GREMLIN Database
CRCB2 - Putative fluoride ion transporter CrcB 2
UniProt: Q9HNW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 128 (111)
Sequences: 3343 (2482)
Seq/√Len: 235.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_G81_T4.2191.00
45_A80_F4.0411.00
16_A20_A3.3261.00
19_G23_A3.2771.00
50_L73_G2.9521.00
101_N105_T2.3381.00
44_A112_G2.2991.00
52_A120_A2.1421.00
25_L76_C2.1201.00
29_V42_A2.0651.00
18_G71_L2.0391.00
44_A108_L2.0061.00
90_T102_V1.9281.00
20_A79_A1.9011.00
47_S109_G1.8481.00
53_L72_L1.8221.00
90_T101_N1.7101.00
55_Y117_R1.7001.00
21_V71_L1.6771.00
90_T98_M1.6171.00
50_L77_L1.6061.00
48_L119_I1.5951.00
21_V76_C1.5531.00
48_L116_G1.5471.00
40_L104_T1.4851.00
42_A80_F1.4481.00
28_T32_A1.4201.00
49_A77_L1.4071.00
41_A45_A1.3971.00
53_L73_G1.3741.00
25_L80_F1.3741.00
50_L113_V1.3701.00
11_S70_T1.3521.00
27_Y31_Q1.3251.00
12_T24_V1.3031.00
24_V28_T1.2981.00
23_A79_A1.2761.00
94_A97_W1.2501.00
116_G120_A1.2331.00
30_A42_A1.2301.00
55_Y59_A1.2241.00
16_A24_V1.2081.00
50_L79_A1.2071.00
33_I38_G1.1821.00
71_L76_C1.1601.00
20_A24_V1.1591.00
55_Y120_A1.1441.00
70_T74_T1.1261.00
40_L108_L1.1051.00
54_A73_G1.0671.00
99_A103_A1.0431.00
48_L112_G1.0331.00
114_L118_A1.0191.00
91_A113_V1.0121.00
104_T108_L0.9691.00
54_A88_V0.9581.00
51_G113_V0.9491.00
52_A56_E0.9471.00
87_A91_A0.9431.00
95_P99_A0.9431.00
96_R99_A0.9221.00
38_G42_A0.9211.00
30_A39_T0.9181.00
39_T89_Q0.9021.00
36_P93_L0.8950.99
37_L41_A0.8910.99
86_F102_V0.8830.99
103_A107_A0.8750.99
87_A113_V0.8620.99
76_C80_F0.8530.99
65_S68_A0.8520.99
86_F109_G0.8510.99
42_A45_A0.8450.99
48_L55_Y0.8350.99
30_A89_Q0.8290.99
14_L67_D0.8230.99
28_T31_Q0.8120.99
69_H73_G0.8050.99
14_L71_L0.8020.99
40_L44_A0.7960.99
23_A77_L0.7920.99
33_I41_A0.7910.99
105_T109_G0.7900.99
29_V41_A0.7840.99
30_A34_A0.7820.99
64_L68_A0.7790.99
85_T89_Q0.7760.99
96_R100_A0.7680.98
17_V20_A0.7680.98
93_L101_N0.7640.98
54_A117_R0.7380.98
47_S113_V0.7160.98
15_V70_T0.7150.98
40_L105_T0.7150.98
89_Q92_G0.7140.98
117_R121_A0.7120.97
52_A55_Y0.7040.97
49_A72_L0.6880.97
31_Q35_G0.6870.97
91_A114_L0.6780.97
68_A71_L0.6760.97
108_L112_G0.6750.97
53_L57_A0.6740.96
115_V118_A0.6610.96
40_L97_W0.6570.96
57_A73_G0.6530.96
106_Y110_F0.6450.95
59_A120_A0.6420.95
118_A121_A0.6350.95
91_A117_R0.6290.95
28_T38_G0.6280.95
52_A116_G0.6150.94
76_C79_A0.6120.94
36_P89_Q0.6110.94
15_V24_V0.6110.94
13_A17_V0.6080.94
21_V25_L0.6070.94
88_V92_G0.5980.93
110_F113_V0.5970.93
100_A104_T0.5950.93
59_A62_S0.5920.93
102_V106_Y0.5880.93
51_G71_L0.5880.93
97_W100_A0.5870.93
11_S67_D0.5860.93
27_Y30_A0.5820.92
115_V119_I0.5780.92
119_I122_T0.5770.92
29_V80_F0.5760.92
47_S87_A0.5730.92
104_T107_A0.5710.92
47_S77_L0.5700.92
49_A52_A0.5700.92
32_A35_G0.5690.92
56_E60_T0.5660.91
18_G86_F0.5640.91
54_A58_A0.5600.91
59_A121_A0.5580.91
16_A19_G0.5570.91
52_A119_I0.5540.90
15_V18_G0.5540.90
12_T28_T0.5530.90
35_G119_I0.5520.90
39_T43_N0.5510.90
86_F106_Y0.5480.90
66_A70_T0.5450.90
114_L117_R0.5440.90
53_L64_L0.5360.89
34_A38_G0.5300.88
101_N109_G0.5260.88
31_Q42_A0.5240.88
57_A60_T0.5220.88
83_Y87_A0.5210.88
74_T85_T0.5200.87
12_T70_T0.5200.87
68_A72_L0.5160.87
29_V33_I0.5130.87
57_A64_L0.5080.86
47_S110_F0.5070.86
25_L29_V0.5040.86
39_T82_T0.5040.86
64_L67_D0.5030.86
19_G101_N0.5020.86
29_V38_G0.5010.85
21_V24_V0.5000.85
12_T54_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tdsE 3 0.5469 8.9 0.925 Contact Map
4q65A 1 0.5156 7.8 0.927 Contact Map
2kv5A 1 0.2344 7.1 0.928 Contact Map
4fc4A 3 0.4531 6.1 0.93 Contact Map
1pw4A 1 0.9922 5.5 0.932 Contact Map
4j05A 3 0.8906 5.1 0.933 Contact Map
4b19A 1 0.2266 5.1 0.933 Contact Map
2l2tA 2 0.2969 4.6 0.934 Contact Map
2cfqA 1 0.9531 4.2 0.935 Contact Map
4tphA 2 0.5234 4.2 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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