KTHY - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

KTHY - Probable thymidylate kinase

UniProt:	Q9HNV4	Sequences: MLVTLEGLDGSGKTTVWESLRASHDDGVTFTAEPTDSQYGQAVRRSESAADADPIAELFLFTADHADHLSRVVSPALDRGDVVISDRYSDSRYAYQGATLADTVPRAMEYVRGIHQPWTRPPDVTLYFDVDPDTGAARSGATNKFETAAFLADVRANYEQLIDYTPERFVRIDATQSPEAVIADAEAALADALPDDAWA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	199 (189)
Sequences:	4632 (3517)
Seq/√Len:	255.8

ECOLI - KTHY
BACSU - KTHY
HALSA - KTHY
SULSO - Q97YW0 KTHY2 KTHY1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
176_Q	184_D	3.797	1.00
23_S	186_E	3.248	1.00
128_F	174_A	2.958	1.00
19_S	182_I	2.890	1.00
98_A	157_N	2.674	1.00
129_D	155_R	2.498	1.00
176_Q	180_A	2.439	1.00
29_T	81_D	2.306	1.00
177_S	180_A	2.200	1.00
134_T	137_A	2.164	1.00
67_D	71_R	2.115	1.00
155_R	159_E	2.088	1.00
143_N	146_E	2.067	1.00
31_T	68_H	1.998	1.00
172_I	181_V	1.985	1.00
17_W	84_I	1.946	1.00
17_W	30_F	1.940	1.00
129_D	159_E	1.897	1.00
21_R	30_F	1.889	1.00
70_S	74_S	1.879	1.00
16_V	185_A	1.817	1.00
16_V	182_I	1.809	1.00
21_R	25_D	1.761	1.00
74_S	78_D	1.735	1.00
182_I	186_E	1.702	1.00
131_D	175_T	1.682	1.00
11_S	130_V	1.669	1.00
170_V	188_A	1.667	1.00
159_E	171_R	1.645	1.00
21_R	84_I	1.615	1.00
126_L	188_A	1.593	1.00
90_D	168_R	1.555	1.00
127_Y	169_F	1.542	1.00
130_V	134_T	1.513	1.00
110_Y	113_G	1.501	1.00
16_V	19_S	1.500	1.00
170_V	192_A	1.474	1.00
152_A	156_A	1.438	1.00
160_Q	164_Y	1.431	1.00
156_A	160_Q	1.393	1.00
2_L	85_S	1.388	1.00
23_S	190_A	1.375	1.00
20_L	189_L	1.365	1.00
23_S	182_I	1.360	1.00
76_A	81_D	1.358	1.00
126_L	185_A	1.352	1.00
4_T	85_S	1.351	1.00
39_Y	52_A	1.339	1.00
74_S	120_R	1.337	1.00
43_V	60_L	1.332	1.00
27_G	190_A	1.331	1.00
162_I	171_R	1.326	1.00
186_E	190_A	1.321	1.00
127_Y	171_R	1.319	1.00
128_F	185_A	1.315	1.00
134_T	175_T	1.303	1.00
53_D	70_S	1.302	1.00
8_L	151_L	1.300	1.00
41_Q	64_D	1.298	1.00
132_P	148_A	1.285	1.00
29_T	76_A	1.282	1.00
148_A	152_A	1.267	1.00
9_D	135_G	1.260	1.00
42_A	45_R	1.257	1.00
5_L	20_L	1.250	1.00
19_S	178_P	1.234	1.00
90_D	125_T	1.232	1.00
160_Q	163_D	1.224	1.00
188_A	192_A	1.224	1.00
66_A	70_S	1.206	1.00
19_S	179_E	1.204	1.00
4_T	90_D	1.200	1.00
94_A	98_A	1.195	1.00
109_E	113_G	1.179	1.00
109_E	164_Y	1.169	1.00
135_G	139_S	1.157	1.00
182_I	185_A	1.153	1.00
58_L	62_T	1.140	1.00
127_Y	162_I	1.136	1.00
133_D	152_A	1.135	1.00
37_S	40_G	1.129	1.00
172_I	188_A	1.121	1.00
130_V	135_G	1.119	1.00
21_R	28_V	1.117	1.00
149_A	152_A	1.111	1.00
149_A	153_D	1.108	1.00
18_E	22_A	1.108	1.00
188_A	191_D	1.100	1.00
184_D	187_A	1.094	1.00
178_P	182_I	1.087	1.00
161_L	169_F	1.084	1.00
15_T	178_P	1.081	1.00
23_S	27_G	1.080	1.00
127_Y	159_E	1.074	1.00
69_L	120_R	1.072	1.00
31_T	85_S	1.066	1.00
126_L	170_V	1.065	1.00
62_T	92_R	1.062	1.00
131_D	134_T	1.048	1.00
136_A	148_A	1.042	1.00
184_D	188_A	1.042	1.00
30_F	84_I	1.042	1.00
55_I	107_A	1.039	1.00
29_T	72_V	1.038	1.00
124_V	170_V	1.033	1.00
28_V	82_V	1.028	1.00
183_A	187_A	1.024	1.00
121_P	165_T	1.023	1.00
100_L	150_F	1.022	1.00
180_A	184_D	1.009	1.00
40_G	64_D	1.007	1.00
16_V	178_P	1.007	1.00
53_D	66_A	1.005	1.00
127_Y	155_R	1.000	1.00
23_S	183_A	0.999	1.00
124_V	192_A	0.998	1.00
62_T	89_S	0.997	1.00
6_E	91_S	0.987	1.00
116_Q	120_R	0.974	1.00
132_P	155_R	0.962	1.00
64_D	68_H	0.961	1.00
103_T	106_R	0.960	1.00
25_D	28_V	0.957	1.00
173_D	176_Q	0.952	1.00
89_S	121_P	0.951	1.00
136_A	139_S	0.950	1.00
55_I	70_S	0.923	1.00
124_V	188_A	0.915	1.00
187_A	190_A	0.908	1.00
61_F	145_F	0.908	1.00
55_I	114_I	0.906	1.00
130_V	174_A	0.903	1.00
101_A	153_D	0.899	1.00
90_D	169_F	0.897	1.00
89_S	116_Q	0.893	1.00
126_L	172_I	0.893	1.00
159_E	162_I	0.887	1.00
99_T	153_D	0.885	1.00
37_S	72_V	0.884	1.00
187_A	191_D	0.883	1.00
93_Y	161_L	0.882	1.00
19_S	22_A	0.869	1.00
136_A	140_G	0.868	1.00
14_T	18_E	0.865	1.00
62_T	112_R	0.864	1.00
107_A	114_I	0.862	1.00
112_R	115_H	0.862	1.00
33_E	68_H	0.843	0.99
8_L	135_G	0.839	0.99
133_D	148_A	0.839	0.99
73_V	83_V	0.838	0.99
106_R	110_Y	0.838	0.99
2_L	88_Y	0.835	0.99
28_V	81_D	0.827	0.99
139_S	142_T	0.824	0.99
4_T	168_R	0.819	0.99
9_D	151_L	0.816	0.99
49_A	52_A	0.811	0.99
22_A	26_D	0.808	0.99
47_E	61_F	0.807	0.99
18_E	30_F	0.800	0.99
75_P	79_R	0.794	0.99
22_A	25_D	0.792	0.99
68_H	85_S	0.788	0.99
72_V	76_A	0.787	0.99
94_A	99_T	0.787	0.99
62_T	115_H	0.780	0.99
162_I	169_F	0.776	0.99
16_V	20_L	0.774	0.99
180_A	183_A	0.771	0.99
157_N	160_Q	0.766	0.99
18_E	21_R	0.764	0.99
53_D	56_A	0.757	0.99
5_L	185_A	0.756	0.99
23_S	26_D	0.749	0.99
129_D	171_R	0.741	0.99
94_A	157_N	0.737	0.98
153_D	156_A	0.735	0.98
27_G	81_D	0.723	0.98
172_I	185_A	0.721	0.98
126_L	189_L	0.720	0.98
65_H	92_R	0.717	0.98
10_G	139_S	0.715	0.98
5_L	17_W	0.712	0.98
109_E	112_R	0.707	0.98
27_G	186_E	0.706	0.98
69_L	73_V	0.704	0.98
109_E	165_T	0.698	0.98
143_N	147_T	0.695	0.98
4_T	169_F	0.695	0.98
40_G	67_D	0.693	0.98
95_Y	150_F	0.692	0.98
76_A	79_R	0.692	0.98
125_T	168_R	0.691	0.98
132_P	152_A	0.686	0.98
8_L	127_Y	0.686	0.98
42_A	49_A	0.682	0.97
58_L	111_V	0.678	0.97
39_Y	42_A	0.662	0.97
42_A	48_S	0.655	0.97
14_T	32_A	0.654	0.97
165_T	169_F	0.648	0.97
32_A	36_D	0.648	0.97
34_P	65_H	0.643	0.96
89_S	112_R	0.643	0.96
93_Y	104_V	0.641	0.96
56_A	66_A	0.640	0.96
116_Q	121_P	0.634	0.96
133_D	137_A	0.634	0.96
24_H	27_G	0.633	0.96
56_A	63_A	0.633	0.96
5_L	16_V	0.629	0.96
16_V	181_V	0.629	0.96
5_L	126_L	0.627	0.96
181_V	184_D	0.626	0.96
16_V	128_F	0.625	0.96
178_P	181_V	0.623	0.96
89_S	115_H	0.620	0.96
55_I	118_W	0.611	0.95
76_A	83_V	0.609	0.95
94_A	154_V	0.608	0.95
165_T	168_R	0.607	0.95
61_F	64_D	0.604	0.95
11_S	135_G	0.603	0.95
32_A	41_Q	0.600	0.95
32_A	35_T	0.600	0.95
109_E	121_P	0.598	0.95
69_L	74_S	0.596	0.95
99_T	150_F	0.594	0.94
91_S	158_Y	0.591	0.94
35_T	44_R	0.587	0.94
69_L	115_H	0.587	0.94
62_T	108_M	0.586	0.94
92_R	96_Q	0.586	0.94
99_T	151_L	0.586	0.94
132_P	135_G	0.585	0.94
61_F	93_Y	0.583	0.94
103_T	107_A	0.579	0.94
100_L	145_F	0.568	0.93
88_Y	120_R	0.567	0.93
150_F	154_V	0.564	0.93
32_A	86_D	0.563	0.93
28_V	84_I	0.560	0.93
151_L	154_V	0.558	0.92
57_E	145_F	0.551	0.92
66_A	118_W	0.550	0.92
16_V	174_A	0.550	0.92
53_D	67_D	0.550	0.92
58_L	108_M	0.549	0.92
58_L	89_S	0.546	0.92
6_E	127_Y	0.546	0.92
19_S	185_A	0.544	0.91
5_L	128_F	0.543	0.91
99_T	154_V	0.542	0.91
183_A	186_E	0.541	0.91
16_V	23_S	0.540	0.91
33_E	65_H	0.539	0.91
46_S	52_A	0.539	0.91
31_T	83_V	0.539	0.91
50_A	71_R	0.535	0.91
2_L	77_L	0.535	0.91
20_L	182_I	0.535	0.91
89_S	92_R	0.533	0.91
113_G	121_P	0.532	0.90
5_L	32_A	0.532	0.90
58_L	92_R	0.532	0.90
85_S	88_Y	0.531	0.90
4_T	125_T	0.531	0.90
31_T	76_A	0.528	0.90
40_G	43_V	0.527	0.90
62_T	111_V	0.525	0.90
115_H	119_T	0.523	0.90
17_W	21_R	0.519	0.89
138_R	174_A	0.519	0.89
6_E	95_Y	0.518	0.89
107_A	110_Y	0.515	0.89
68_H	72_V	0.515	0.89
116_Q	119_T	0.514	0.89
59_F	114_I	0.514	0.89
108_M	112_R	0.507	0.88
48_S	52_A	0.505	0.88
106_R	109_E	0.503	0.88
56_A	59_F	0.501	0.88
103_T	108_M	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3czpA	2	0.8342	100	0.378	Contact Map
2plrA	2	0.9497	100	0.418	Contact Map
3hjnA	2	0.9347	100	0.422	Contact Map
1nn5A	2	0.9497	100	0.429	Contact Map
1gtvA	2	0.9296	100	0.44	Contact Map
2yogA	1	0.9146	100	0.441	Contact Map
2pbrA	2	0.9648	100	0.452	Contact Map
4edhA	2	0.9749	100	0.456	Contact Map
1p6xA	3	0.9799	100	0.456	Contact Map
3czqA	3	0.8643	100	0.457	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.