GREMLIN Database
Q9HNW6 - Peptidyl-prolyl isomerase
UniProt: Q9HNW6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (144)
Sequences: 8503 (4588)
Seq/√Len: 382.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_P163_E3.5401.00
139_L166_G3.4101.00
119_G159_M3.0271.00
75_A184_R2.6631.00
24_D157_D2.6171.00
17_H22_E2.5331.00
115_H122_S2.4851.00
117_G154_A2.3801.00
77_V90_G2.2011.00
122_S136_F2.1841.00
37_E41_N1.9671.00
78_S179_E1.9601.00
25_I121_L1.9371.00
23_F162_V1.9161.00
105_F131_N1.8901.00
168_V180_I1.8891.00
26_E154_A1.6541.00
84_E166_G1.6171.00
88_I139_L1.6161.00
20_E164_T1.6061.00
34_R106_A1.6041.00
169_E177_A1.5951.00
17_H186_E1.5741.00
17_H184_R1.5721.00
138_T142_Q1.5311.00
29_D36_V1.5231.00
23_F155_V1.5161.00
26_E156_T1.4801.00
17_H183_D1.4581.00
84_E167_D1.4491.00
120_V154_A1.4381.00
116_D120_V1.4371.00
71_D102_G1.4361.00
171_D177_A1.4241.00
31_R113_L1.4111.00
82_I165_I1.4091.00
84_E170_T1.3901.00
83_I87_M1.3891.00
165_I180_I1.3761.00
88_I165_I1.3721.00
170_T174_D1.3551.00
26_E29_D1.3531.00
120_V138_T1.3521.00
79_F90_G1.3521.00
72_S75_A1.3361.00
115_H146_D1.3131.00
117_G120_V1.3131.00
155_V159_M1.3121.00
43_A185_V1.3061.00
116_D154_A1.3001.00
163_E166_G1.2671.00
31_R112_D1.2601.00
73_L93_P1.2391.00
106_A129_D1.2141.00
114_T146_D1.2091.00
182_I185_V1.1931.00
83_I174_D1.1931.00
119_G163_E1.1901.00
109_F147_G1.1791.00
27_L36_V1.1761.00
97_G100_G1.1451.00
85_G140_D1.1231.00
78_S181_T1.1201.00
28_Y31_R1.1151.00
40_L44_R1.1031.00
100_G133_S1.0981.00
32_A36_V1.0811.00
41_N44_R1.0801.00
155_V162_V1.0711.00
122_S146_D1.0601.00
78_S95_G1.0541.00
41_N71_D1.0511.00
105_F108_E1.0411.00
78_S175_A1.0391.00
28_Y154_A1.0261.00
125_N130_T1.0251.00
104_E132_G1.0201.00
137_I162_V1.0191.00
120_V151_V1.0031.00
36_V40_L1.0001.00
107_D125_N0.9841.00
73_L133_S0.9751.00
41_N102_G0.9711.00
168_V178_S0.9651.00
171_D175_A0.9601.00
96_T99_G0.9581.00
93_P99_G0.9421.00
139_L162_V0.9401.00
159_M162_V0.9341.00
107_D131_N0.9241.00
114_T143_P0.9191.00
169_E174_D0.9131.00
101_P132_G0.9091.00
25_I137_I0.9031.00
77_V92_D0.8951.00
81_R89_Q0.8831.00
22_E186_E0.8821.00
94_T98_R0.8811.00
19_S183_D0.8811.00
121_L152_F0.8801.00
42_L185_V0.8781.00
104_E126_S0.8561.00
80_H95_G0.8501.00
24_D156_T0.8481.00
82_I139_L0.8471.00
82_I88_I0.8471.00
107_D129_D0.8441.00
34_R37_E0.8381.00
122_S151_V0.8341.00
82_I180_I0.8291.00
110_H147_G0.8281.00
73_L101_P0.8231.00
159_M163_E0.8181.00
89_Q134_Q0.8161.00
20_E168_V0.8141.00
80_H134_Q0.8071.00
20_E178_S0.7901.00
125_N149_H0.7891.00
137_I155_V0.7841.00
37_E40_L0.7841.00
126_S130_T0.7781.00
87_M144_H0.7741.00
76_G181_T0.7731.00
87_M139_L0.7641.00
85_G166_G0.7641.00
160_D164_T0.7611.00
103_Y132_G0.7531.00
84_E139_L0.7401.00
125_N131_N0.7391.00
89_Q124_A0.7391.00
115_H136_F0.7381.00
158_G161_V0.7321.00
161_V164_T0.7291.00
118_P159_M0.7271.00
143_P146_D0.7261.00
116_D141_A0.7241.00
92_D97_G0.7201.00
118_P140_D0.7171.00
39_F43_A0.7131.00
19_S181_T0.7091.00
170_T176_P0.7081.00
32_A150_A0.7031.00
92_D99_G0.7031.00
25_I155_V0.6970.99
81_R124_A0.6900.99
23_F137_I0.6870.99
174_D177_A0.6840.99
76_G183_D0.6770.99
35_T123_M0.6720.99
95_G99_G0.6710.99
94_T100_G0.6690.99
123_M131_N0.6650.99
32_A35_T0.6600.99
72_S101_P0.6550.99
32_A109_F0.6540.99
42_L71_D0.6510.99
75_A185_V0.6500.99
29_D37_E0.6460.99
97_G101_P0.6450.99
113_L151_V0.6400.99
114_T147_G0.6390.99
115_H138_T0.6390.99
116_D146_D0.6330.99
140_D144_H0.6280.99
118_P141_A0.6270.99
118_P139_L0.6190.99
88_I137_I0.6170.99
164_T167_D0.6090.99
156_T160_D0.6080.99
77_V93_P0.6050.99
175_A179_E0.6040.99
73_L77_V0.6000.98
24_D158_G0.5960.98
102_G132_G0.5950.98
29_D40_L0.5920.98
127_G148_R0.5900.98
35_T150_A0.5860.98
171_D174_D0.5850.98
96_T100_G0.5850.98
109_F112_D0.5840.98
35_T152_F0.5830.98
127_G130_T0.5820.98
90_G121_L0.5810.98
40_L43_A0.5780.98
35_T39_F0.5750.98
93_P132_G0.5750.98
170_T177_A0.5720.98
34_R105_F0.5700.98
77_V94_T0.5660.98
80_H124_A0.5640.98
23_F165_I0.5540.97
139_L163_E0.5540.97
109_F113_L0.5530.97
72_S184_R0.5510.97
93_P96_T0.5500.97
92_D100_G0.5450.97
28_Y121_L0.5450.97
41_N72_S0.5400.97
107_D149_H0.5400.97
121_L153_G0.5370.97
28_Y120_V0.5330.97
36_V39_F0.5310.97
77_V182_I0.5280.97
18_T21_G0.5260.96
163_E167_D0.5250.96
105_F123_M0.5220.96
164_T168_V0.5170.96
43_A183_D0.5090.96
39_F42_L0.5080.96
17_H20_E0.5050.96
86_F89_Q0.5040.96
131_N150_A0.5020.95
157_D160_D0.5010.95
20_E180_I0.5000.95
78_S96_T0.5000.95
86_F145_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w74A 1 0.8942 100 0.199 Contact Map
2k7nA 1 0.8624 100 0.21 Contact Map
2fu0A 1 0.8042 100 0.211 Contact Map
2x7kA 1 0.8519 100 0.216 Contact Map
3bo7A 3 0.8042 100 0.219 Contact Map
2poeA 1 0.8148 100 0.221 Contact Map
2b71A 1 0.8466 100 0.223 Contact Map
1zkcA 1 0.8519 100 0.224 Contact Map
2ok3A 1 0.8042 100 0.226 Contact Map
2a2nA 1 0.8466 100 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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