GREMLIN Database
COFC - 2-phospho-L-lactate guanylyltransferase
UniProt: Q9HNV0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (183)
Sequences: 648 (481)
Seq/√Len: 35.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_A161_R3.6711.00
176_F180_T3.5111.00
48_P52_A3.4991.00
52_A55_P3.2411.00
75_V88_V2.9091.00
134_S142_D2.7731.00
110_D131_V2.6231.00
3_T41_V2.5761.00
104_V162_L2.5461.00
17_A26_R2.5051.00
104_V123_V2.2750.99
52_A56_V2.2000.99
168_D171_D2.1750.99
3_T87_A2.1670.99
124_V131_V2.0770.99
32_A36_D2.0610.99
46_G52_A2.0480.99
123_V162_L2.0410.99
44_A102_R2.0120.98
7_F34_L2.0040.98
147_A151_G1.9420.98
48_P54_A1.9350.98
41_V89_V1.8720.97
6_P53_T1.8610.97
35_A182_R1.8340.97
45_G102_R1.8280.97
116_G164_A1.8140.97
29_F183_T1.7730.96
111_V125_L1.7490.96
72_S75_V1.7360.96
49_V52_A1.7260.96
147_A152_L1.7100.96
3_T101_I1.7060.96
26_R33_M1.6770.95
70_A78_A1.6670.95
48_P53_T1.6630.95
5_V38_L1.6540.95
184_R188_I1.5800.93
72_S133_V1.5720.93
87_A125_L1.5660.93
4_V78_A1.5620.93
121_T124_V1.5460.92
155_T160_F1.5160.92
113_L159_S1.4170.89
96_A100_A1.3980.88
36_D40_A1.3810.87
37_V163_A1.3500.86
33_M187_L1.3370.86
176_F187_L1.3300.85
110_D124_V1.3240.85
115_P140_F1.3120.84
173_V176_F1.3080.84
48_P63_P1.2860.83
78_A103_R1.2720.83
137_G158_D1.2560.82
8_D167_D1.2530.82
5_V41_V1.2480.81
71_L93_L1.2420.81
111_V115_P1.2300.80
67_D87_A1.2270.80
46_G53_T1.2190.80
38_L60_V1.2010.79
41_V101_I1.1940.78
147_A157_V1.1770.77
70_A77_A1.1760.77
20_F106_A1.1750.77
172_L175_V1.1720.77
34_L161_R1.1660.77
30_A116_G1.1650.77
76_A132_P1.1650.77
166_V172_L1.1640.77
6_P122_N1.1560.76
50_V108_S1.1500.76
34_L91_A1.1410.75
112_V140_F1.1370.75
117_S171_D1.1280.74
3_T33_M1.1160.73
70_A74_A1.1060.73
75_V135_Y1.1040.73
26_R30_A1.1000.72
87_A105_F1.0920.72
124_V171_D1.0880.71
30_A34_L1.0610.70
56_V169_A1.0450.68
9_P12_P1.0350.68
115_P122_N1.0280.67
90_M116_G1.0080.66
130_D182_R1.0060.65
19_F169_A1.0060.65
8_D41_V0.9980.65
75_V91_A0.9960.65
7_F90_M0.9940.64
35_A39_G0.9850.64
164_A174_D0.9730.63
151_G155_T0.9720.63
141_R145_T0.9670.62
89_V163_A0.9550.61
79_I86_T0.9550.61
14_S171_D0.9520.61
50_V54_A0.9460.61
79_I133_V0.9380.60
61_D112_V0.9370.60
73_T102_R0.9330.59
147_A154_V0.9200.58
77_A91_A0.9200.58
69_R177_V0.9180.58
36_D183_T0.9170.58
6_P116_G0.9060.57
14_S43_D0.9000.57
50_V85_P0.8940.56
74_A78_A0.8710.54
151_G154_V0.8640.54
40_A98_P0.8640.54
20_F187_L0.8630.54
51_V145_T0.8630.54
121_T171_D0.8630.54
113_L162_L0.8590.53
36_D181_R0.8570.53
75_V79_I0.8450.52
122_N147_A0.8400.52
48_P56_V0.8380.51
87_A104_V0.8370.51
93_L171_D0.8350.51
170_S173_V0.8340.51
12_P30_A0.8270.50
94_A100_A0.8190.50
29_F51_V0.8160.49
5_V34_L0.8130.49
18_E169_A0.8110.49
174_D178_H0.8080.49
24_E170_S0.7980.48
76_A133_V0.7950.48
66_V169_A0.7940.48
130_D141_R0.7930.47
7_F33_M0.7920.47
88_V175_V0.7900.47
13_K16_L0.7900.47
95_L178_H0.7860.47
46_G55_P0.7850.47
152_L155_T0.7840.47
105_F116_G0.7770.46
91_A171_D0.7760.46
47_D185_E0.7750.46
98_P170_S0.7730.46
168_D179_N0.7680.45
11_D81_D0.7670.45
117_S164_A0.7660.45
5_V65_T0.7620.45
37_V89_V0.7600.45
5_V157_V0.7500.44
137_G174_D0.7480.44
67_D136_H0.7440.43
73_T84_L0.7420.43
41_V47_D0.7390.43
182_R185_E0.7370.43
73_T90_M0.7280.42
147_A155_T0.7260.42
100_A104_V0.7240.42
33_M36_D0.7190.41
170_S188_I0.7180.41
12_P159_S0.7170.41
119_G137_G0.7140.41
20_F77_A0.7130.41
85_P128_T0.7120.41
38_L91_A0.7120.41
112_V144_V0.7110.40
101_I126_A0.7090.40
31_Y168_D0.7060.40
74_A86_T0.6970.39
62_A185_E0.6950.39
32_A166_V0.6940.39
41_V60_V0.6930.39
128_T132_P0.6930.39
110_D152_L0.6910.39
104_V125_L0.6900.39
91_A163_A0.6850.38
26_R142_D0.6810.38
63_P109_G0.6800.38
38_L140_F0.6800.38
125_L147_A0.6790.38
18_E50_V0.6750.38
54_A62_A0.6750.38
45_G114_A0.6710.37
120_G139_S0.6660.37
120_G165_D0.6660.37
139_S165_D0.6660.37
92_D120_G0.6660.37
92_D165_D0.6660.37
92_D139_S0.6660.37
39_G56_V0.6630.37
115_P163_A0.6610.36
112_V116_G0.6600.36
33_M37_V0.6570.36
20_F33_M0.6520.36
138_V142_D0.6510.36
10_R182_R0.6490.35
180_T184_R0.6440.35
33_M182_R0.6370.34
151_G157_V0.6360.34
75_V86_T0.6350.34
39_G173_V0.6330.34
3_T169_A0.6330.34
112_V115_P0.6310.34
67_D121_T0.6280.34
7_F30_A0.6250.34
4_V27_R0.6210.33
79_I164_A0.6210.33
76_A177_V0.6200.33
94_A126_A0.6180.33
8_D12_P0.6170.33
4_V134_S0.6170.33
20_F70_A0.6150.33
97_T164_A0.6140.33
4_V177_V0.6120.33
94_A97_T0.6100.32
41_V162_L0.6070.32
72_S91_A0.6050.32
70_A73_T0.6050.32
134_S146_A0.6020.32
48_P99_D0.6010.32
6_P34_L0.6010.32
151_G158_D0.6010.32
133_V136_H0.5980.32
7_F12_P0.5950.31
6_P90_M0.5930.31
21_A160_F0.5910.31
43_D47_D0.5880.31
38_L77_A0.5870.31
19_F84_L0.5830.30
76_A91_A0.5830.30
94_A135_Y0.5810.30
30_A167_D0.5800.30
31_Y100_A0.5770.30
31_Y35_A0.5760.30
14_S73_T0.5750.30
36_D133_V0.5750.30
31_Y75_V0.5710.30
145_T185_E0.5680.29
21_A96_A0.5670.29
10_R17_A0.5640.29
6_P33_M0.5600.29
126_A131_V0.5590.29
25_E186_W0.5580.29
175_V181_R0.5580.29
21_A65_T0.5580.29
48_P55_P0.5540.28
37_V111_V0.5540.28
6_P123_V0.5540.28
108_S125_L0.5530.28
12_P100_A0.5510.28
27_R111_V0.5510.28
104_V113_L0.5500.28
30_A119_G0.5500.28
12_P34_L0.5490.28
111_V147_A0.5440.28
38_L73_T0.5410.27
97_T100_A0.5390.27
111_V163_A0.5390.27
96_A162_L0.5370.27
30_A44_A0.5350.27
122_N161_R0.5300.27
185_E188_I0.5290.27
4_V70_A0.5280.27
3_T81_D0.5280.27
27_R187_L0.5250.26
175_V180_T0.5250.26
18_E26_R0.5230.26
40_A44_A0.5210.26
118_G166_V0.5110.25
21_A186_W0.5100.25
95_L163_A0.5040.25
35_A184_R0.5040.25
118_G173_V0.5010.25
14_S66_V0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i5eA 2 0.9761 100 0.52 Contact Map
3cgxA 1 0.9043 99.9 0.596 Contact Map
2weeA 1 0.8134 99 0.802 Contact Map
3rsbA 1 0.7656 99 0.804 Contact Map
2dpwA 1 0.8086 99 0.804 Contact Map
2wawA 1 0.8325 98.9 0.807 Contact Map
2px7A 2 0.8086 98.9 0.812 Contact Map
3d5nA 2 0.7703 98.8 0.815 Contact Map
4kt7A 4 0.823 98.7 0.821 Contact Map
2xwlA 2 0.866 98.7 0.821 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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