GREMLIN Database
Q9HNV6 - Pyruvate dehydrogenase alpha subunit
UniProt: Q9HNV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 322 (287)
Sequences: 8840 (5201)
Seq/√Len: 307.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_H173_Y3.9321.00
168_A171_D3.3221.00
178_V194_D2.9691.00
184_D187_A2.6121.00
178_V205_I2.5991.00
165_S168_A2.5341.00
256_D259_F2.5251.00
113_A196_L2.4881.00
257_A261_E2.3111.00
113_A143_V2.2841.00
148_N208_E2.1561.00
200_R203_T2.1431.00
196_L200_R2.1371.00
118_F144_F2.1231.00
235_A238_T2.1081.00
179_Q210_L2.0351.00
262_E266_A2.0341.00
118_F146_C1.9941.00
99_V131_G1.9931.00
105_M114_S1.9921.00
132_M170_A1.9481.00
189_Y193_T1.9351.00
36_A117_Y1.9331.00
65_D68_L1.9261.00
86_P97_H1.9251.00
137_V162_A1.8901.00
247_D250_H1.8721.00
139_D162_A1.8571.00
134_F138_F1.8511.00
176_E205_I1.8421.00
276_E280_A1.8391.00
176_E200_R1.8371.00
46_L189_Y1.8291.00
197_A201_D1.8101.00
63_A67_L1.8031.00
119_G122_A1.7951.00
288_E291_D1.7821.00
234_P238_T1.7781.00
63_A66_L1.7411.00
250_H257_A1.7211.00
19_W279_E1.7121.00
167_A208_E1.7111.00
246_A250_H1.7111.00
47_F189_Y1.6961.00
95_I128_F1.6951.00
44_D48_P1.6871.00
150_N210_L1.6731.00
132_M173_Y1.6711.00
268_A272_D1.6651.00
48_P52_S1.6521.00
212_Y222_D1.6381.00
259_F262_E1.6361.00
105_M110_S1.6341.00
64_S277_T1.6181.00
178_V191_T1.6051.00
141_P176_E1.6011.00
105_M112_Q1.5941.00
266_A270_E1.5901.00
167_A179_Q1.5811.00
269_D273_D1.5781.00
47_F101_A1.5771.00
145_F192_V1.5731.00
64_S68_L1.5661.00
272_D276_E1.5641.00
63_A68_L1.5511.00
103_M107_Y1.5171.00
44_D52_S1.5171.00
179_Q208_E1.5161.00
245_Y248_Y1.5111.00
141_P202_G1.5071.00
265_D269_D1.5031.00
64_S273_D1.4621.00
273_D277_T1.4521.00
246_A264_F1.4471.00
146_C166_I1.4451.00
64_S67_L1.4401.00
118_F122_A1.4321.00
128_F132_M1.4171.00
65_D69_F1.4141.00
190_E194_D1.4071.00
247_D251_D1.3991.00
167_A171_D1.3971.00
260_V264_F1.3941.00
41_A111_G1.3911.00
167_A177_G1.3881.00
39_A145_F1.3851.00
115_L143_V1.3831.00
44_D50_Y1.3661.00
133_N161_T1.3611.00
277_T281_A1.3571.00
180_V191_T1.3491.00
258_G262_E1.3461.00
36_A192_V1.3371.00
126_G130_Q1.3331.00
195_A205_I1.3131.00
32_S62_P1.3061.00
244_R248_Y1.2931.00
170_A177_G1.2891.00
51_R268_A1.2881.00
98_A116_A1.2731.00
43_D112_Q1.2711.00
193_T197_A1.2521.00
180_V187_A1.2471.00
183_N214_Q1.2451.00
64_S69_F1.2431.00
45_W48_P1.2421.00
95_I132_M1.2351.00
102_G142_V1.2321.00
176_E194_D1.2181.00
121_G152_A1.2121.00
255_I260_V1.2071.00
286_V289_L1.1921.00
246_A260_V1.1881.00
219_T235_A1.1671.00
260_V263_C1.1661.00
276_E279_E1.1591.00
278_A282_G1.1511.00
258_G261_E1.1481.00
44_D51_R1.1371.00
163_S166_I1.1341.00
75_E81_D1.1331.00
99_V144_F1.1241.00
261_E265_D1.1241.00
236_W239_A1.1211.00
95_I144_F1.1201.00
44_D47_F1.1201.00
267_A271_I1.1151.00
285_A288_E1.1111.00
194_D197_A1.1051.00
145_F209_S1.1011.00
103_M138_F1.0971.00
243_D247_D1.0911.00
63_A69_F1.0901.00
20_M233_L1.0841.00
274_A278_A1.0781.00
48_P53_N1.0771.00
217_H236_W1.0741.00
118_F123_T1.0721.00
132_M175_F1.0721.00
248_Y252_Q1.0621.00
36_A145_F1.0461.00
146_C206_L1.0451.00
62_P65_D1.0451.00
250_H253_G1.0411.00
270_E274_A1.0381.00
277_T280_A1.0351.00
188_V209_S1.0321.00
59_R119_G1.0321.00
263_C267_A1.0301.00
223_P226_Y1.0291.00
50_Y53_N1.0281.00
36_A115_L1.0271.00
212_Y221_D1.0211.00
250_H260_V1.0181.00
17_R20_M1.0171.00
143_V205_I1.0141.00
270_E273_D1.0131.00
273_D276_E1.0071.00
170_A206_L1.0051.00
186_L190_E1.0011.00
95_I131_G0.9951.00
9_E27_K0.9911.00
115_L192_V0.9841.00
56_Q101_A0.9811.00
214_Q226_Y0.9801.00
141_P201_D0.9791.00
177_G208_E0.9781.00
192_V207_V0.9761.00
261_E264_F0.9721.00
246_A249_L0.9711.00
220_S225_R0.9701.00
233_L237_R0.9621.00
183_N211_T0.9601.00
45_W50_Y0.9511.00
191_T207_V0.9391.00
56_Q84_V0.9381.00
136_G175_F0.9331.00
143_V196_L0.9321.00
272_D275_V0.9321.00
96_P131_G0.9291.00
193_T196_L0.9251.00
286_V290_F0.9241.00
49_T267_A0.9221.00
243_D246_A0.9171.00
289_L293_V0.9071.00
267_A270_E0.9071.00
45_W52_S0.9031.00
10_R13_A0.9031.00
47_F52_S0.8991.00
81_D84_V0.8971.00
263_C266_A0.8961.00
32_S117_Y0.8921.00
220_S232_D0.8901.00
141_P200_R0.8901.00
182_G211_T0.8891.00
254_V258_G0.8871.00
35_G188_V0.8791.00
32_S209_S0.8731.00
187_A190_E0.8641.00
255_I259_F0.8601.00
230_E233_L0.8581.00
219_T232_D0.8551.00
71_R292_H0.8511.00
232_D235_A0.8501.00
79_D82_H0.8451.00
150_N158_E0.8441.00
101_A114_S0.8431.00
283_A286_V0.8371.00
106_S141_P0.8351.00
171_D179_Q0.8351.00
36_A39_A0.8331.00
274_A277_T0.8331.00
99_V142_V0.8311.00
282_G285_A0.8281.00
117_Y145_F0.8211.00
88_A93_S0.8141.00
178_V195_A0.8131.00
44_D53_N0.8131.00
124_S152_A0.8131.00
252_Q256_D0.8121.00
14_L17_R0.8121.00
9_E13_A0.8111.00
42_G185_P0.8101.00
32_S36_A0.8071.00
271_I275_V0.8051.00
34_V236_W0.8031.00
249_L254_V0.7951.00
45_W105_M0.7951.00
181_D187_A0.7941.00
10_R272_D0.7941.00
290_F294_Y0.7911.00
234_P237_R0.7901.00
161_T166_I0.7881.00
48_P51_R0.7851.00
279_E290_F0.7841.00
39_A209_S0.7820.99
141_P205_I0.7820.99
244_R247_D0.7820.99
90_P93_S0.7810.99
150_N156_P0.7810.99
139_D202_G0.7810.99
248_Y251_D0.7780.99
235_A239_A0.7780.99
264_F267_A0.7750.99
47_F50_Y0.7720.99
12_L16_R0.7700.99
226_Y229_E0.7680.99
98_A144_F0.7680.99
245_Y249_L0.7640.99
47_F196_L0.7630.99
264_F268_A0.7620.99
253_G257_A0.7620.99
148_N210_L0.7580.99
156_P224_D0.7570.99
143_V195_A0.7560.99
44_D49_T0.7560.99
279_E283_A0.7540.99
31_G35_G0.7520.99
191_T195_A0.7520.99
177_G206_L0.7500.99
269_D272_D0.7470.99
230_E234_P0.7410.99
157_R161_T0.7390.99
217_H232_D0.7380.99
49_T52_S0.7350.99
156_P159_R0.7330.99
248_Y253_G0.7330.99
192_V196_L0.7330.99
96_P127_D0.7310.99
262_E265_D0.7270.99
217_H235_A0.7230.99
39_A189_Y0.7200.99
181_D184_D0.7190.99
59_R117_Y0.7170.99
288_E292_H0.7170.99
214_Q237_R0.7170.99
43_D59_R0.7160.99
250_H254_V0.7160.99
218_T232_D0.7150.99
40_L115_L0.7110.99
38_H185_P0.7080.99
115_L196_L0.7050.99
124_S160_Q0.7040.99
250_H255_I0.7040.99
266_A269_D0.7010.99
116_A144_F0.7000.99
278_A283_A0.6950.99
56_Q61_V0.6940.99
56_Q98_A0.6930.99
282_G286_V0.6930.99
73_R292_H0.6910.99
176_E202_G0.6900.99
264_F271_I0.6890.99
123_T128_F0.6860.99
238_T244_R0.6830.99
95_I118_F0.6820.99
143_V192_V0.6800.99
99_V140_A0.6790.99
146_C208_E0.6770.99
244_R249_L0.6720.98
260_V271_I0.6700.98
260_V267_A0.6690.98
284_P289_L0.6670.98
46_L52_S0.6670.98
42_G188_V0.6640.98
229_E234_P0.6640.98
152_A160_Q0.6620.98
234_P245_Y0.6580.98
39_A193_T0.6580.98
139_D203_T0.6570.98
287_D291_D0.6540.98
14_L275_V0.6530.98
124_S169_K0.6530.98
255_I263_C0.6510.98
289_L294_Y0.6500.98
98_A142_V0.6490.98
249_L253_G0.6460.98
197_A200_R0.6430.98
190_E193_T0.6430.98
195_A207_V0.6420.98
115_L145_F0.6360.98
136_G174_G0.6360.98
137_V160_Q0.6350.98
248_Y254_V0.6350.98
91_I125_E0.6320.98
129_H132_M0.6320.98
170_A175_F0.6320.98
163_S168_A0.6290.98
32_S145_F0.6260.98
263_C271_I0.6240.98
289_L295_A0.6230.98
241_P244_R0.6220.97
221_D224_D0.6220.97
67_L70_R0.6200.97
221_D226_Y0.6190.97
242_V246_A0.6150.97
186_L245_Y0.6130.97
171_D177_G0.6100.97
222_D226_Y0.6060.97
187_A191_T0.6060.97
32_S59_R0.6060.97
144_F206_L0.6040.97
287_D290_F0.6030.97
63_A270_E0.6030.97
45_W51_R0.6010.97
71_R80_H0.5990.97
151_W232_D0.5980.97
20_M236_W0.5970.97
180_V209_S0.5920.97
271_I274_A0.5920.97
47_F85_F0.5920.97
178_V207_V0.5910.97
251_D254_V0.5880.96
180_V188_V0.5870.96
136_G162_A0.5870.96
105_M108_T0.5860.96
20_M24_P0.5860.96
247_D253_G0.5860.96
217_H221_D0.5840.96
43_D111_G0.5840.96
264_F275_V0.5840.96
46_L50_Y0.5830.96
92_A128_F0.5810.96
63_A70_R0.5790.96
292_H295_A0.5780.96
220_S226_Y0.5760.96
293_V297_R0.5750.96
35_G39_A0.5730.96
26_F54_A0.5720.96
236_W240_D0.5710.96
268_A279_E0.5690.96
250_H256_D0.5680.96
47_F193_T0.5660.96
39_A196_L0.5660.96
36_A209_S0.5640.96
38_H189_Y0.5580.95
291_D295_A0.5570.95
284_P287_D0.5560.95
227_R232_D0.5560.95
11_A70_R0.5560.95
47_F51_R0.5510.95
98_A114_S0.5510.95
113_A200_R0.5500.95
267_A272_D0.5490.95
24_P233_L0.5480.95
133_N163_S0.5480.95
42_G82_H0.5470.95
265_D268_A0.5440.95
232_D236_W0.5440.95
241_P245_Y0.5440.95
280_A287_D0.5420.94
45_W85_F0.5410.94
291_D294_Y0.5400.94
289_L292_H0.5390.94
10_R14_L0.5380.94
111_G201_D0.5380.94
26_F33_Q0.5380.94
182_G188_V0.5370.94
216_A223_P0.5360.94
292_H296_E0.5350.94
163_S169_K0.5330.94
283_A289_L0.5330.94
255_I258_G0.5300.94
92_A122_A0.5300.94
34_V217_H0.5290.94
153_I156_P0.5280.94
279_E282_G0.5280.94
165_S179_Q0.5270.94
268_A271_I0.5260.94
45_W53_N0.5220.93
290_F293_V0.5210.93
123_T166_I0.5200.93
169_K173_Y0.5190.93
259_F263_C0.5190.93
38_H41_A0.5170.93
146_C161_T0.5150.93
110_S278_A0.5150.93
165_S210_L0.5130.93
124_S161_T0.5130.93
10_R275_V0.5120.93
156_P222_D0.5090.92
57_L63_A0.5090.92
254_V257_A0.5050.92
251_D255_I0.5030.92
46_L49_T0.5030.92
256_D262_E0.5030.92
150_N157_R0.5020.92
39_A117_Y0.5010.92
136_G139_D0.5000.92
18_G21_P0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bfdA 2 0.9255 100 0.27 Contact Map
1qs0A 2 0.9534 100 0.27 Contact Map
1umdA 2 0.9658 100 0.27 Contact Map
1w85A 2 0.972 100 0.276 Contact Map
2ozlA 2 0.9658 100 0.316 Contact Map
2yicA 2 0.9317 100 0.405 Contact Map
2xt6A 2 0.9286 100 0.408 Contact Map
2jgdA 2 0.8913 100 0.423 Contact Map
1itzA 2 0.972 100 0.541 Contact Map
3m49A 2 0.972 100 0.554 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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