GREMLIN Database
Q9HNV8 - TRK potassium uptake system protein
UniProt: Q9HNV8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (212)
Sequences: 8654 (6141)
Seq/√Len: 421.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_G90_T3.7491.00
213_K231_D3.7011.00
186_V227_L3.6481.00
40_V85_G3.3051.00
38_V99_A3.1681.00
102_I119_G3.1011.00
211_F225_E2.8231.00
85_G115_A2.7781.00
67_Y82_E2.6721.00
213_K228_E2.6061.00
198_S224_S2.5811.00
116_C146_V2.4781.00
39_I50_A2.3901.00
188_D229_T2.2441.00
196_S199_E2.2441.00
92_L97_D2.1621.00
70_A80_V2.1201.00
238_E241_T2.1091.00
36_D59_A2.1031.00
195_Y199_E2.0191.00
213_K225_E1.9951.00
197_I208_L1.9141.00
196_S226_T1.8571.00
95_G98_T1.8521.00
67_Y71_E1.8411.00
120_N126_T1.8351.00
120_N147_D1.8151.00
116_C128_L1.8111.00
38_V96_I1.8101.00
64_E70_A1.8051.00
205_G241_T1.7841.00
136_E151_Y1.7821.00
43_G46_G1.7681.00
40_V102_I1.7631.00
54_T78_F1.7401.00
194_G228_E1.7341.00
193_R229_T1.7061.00
94_A99_A1.6051.00
198_S223_P1.5371.00
42_A62_V1.5371.00
69_R72_R1.5341.00
125_R147_D1.5311.00
38_V102_I1.5271.00
102_I115_A1.4991.00
64_E80_V1.4991.00
88_E92_L1.4831.00
201_E204_A1.4811.00
194_G229_T1.4681.00
192_M200_L1.4661.00
183_Q232_R1.4371.00
35_M100_D1.4221.00
116_C126_T1.4201.00
81_V94_A1.4181.00
83_G94_A1.4021.00
92_L122_H1.3971.00
183_Q234_A1.3921.00
37_I101_A1.3801.00
47_S73_A1.3761.00
62_V77_G1.3431.00
43_G129_R1.3421.00
89_D92_L1.3351.00
49_T103_G1.3281.00
208_L235_V1.3191.00
222_L225_E1.3111.00
40_V115_A1.2931.00
42_A73_A1.2901.00
104_A119_G1.2791.00
46_G105_L1.2711.00
203_P207_R1.2711.00
136_E140_R1.2501.00
227_L233_I1.2481.00
104_A112_N1.2381.00
185_T232_R1.2331.00
66_D69_R1.2221.00
61_T99_A1.1741.00
51_R76_E1.1671.00
217_S220_L1.1661.00
237_A242_L1.1561.00
241_T244_S1.1331.00
72_R76_E1.1171.00
211_F231_D1.1121.00
42_A70_A1.1071.00
109_L112_N1.0981.00
49_T157_A1.0911.00
157_A161_K1.0881.00
186_V193_R1.0811.00
228_E231_D1.0791.00
104_A116_C1.0691.00
73_A76_E1.0631.00
111_T115_A1.0621.00
121_H141_K1.0621.00
128_L146_V1.0581.00
88_E118_V1.0551.00
77_G80_V1.0551.00
206_A237_A1.0501.00
81_V90_T1.0491.00
126_T147_D1.0371.00
40_V63_I1.0351.00
90_T94_A1.0281.00
185_T230_G1.0261.00
42_A64_E1.0261.00
89_D93_D1.0211.00
237_A241_T1.0191.00
45_V129_R1.0121.00
96_I123_D1.0111.00
36_D98_T1.0101.00
106_T115_A1.0101.00
108_D111_T0.9981.00
125_R148_E0.9951.00
106_T111_T0.9911.00
73_A80_V0.9901.00
184_L235_V0.9861.00
50_A62_V0.9841.00
179_L236_L0.9631.00
63_I90_T0.9551.00
46_G50_A0.9521.00
35_M58_H0.9501.00
193_R228_E0.9441.00
106_T109_L0.9431.00
200_L227_L0.9411.00
39_I46_G0.9311.00
63_I83_G0.9281.00
63_I94_A0.9271.00
212_G232_R0.9251.00
36_D99_A0.9151.00
133_D154_R0.9131.00
68_D71_E0.9091.00
36_D61_T0.9031.00
155_L159_G0.9011.00
38_V94_A0.9011.00
43_G64_E0.8971.00
197_I221_P0.8831.00
180_Q239_F0.8801.00
210_A218_L0.8681.00
210_A234_A0.8671.00
49_T105_L0.8641.00
206_A245_V0.8581.00
102_I124_C0.8561.00
46_G129_R0.8501.00
120_N145_E0.8481.00
47_S51_R0.8481.00
46_G64_E0.8481.00
68_D72_R0.8471.00
39_I60_V0.8451.00
194_G226_T0.8451.00
48_R51_R0.8441.00
64_E69_R0.8421.00
42_A47_S0.8361.00
207_R223_P0.8341.00
71_E75_T0.8331.00
61_T94_A0.8301.00
235_V245_V0.8231.00
198_S222_L0.8181.00
37_I58_H0.8161.00
91_L94_A0.8141.00
58_H100_D0.8121.00
36_D100_D0.8091.00
192_M245_V0.7961.00
214_H228_E0.7961.00
199_E226_T0.7961.00
96_I122_H0.7941.00
43_G85_G0.7931.00
196_S224_S0.7911.00
189_E193_R0.7911.00
58_H165_L0.7901.00
181_V209_L0.7881.00
109_L135_R0.7861.00
221_P225_E0.7821.00
54_T60_V0.7791.00
106_T112_N0.7721.00
60_V78_F0.7721.00
91_L96_I0.7701.00
91_L122_H0.7671.00
209_L236_L0.7651.00
110_N114_I0.7631.00
117_M155_L0.7581.00
186_V190_A0.7571.00
103_G106_T0.7551.00
130_I139_Y0.7541.00
117_M121_H0.7531.00
88_E122_H0.7521.00
61_T81_V0.7441.00
119_G123_D0.7431.00
121_H137_D0.7411.00
39_I62_V0.7411.00
96_I99_A0.7391.00
46_G85_G0.7341.00
195_Y200_L0.7331.00
38_V61_T0.7261.00
242_L246_R0.7251.00
154_R158_I0.7201.00
73_A77_G0.7161.00
126_T146_V0.7121.00
159_G163_A0.7091.00
54_T77_G0.7061.00
101_A127_V0.7021.00
64_E82_E0.7011.00
101_A125_R0.7011.00
62_V78_F0.6941.00
187_T229_T0.6931.00
197_I223_P0.6911.00
212_G218_L0.6911.00
245_V249_L0.6901.00
37_I53_V0.6891.00
92_L96_I0.6821.00
112_N128_L0.6801.00
112_N135_R0.6801.00
50_A78_F0.6791.00
218_L225_E0.6781.00
188_D191_P0.6771.00
74_R80_V0.6761.00
117_M144_D0.6721.00
52_V157_A0.6701.00
53_V60_V0.6701.00
244_S247_Q0.6681.00
86_T111_T0.6660.99
47_S76_E0.6650.99
243_D246_R0.6640.99
176_A179_L0.6580.99
219_A225_E0.6580.99
148_E163_A0.6550.99
87_S90_T0.6500.99
52_V56_E0.6490.99
62_V73_A0.6480.99
39_I49_T0.6460.99
48_R157_A0.6460.99
54_T76_E0.6450.99
225_E228_E0.6440.99
65_Q84_D0.6410.99
205_G238_E0.6380.99
174_D180_Q0.6370.99
63_I81_V0.6360.99
202_L208_L0.6350.99
47_S72_R0.6330.99
178_H238_E0.6330.99
213_K219_A0.6320.99
118_V122_H0.6310.99
110_N132_E0.6300.99
115_A119_G0.6300.99
203_P206_A0.6280.99
48_R52_V0.6270.99
105_L129_R0.6230.99
169_V175_L0.6200.99
79_D82_E0.6200.99
220_L223_P0.6190.99
105_L109_L0.6180.99
99_A102_I0.6180.99
197_I202_L0.6150.99
52_V55_N0.6130.99
70_A74_R0.6090.99
140_R148_E0.6070.99
155_L158_I0.6060.99
158_I162_N0.5990.99
90_T93_D0.5970.99
110_N135_R0.5950.99
167_G175_L0.5930.99
51_R54_T0.5920.99
117_M123_D0.5900.99
146_V149_I0.5820.99
37_I103_G0.5820.99
136_E154_R0.5800.99
196_S200_L0.5780.99
71_E74_R0.5770.99
213_K230_G0.5730.98
51_R55_N0.5730.98
50_A60_V0.5720.98
193_R227_L0.5710.98
202_L206_A0.5700.98
92_L95_G0.5670.98
96_I102_I0.5650.98
91_L119_G0.5620.98
182_V242_L0.5600.98
61_T79_D0.5580.98
43_G106_T0.5560.98
73_A78_F0.5550.98
41_G46_G0.5540.98
37_I164_L0.5530.98
109_L132_E0.5520.98
38_V83_G0.5520.98
45_V153_E0.5500.98
131_D153_E0.5500.98
84_D87_S0.5490.98
63_I85_G0.5480.98
213_K218_L0.5460.98
178_H239_F0.5430.98
212_G234_A0.5430.98
133_D136_E0.5420.98
235_V242_L0.5410.98
87_S134_Y0.5410.98
95_G99_A0.5370.98
42_A46_G0.5360.98
64_E85_G0.5350.98
208_L223_P0.5350.98
132_E135_R0.5340.98
96_I119_G0.5330.98
154_R157_A0.5330.98
244_S248_I0.5300.98
110_N113_F0.5270.97
159_G162_N0.5250.97
197_I227_L0.5250.97
70_A82_E0.5240.97
37_I100_D0.5240.97
177_E212_G0.5210.97
203_P223_P0.5180.97
141_K144_D0.5160.97
172_I234_A0.5120.97
40_V104_A0.5120.97
45_V135_R0.5100.97
199_E224_S0.5090.97
158_I161_K0.5060.97
160_A163_A0.5050.97
186_V230_G0.5040.97
169_V172_I0.5040.97
96_I124_C0.5040.97
131_D135_R0.5030.97
116_C139_Y0.5010.97
195_Y201_E0.5010.97
109_L131_D0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lnqA 6 0.8649 100 0.301 Contact Map
4gx0A 3 0.9807 100 0.31 Contact Map
2aefA 2 0.8263 100 0.321 Contact Map
4g65A 2 0.9575 100 0.325 Contact Map
3l4bC 2 0.8224 100 0.373 Contact Map
3mt5A 5 0.8224 100 0.373 Contact Map
3nafA 3 0.8842 100 0.373 Contact Map
4hpfA 3 0.7761 100 0.412 Contact Map
4j91A 3 0.8147 100 0.433 Contact Map
3l9wA 2 0.695 99.9 0.591 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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