Q9HNV6 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

Q9HNV6 - Pyruvate dehydrogenase alpha subunit

UniProt:	Q9HNV6	Sequences: MVRARHFDERALALQRRGWMPGYPPFKGQEGSQVGAAHALAGDDWLFPTYRSNAMQLARGVPASDLLLFRRGRAEFHSDHDHNVFPQAVPIASQIPHAVGAGMAMSYTDSGQASLAYFGDGATSEGDFHQGMNFAGVFDAPVVFFCENNNWAISLPRERQTASDSIAAKADAYGFEGVQVDGNDPLAVYETVTDALAGARDGTPILVESLTYRQGAHTTSDDPDRYRPEEEDLPAWRTADPVDRYADYLHDQGVIDAGFVEECFDAAADEIDDAVETAEAAGAPAVDELFDHVYAERTPRIDDQKAWLESWLETHDPQEMEF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	322 (287)
Sequences:	8840 (5201)
Seq/√Len:	307.0

ECOLI - TKT1 TKT2
BACSU - ODPA ACOA ODBA TKT
HALSA - Q9HNV6 Q9HN77
SULSO - Q97Y23 Q97YF6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_H	173_Y	3.932	1.00
168_A	171_D	3.322	1.00
178_V	194_D	2.969	1.00
184_D	187_A	2.612	1.00
178_V	205_I	2.599	1.00
165_S	168_A	2.534	1.00
256_D	259_F	2.525	1.00
113_A	196_L	2.488	1.00
257_A	261_E	2.311	1.00
113_A	143_V	2.284	1.00
148_N	208_E	2.156	1.00
200_R	203_T	2.143	1.00
196_L	200_R	2.137	1.00
118_F	144_F	2.123	1.00
235_A	238_T	2.108	1.00
179_Q	210_L	2.035	1.00
262_E	266_A	2.034	1.00
118_F	146_C	1.994	1.00
99_V	131_G	1.993	1.00
105_M	114_S	1.992	1.00
132_M	170_A	1.948	1.00
189_Y	193_T	1.935	1.00
36_A	117_Y	1.933	1.00
65_D	68_L	1.926	1.00
86_P	97_H	1.925	1.00
137_V	162_A	1.890	1.00
247_D	250_H	1.872	1.00
139_D	162_A	1.857	1.00
134_F	138_F	1.851	1.00
176_E	205_I	1.842	1.00
276_E	280_A	1.839	1.00
176_E	200_R	1.837	1.00
46_L	189_Y	1.829	1.00
197_A	201_D	1.810	1.00
63_A	67_L	1.803	1.00
119_G	122_A	1.795	1.00
288_E	291_D	1.782	1.00
234_P	238_T	1.778	1.00
63_A	66_L	1.741	1.00
250_H	257_A	1.721	1.00
19_W	279_E	1.712	1.00
167_A	208_E	1.711	1.00
246_A	250_H	1.711	1.00
47_F	189_Y	1.696	1.00
95_I	128_F	1.695	1.00
44_D	48_P	1.687	1.00
150_N	210_L	1.673	1.00
132_M	173_Y	1.671	1.00
268_A	272_D	1.665	1.00
48_P	52_S	1.652	1.00
212_Y	222_D	1.638	1.00
259_F	262_E	1.636	1.00
105_M	110_S	1.634	1.00
64_S	277_T	1.618	1.00
178_V	191_T	1.605	1.00
141_P	176_E	1.601	1.00
105_M	112_Q	1.594	1.00
266_A	270_E	1.590	1.00
167_A	179_Q	1.581	1.00
269_D	273_D	1.578	1.00
47_F	101_A	1.577	1.00
145_F	192_V	1.573	1.00
64_S	68_L	1.566	1.00
272_D	276_E	1.564	1.00
63_A	68_L	1.551	1.00
103_M	107_Y	1.517	1.00
44_D	52_S	1.517	1.00
179_Q	208_E	1.516	1.00
245_Y	248_Y	1.511	1.00
141_P	202_G	1.507	1.00
265_D	269_D	1.503	1.00
64_S	273_D	1.462	1.00
273_D	277_T	1.452	1.00
246_A	264_F	1.447	1.00
146_C	166_I	1.445	1.00
64_S	67_L	1.440	1.00
118_F	122_A	1.432	1.00
128_F	132_M	1.417	1.00
65_D	69_F	1.414	1.00
190_E	194_D	1.407	1.00
247_D	251_D	1.399	1.00
167_A	171_D	1.397	1.00
260_V	264_F	1.394	1.00
41_A	111_G	1.391	1.00
167_A	177_G	1.388	1.00
39_A	145_F	1.385	1.00
115_L	143_V	1.383	1.00
44_D	50_Y	1.366	1.00
133_N	161_T	1.361	1.00
277_T	281_A	1.357	1.00
180_V	191_T	1.349	1.00
258_G	262_E	1.346	1.00
36_A	192_V	1.337	1.00
126_G	130_Q	1.333	1.00
195_A	205_I	1.313	1.00
32_S	62_P	1.306	1.00
244_R	248_Y	1.293	1.00
170_A	177_G	1.289	1.00
51_R	268_A	1.288	1.00
98_A	116_A	1.273	1.00
43_D	112_Q	1.271	1.00
193_T	197_A	1.252	1.00
180_V	187_A	1.247	1.00
183_N	214_Q	1.245	1.00
64_S	69_F	1.243	1.00
45_W	48_P	1.242	1.00
95_I	132_M	1.235	1.00
102_G	142_V	1.232	1.00
176_E	194_D	1.218	1.00
121_G	152_A	1.212	1.00
255_I	260_V	1.207	1.00
286_V	289_L	1.192	1.00
246_A	260_V	1.188	1.00
219_T	235_A	1.167	1.00
260_V	263_C	1.166	1.00
276_E	279_E	1.159	1.00
278_A	282_G	1.151	1.00
258_G	261_E	1.148	1.00
44_D	51_R	1.137	1.00
163_S	166_I	1.134	1.00
75_E	81_D	1.133	1.00
99_V	144_F	1.124	1.00
261_E	265_D	1.124	1.00
236_W	239_A	1.121	1.00
95_I	144_F	1.120	1.00
44_D	47_F	1.120	1.00
267_A	271_I	1.115	1.00
285_A	288_E	1.111	1.00
194_D	197_A	1.105	1.00
145_F	209_S	1.101	1.00
103_M	138_F	1.097	1.00
243_D	247_D	1.091	1.00
63_A	69_F	1.090	1.00
20_M	233_L	1.084	1.00
274_A	278_A	1.078	1.00
48_P	53_N	1.077	1.00
217_H	236_W	1.074	1.00
118_F	123_T	1.072	1.00
132_M	175_F	1.072	1.00
248_Y	252_Q	1.062	1.00
36_A	145_F	1.046	1.00
146_C	206_L	1.045	1.00
62_P	65_D	1.045	1.00
250_H	253_G	1.041	1.00
270_E	274_A	1.038	1.00
277_T	280_A	1.035	1.00
188_V	209_S	1.032	1.00
59_R	119_G	1.032	1.00
263_C	267_A	1.030	1.00
223_P	226_Y	1.029	1.00
50_Y	53_N	1.028	1.00
36_A	115_L	1.027	1.00
212_Y	221_D	1.021	1.00
250_H	260_V	1.018	1.00
17_R	20_M	1.017	1.00
143_V	205_I	1.014	1.00
270_E	273_D	1.013	1.00
273_D	276_E	1.007	1.00
170_A	206_L	1.005	1.00
186_L	190_E	1.001	1.00
95_I	131_G	0.995	1.00
9_E	27_K	0.991	1.00
115_L	192_V	0.984	1.00
56_Q	101_A	0.981	1.00
214_Q	226_Y	0.980	1.00
141_P	201_D	0.979	1.00
177_G	208_E	0.978	1.00
192_V	207_V	0.976	1.00
261_E	264_F	0.972	1.00
246_A	249_L	0.971	1.00
220_S	225_R	0.970	1.00
233_L	237_R	0.962	1.00
183_N	211_T	0.960	1.00
45_W	50_Y	0.951	1.00
191_T	207_V	0.939	1.00
56_Q	84_V	0.938	1.00
136_G	175_F	0.933	1.00
143_V	196_L	0.932	1.00
272_D	275_V	0.932	1.00
96_P	131_G	0.929	1.00
193_T	196_L	0.925	1.00
286_V	290_F	0.924	1.00
49_T	267_A	0.922	1.00
243_D	246_A	0.917	1.00
289_L	293_V	0.907	1.00
267_A	270_E	0.907	1.00
45_W	52_S	0.903	1.00
10_R	13_A	0.903	1.00
47_F	52_S	0.899	1.00
81_D	84_V	0.897	1.00
263_C	266_A	0.896	1.00
32_S	117_Y	0.892	1.00
220_S	232_D	0.890	1.00
141_P	200_R	0.890	1.00
182_G	211_T	0.889	1.00
254_V	258_G	0.887	1.00
35_G	188_V	0.879	1.00
32_S	209_S	0.873	1.00
187_A	190_E	0.864	1.00
255_I	259_F	0.860	1.00
230_E	233_L	0.858	1.00
219_T	232_D	0.855	1.00
71_R	292_H	0.851	1.00
232_D	235_A	0.850	1.00
79_D	82_H	0.845	1.00
150_N	158_E	0.844	1.00
101_A	114_S	0.843	1.00
283_A	286_V	0.837	1.00
106_S	141_P	0.835	1.00
171_D	179_Q	0.835	1.00
36_A	39_A	0.833	1.00
274_A	277_T	0.833	1.00
99_V	142_V	0.831	1.00
282_G	285_A	0.828	1.00
117_Y	145_F	0.821	1.00
88_A	93_S	0.814	1.00
178_V	195_A	0.813	1.00
44_D	53_N	0.813	1.00
124_S	152_A	0.813	1.00
252_Q	256_D	0.812	1.00
14_L	17_R	0.812	1.00
9_E	13_A	0.811	1.00
42_G	185_P	0.810	1.00
32_S	36_A	0.807	1.00
271_I	275_V	0.805	1.00
34_V	236_W	0.803	1.00
249_L	254_V	0.795	1.00
45_W	105_M	0.795	1.00
181_D	187_A	0.794	1.00
10_R	272_D	0.794	1.00
290_F	294_Y	0.791	1.00
234_P	237_R	0.790	1.00
161_T	166_I	0.788	1.00
48_P	51_R	0.785	1.00
279_E	290_F	0.784	1.00
39_A	209_S	0.782	0.99
141_P	205_I	0.782	0.99
244_R	247_D	0.782	0.99
90_P	93_S	0.781	0.99
150_N	156_P	0.781	0.99
139_D	202_G	0.781	0.99
248_Y	251_D	0.778	0.99
235_A	239_A	0.778	0.99
264_F	267_A	0.775	0.99
47_F	50_Y	0.772	0.99
12_L	16_R	0.770	0.99
226_Y	229_E	0.768	0.99
98_A	144_F	0.768	0.99
245_Y	249_L	0.764	0.99
47_F	196_L	0.763	0.99
264_F	268_A	0.762	0.99
253_G	257_A	0.762	0.99
148_N	210_L	0.758	0.99
156_P	224_D	0.757	0.99
143_V	195_A	0.756	0.99
44_D	49_T	0.756	0.99
279_E	283_A	0.754	0.99
31_G	35_G	0.752	0.99
191_T	195_A	0.752	0.99
177_G	206_L	0.750	0.99
269_D	272_D	0.747	0.99
230_E	234_P	0.741	0.99
157_R	161_T	0.739	0.99
217_H	232_D	0.738	0.99
49_T	52_S	0.735	0.99
156_P	159_R	0.733	0.99
248_Y	253_G	0.733	0.99
192_V	196_L	0.733	0.99
96_P	127_D	0.731	0.99
262_E	265_D	0.727	0.99
217_H	235_A	0.723	0.99
39_A	189_Y	0.720	0.99
181_D	184_D	0.719	0.99
59_R	117_Y	0.717	0.99
288_E	292_H	0.717	0.99
214_Q	237_R	0.717	0.99
43_D	59_R	0.716	0.99
250_H	254_V	0.716	0.99
218_T	232_D	0.715	0.99
40_L	115_L	0.711	0.99
38_H	185_P	0.708	0.99
115_L	196_L	0.705	0.99
124_S	160_Q	0.704	0.99
250_H	255_I	0.704	0.99
266_A	269_D	0.701	0.99
116_A	144_F	0.700	0.99
278_A	283_A	0.695	0.99
56_Q	61_V	0.694	0.99
56_Q	98_A	0.693	0.99
282_G	286_V	0.693	0.99
73_R	292_H	0.691	0.99
176_E	202_G	0.690	0.99
264_F	271_I	0.689	0.99
123_T	128_F	0.686	0.99
238_T	244_R	0.683	0.99
95_I	118_F	0.682	0.99
143_V	192_V	0.680	0.99
99_V	140_A	0.679	0.99
146_C	208_E	0.677	0.99
244_R	249_L	0.672	0.98
260_V	271_I	0.670	0.98
260_V	267_A	0.669	0.98
284_P	289_L	0.667	0.98
46_L	52_S	0.667	0.98
42_G	188_V	0.664	0.98
229_E	234_P	0.664	0.98
152_A	160_Q	0.662	0.98
234_P	245_Y	0.658	0.98
39_A	193_T	0.658	0.98
139_D	203_T	0.657	0.98
287_D	291_D	0.654	0.98
14_L	275_V	0.653	0.98
124_S	169_K	0.653	0.98
255_I	263_C	0.651	0.98
289_L	294_Y	0.650	0.98
98_A	142_V	0.649	0.98
249_L	253_G	0.646	0.98
197_A	200_R	0.643	0.98
190_E	193_T	0.643	0.98
195_A	207_V	0.642	0.98
115_L	145_F	0.636	0.98
136_G	174_G	0.636	0.98
137_V	160_Q	0.635	0.98
248_Y	254_V	0.635	0.98
91_I	125_E	0.632	0.98
129_H	132_M	0.632	0.98
170_A	175_F	0.632	0.98
163_S	168_A	0.629	0.98
32_S	145_F	0.626	0.98
263_C	271_I	0.624	0.98
289_L	295_A	0.623	0.98
241_P	244_R	0.622	0.97
221_D	224_D	0.622	0.97
67_L	70_R	0.620	0.97
221_D	226_Y	0.619	0.97
242_V	246_A	0.615	0.97
186_L	245_Y	0.613	0.97
171_D	177_G	0.610	0.97
222_D	226_Y	0.606	0.97
187_A	191_T	0.606	0.97
32_S	59_R	0.606	0.97
144_F	206_L	0.604	0.97
287_D	290_F	0.603	0.97
63_A	270_E	0.603	0.97
45_W	51_R	0.601	0.97
71_R	80_H	0.599	0.97
151_W	232_D	0.598	0.97
20_M	236_W	0.597	0.97
180_V	209_S	0.592	0.97
271_I	274_A	0.592	0.97
47_F	85_F	0.592	0.97
178_V	207_V	0.591	0.97
251_D	254_V	0.588	0.96
180_V	188_V	0.587	0.96
136_G	162_A	0.587	0.96
105_M	108_T	0.586	0.96
20_M	24_P	0.586	0.96
247_D	253_G	0.586	0.96
217_H	221_D	0.584	0.96
43_D	111_G	0.584	0.96
264_F	275_V	0.584	0.96
46_L	50_Y	0.583	0.96
92_A	128_F	0.581	0.96
63_A	70_R	0.579	0.96
292_H	295_A	0.578	0.96
220_S	226_Y	0.576	0.96
293_V	297_R	0.575	0.96
35_G	39_A	0.573	0.96
26_F	54_A	0.572	0.96
236_W	240_D	0.571	0.96
268_A	279_E	0.569	0.96
250_H	256_D	0.568	0.96
47_F	193_T	0.566	0.96
39_A	196_L	0.566	0.96
36_A	209_S	0.564	0.96
38_H	189_Y	0.558	0.95
291_D	295_A	0.557	0.95
284_P	287_D	0.556	0.95
227_R	232_D	0.556	0.95
11_A	70_R	0.556	0.95
47_F	51_R	0.551	0.95
98_A	114_S	0.551	0.95
113_A	200_R	0.550	0.95
267_A	272_D	0.549	0.95
24_P	233_L	0.548	0.95
133_N	163_S	0.548	0.95
42_G	82_H	0.547	0.95
265_D	268_A	0.544	0.95
232_D	236_W	0.544	0.95
241_P	245_Y	0.544	0.95
280_A	287_D	0.542	0.94
45_W	85_F	0.541	0.94
291_D	294_Y	0.540	0.94
289_L	292_H	0.539	0.94
10_R	14_L	0.538	0.94
111_G	201_D	0.538	0.94
26_F	33_Q	0.538	0.94
182_G	188_V	0.537	0.94
216_A	223_P	0.536	0.94
292_H	296_E	0.535	0.94
163_S	169_K	0.533	0.94
283_A	289_L	0.533	0.94
255_I	258_G	0.530	0.94
92_A	122_A	0.530	0.94
34_V	217_H	0.529	0.94
153_I	156_P	0.528	0.94
279_E	282_G	0.528	0.94
165_S	179_Q	0.527	0.94
268_A	271_I	0.526	0.94
45_W	53_N	0.522	0.93
290_F	293_V	0.521	0.93
123_T	166_I	0.520	0.93
169_K	173_Y	0.519	0.93
259_F	263_C	0.519	0.93
38_H	41_A	0.517	0.93
146_C	161_T	0.515	0.93
110_S	278_A	0.515	0.93
165_S	210_L	0.513	0.93
124_S	161_T	0.513	0.93
10_R	275_V	0.512	0.93
156_P	222_D	0.509	0.92
57_L	63_A	0.509	0.92
254_V	257_A	0.505	0.92
251_D	255_I	0.503	0.92
46_L	49_T	0.503	0.92
256_D	262_E	0.503	0.92
150_N	157_R	0.502	0.92
39_A	117_Y	0.501	0.92
136_G	139_D	0.500	0.92
18_G	21_P	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bfdA	2	0.9255	100	0.27	Contact Map
1qs0A	2	0.9534	100	0.27	Contact Map
1umdA	2	0.9658	100	0.27	Contact Map
1w85A	2	0.972	100	0.276	Contact Map
2ozlA	2	0.9658	100	0.316	Contact Map
2yicA	2	0.9317	100	0.405	Contact Map
2xt6A	2	0.9286	100	0.408	Contact Map
2jgdA	2	0.8913	100	0.423	Contact Map
1itzA	2	0.972	100	0.541	Contact Map
3m49A	2	0.972	100	0.554	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.