GREMLIN Database
Q9HNV2 - Cell division protein
UniProt: Q9HNV2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (279)
Sequences: 2731 (1326)
Seq/√Len: 79.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_A112_T4.7761.00
39_I77_K4.2741.00
39_I78_H4.1621.00
69_S109_S4.0991.00
112_T115_R3.9161.00
191_S294_Q3.8391.00
96_S126_D3.8281.00
38_D41_E3.2431.00
77_K116_E3.1941.00
59_V72_S3.0611.00
196_N228_S3.0581.00
197_N265_G3.0181.00
44_G47_D2.9951.00
89_G117_V2.9741.00
117_V120_L2.9731.00
193_T294_Q2.8081.00
77_K81_R2.7001.00
252_L270_R2.6561.00
93_L103_T2.6231.00
63_L110_F2.6151.00
141_E144_E2.5761.00
144_E147_V2.4261.00
176_I180_A2.3501.00
179_L302_S2.3151.00
43_Q81_R2.2801.00
39_I43_Q2.1891.00
259_K290_S2.1641.00
100_G104_L2.1561.00
32_A36_E2.1021.00
104_L108_R2.0931.00
93_L107_A2.0771.00
33_E36_E2.0591.00
256_G261_L2.0431.00
89_G120_L2.0411.00
43_Q82_I2.0061.00
43_Q78_H1.9361.00
228_S231_R1.9211.00
49_I57_F1.9121.00
227_T268_R1.9011.00
111_Q115_R1.8731.00
192_E228_S1.8391.00
46_I82_I1.8111.00
156_A170_V1.7751.00
147_V151_G1.7731.00
41_E44_G1.7461.00
12_V45_A1.7231.00
234_A299_V1.6901.00
46_I57_F1.6781.00
230_V273_L1.6641.00
191_S296_A1.6461.00
271_K275_D1.6371.00
108_R112_T1.6071.00
178_T249_R1.6031.00
132_G264_K1.6021.00
29_E33_E1.5901.00
40_D43_Q1.5811.00
227_T231_R1.5771.00
35_A71_G1.5691.00
78_H82_I1.5530.99
266_I284_G1.5500.99
166_A287_Y1.5490.99
134_S137_G1.5410.99
257_P260_Y1.5380.99
89_G113_F1.5370.99
36_E77_K1.5370.99
260_Y293_D1.5180.99
119_N179_L1.5160.99
29_E32_A1.4800.99
26_A177_N1.4720.99
167_E286_D1.4640.99
61_S91_G1.4400.99
267_E271_K1.4220.99
20_K55_D1.4200.99
168_S284_G1.3980.99
194_V197_N1.3730.99
261_L295_V1.3700.99
133_E138_G1.3590.99
42_V78_H1.3390.98
250_A277_T1.3380.98
26_A283_R1.3350.98
186_T242_C1.3310.98
107_A111_Q1.3050.98
90_I150_F1.2940.98
137_G140_D1.2850.98
135_V286_D1.2780.98
149_R187_I1.2660.98
236_G240_L1.2600.98
101_I281_E1.2340.97
136_Q288_P1.2340.97
249_R280_M1.2330.97
49_I84_T1.2150.97
140_D143_N1.2100.97
249_R278_G1.2050.97
277_T280_M1.1970.97
119_N182_G1.1970.97
27_D177_N1.1840.97
112_T116_E1.1780.96
14_I71_G1.1560.96
253_V287_Y1.1470.96
16_Q41_E1.1340.96
231_R235_L1.1260.95
198_S230_V1.1070.95
57_F84_T1.1040.95
193_T293_D1.1000.95
127_A130_K1.0990.95
229_L297_S1.0990.95
13_L16_Q1.0880.95
269_G295_V1.0830.94
108_R111_Q1.0760.94
99_G282_V1.0700.94
129_R267_E1.0690.94
245_E276_Q1.0690.94
151_G155_G1.0610.94
314_Q318_I1.0470.93
12_V42_V1.0420.93
18_R33_E1.0390.93
128_W142_I1.0240.93
260_Y292_S1.0160.92
57_F75_I1.0100.92
43_Q47_D1.0070.92
101_I105_N1.0060.92
96_S271_K0.9990.92
166_A253_V0.9980.92
255_A287_Y0.9950.91
55_D129_R0.9900.91
10_N45_A0.9880.91
133_E264_K0.9870.91
178_T283_R0.9840.91
135_V139_Y0.9820.91
24_V30_L0.9790.91
227_T272_W0.9700.90
271_K274_E0.9620.90
42_V46_I0.9580.90
103_T107_A0.9560.90
40_D44_G0.9530.90
132_G262_N0.9530.90
256_G266_I0.9440.89
261_L266_I0.9430.89
102_Y283_R0.9420.89
249_R303_G0.9370.89
93_L124_D0.9320.88
46_I49_I0.9300.88
134_S262_N0.9230.88
289_V296_A0.9200.88
272_W275_D0.9160.88
110_F122_V0.9100.87
128_W263_R0.9100.87
248_E278_G0.9040.87
318_I321_Q0.9010.87
196_N268_R0.9000.87
128_W143_N0.9000.87
228_S232_K0.8940.86
252_L297_S0.8940.86
310_I313_L0.8860.86
270_R284_G0.8810.86
143_N270_R0.8800.85
27_D33_E0.8800.85
5_H271_K0.8790.85
126_D129_R0.8760.85
256_G295_V0.8720.85
313_L319_E0.8670.85
126_D130_K0.8610.84
74_V78_H0.8600.84
7_P10_N0.8570.84
316_V321_Q0.8550.84
313_L317_A0.8500.83
155_G158_E0.8490.83
188_G233_A0.8480.83
104_L107_A0.8460.83
310_I314_Q0.8450.83
149_R240_L0.8420.83
236_G304_V0.8370.82
111_Q114_V0.8250.82
182_G189_Y0.8170.81
198_S295_V0.8120.81
63_L91_G0.8100.80
127_A236_G0.8060.80
35_A42_V0.8050.80
114_V184_V0.8050.80
272_W276_Q0.8040.80
184_V252_L0.7980.79
269_G297_S0.7980.79
134_S147_V0.7900.79
310_I315_E0.7850.78
74_V77_K0.7810.78
131_S264_K0.7760.77
231_R272_W0.7750.77
160_E167_E0.7680.77
178_T280_M0.7660.77
249_R281_E0.7650.76
181_G240_L0.7600.76
93_L240_L0.7600.76
59_V76_A0.7560.76
16_Q38_D0.7520.75
229_L233_A0.7520.75
93_L110_F0.7510.75
314_Q317_A0.7510.75
267_E274_E0.7490.75
177_N283_R0.7470.75
309_R312_E0.7460.75
61_S72_S0.7440.74
315_E318_I0.7430.74
56_A268_R0.7410.74
101_I104_L0.7360.74
35_A74_V0.7350.74
313_L316_V0.7340.73
30_L33_E0.7330.73
6_I11_R0.7300.73
143_N284_G0.7300.73
257_P262_N0.7280.73
56_A87_V0.7260.73
152_I187_I0.7240.72
153_L158_E0.7230.72
131_S268_R0.7220.72
18_R30_L0.7210.72
136_Q259_K0.7160.72
151_G289_V0.7160.72
59_V75_I0.7150.71
314_Q321_Q0.7140.71
23_G66_G0.7100.71
59_V89_G0.7090.71
80_K181_G0.7060.70
263_R286_D0.7040.70
250_A301_L0.7030.70
93_L300_L0.7010.70
56_A121_L0.6980.70
47_D82_I0.6960.69
11_R304_V0.6950.69
81_R177_N0.6950.69
130_K134_S0.6950.69
39_I42_V0.6950.69
156_A300_L0.6930.69
295_V307_V0.6930.69
104_L279_S0.6900.69
126_D267_E0.6900.69
192_E198_S0.6900.69
58_L185_S0.6890.69
194_V198_S0.6860.68
159_V287_Y0.6840.68
25_G66_G0.6840.68
182_G249_R0.6820.68
312_E321_Q0.6790.68
313_L318_I0.6740.67
84_T186_T0.6710.67
190_A229_L0.6700.66
151_G189_Y0.6700.66
312_E317_A0.6670.66
312_E316_V0.6650.66
315_E320_A0.6640.66
256_G288_P0.6620.66
308_P311_K0.6600.65
152_I170_V0.6590.65
316_V320_A0.6590.65
97_D284_G0.6570.65
309_R313_L0.6570.65
197_N262_N0.6540.65
157_G175_I0.6530.64
136_Q260_Y0.6520.64
4_E11_R0.6490.64
23_G68_G0.6470.64
313_L321_Q0.6450.64
78_H81_R0.6440.63
89_G110_F0.6410.63
105_N108_R0.6390.63
261_L284_G0.6380.63
311_K319_E0.6360.62
130_K227_T0.6350.62
26_A105_N0.6340.62
105_N304_V0.6330.62
184_V305_N0.6320.62
14_I46_I0.6310.62
110_F120_L0.6290.62
158_E252_L0.6280.61
11_R44_G0.6260.61
314_Q319_E0.6250.61
103_T126_D0.6240.61
17_S37_E0.6240.61
119_N227_T0.6230.61
152_I298_V0.6230.61
314_Q320_A0.6210.61
56_A179_L0.6210.61
189_Y240_L0.6200.61
167_E288_P0.6180.60
248_E303_G0.6180.60
311_K315_E0.6130.60
158_E260_Y0.6110.59
13_L63_L0.6110.59
35_A150_F0.6100.59
256_G264_K0.6090.59
40_D45_A0.6090.59
315_E319_E0.6090.59
177_N281_E0.6060.59
60_I146_I0.6060.59
130_K136_Q0.6060.59
143_N266_I0.6050.59
14_I136_Q0.6040.59
4_E111_Q0.6040.59
13_L37_E0.6030.58
254_T264_K0.6030.58
90_I146_I0.6010.58
260_Y282_V0.5990.58
89_G153_L0.5990.58
124_D145_E0.5990.58
123_F177_N0.5980.58
21_G66_G0.5970.58
5_H160_E0.5960.58
264_K267_E0.5920.57
122_V130_K0.5920.57
243_E250_A0.5920.57
192_E297_S0.5920.57
160_E287_Y0.5910.57
14_I38_D0.5900.57
119_N133_E0.5890.57
91_G122_V0.5880.56
153_L175_I0.5880.56
317_A320_A0.5860.56
300_L304_V0.5850.56
129_R264_K0.5850.56
243_E276_Q0.5830.56
170_V283_R0.5820.56
20_K140_D0.5810.56
262_N288_P0.5810.56
255_A302_S0.5800.55
248_E305_N0.5800.55
149_R241_P0.5790.55
230_V254_T0.5780.55
41_E47_D0.5780.55
263_R281_E0.5780.55
179_L185_S0.5770.55
190_A233_A0.5760.55
60_I132_G0.5750.55
119_N185_S0.5740.55
6_I243_E0.5740.55
280_M296_A0.5740.55
227_T275_D0.5730.55
26_A34_I0.5720.54
277_T282_V0.5720.54
308_P313_L0.5710.54
49_I55_D0.5690.54
80_K232_K0.5690.54
309_R320_A0.5680.54
128_W170_V0.5670.54
138_G263_R0.5650.54
45_A49_I0.5650.54
97_D139_Y0.5640.53
309_R318_I0.5620.53
257_P292_S0.5620.53
173_S247_S0.5590.53
139_Y168_S0.5580.53
129_R152_I0.5570.53
312_E315_E0.5530.52
309_R319_E0.5530.52
310_I317_A0.5520.52
307_V310_I0.5520.52
60_I142_I0.5510.52
317_A321_Q0.5510.52
298_V304_V0.5510.52
311_K318_I0.5500.52
182_G302_S0.5500.52
182_G280_M0.5490.51
134_S306_D0.5480.51
55_D173_S0.5480.51
193_T309_R0.5460.51
6_I122_V0.5450.51
12_V38_D0.5450.51
27_D108_R0.5450.51
36_E39_I0.5440.51
315_E321_Q0.5430.51
26_A150_F0.5410.50
154_F157_G0.5400.50
121_L147_V0.5380.50
123_F142_I0.5380.50
91_G113_F0.5360.50
28_N35_A0.5350.50
101_I279_S0.5340.50
135_V182_G0.5340.50
38_D184_V0.5330.49
123_F311_K0.5330.49
133_E304_V0.5330.49
168_S286_D0.5310.49
39_I81_R0.5310.49
38_D75_I0.5310.49
131_S195_D0.5300.49
87_V302_S0.5280.49
57_F79_L0.5270.49
231_R251_L0.5260.49
259_K292_S0.5260.49
188_G275_D0.5250.48
80_K267_E0.5250.48
117_V253_V0.5240.48
313_L320_A0.5230.48
137_G264_K0.5220.48
124_D241_P0.5200.48
72_S75_I0.5190.48
197_N261_L0.5190.48
38_D259_K0.5170.47
100_G278_G0.5140.47
152_I160_E0.5130.47
234_A272_W0.5120.47
10_N251_L0.5120.47
58_L175_I0.5100.46
232_K235_L0.5090.46
254_T269_G0.5080.46
56_A175_I0.5070.46
8_E74_V0.5070.46
151_G159_V0.5060.46
135_V266_I0.5050.46
114_V305_N0.5050.46
308_P315_E0.5050.46
149_R189_Y0.5040.46
86_P172_S0.5040.46
310_I321_Q0.5020.45
159_V300_L0.5020.45
123_F129_R0.5010.45
29_E108_R0.5000.45
32_A235_L0.5000.45
121_L143_N0.5000.45
245_E300_L0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b46A 1 0.8171 100 0.354 Contact Map
2r751 1 0.8057 100 0.387 Contact Map
2vapA 1 0.7914 100 0.392 Contact Map
4b45A 1 0.8314 100 0.396 Contact Map
2vawA 1 0.7543 100 0.397 Contact Map
4m8iA 1 0.7686 100 0.399 Contact Map
4ei7A 1 0.84 100 0.399 Contact Map
1ofuA 1 0.7571 100 0.4 Contact Map
1rq2A 2 0.74 100 0.401 Contact Map
2vxyA 2 0.7543 100 0.402 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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