GREMLIN Database
KTHY - Probable thymidylate kinase
UniProt: Q9HNV4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (189)
Sequences: 4632 (3517)
Seq/√Len: 255.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_Q184_D3.7971.00
23_S186_E3.2481.00
128_F174_A2.9581.00
19_S182_I2.8901.00
98_A157_N2.6741.00
129_D155_R2.4981.00
176_Q180_A2.4391.00
29_T81_D2.3061.00
177_S180_A2.2001.00
134_T137_A2.1641.00
67_D71_R2.1151.00
155_R159_E2.0881.00
143_N146_E2.0671.00
31_T68_H1.9981.00
172_I181_V1.9851.00
17_W84_I1.9461.00
17_W30_F1.9401.00
129_D159_E1.8971.00
21_R30_F1.8891.00
70_S74_S1.8791.00
16_V185_A1.8171.00
16_V182_I1.8091.00
21_R25_D1.7611.00
74_S78_D1.7351.00
182_I186_E1.7021.00
131_D175_T1.6821.00
11_S130_V1.6691.00
170_V188_A1.6671.00
159_E171_R1.6451.00
21_R84_I1.6151.00
126_L188_A1.5931.00
90_D168_R1.5551.00
127_Y169_F1.5421.00
130_V134_T1.5131.00
110_Y113_G1.5011.00
16_V19_S1.5001.00
170_V192_A1.4741.00
152_A156_A1.4381.00
160_Q164_Y1.4311.00
156_A160_Q1.3931.00
2_L85_S1.3881.00
23_S190_A1.3751.00
20_L189_L1.3651.00
23_S182_I1.3601.00
76_A81_D1.3581.00
126_L185_A1.3521.00
4_T85_S1.3511.00
39_Y52_A1.3391.00
74_S120_R1.3371.00
43_V60_L1.3321.00
27_G190_A1.3311.00
162_I171_R1.3261.00
186_E190_A1.3211.00
127_Y171_R1.3191.00
128_F185_A1.3151.00
134_T175_T1.3031.00
53_D70_S1.3021.00
8_L151_L1.3001.00
41_Q64_D1.2981.00
132_P148_A1.2851.00
29_T76_A1.2821.00
148_A152_A1.2671.00
9_D135_G1.2601.00
42_A45_R1.2571.00
5_L20_L1.2501.00
19_S178_P1.2341.00
90_D125_T1.2321.00
160_Q163_D1.2241.00
188_A192_A1.2241.00
66_A70_S1.2061.00
19_S179_E1.2041.00
4_T90_D1.2001.00
94_A98_A1.1951.00
109_E113_G1.1791.00
109_E164_Y1.1691.00
135_G139_S1.1571.00
182_I185_A1.1531.00
58_L62_T1.1401.00
127_Y162_I1.1361.00
133_D152_A1.1351.00
37_S40_G1.1291.00
172_I188_A1.1211.00
130_V135_G1.1191.00
21_R28_V1.1171.00
149_A152_A1.1111.00
149_A153_D1.1081.00
18_E22_A1.1081.00
188_A191_D1.1001.00
184_D187_A1.0941.00
178_P182_I1.0871.00
161_L169_F1.0841.00
15_T178_P1.0811.00
23_S27_G1.0801.00
127_Y159_E1.0741.00
69_L120_R1.0721.00
31_T85_S1.0661.00
126_L170_V1.0651.00
62_T92_R1.0621.00
131_D134_T1.0481.00
136_A148_A1.0421.00
184_D188_A1.0421.00
30_F84_I1.0421.00
55_I107_A1.0391.00
29_T72_V1.0381.00
124_V170_V1.0331.00
28_V82_V1.0281.00
183_A187_A1.0241.00
121_P165_T1.0231.00
100_L150_F1.0221.00
180_A184_D1.0091.00
40_G64_D1.0071.00
16_V178_P1.0071.00
53_D66_A1.0051.00
127_Y155_R1.0001.00
23_S183_A0.9991.00
124_V192_A0.9981.00
62_T89_S0.9971.00
6_E91_S0.9871.00
116_Q120_R0.9741.00
132_P155_R0.9621.00
64_D68_H0.9611.00
103_T106_R0.9601.00
25_D28_V0.9571.00
173_D176_Q0.9521.00
89_S121_P0.9511.00
136_A139_S0.9501.00
55_I70_S0.9231.00
124_V188_A0.9151.00
187_A190_A0.9081.00
61_F145_F0.9081.00
55_I114_I0.9061.00
130_V174_A0.9031.00
101_A153_D0.8991.00
90_D169_F0.8971.00
89_S116_Q0.8931.00
126_L172_I0.8931.00
159_E162_I0.8871.00
99_T153_D0.8851.00
37_S72_V0.8841.00
187_A191_D0.8831.00
93_Y161_L0.8821.00
19_S22_A0.8691.00
136_A140_G0.8681.00
14_T18_E0.8651.00
62_T112_R0.8641.00
107_A114_I0.8621.00
112_R115_H0.8621.00
33_E68_H0.8430.99
8_L135_G0.8390.99
133_D148_A0.8390.99
73_V83_V0.8380.99
106_R110_Y0.8380.99
2_L88_Y0.8350.99
28_V81_D0.8270.99
139_S142_T0.8240.99
4_T168_R0.8190.99
9_D151_L0.8160.99
49_A52_A0.8110.99
22_A26_D0.8080.99
47_E61_F0.8070.99
18_E30_F0.8000.99
75_P79_R0.7940.99
22_A25_D0.7920.99
68_H85_S0.7880.99
72_V76_A0.7870.99
94_A99_T0.7870.99
62_T115_H0.7800.99
162_I169_F0.7760.99
16_V20_L0.7740.99
180_A183_A0.7710.99
157_N160_Q0.7660.99
18_E21_R0.7640.99
53_D56_A0.7570.99
5_L185_A0.7560.99
23_S26_D0.7490.99
129_D171_R0.7410.99
94_A157_N0.7370.98
153_D156_A0.7350.98
27_G81_D0.7230.98
172_I185_A0.7210.98
126_L189_L0.7200.98
65_H92_R0.7170.98
10_G139_S0.7150.98
5_L17_W0.7120.98
109_E112_R0.7070.98
27_G186_E0.7060.98
69_L73_V0.7040.98
109_E165_T0.6980.98
143_N147_T0.6950.98
4_T169_F0.6950.98
40_G67_D0.6930.98
95_Y150_F0.6920.98
76_A79_R0.6920.98
125_T168_R0.6910.98
132_P152_A0.6860.98
8_L127_Y0.6860.98
42_A49_A0.6820.97
58_L111_V0.6780.97
39_Y42_A0.6620.97
42_A48_S0.6550.97
14_T32_A0.6540.97
165_T169_F0.6480.97
32_A36_D0.6480.97
34_P65_H0.6430.96
89_S112_R0.6430.96
93_Y104_V0.6410.96
56_A66_A0.6400.96
116_Q121_P0.6340.96
133_D137_A0.6340.96
24_H27_G0.6330.96
56_A63_A0.6330.96
5_L16_V0.6290.96
16_V181_V0.6290.96
5_L126_L0.6270.96
181_V184_D0.6260.96
16_V128_F0.6250.96
178_P181_V0.6230.96
89_S115_H0.6200.96
55_I118_W0.6110.95
76_A83_V0.6090.95
94_A154_V0.6080.95
165_T168_R0.6070.95
61_F64_D0.6040.95
11_S135_G0.6030.95
32_A41_Q0.6000.95
32_A35_T0.6000.95
109_E121_P0.5980.95
69_L74_S0.5960.95
99_T150_F0.5940.94
91_S158_Y0.5910.94
35_T44_R0.5870.94
69_L115_H0.5870.94
62_T108_M0.5860.94
92_R96_Q0.5860.94
99_T151_L0.5860.94
132_P135_G0.5850.94
61_F93_Y0.5830.94
103_T107_A0.5790.94
100_L145_F0.5680.93
88_Y120_R0.5670.93
150_F154_V0.5640.93
32_A86_D0.5630.93
28_V84_I0.5600.93
151_L154_V0.5580.92
57_E145_F0.5510.92
66_A118_W0.5500.92
16_V174_A0.5500.92
53_D67_D0.5500.92
58_L108_M0.5490.92
58_L89_S0.5460.92
6_E127_Y0.5460.92
19_S185_A0.5440.91
5_L128_F0.5430.91
99_T154_V0.5420.91
183_A186_E0.5410.91
16_V23_S0.5400.91
33_E65_H0.5390.91
46_S52_A0.5390.91
31_T83_V0.5390.91
50_A71_R0.5350.91
2_L77_L0.5350.91
20_L182_I0.5350.91
89_S92_R0.5330.91
113_G121_P0.5320.90
5_L32_A0.5320.90
58_L92_R0.5320.90
85_S88_Y0.5310.90
4_T125_T0.5310.90
31_T76_A0.5280.90
40_G43_V0.5270.90
62_T111_V0.5250.90
115_H119_T0.5230.90
17_W21_R0.5190.89
138_R174_A0.5190.89
6_E95_Y0.5180.89
107_A110_Y0.5150.89
68_H72_V0.5150.89
116_Q119_T0.5140.89
59_F114_I0.5140.89
108_M112_R0.5070.88
48_S52_A0.5050.88
106_R109_E0.5030.88
56_A59_F0.5010.88
103_T108_M0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3czpA 2 0.8342 100 0.378 Contact Map
2plrA 2 0.9497 100 0.418 Contact Map
3hjnA 2 0.9347 100 0.422 Contact Map
1nn5A 2 0.9497 100 0.429 Contact Map
1gtvA 2 0.9296 100 0.44 Contact Map
2yogA 1 0.9146 100 0.441 Contact Map
2pbrA 2 0.9648 100 0.452 Contact Map
4edhA 2 0.9749 100 0.456 Contact Map
1p6xA 3 0.9799 100 0.456 Contact Map
3czqA 3 0.8643 100 0.457 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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