96
156_M160_H0.8120.96
111_V337_I0.8110.96
52_A186_V0.8100.96
209_F218_M0.8080.96
67_L221_T0.8050.96
237_Q241_G0.8050.96
47_Q179_D0.8040.96
22_P56_A0.8020.96
160_H349_L0.8020.96
218_M235_M0.8010.96
318_Y323_V0.7980.95
79_R172_P0.7970.95
41_L197_A0.7930.95
35_E39_R0.7930.95
147_E169_A0.7900.95
142_L346_L0.7890.95
314_A326_L0.7880.95
27_D63_N0.7870.95
34_R69_A0.7780.95
99_A278_E0.7780.95
96_D101_S0.7770.95
297_L343_E0.7770.95
106_V139_L0.7760.95
56_A60_K0.7740.95
270_E327_D0.7730.95
30_R68_G0.7690.94
240_E246_R0.7690.94
43_L176_A0.7630.94
107_A297_L0.7580.94
214_F217_K0.7570.94
64_P227_H0.7560.94
247_P277_T0.7550.94
318_Y325_T0.7540.94
150_P154_A0.7520.94
315_L326_L0.7510.94
111_V313_A0.7490.94
102_A305_F0.7430.93
153_S165_Y0.7420.93
112_A115_A0.7400.93
245_V271_Y0.7370.93
89_V119_I0.7370.93
141_A286_A0.7320.93
110_I345_L0.7310.93
131_K286_A0.7290.93
231_E257_A0.7260.93
155_R158_D0.7240.92
101_S242_Y0.7180.92
234_L264_F0.7150.92
51_G180_R0.7140.92
210_Y214_F0.7110.92
144_V346_L0.7090.92
216_E253_A0.7080.92
36_A40_I0.7070.92
317_L323_V0.7060.91
234_L252_V0.7050.91
207_G218_M0.6990.91
81_T153_S0.6960.91
304_Q307_D0.6890.90
83_A157_V0.6880.90
16_E185_G0.6870.90
110_I349_L0.6850.90
78_S197_A0.6840.90
321_T332_A0.6820.90
64_P217_K0.6810.90
174_V197_A0.6780.90
47_Q176_A0.6760.90
31_E35_E0.6720.89
110_I162_F0.6720.89
34_R38_Q0.6720.89
25_A59_W0.6690.89
242_Y278_E0.6680.89
345_L349_L0.6670.89
306_H310_L0.6660.89
206_L319_A0.6650.89
318_Y326_L0.6590.88
336_V342_A0.6560.88
152_A156_M0.6560.88
100_R282_V0.6550.88
57_N62_N0.6540.88
41_L176_A0.6510.88
240_E247_P0.6500.88
212_L263_D0.6500.88
37_F189_F0.6470.88
23_K59_W0.6450.87
288_D291_T0.6450.87
149_T169_A0.6440.87
138_V142_L0.6440.87
67_L192_T0.6440.87
54_W174_V0.6430.87
79_R150_P0.6420.87
204_V320_R0.6410.87
136_K140_D0.6410.87
100_R130_Q0.6400.87
30_R65_E0.6390.87
114_A342_A0.6380.87
75_Y228_A0.6370.87
21_G25_A0.6370.87
346_L350_R0.6320.86
240_E250_T0.6310.86
254_E262_A0.6290.86
153_S156_M0.6250.86
326_L329_G0.6250.86
306_H309_V0.6230.86
317_L333_A0.6210.85
220_E261_L0.6210.85
317_L322_D0.6180.85
222_V230_F0.6180.85
66_E69_A0.6160.85
70_Y193_V0.6160.85
112_A313_A0.6150.85
276_E280_L0.6150.85
188_T191_N0.6140.85
109_G162_F0.6140.85
120_V165_Y0.6120.84
168_P182_D0.6120.84
256_D262_A0.6110.84
141_A290_A0.6110.84
318_Y329_G0.6110.84
292_I296_V0.6090.84
318_Y322_D0.6080.84
16_E20_S0.6070.84
107_A296_V0.6070.84
83_A154_A0.6070.84
271_Y326_L0.6060.84
72_D76_E0.6050.84
283_E292_I0.6040.84
96_D100_R0.6040.84
71_V193_V0.6020.84
55_L184_M0.6000.83
330_I334_E0.6000.83
247_P278_E0.5980.83
112_A317_L0.5980.83
63_N66_E0.5970.83
223_R260_D0.5920.83
264_F318_Y0.5920.83
145_R152_A0.5910.82
71_V74_M0.5900.82
89_V202_A0.5880.82
52_A59_W0.5870.82
269_P274_D0.5850.82
303_D306_H0.5850.82
220_E227_H0.5850.82
215_A263_D0.5840.82
51_G55_L0.5820.81
110_I346_L0.5820.81
255_W258_G0.5810.81
234_L326_L0.5790.81
291_T300_E0.5790.81
56_A59_W0.5790.81
310_L337_I0.5780.81
240_E278_E0.5770.81
247_P280_L0.5750.81
110_I144_V0.5740.81
73_V76_E0.5740.81
135_Y138_V0.5730.80
281_H308_A0.5720.80
336_V345_L0.5670.80
36_A39_R0.5670.80
89_V319_A0.5660.80
99_A282_V0.5660.80
207_G222_V0.5640.79
215_A251_T0.5640.79
212_L239_L0.5640.79
249_S275_F0.5620.79
91_C192_T0.5610.79
314_A325_T0.5590.79
107_A131_K0.5580.79
71_V75_Y0.5570.79
310_L314_A0.5560.78
138_V346_L0.5550.78
52_A56_A0.5550.78
120_V157_V0.5550.78
342_A346_L0.5550.78
110_I114_A0.5520.78
207_G235_M0.5520.78
161_G345_L0.5510.78
328_E331_E0.5510.78
101_S104_L0.5500.78
219_V255_W0.5500.78
293_T297_L0.5490.78
94_N194_E0.5480.77
142_L294_K0.5470.77
22_P53_F0.5460.77
151_E154_A0.5460.77
296_V301_R0.5450.77
317_L329_G0.5450.77
58_R185_G0.5450.77
18_V39_R0.5430.77
97_G128_P0.5420.77
89_V108_A0.5410.77
340_G343_E0.5400.76
108_A309_V0.5390.76
83_A86_A0.5380.76
232_R321_T0.5380.76
107_A309_V0.5380.76
32_Q69_A0.5380.76
96_D129_S0.5380.76
239_L246_R0.5370.76
81_T165_Y0.5370.76
271_Y311_V0.5340.76
54_W177_L0.5330.76
257_A262_A0.5330.76
232_R318_Y0.5310.75
110_I293_T0.5310.75
52_A180_R0.5310.75
292_I305_F0.5290.75
313_A316_R0.5290.75
91_C109_G0.5270.75
78_S171_N0.5260.75
159_E344_A0.5250.74
339_D342_A0.5230.74
17_V20_S0.5230.74
127_V210_Y0.5220.74
301_R304_Q0.5220.74
71_V196_L0.5200.74
156_M162_F0.5190.74
21_G29_D0.5190.74
95_Y195_T0.5180.73
236_F245_V0.5170.73
341_T345_L0.5160.73
314_A333_A0.5150.73
145_R148_L0.5150.73
96_D99_A0.5150.73
83_A88_P0.5150.73
299_G306_H0.5140.73
268_T275_F0.5120.73
86_A158_D0.5120.73
48_T55_L0.5110.72
46_D180_R0.5100.72
328_E332_A0.5100.72
317_L332_A0.5090.72
205_H233_V0.5070.72
103_V121_V0.5060.72
125_D166_Y0.5050.72
301_R305_F0.5050.72
40_I53_F0.5050.72
17_V21_G0.5040.71
94_N121_V0.5020.71
236_F252_V0.5010.71
217_K220_E0.5010.71
118_P161_G0.5010.71
33_A37_F0.5000.71
46_D50_L0.5000.71
92_G243_D0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gtnA 2 0.9233 100 0.094 Contact Map
1khdA 2 0.9318 100 0.101 Contact Map
1vquA 2 0.9318 100 0.103 Contact Map
4giuA 2 0.9375 100 0.113 Contact Map
4hkmA 2 0.9176 100 0.122 Contact Map
2elcA 4 0.9233 100 0.122 Contact Map
1o17A 2 0.929 100 0.132 Contact Map
4muoA 2 0.8636 100 0.18 Contact Map
3h5qA 2 0.8438 100 0.324 Contact Map
1brwA 2 0.8352 100 0.334 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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