GREMLIN Database
CRCB1 - Putative fluoride ion transporter CrcB 1
UniProt: Q9HNW2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (110)
Sequences: 4197 (3233)
Seq/√Len: 308.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_V74_F4.0831.00
46_G75_T3.9791.00
50_L67_G3.0421.00
16_G20_A3.0081.00
13_A17_A2.8031.00
44_V110_A2.5051.00
99_H103_N2.2601.00
17_A73_A2.2411.00
15_G65_L2.2211.00
22_L70_A2.0811.00
84_V100_A1.9011.00
44_V106_G1.8991.00
55_F115_W1.8781.00
26_V42_V1.7281.00
84_V99_H1.7161.00
84_V96_A1.6941.00
47_S107_A1.6371.00
53_L66_F1.5951.00
18_L70_A1.5781.00
41_V45_V1.5411.00
18_L65_L1.4881.00
92_R95_A1.4881.00
42_V74_F1.4461.00
50_L111_V1.4271.00
24_W28_A1.4141.00
40_L102_G1.4031.00
22_L74_F1.3691.00
9_A21_V1.3601.00
30_T38_G1.3581.00
48_F114_A1.3311.00
48_F117_L1.3271.00
17_A21_V1.3201.00
86_A89_D1.3151.00
49_V71_C1.3071.00
112_A116_L1.2751.00
25_R29_A1.2671.00
53_L67_G1.2511.00
20_A73_A1.2411.00
52_A56_A1.2401.00
21_V25_R1.2361.00
50_L71_C1.2301.00
13_A21_V1.2231.00
8_P64_L1.2211.00
39_T83_D1.2131.00
32_T37_A1.2111.00
54_T82_V1.1981.00
97_A101_L1.1961.00
50_L73_A1.1601.00
27_V42_V1.0841.00
88_V96_A1.0501.00
48_F110_A1.0361.00
65_L70_A1.0061.00
35_Y40_L0.9961.00
79_S83_D0.9941.00
102_G106_G0.9871.00
40_L106_G0.9811.00
40_L44_V0.9811.00
64_L68_T0.9771.00
94_V97_A0.9621.00
88_V93_P0.9611.00
52_A55_F0.9461.00
54_T67_G0.9011.00
85_V111_V0.8991.00
83_D86_A0.8991.00
81_S104_L0.8971.00
102_G105_L0.8851.00
85_V115_W0.8841.00
106_G110_A0.8801.00
113_L116_L0.8731.00
14_A17_A0.8471.00
27_V31_P0.8441.00
38_G42_V0.8431.00
85_V112_A0.8421.00
12_V64_L0.8381.00
63_M67_G0.8321.00
93_P97_A0.8291.00
25_R28_A0.8251.00
30_T41_V0.8211.00
60_A64_L0.8181.00
94_V98_G0.8131.00
36_P87_L0.8071.00
101_L105_L0.8011.00
81_S85_V0.8011.00
103_N107_A0.8011.00
11_L61_D0.7971.00
60_A63_M0.7921.00
42_V45_V0.7810.99
86_A90_A0.7760.99
58_A62_T0.7740.99
111_V114_A0.7660.99
26_V30_T0.7620.99
47_S111_V0.7610.99
112_A115_W0.7510.99
98_G102_G0.7430.99
81_S111_V0.7420.99
59_D62_T0.7410.99
12_V15_G0.7380.99
33_T37_A0.7380.99
108_G111_V0.7280.99
52_A117_L0.7190.99
22_L26_V0.7140.99
48_F55_F0.7090.99
37_A41_V0.7030.99
51_A111_V0.7000.99
70_A73_A0.6980.99
61_D64_L0.6930.99
82_V86_A0.6920.99
27_V83_D0.6890.99
52_A114_A0.6890.99
53_L57_A0.6830.99
9_A64_L0.6830.99
96_A104_L0.6820.99
80_F100_A0.6780.99
80_F107_A0.6680.98
62_T66_F0.6590.98
57_A67_G0.6570.98
70_A74_F0.6470.98
47_S81_S0.6460.98
64_L67_G0.6450.98
77_F81_S0.6270.98
62_T65_L0.6270.98
87_L99_H0.6260.98
47_S50_L0.6140.97
12_V91_D0.6060.97
18_L22_L0.6050.97
26_V74_F0.6010.97
40_L103_N0.6010.97
26_V41_V0.5880.97
109_L113_L0.5810.96
81_S84_V0.5810.96
11_L65_L0.5810.96
8_P61_D0.5810.96
95_A99_H0.5780.96
34_E92_R0.5760.96
33_T95_A0.5720.96
109_L112_A0.5630.96
23_R69_G0.5630.96
49_V66_F0.5600.95
20_A71_C0.5590.95
82_V111_V0.5580.95
40_L95_A0.5580.95
14_A18_L0.5570.95
110_A113_L0.5530.95
18_L21_V0.5510.95
9_A25_R0.5470.95
26_V45_V0.5450.95
15_G80_F0.5420.95
15_G70_A0.5400.94
100_A104_L0.5390.94
105_L109_L0.5380.94
51_A114_A0.5370.94
26_V38_G0.5350.94
67_G79_S0.5340.94
22_L25_R0.5330.94
39_T76_T0.5310.94
12_V73_A0.5280.94
9_A13_A0.5230.93
89_D115_W0.5170.93
10_V14_A0.5150.93
51_A55_F0.5130.93
35_Y38_G0.5110.93
27_V39_T0.5090.93
35_Y87_L0.5030.92
73_A80_F0.5020.92
113_L117_L0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ldsA 2 0.9832 15.3 0.909 Contact Map
4j05A 3 0.9832 10.5 0.916 Contact Map
4tphA 2 0.9748 8.4 0.919 Contact Map
4xnjA 1 0.9916 7.9 0.92 Contact Map
4ikvA 1 0.9916 6.9 0.922 Contact Map
4gc0A 1 0.9832 6.4 0.923 Contact Map
3wdoA 1 0.9664 5.4 0.926 Contact Map
4q65A 1 0.9916 5.2 0.926 Contact Map
1pw4A 1 0.9664 4.5 0.929 Contact Map
4oh3A 2 0.9916 4.5 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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